Clinical trials: sponsored by Penn State University
Cardiovascular Disease, Inflammation
Safety and Feasibility of an Endotoxemia Model
The purpose of this study is to establish the safety and feasibility of low dose LPS administration to a small subset of humans in preparation for a larger USDA funded study examining what is the lowest effective dose of EPA +…
- Trial name
- NCT01329965
- Testing
- LPS (reference endotoxin, E. coli O113:H10:K:neg, manufactured under GMP)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease, Hyperlipidemia
The Effect of Avocado on Cardiovascular Disease (CVD) Risk Factors
The investigators propose to evaluate the effects of avocado consumption (by incorporating 1 unit of fruit per day into a healthy diet) on multiple cardiovascular disease (CVD) risk factors.
- Trial name
- NCT01235832
- Testing
- Avocado Diet, Lower-Fat Diet, Moderate Fat Diet
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Penn State University
Cardiovascular Disease
Canola Oil Multicentre Intervention Trial (COMIT)
The objectives of this study are to examine how the consumption of treatment oils (including canola oil, DHA enriched canola-oil, high oleic acid canola oil, flax oil, and safflower oil) influence endothelial function…
- Trial name
- COMIT (NCT01233778)
- Testing
- Canola Oil, High Oleic Acid + DHA Canola Oil, High Oleic Acid Canola Oil
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Penn State University
Cardiovascular Disease
Effects of Freeze Dried Strawberry Powder Supplementation on Vascular Function and Blood Markers of Cardiovascular Risk
The purpose of this study is to evaluate the effects of freeze dried strawberry powder on LDL cholesterol, central and peripheral blood pressure, indices of arterial stiffness, and other lipid and lipoprotein concentrations.
- Trial name
- NCT02557334
- Testing
- Low Dose Strawberry Powder, High Dose Strawberry Powder
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Penn State University
Cardiovascular Diseases
Diet Quality, Pecans, and Cardiometabolic Health
A three-period, randomized, crossover controlled feeding trial will be conducted to examine the effect of including 2 oz./day of pecans, as a snack, in a diet representative of average American intake, compared to a diet…
- Trial name
- NCT04487808
- Testing
- Pecan, Average American Diet devoid of nuts
- Volunteers
- healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease, Inflammation
Effect of a Spice Blend on Cardiovascular Risk Factors and Diet Satisfaction
This study is a randomized 3-period crossover, controlled feeding study designed to evaluate the effects of the most commonly consumed spices in the U.S.
- Trial name
- NCT03064932
- Testing
- Controlled feeding diet
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Penn State University
Type 2 Diabetes Mellitus, Cardiovascular Diseases
The Effect of Potatoes on Markers of Cardiometabolic Health
A 2-period randomized cross-over trial will be conducted to determine the effect of incorporating 1 medium size potato, compared to an isocaloric portion of refined grains, on fasting glucose levels, insulin sensitivity, blood…
- Trial name
- NCT03495284
- Testing
- Potato-based side dish, Refined grain-based
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease Risk Factors
Effects of Cranberry Juice on Cardiovascular Risk Factors
The purpose of this study is to evaluate the effects of cranberry juice on central and peripheral blood pressure, indices of arterial stiffness, lipid and lipoprotein concentrations and size characteristics, and HDL function.
