Clinical trials: sponsored by Penn State University
Achilles Tendon Rupture
NMES for Achilles Tendon Rupture
The majority of patients suffering an Achilles tendon rupture develop long term functional deficits in the affected leg. The goal of the proposed study is to evaluate a new rehabilitation protocol using Neuromuscular Electrical…
- Trial name
- NCT04727047
- Testing
- neuromuscular electrical stimulation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Penn State University
Lung Cancer
Piloting a Virtual Navigation (VN) System for Bronchoscopic Lung Nodule Sampling
The overall goal is to evaluate the role of a Virtual Navigation (VN) system (the Virtual Navigator) in the bronchoscopic evaluation and tissue sampling of lung cancer and other chest lesions at the Penn State Hershey Medical…
- Trial name
- NCT05599321
- Testing
- Virtual Navigation System
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Penn State University
Obesity, Childhood, Eating Behavior
Study of Brain, Reward, and Kids' Eating
Children from rural communities are at greater risk for obesity than children from more urban communities. However, some children are resilient to obesity despite greater exposure to obesogenic influences in rural communities…
- Trial name
- BRAKE (NCT05456516)
- Testing
- Food Rating
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Penn State University
Breast Cancer, Leukemia
HeartPhone Cancer Survivors Trial 2019
This is a behavioral study that will examine changes in physical activity and vascular health in response to a digital tool (app) that will appear on participant's lock screen of their Android phone.
- Conditions
- Breast Cancer, Leukemia, Lymphoma
- Trial name
- NCT03953326
- Testing
- HeartPhone app, Acetylcholine, Sodium Nitroprusside
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Penn State University
Alzheimer's Disease and Related Dementias
Smart Lighting for Nursing Home Residents With Dementia
This proposed study seeks to develop a smart ambient bright light (SABL) intervention to provide auto-controlled, consistent indoor lighting that incorporates natural daylight.
- Trial name
- NCT05825404
- Testing
- Smart Ambient Bright Light (SABL), Control
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Penn State University
Cardiovascular Diseases, Infant ALL
Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH)
This pilot study aims to examine the feasibility and acceptability of adding a cardiovascular health module to the existing Nurse Family Partnership (NFP) home visitation program delivered by trained nurses in the Northern…
- Conditions
- Cardiovascular Diseases, Infant ALL, Maternal Behavior, Childhood Obesity
- Trial name
- ENRICH (NCT05824741)
- Testing
- Infant Cardiovascular Health (CVH) Promotion
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Diseases, Pregnancy Related
Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) During Pregnancy
This pilot study aims to examine the feasibility and acceptability of adding a cardiovascular health module to the existing Nurse Family Partnership (NFP) home visitation program delivered by trained nurses in the Northern…
- Conditions
- Cardiovascular Diseases, Pregnancy Related, Sedentary Behavior
- Trial name
- ENRICH (NCT05822531)
- Testing
- Maternal CVH Intervention
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Penn State University
Social Anxiety Disorder
Efficacy of Virtual Reality Exposure Therapy Scripts for Social Phobia
The purpose of this study is to test the efficacy virtual reality videos to facilitate exposure therapy in social anxiety disorder (SAD). The exposure therapy videos are the focus of this experiment.
- Trial name
- NCT04850989
- Testing
- Pico Goblin VR headset
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Penn State University
Smoking, Tobacco
Examining Brain Responses Linked to Emotion in Individuals Who Smoke Cigarettes
The study will use functional magnetic resonance imaging and facial coding methods to study individuals who smoke cigarettes. Smoking expectancy (the extent to which one perceives an opportunity to smoke a cigarette) will be…
- Trial name
- NCT04310735
- Testing
- Verbal smoking expectancy manipulation
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Diseases
Cardiometabolic Effects of Pecans as a Snack
A randomized, 2-arm, parallel trial will be conducted to examine the effect of pecans on markers of peripheral vascular health, lipids and lipoproteins, blood pressure, and glycemic control.
