Clinical trials: sponsored by Poitiers University Hospital
Morbid Obesity
Sugammadex Dosage Based on Ideal Body Weight for Profound Rocuronium-induced Neuromuscular Blockade Reversal in Morbidly Obese Patients
This randomized double blind clinical trial focuses on patients with Body Masse Index ≥ 40 kg/m2, undergoing scheduled surgery. Neuromuscular transmission monitoring at the adductor is performed using.
- Trial name
- NCT02545595
- Testing
- Sugammadex 1 mg/kg, Sugammadex 2 mg/kg, Sugammadex 4 mg/kg
- Where
- France
- Sponsor
- Poitiers University Hospital
Delirium Symptoms
Role of REM Sleep Alterations in Post Operative Delirium After Cardiac Surgery
Acute confusional states known as delirium frequently occur in Intensive Care Units (ICU), mostly after cardiac surgery, leading to serious consequences.
- Trial name
- NCT02801318
- Testing
- Polysomnography
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Steinert's Disease
Compare Train and 3D-4D Left Ventricular Systolic Function in Subjects Suffering From Dystrophy and Healthy Subjects
Steinert's disease is an orphan disease. The prognosis of patients with this disease is conditioned by cardiac involvement. Search an early stage alterations in contractile function in subjects suffering from dystrophy would…
- Trial name
- NCT02930408
- Testing
- electrocardiogram, Echocardiography
- Volunteers
- 70 people
- Sponsor
- Poitiers University Hospital
Multiple Myeloma, Impaired Renal Function
Pharmacokinetics of Lenalidomide (Revlimid®) in Patients With Multiple Myeloma and Impaired Renal Function
The purpose of this study is to determine the pharmacokinetic profile of Revlimid® in patients presenting with Multiple Myeloma and impaired renal function, the safety of Revlimid® in the enrolled patients population.
- Trial name
- NCT00779922
- Testing
- lenalidomide
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Poitiers University Hospital
Chronic Myeloid Leukemia
Glivec in Pediatric Chronic Myeloid Leukemia (CML)
It is a phase 4 study, not randomised and multicentric. Within 2 months after the diagnosis, the patients daily receive imatinib by oral way during at least 1 year (260mg/m² once a day), i.e. until the cytogenetic analysis.
- Trial name
- NCT00845221
- Testing
- Imatinib mesylate 100 mg (Glivec)
- Where
- 3 sites in France
- Volunteers
- 44 people
- Sponsor
- Poitiers University Hospital
Bacterial Infection, Brain Injury
Cerebral Antibiotics Distribution After Acute Brain Injury
The aim of the study is to explore the distribution of antibiotics in the brain after an acute brain injury because brain infections treatment is still an health care problem.
- Trial name
- NCT01059890
- Testing
- cefotaxime, Metronidazole, Ciprofloxacin
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Poitiers University Hospital
Gram-negative Bacteria
Population Pharmacokinetic Study of Colistin in Patients Infected With Multiresistant Gram-negative Bacteria
Nosocomial infections have become a major health problem. They induced important use of antibiotics which is a preponderant factor for the development of bacterial resistance.
- Trial name
- NCT01060891
- Testing
- colimycin
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Poitiers University Hospital
Non-oncological Indication to Ureteral Stenting
Evaluation of the Efficacy of Tamsulosin (Alpha Blockers) Compared to Phloroglucinol in Improving JJ Ureteral Stent Tolerance. A Randomized Controlled Trial
JJ ureteral stent represents an advance in the management of the upper urinary tract obstruction as it allows the patient to resume his activities although he is stented between the kidney and the bladder.
- Trial name
- NCT01061073
- Testing
- Omexel, spasfon
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Poitiers University Hospital
Parkinson's Disease
Clinical and Economic Impact of Duodopa: Long-term Effectiveness Study in Advanced Parkinson's Disease Patients
The goal of this multicentric prospective randomized controlled clinical and economic study is to investigate the effectiveness and cost-utility of long-term continuous intraduodenal infusion of levodopa ( DUODOPA), compared to…
- Trial name
- NCT01291537
- Testing
- Duodopa, best médical treatment
- Where
- 20 sites in France
- Volunteers
- 56 people
- Sponsor
- Poitiers University Hospital
Acute Lung Injury, Acute Respiratory Failure
Clinical Effect of the Association of Noninvasive Ventilation and High Flow Nasal Oxygen Therapy in Resuscitation of Patients With Acute Lung Injury (FLORALI Study)
The aim of the study is to compare, in patients with acute respiratory failure/acute lung injury the efficacy of three different methods of oxygenation to prevent endotracheal intubation : 1.
- Trial name
- FLORALI (NCT01320384)
- Testing
- O2 conventional, O2-HFN : high flow nasal oxygen therapy, O2-HFN/NPPV : association of high flow nasal oxygen therapy and non invasive positive pressure ventilation
- Where
- France
- Volunteers
- 313 people
- Sponsor
- Poitiers University Hospital
Alzheimer's Disease
Cytokines and Cognitive Decline in Alzheimer's Disease
Amyloid plaques and neurofibrillary tangles are the 2 well-known etiopathological hallmarks of Alzheimer's disease (AD). Beside these 2 lesions, inflammation response is described in the brain of patients with AD.