- Trial name
- NCT02556749
- Testing
- Cranberry Juice Beverage
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Penn State University
Cardiovascular Diseases, Metabolic Syndrome
Effect of Dried Fruit on Cardiometabolic Risk Factors
This is a 2-period randomized crossover study with free-living subjects on self-selected diets. The objective of this study is to compare the effects of ¾ cup of a blend of dried plums, figs, dates and raisins (DPFDR) with an…
- Trial name
- NCT03020758
- Testing
- Dried Fruit, High Carbohydrate Snack
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Penn State University
Nutrition, Diet Modification
Validation of a Diet Risk Screening Tool
Cardiovascular disease (CVD) is responsible for 1 in 4 deaths in the US annually. Nutrition is an important part of prevention and management of CVD and other chronic diseases, but only about 25% of patients with a chronic…
- Conditions
- Nutrition, Diet Modification, Preventive Medicine, Cardiovascular Diseases
- Trial name
- DRS (NCT03805373)
- Testing
- Diet Assessment Survey
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Penn State University
Type 2 Diabetes, Cardiovascular Diseases
Pistachios Blood Sugar Control, Heart and Gut Health
A two-period randomized crossover study will be conducted to evaluate the effect of nighttime pistachio consumption (i.e., after dinner and before sleep) on fasting blood sugar levels, longer-term blood sugar control, and risk…
- Trial name
- NCT04056208
- Testing
- Pistachio, Usual care
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Penn State University
Obesity, Cardiovascular Disease
The WORLD (Weight Optimization: Revamping Lifestyles Using the Dietary Guidelines) Study - Developing, Implementing, and Testing an Education Program
The WORLD study is a single-center, year-long randomized controlled trial in free-living women. Participants were randomly assigned to follow either a lower-fat (LF) diet or a moderate-fat (MF) diet for weight management in a…
- Trial name
- WORLD (NCT00847574)
- Testing
- Moderate-fat, Lower-fat
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Penn State University
Type2 Diabetes, Cardiovascular Diseases
Peanuts and Glycemic Control
A two-period randomized crossover study will be conducted to determine the effect of peanuts on glycemic control, and elucidate the role of the microbiome in glucose regulation, in individuals with impaired fasting glucose.
- Trial name
- NCT03654651
- Testing
- Peanut, High carbohydrate snack
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Penn State University
Stress, Psychological Stress
Understanding Everyday Stress
This research study is being done to better understand how people experience stress in everyday life and how that stress may relate to sleep and physical activity.
- Trial name
- NCT05502575
- Testing
- Self-monitoring and personalized stress management, Self-monitoring and general stress management
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Penn State University
Underage Drinking, Driving Under the Influence
Project MADD - NIH Underage DUI and Ride
Project MADD was designed to attempt to curb the alarming trends related to drunk driving and to move the field forward by testing a brief parent-intervention's ability to change adolescents' drinking, impaired driving, and…
- Conditions
- Underage Drinking, Driving Under the Influence, Drinking, Teen
- Trial name
- NCT03506880
- Testing
- MADD Materials, Surgeon General Materials
- Where
- United States
- Volunteers
- 2,352 people, healthy volunteers welcome
- Sponsor
- Penn State University
Overweight and Obesity, Physical Activity
Healthy Mom Zone: A Gestational Weight Gain Management Intervention
The purpose is to establish feasibility of delivering an individually-tailored, behavioral intervention to manage gestational weight gain [GWG] that adapts to the unique needs and challenges of overweight/obese pregnant women…
- Conditions
- Overweight and Obesity, Physical Activity, Weight Change, Body, Eating Behavior
- Trial name
- HMZ (NCT03945266)
- Testing
- Intervention group, Control group
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Penn State University
Appetite Self-regulation, Pediatric Obesity
Food Form & Energy Intake
This study primarily aims to examine how food presented in various forms (i.e., solid, semi-solid, and liquid) affects children's ability to self-regulate energy intake at a subsequent meal.
- Trial name
- NCT05258097
- Where
- 2 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Penn State University
Postmenopausal Women
Postmenopausal Women and Their Endothelium
The purpose of this study is to test the effects of a one time dose and 7-days of inorganic nitrate (supplied in the form of beetroot juice) on blood vessel function and resting blood pressure in healthy, postmenopausal women.
- Trial name
- NCT03644472
- Testing
- nitrate rich beetroot juice, nitrate depleted beetroot juice
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cannabis Use Disorder
Resistance Exercise and Cannabis Use
Cannabis is the most widely used illicit drug and rates of hazardous use, and cannabis use disorders (CUDs), have continued to rise in recent years.
- Trial name
- NCT03867786
- Testing
- Exercise, Video Control
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Penn State University
Stress, Externalizing Symptoms
Teenage Health and Wellness Study
This study evaluates the effects of mindfulness on physiological stress mechanisms implicated in externalizing behaviors and symptoms of affective and traumatic stress among urban adolescents.
- Conditions
- Stress, Externalizing Symptoms, Depression Symptoms, Anxiety
- Trial name
- THAW (NCT03989934)
- Testing
- The Mind in Action, Healthy Topics
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Penn State University