Clinical trials: sponsored by Poitiers University Hospital
End Stage Renal Disease, Dialysis Related Complication
Comparison of Hemodialysis With Medium Cut-off Dialyzer (Theranova) and High Flux Dialyzer
The aim of this study is to evaluate the removal of midle molecules and inflammatory cytokines with the Theranova-500 ™ dialyzer (medium cut-off membrane, Baxter®) versus a high flux dialyzer Elisio-21H ™ (High-flux membrane…
- Conditions
- End Stage Renal Disease, Dialysis Related Complication, Dialysis Amyloidosis
- Trial name
- THERANOVA (NCT03211676)
- Testing
- Theranova-500 dialyzer, Elisio-21H
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Poitiers University Hospital
Smoking Cessation
Trial to Evaluate the Efficacy of Simvastatin for Smoking Cessation
Tobacco smoking is the number one preventable cause of disease worldwide. Unfortunately, there are few smoking cessation agents and their effectiveness has been shown to be relatively limited and is associated with potential…
- Trial name
- ADDICSTATINE (NCT02399709)
- Testing
- simvastatin
- Where
- France
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Anesthesia General
Study of the Effect of the Supine Position at Brain Velocities in Noncerebro - Injured Patient
To evaluate the pulsatility index changes after setting supine position in non brain- injured patient under general anesthesia.
- Trial name
- D-Velocity (NCT02930096)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Poitiers University Hospital
Carbon Monoxide Poisoning
Occult Carbon Monoxide Poisoning Detection by Pulsated Carboxymetry in an Emergency Department
In France, the carbon monoxide is one of the first causes of the accidental poisonings with approximately 8000 cases a year, among which 500 deaths.
- Trial name
- MAS-CO (NCT02931448)
- Testing
- Dosage of the blood HbCO thanks to the carboxymeter MASIMO RAD 57
- Where
- France
- Sponsor
- Poitiers University Hospital
Prolapse of the Uterus
Evaluation of the Position of Promontofixation Prostheses in Perineal Ultrasound
Indirect promontofixation with prostheses is the standard surgical technique for the reference of uterine prolapse. There is no validated examination to control the position of the prostheses postoperatively.
- Trial name
- PROMONOTECHO (NCT03634878)
- Testing
- perineal ultrasound
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Chronic Myeloid Leukemia
STI571 ProspectIve RandomIzed Trial: SPIRIT
To test whether increasing the dose of imatinib or combining it with IFNalpha or ara-C increases the rate of molecular response (as measured by the decrease in BCR-ABL transcripts after 12 months of treatment) in patients with…
- Trial name
- SPIRIT (NCT00219739)
- Testing
- Imatinib mesylate 400 mg, Imatinib mesylate 600 mg, Imatinib 400 mg + Peg-Interferon
- Where
- France
- Volunteers
- 789 people
- Sponsor
- Poitiers University Hospital
Mesenteric Ischemia, Permeability CT Technics
Dynamic Contrast Enhancement Computed Tomography Based Technic to Assess Gastro Intestinal Wall Perfusion : Feasibility Study
This feasibility study has therefore several aims: 1. construct a dedicated CT perfusion protocol for GIT wall perfusion; 2. used a two-compartment pharmacokinetic model which is more adapted that a unique compartment model; 3.
- Trial name
- PERFE-CT (NCT03367065)
- Testing
- Dynamic contrast enhanced computerised tomography
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Poitiers University Hospital
Naive Patients With Uncomplicated Proliferative Diabetic Retinopathy
Safety and Efficacy of Aflibercept in Proliferative Diabetic Retinopathy.
Proliferative diabetic retinopathy is a serious complication of diabetes mellitus, partly consecutive to upregulation of vascular endothelial growth factor (VEGF) as a consequence of retinal ischemia leads.
- Trial name
- NCT02151695
- Testing
- panretinal photocoagulation, Aflibercept intravitreal injections
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Poitiers University Hospital
Pancreatic Cancer, Gastric Cancer
Kinetics of Microparticles Under Chemotherapy in Patients With Gastric or Pancreatic Cancer
Microparticles have recently emerged as a thrombotic risk marker with a potential role in determining which patients are at greatest risk for developing thrombosis.
- Trial name
- DOMICA (NCT03471468)
- Testing
- kinetics of microparticles under chemotherapy
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Poitiers University Hospital
Flutter, Atrial, Over 18 Years Old
Hypnosis in Interventional Electrophysiology
Hypnosis has already shown to decrease pain and anxiety in different surgical specialities. Nevertheless, its input has never been studied in cardiology.
- Trial name
- PAINLESS (NCT03250871)
- Testing
- Hypnosis
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Poitiers University Hospital
Chronic Phase of Chronic Myeloid Leukemia
Combination of Dasatinib and Peg-Interferon Alpha 2b in First Line for Chronic Myeloid Leukemia in Chronic Phase
Interferon alpha was a therapy used in Chronic Myeloid Leukemia in Chronic phase prior to the advent of tyrosine kinase inhibitors.
