Clinical trials: sponsored by Poitiers University Hospital
ICU, Extubation
Comparison of Patient Work of Breathing and Tidal Volumes With High Flow Nasal Cannula Oxygen Therapy and NIV (Non-Invasive Ventilation) After Extubation in the ICU.
This study is aimed at evaluating patient work of breathing and tidal volumes with three methods of oxygenation: standard oxygen, high-flow oxygen therapy and non-invasive ventilation.
- Conditions
- ICU, Extubation, Non-invasive Ventilation, High-Flow Nasal Oxygen Therapy
- Trial name
- OVNI (NCT04036175)
- Testing
- High-Flow Nasal Oxygen / Non-invasive ventilation / Standard oxygen
- Where
- 2 sites in France
- Volunteers
- 25 people
- Sponsor
- Poitiers University Hospital
Neuropathy, Optic
OCT Angiography in Arteritic and Non Arteritic Anterior Ischemic Neuropathy
Anterior ischaemic optic neuropathy results from infarction of retrolaminar portion of the optic nerve head, caused by occlusion of the posterior ciliary artery.
- Trial name
- NOIA (NCT03642899)
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Vertigo, Peripheral, Vertigo, Brain Stem
Copeptin and the S-100b Protein in Stroke
This study evaluated the value of using copetin and protein S 100 b to eliminate the diagnosis of stroke in patients presenting with vertigo in emergency departments.
- Conditions
- Vertigo, Peripheral, Vertigo, Brain Stem, Vertigo; Central, Vertigo; Cerebral
- Trial name
- NCT03974464
- Testing
- copeptin, PS100
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Ventilation-associated Pneumonia, Severe Trauma Patient
Impact of the Addition of a Device Providing Continuous Pneumatic Regulation of Tube Cuff Pressure to an Overall Strategy Aimed at Preventing Ventilator-associated Pneumonia in the Severe Trauma Patient. A Multicentre, Randomised, Controlled Study.
Ventilation-associated pneumonia is the main site of healthcare-associated infections in the severe trauma patient, with a mean incidence rate of 35%.
- Trial name
- AGATE (NCT02534974)
- Testing
- NOSTEN
- Where
- 13 sites in France
- Volunteers
- 440 people
- Sponsor
- Poitiers University Hospital
Kidney Transplant; Complications
Immunosuppression's Long Term Impact on Anti-tumoral Oversight in Kidney Transplantation
Cancer is a well known complication about long term transplantation. Cancer outcomes are due to the immunosuppressive treatment that prevents transplanted people from rejection.
- Trial name
- NCT03227965
- Testing
- Immune cells population assesment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Failed Back Surgery Syndrome
Value of Target-controlled Intravenous Anaesthesia (TCIVA) in Spinal Cord Stimulation
Study design 60 patients Monocenter prospective study Randomized in 2 groups 36 months Objectives Demonstrate the superiority of target controlled intravenous anesthesia versus total anesthesia with the low back paresthesia…
- Trial name
- AIVOC (NCT02821897)
- Testing
- Target-controlled intravenous anaesthesia, Total anaesthesia
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Poitiers University Hospital
Polytraumatises With Rib Fractures
Medico-Economic Analysis of Management of Flail Chest Between Medical Treatment and Surgical Treatment With Stracos
Optimize the management of polytraumatises with flail chest: surgical treatment Stracos by decreasing the length of stay and the late complications: pain chronicles, quality of life, respiratory function
- Trial name
- EMVOLS (NCT02635165)
- Testing
- Thoracic osteosyntheses with Stracos
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Poitiers University Hospital
Acute Respiratory Failure Requiring Reintubation
High-flow Nasal Cannula Oxygen Therapy With or Without NIV During the Weaning Period
Prospective multicenter randomized controlled open-label trial comparing 2 strategies of oxygenation during the post-extubation period in ICU patients at high risk of extubation failure.
- Trial name
- HIGH-WEAN (NCT03121482)
- Testing
- HFNC, NIV
- Where
- France
- Volunteers
- 650 people
- Sponsor
- Poitiers University Hospital
Pneumonia
Population Pharmacokinetic (PK) Study of Zinforo (Ceftaroline) in Critical Care Patients With Early-onset Pneumonia and Normal or Augmented Renal Clearance
Pneumonia is the most frequent infection in critically ill patients and remains a significant challenge to intensivists world-wide due to persisting high mortality and morbidity.