- Trial name
- NCT05071807
- Testing
- Pecans, Usual Care
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Penn State University
Endometriosis
MicroRNA Activation of LOX-1 Mechanisms in Endometriosis
Endometriosis is a disorder that occurs in women. With endometriosis, tissue that should be found in the womb is found in sites outside of the womb.
- Trial name
- NCT05331053
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Penn State University
Alzheimer Disease
A Family-centered Intervention for Acutely-ill Persons With Dementia
This study will address the effectiveness of Family-centered Function Focused Care (Fam-FFC). Fam-FFC is a theoretically-based approach to care in which family caregivers partner with nurses to prevent functional decline and…
- Trial name
- NCT03046121
- Testing
- Family-centered Function-focused Care (Fam-FFC)
- Where
- 3 sites in United States
- Volunteers
- 461 people
- Sponsor
- Penn State University
Type2 Diabetes
Almond Butter and Fasting Glucose
A two-period randomized crossover study will be conducted to determine the effect of almond butter as an evening snack on fasting blood glucose in adults with type 2 diabetes, not taking insulin.
- Trial name
- NCT03826472
- Testing
- Almond Butter
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Penn State University
Hypertension,Essential
Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans
High blood pressure can cause physical changes to the blood vessels of the body (remodeling). If a person who has high blood pressure also has a lot of blood vessel remodeling with their condition, they are more likely to have…
- Trial name
- H2SPharm (NCT03179163)
- Testing
- Captopril Pill, Enalapril Pill, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease, Inflammation
Dose Response Effects of Marine Omega-3 Fatty Acids on Inflammation
The purpose of this study is to determine the lowest effective dose of EPA + DHA (300, 600, 900 and 1,800 mg/day delivered as fish oil supplements) that significantly attenuates the inflammatory response to in vivo and ex vivo…
- Trial name
- NCT01078909
- Testing
- Eicosapentaenoic Acid and Docosahexaenoic Acid (EPA + DHA)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Penn State University
Inflammatory Responses
Effects of a Prescription Omega-3 Fatty Acid Concentrate on Induced Inflammation
The purpose of this study is to assess whether the marine omega-3 fatty acids can attenuate inflammatory responses to endotoxin challenge.
- Trial name
- PRONOVA (NCT01813110)
- Testing
- 4 g prescription omega-3 concentrate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease
Postprandial Effects of Walnut Components Versus Whole Walnuts on Cardiovascular Disease (CVD) Risk Reduction
The purpose of this study is to evaluate the acute, postprandial effects and mechanism of action of various walnut components (separated nut skins, de-fatted nut meat, nut oil) versus whole walnuts on oxidative stress…
- Trial name
- NCT00938340
- Testing
- Walnut "meat", Walnut Oil, Walnut Skins
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Penn State University
Type2 Diabetes, Cardiovascular Diseases
Peanuts and Glycemic Control
A two-period randomized crossover study will be conducted to determine the effect of peanuts on glycemic control, and elucidate the role of the microbiome in glucose regulation, in individuals with impaired fasting glucose.
- Trial name
- NCT03654651
- Testing
- Peanut, High carbohydrate snack
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Penn State University
Underage Drinking, Driving Under the Influence
Project MADD - NIH Underage DUI and Ride
Project MADD was designed to attempt to curb the alarming trends related to drunk driving and to move the field forward by testing a brief parent-intervention's ability to change adolescents' drinking, impaired driving, and…
- Conditions
- Underage Drinking, Driving Under the Influence, Drinking, Teen
- Trial name
- NCT03506880
- Testing
- MADD Materials, Surgeon General Materials
- Where
- United States
- Volunteers
- 2,352 people, healthy volunteers welcome
- Sponsor
- Penn State University
Overweight and Obesity, Physical Activity
Healthy Mom Zone: A Gestational Weight Gain Management Intervention
The purpose is to establish feasibility of delivering an individually-tailored, behavioral intervention to manage gestational weight gain [GWG] that adapts to the unique needs and challenges of overweight/obese pregnant women…
- Conditions
- Overweight and Obesity, Physical Activity, Weight Change, Body, Eating Behavior
- Trial name
- HMZ (NCT03945266)
- Testing
- Intervention group, Control group
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Penn State University