- Trial name
- NCT01872442
- Testing
- Dasatinib, Peg-Interferon alpha2b
- Sponsor
- Poitiers University Hospital
Influenza, Respiratory Virus Syncitial
Extra-pulmonary Clinical Manifestations of Influenza Virus and Respiratory Syncitial Virus Infections
The purpose of this study is to describe extra-pulmonary clinical manifestations of Influenza virus and Respiratory Syncitial Virus infections in hospitalized adults at a French university hospital.
- Conditions
- Influenza, Respiratory Virus Syncitial, Extra-respiratory
- Trial name
- GIVRE (NCT03757546)
- Testing
- observational
- Where
- France
- Volunteers
- 252 people
- Sponsor
- Poitiers University Hospital
Mechanical Ventilation, Acute Respiratory Distress Syndrome
Ventilation's Parameters Applied in Emergency Medicine. A Prospective Observational Study
To prospectively assess the mechanical ventilation management when its provided by Emergency Physicians in French Hospital, and to assess complications and outcome of these patients.
- Conditions
- Mechanical Ventilation, Acute Respiratory Distress Syndrome, Protective Ventilation, Survival
- Trial name
- PARAVENT (NCT03351920)
- Testing
- mechanical ventilation
- Where
- 7 sites in France
- Volunteers
- 229 people
- Sponsor
- Poitiers University Hospital
Subarachnoid Haemorrhage (SAH)
Evaluation of Transcutaneous Trigeminal Nerve Stimulation for Prevention of Cerebral Vasospasm After Subarachnoid Haemorrhage
Subarachnoid haemorrhage (SAH) secondary to ruptured aneurysm represents 5 to 15% of all cases of stroke. The mortality rate of SAH is 40% and the risk of serious neurological sequelae among survivors is 10 to 20%.The causes of…
- Trial name
- TRIVASOSTIM (NCT02482883)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
General Anesthesia
Safety and Feasibility of a New Neuromuscular Monitoring Device
The aim of the study is to compare, during general anesthesia using neuromuscular blocking agent, the feasibility of a new mechanographic device (ITF handle and Visual ITF software) with a standard acceleromyographic device (TOF…
- Trial name
- MONITOF (NCT03847740)
- Testing
- Isometric Trumb Force handle
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Poitiers University Hospital
Intravascular-catheter Colonization, Catheter Failure
Chlorhexidine-Alcohol Versus Povidone Iodine-Alcohol, Combined or Not With Use of a Bundle of New Devices, for Prevention of Intravascular-catheter Colonization and Catheter Failure
Short peripheral intravenous catheters (PVC) are the most frequently used invasive medical devices in hospitals. Unfortunately, PVCs often fail before the end of treatment due to the occurrence of complications, which can be…
- Trial name
- CLEAN3 (NCT03757143)
- Testing
- Povidone-Iodine-Alcohol, Chlorhexidine-Alcohol, Insyte Autoguard BC Winged
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Poitiers University Hospital
Laryngoscopy, Anesthesic Aduction
Comparison Between the Neuromuscular Blockade Onset Monitoring and the Expectation of a Fixed Delay After Curarization on the Quality of Laryngoscopy During Intubation in Elective Surgery (MONITURARE)
During anesthetic induction, the relevance of neuromuscular blockade (NMB) onset monitoring cannot be asserted and its superiority over waiting for a fixed delay (corresponding to pharmacokinetic knowledge of the neuromuscular…
- Conditions
- Laryngoscopy, Anesthesic Aduction, Neuromuscular Blockade, Monitoring
- Trial name
- MONITURARE (NCT03981042)
- Testing
- Monitoring
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Poitiers University Hospital
Traumatic Brain Injury
Becoming Traumatic Brain Injured Patients at Day 7 of Their Trauma
To study the future of traumatic brain injured patients at day 7 of their trauma Primary endpoint: Fate, classified as survival with or without sequelae, death.
- Trial name
- NCT04077268
- Testing
- GOS-E
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Poitiers University Hospital
Acute Respiratory Failure, Immunosuppression
HFNC Alone or Associated With NIV for Immunocompromised Patients Admitted to ICU for Acute Respiratory Failure
Acute respiratory failure is the leading cause of ICU admission of immunocompromized patients. In this subgroup of patients, the need for intubation and invasive mechanical ventilation occurs in about 50% of cases and is…
- Trial name
- FLORALI-IM (NCT02978300)
- Testing
- NIV/HFNC, HFNC
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Poitiers University Hospital
Kidney Transplant, Immunosuppression
Prospective Cohort of Kidney Transplanted Patients Receiving an Extended Releasing Tacrolimus-Everolimus Association
The tacrolimus-Everolimus association is used as an immunospressive treatment after a kidney transplant. It combined immunosupressive properties of both products and reduce the nephrotoxicity of tacrolimus by lowering the dosage.
- Trial name
- NCT03228576
- Testing
- Extended release Tacrolimus-Everolimus association
- Where
- 9 sites in France
- Volunteers
- 16 people
- Sponsor
- Poitiers University Hospital