- Trial name
- NCT01351142
- Testing
- blood test and cognitive tests
- Where
- 10 sites in France
- Volunteers
- 133 people
- Sponsor
- Poitiers University Hospital
Obesity
Oral Sodium Blood Pressure in Normal Weight, Overweight and Obese Volunteers
The primary objective of this study is to analyze the sensitivity of blood pressure to oral salt intake. Matched male and female participants will be selected as normal weight, overweight, and obese.
- Trial name
- PLADSEL (NCT01532401)
- Testing
- sodium chloride, Methylcellulose crystalline
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Poitiers University Hospital
Cystic Fibrosis
Pharmacokinetic Study of Aerosolized Colimycin in Cystic Fibrosis
Pharmacokinetics of colimycin will be assessed during 12 hours after administration of 2M UI colimycin either as an aerosol or after IV injection, the administration being separated by 5 to 10 days intervals
- Trial name
- COLI-VLM (NCT01537614)
- Testing
- COLIMYCINE inhalation, COLIMYCINE injectable
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Poitiers University Hospital
Preventing Catheter Related Infection
Prospective Randomized Controlled Multicenter Trial of 4 Antiseptic Strategies for Prevention of Catheter Infection in Intensive Care Unit for Adults Patients
Catheter related infection is the third cause of nosocomial infection in ICUs. Most of them are avoidable and can be prevent by improving aseptic practices during catheter insertion and maintenance.
- Trial name
- CLEAN (NCT01629550)
- Testing
- skin disinfection prior catheter insertion
- Where
- 5 sites in France
- Volunteers
- 2,400 people
- Sponsor
- Poitiers University Hospital
Alternative Method of Apnea Test
Comparison of Two Strategies to Realize Apnea Test for the Diagnostic of Brain Death in Potential Organ Donors (CPAPNEE STUDY)
Clinical diagnostic of brain death requires a non-reactive coma, absence of brain stem reflex, and absence of spontaneous breathing.
- Trial name
- NCT01649726
- Testing
- Apnea test - control, Apnea test - CPAP
- Where
- 13 sites in France
- Volunteers
- 208 people
- Sponsor
- Poitiers University Hospital
Feeling Anxious
Comparing the Efficacy of Pregabalin and Hydroxyzine on the Anxiety Score
The insertion of long-lasting intravenous device is done under local anesthesia. Currently, in the investigators hospital, no premedication is given to the patients.
- Trial name
- NCT01675986
- Testing
- hydroxyzine, Pregabalin, Lactose
- Where
- France
- Volunteers
- 306 people
- Sponsor
- Poitiers University Hospital
Scarred Uterus
A Comparison of Balloon Catheter Versus Ocytocin for Cervical Ripening on Scarred Uterus With Unfavorable Cervix
Increasing cesarean rate in France is worrying. Different methods are described for ripening labor : the use of prostaglandins is described but maybe dangerous for patients with scarred uterus and is not recommended.
- Trial name
- NCT01711060
- Testing
- oxytocin, balloon catheter
- Where
- 7 sites in France
- Volunteers
- 204 people
- Sponsor
- Poitiers University Hospital
Supratentorial Brain Tumor
Perioperative Evaluation of Intracranial Hypertension by Ultrasound Measurement of Variations in the Diameter of the Sheath of the Optic Nerve in the Excision of a Tumor or Biopsy Supratentorial Brain
Neurosurgery for supratentorial brain tumor is frequently associated with preoperative intracranial hypertension. The evaluation of intracranial pressure is available noninvasively by measuring the diameter of the optic nerve…
- Trial name
- NCT01864499
- Testing
- ultrasound measurement of variations in the diameter of the sheath of the optic nerve
- Sponsor
- Poitiers University Hospital
Alternative Method of Apnea Test
Comparison of Two Strategies to Realize Apnea Test for the Diagnostic of Brain in Potentiel Organ Donors.
Clinical diagnostic of brain death requires a non-reactive coma, absence of brain stem reflex, and absence of spontaneous breathing.
- Trial name
- APNEE REA (NCT01911286)
- Testing
- Apnea test - Standard, Apnea test - CPAP
- Where
- 17 sites in France
- Volunteers
- 208 people
- Sponsor
- Poitiers University Hospital
Renal Failure, Critical Care
Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure
Treatment of infections in critically ill patients remains a significant challenge to intensivists world-wide with persisting high mortality and morbidity.
- Conditions
- Renal Failure, Critical Care, Gram Positive Bacteria
- Trial name
- DAPTOREA (NCT02142075)
- Testing
- Daptomycin
- Where
- 4 sites in France
- Sponsor
- Poitiers University Hospital