Clinical trials: sponsored by Peking University Third Hospital
Recurrent Implantation Failure
Zishen Yutai Pill for Patients With Recurrent Implantation Failure
The goal of this clinical trial is to evaluate the efficacy of Zishen Yutai Pill (ZYP) on pregnancy outcomes following embryo transfer and its safety in patients with recurrent implantation failure.
- Trial name
- NCT07641088
- Testing
- Zishen Yutai Pill
- Where
- 13 sites in China
- Volunteers
- 878 people
- Sponsor
- Peking University Third Hospital
Cardiac Arrest (CA), Post Cardiac Arrest Syndrome
TNF-α Antagonists Mitigate Systemic Inflammatory Response After Cardiac Arrest.
The investigators assessed the effect of TNF-α antagonism within 6 hours of return of spontaneous circulation on 30-day mortality in patients who remained comatose after cardiopulmonary resuscitation (CPR) following cardiac…
- Trial name
- NCT07176754
- Testing
- Infliximab
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Peking University Third Hospital
Articular, Range of Motion
Efficacy Evaluation of Intelligent Rehabilitation Programs Based on AI-Powered Digital Rehabilitation System for Subacromial Impingement Syndrome
This non-randomized controlled trial will compare the efficacy of a conventional rehabilitation program versus an AI-based digital rehabilitation system in patients with subacromial impingement syndrome (SIS).
- Trial name
- NCT07638761
- Testing
- Home-based Rehabilitation Training Combined with Intelligent Rehabilitation Training, Traditional Rehabilitation Training, Prescribe home-based rehabilitation prescriptions for home rehabilitation training
- Where
- China
- Volunteers
- 93 people
- Sponsor
- Peking University Third Hospital
Patellofemoral Pain
Mobile-Based Telerehabilitation With Sensors for Adherence and Efficacy in Chronic Patellofemoral Pain: A Randomized Controlled Trial
This study is a prospective, single-center trial involving 174 patients diagnosed with patellofemoral pain. The study adhered to ethical guidelines and obtained informed consent from all participants.
- Trial name
- NCT06651996
- Testing
- one session of face-to-face telerehabilitation tutorial (OST), Three session of face-to-face telerehabilitation tutorials (TST), Six session of face-to-face telerehabilitation tutorials (SST)
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Peking University Third Hospital
Spinal Muscular Atrophy (SMA)
Robot-assisted Training
The goal of this clinical trial is to evaluate the long-term effects of isokinetic rehabilitation training in patients with spinal muscular atrophy (SMA).
- Trial name
- NCT06648486
- Testing
- With the assistance of wearable isokinetic training robot （ 7 children with SMA type II）
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Peking University Third Hospital
Ankle Sprain, Hypermobility, Joint
Comparison of MBR + Suture Tape and MBR for CLAI : A Prospective Cohort Study
GJL is a risk factor for postoperative recurrent instability following an MBR for CLAI. Additional suture tape augmentation has been suggested to provide more strength and stability.
- Trial name
- NCT06897293
- Testing
- Modified Broström procedure + Suture tape augmentation operation, Modified Broström procedure operation
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Peking University Third Hospital
Female Fertility Decline, Diminished Ovarian Reserve
Early Prevention and Precision Management of Female Fertility Decline
Female fertility decline has become an important public health issue in China, with a substantial proportion of women of reproductive age experiencing reduced ovarian reserve.
- Conditions
- Female Fertility Decline, Diminished Ovarian Reserve, Reproductive Health, Infertility Prevention
- Trial name
- OvaRePred-Plus (NCT07581444)
- Testing
- Comprehensive Lifestyle Intervention, Routine Clinical Care
- Volunteers
- 384 people
- Sponsor
- Peking University Third Hospital
Antibiotic, Allergic Diseases
Probiotic Intervention on the Development of Allergic Diseases in Infants Exposed to Antibiotics Early in Life
Early antibiotic exposure is an important environmental factor that disrupts the establishment of the infant gut microbiota and leads to microbial dysbiosis.
- Conditions
- Antibiotic, Allergic Diseases, Infants, Probiotic
- Trial name
- NCT07532421
- Testing
- Probiotic mixture
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Coronary Artery Bypass
Prospective Cohort Study on Fuzheng Yangxin Prescription For Rapid Rehabilitation of Patients With Qi-Yin Deficiency Syndrome After Coronary Artery Bypass Grafting
Data from the Global Burden of Disease Study 2021, recently published in the Lancet, show that ischaemic heart disease remains the first most common cause of death worldwide.