- Trial name
- CEFTAREA (NCT03025841)
- Testing
- Ceftaroline
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Poitiers University Hospital
Type 3 Choroidal Neovascularization
Efficacy of Aflibercept (Eylea®) on Choroidal Neovascularization (Type 3)
This is a one-year pilot, interventional, prospective, single arm, non-randomized, multicentric (3 centers) controlled study that aims to evaluate the response of type 3 choroidal neovascularization to treatment by Aflibercept…
- Trial name
- ATTRACT (NCT02320474)
- Testing
- Aflibercept
- Where
- 2 sites in France
- Volunteers
- 26 people
- Sponsor
- Poitiers University Hospital
Sleep Quality, Hypoxemic Acute Respiratory Failure
Sleep Quality and Risk of Intubation in Intensive Care Units Patients With Hypoxemic Acute Respiratory Failure
The aim of the study is to evaluate the impact of sleep quality on intubation rate in intensive care units patients with acute respiratory failure
- Conditions
- Sleep Quality, Hypoxemic Acute Respiratory Failure, Intubation Risk
- Trial name
- HIGH SLEEP (NCT02907008)
- Testing
- Polysomnography
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Poitiers University Hospital
Broncho Chronic Obstructive Pulmonary Disease
Interest of Branched Chain Amino Acids Associated With a Respiratory Rehabilitation Program in Patients Broncho Chronic Obstructive Pulmonary Disease
Respiratory rehabilitation is one of the main treatments for COPD in the early stages of the disease (Stage 2 of GOLD) with a recognized effect on improving the capacity of the patients to exert effort by fighting against…
- Trial name
- REHABAAR (NCT03644836)
- Testing
- Amino Acids
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Brain Injured Patients
Validation of a Physiological Based Pharmacokinetic Model by the Study of Paracetamol Distribution in the Brain Compartments in Brain Injured Patients
Brain is composed of several anatomical compartments separated by physiological barriers allowing the maintenance of homeostasis.
- Trial name
- NCT03223506
- Testing
- Paracetamol
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Poitiers University Hospital
Chronic Obstructive Pulmonary Disease, High-flow Nasal Cannula
High-flow Nasal Cannula Nebulization of Beta 2 Adrenergic Agonist During Acute Exacerbation of Chronic Obstructive Pulmonary Disease
High-flow nasal cannula is an oxygenation technique increasingly used for patients admitted for acute respiratory failure. Literature essentially concerns "de novo" acute hypoxemic failure and the interest of high-flow during…
- Trial name
- OPTINEB (NCT03449056)
- Testing
- salbutamol
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Poitiers University Hospital
Instrumental Delivery; Nec, Affecting Fetus or Newborn
Neonatal Outcomes in Instrumental Delivery
The aim of this study is to compare the impact of instrumental delivery on newborn head mark and newborn comfort over the impact of non-instrumental delivery.
- Trial name
- NCT03337880
- Testing
- instrumental delivery
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Poitiers University Hospital
75 Years Old and More, Cancer
Tool for the Detection of Oncogeriatric Fragility in Patients Aged ≥75 Years Undergoing Oncological Treatment.(D-FOG)
Many cancers are diagnosed after 75 years. Treatment in chemotherapy begins without evidence of geriatric risk factors. A new tool for screening for geriatric fragilities is used, a self-administered questionnaire carried out by…
- Conditions
- 75 Years Old and More, Cancer, Chemotherapy
- Trial name
- D-FOG (NCT03261128)
- Testing
- Self-questionnaire
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Continuous Non Invasive Cutaneous Temperature, Zero Heat Flux Method
Accuracy of Zero Heat Flux Cutaneous Temperature in Intensive Care Adults
Temperature is one of the vital signs usually monitored in patients of ICUs. Indeed, fever occurs frequently in ICU especially in brain injured patients and may require targeted temperature management (TTM) in special case as…
- Conditions
- Continuous Non Invasive Cutaneous Temperature, Zero Heat Flux Method, Esophageal Temperature, Arterial Temperature
- Trial name
- TempCore (NCT02931227)
- Testing
- temperature obtained by the non-invasive method of zero-heat flux, esophageal temperature, intracerebral temperature
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Poitiers University Hospital
Acute Respiratory Failure, Cancer
Oxygenation Methods and Non-invasive Ventilation in Patients With Acute Respiratory Failure and a do Not Intubate Order
ICU care of patients considered "palliative" but without contraindications to admission to intensive care, for whom a do-not intubate order decision was made upon admission represents a particular target for non-invasive…
- Conditions
- Acute Respiratory Failure, Cancer, Hematologic Malignancy, Cardiac Insufficiency
- Trial name
- OXYPAL (NCT03673631)
- Testing
- NIV, NFHC-O2
- Where
- France
- Volunteers
- 330 people
- Sponsor
- Poitiers University Hospital
Myocardial Infarction
Assessment of Spontaneous Baroreflex Sensitivity in Carriers of Implantable Cardioverter Defibrillators: Association With Disorders of the Ventricular Heart Rate. Case-control Study
We must implement 8 implantable cardioverter defibrillators (ICDs) to save a life in 3 years after myocardial infarction (MI) in primary prevention.
- Trial name
- BARODEF (NCT02930382)
- Testing
- Baroreflex assessment
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Poitiers University Hospital
Unresecable Stage IIIc or IV Melanoma
Study of the Variations of Albumin Level for Patients With Unresecable Stage IIIc or Stage IV Melanoma Treated by Anti BRAF and Anti MEK
The therapeutic arsenal of metastatic melanoma has changed considerably over the past 10 years. The treatment of metastatic melanoma is now based on immunotherapy and targeted therapies, while the place of conventional…
- Trial name
- SVALMEL (NCT03553329)
- Testing
- dabrafenib
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Poitiers University Hospital