- Trial name
- NCT06961136
- Testing
- Fuzheng Yangxin prescription
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University Third Hospital
Malignant Solid Brain Tumors, Glioblastoma (GBM)
NK Cell Therapy for Malignant Solid Brain Tumors
This is a multi-center, open-label investigator-initiated trial (IIT) designed to evaluate the safety, tolerability, and feasibility of combined intracranial and intravenous administration of ex vivo expanded and activated…
- Conditions
- Malignant Solid Brain Tumors, Glioblastoma (GBM), Glioblastoma Multiforme (GBM), Brain Metastasis
- Trial name
- NCT07552233
- Testing
- Autologous NK cells
- Where
- 4 sites in China
- Volunteers
- 27 people
- Sponsor
- Peking University Third Hospital
Diabetic Foot
Platelet Rich Plasma VS Platelet Fibrin Plasma in Treatment of Diabetes Related Wound：a Randomized Controlled Trial
The goal of this randomized control trial is to compare the efficacy and safety of Platelet Rich Plasma VS Platelet Fibrin Plasma in patients with diabetes foot ulcer.
- Trial name
- NCT05979584
- Testing
- Platelet Fibrin Plasma, Platelet Rich Plasma
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Peking University Third Hospital
Anterior Cruciate Ligament Rupture
Effects of Preoperative Rehabilitation on Tendon Healing, Bone Mineral Density, and Cartilage After ACLR and Patellar Dislocation
To explore the effect of preoperative exercise rehabilitation on bone mineral density, tendon bone healing, change of cartilage, and gait feature in patients with anterior cruciate ligament rupture.
- Trial name
- NCT05924178
- Testing
- exercise rehablitation, routine treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Ovarian Cancer, Breast Cancer
A Bidirectional Cohort Study on Prophylactic Resection Surgery in Populations at Moderate-to-High Risk for Hereditary Ovarian Cancer
The goal of this multi-center observational study is to learn about the effectiveness and safety of different prophylactic (preventive) surgical options in women at moderate-to-high genetic risk for hereditary ovarian cancer…
- Trial name
- NCT07532434
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Peking University Third Hospital
Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC)
Validation of RCC Predicting Model With Emulated-target Trial
This single-center study utilizes real-world data (2012-2024) from 4700 renal cell carcinoma (RCC) patients at Peking University Third Hospital to: (1) Develop and validate a prognostic prediction model specifically for RCC…
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC), Tumor Thrombus, Prognosis
- Trial name
- RCCETT (NCT07117227)
- Testing
- Model-guided adjuvant treatment, No adjuvant treatment
- Where
- China
- Volunteers
- 4,700 people
- Sponsor
- Peking University Third Hospital
Anterior Cruciate Ligament (ACL) Tear
Effects of a Preoperative Cognitive-Behavioral Intervention on Kinesiophobia and Function in Anterior Cruciate Ligament Reconstruction
This study aims to systematically elucidate the integrative effects of psychological rehabilitation on the "brain-psychology-motor" triad in patients with anterior cruciate ligament (ACL) rupture.
- Trial name
- NCT07423767
- Testing
- Cognitive-Behavioral Intervention, Control group
- Where
- 2 sites in China
- Volunteers
- 44 people
- Sponsor
- Peking University Third Hospital
Rheumatoid Arthritis
Prospective Cohort Study on Refractory Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic erosive arthritis. Without timely and appropriate treatment, it can lead to joint destruction and disability.
- Trial name
- NCT07126431
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
HRD-negative Epithelial Ovarian Cancer
A Single-center, Dose-escalation Clinical Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of Tumor Neoantigen-pulsed Autologous Dendritic Cell Injection (YS247) in Study Participants With HRD-negative Epithelial Ovarian Cancer
This is a single-center, open-label, dose-escalation, multiple-dose investigator-initiated exploratory study designed to evaluate the safety, tolerability and preliminary efficacy of tumor neoantigen-pulsed autologous dendritic…
- Trial name
- YS247 (NCT07455071)
- Testing
- Tumor Neoantigen-Sensitized Autologous Dendritic Cell Injection (YS247)
- Volunteers
- 9 people
- Sponsor
- Peking University Third Hospital
Diabetic Foot Disease, Diabete Mellitus
Detection of Diabetic Foot Skin Damage Using Plantar Mechanical Parameters
Diabetes represents one of the major chronic diseases, with diabetic ulcers being a significant adverse prognosis. Approximately 80% of lower limb amputations are attributed to diabetic foot ulcers, which constitute a primary…
- Conditions
- Diabetic Foot Disease, Diabete Mellitus, Mechanical Factor
- Trial name
- NCT07470255
- Testing
- Detection of the elastic modulus of the plantar skin
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Patellar Tendinopathy
Bilateral Lower Limb Biomechanics During Side-Cutting in Unilateral Patellar Tendinopathy
Patellar tendinopathy (PT) is a common overuse injury in sports that involve jumping and directional changes. The biomechanical differences between individuals with PT and healthy controls during side-cutting, as well as whether…
- Trial name
- NCT07463560
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
MCL, Relapsed or Refractory Mantle Cell Lymphoma (MCL)
Glofitamab Combined With Lenalidomide in High Risk Patients With Relapsed or Refractory Mantle Cell Lymphoma
A single-arm, open-label, multi-center clinical study of glofitamab combined with lenalidomide in high risk patients with relapsed or refractory Mantle Cell Lymphoma previously treated with a BTK Inhibitor.
- Trial name
- NCT07460362
- Testing
- Glofitamab, Lenalidomide
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Peking University Third Hospital