Clinical trials: sponsored by Poitiers University Hospital
Laparoscopic Surgery, Neuromuscular Blocking Agents
Study of the Relationship Between Curarization and Pneumoperitoneum in Laparoscopic Surgery
The number of surgical procedures is increasing worldwide (1). Laparoscopic surgery is one of the surgical techniques that has become indispensable. Laparoscopic surgery is less invasive than laparotomy.
- Conditions
- Laparoscopic Surgery, Neuromuscular Blocking Agents, Pneumoperitoneum
- Trial name
- PneumandTOF (NCT07005518)
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 200 people
- Sponsor
- Poitiers University Hospital
Catheterization, Catheterization, Peripheral
Failure of First-attempt Insertion and Analysis of Practices Related to Peripheral Intravenous Catheters in the Emergency Department:
Peripheral intravenous catheters (PIVCs) are essential for the management of hospitalised patients, particularly in emergency departments, where they are used to administer intravenous treatments to more than half of all…
- Conditions
- Catheterization, Catheterization, Peripheral, Catheters, Vascular Access Devices
- Trial name
- CATHIRU (NCT06851585)
- Testing
- CathIRU Cohort
- Where
- France
- Volunteers
- 4,312 people
- Sponsor
- Poitiers University Hospital
Pain, Intractable
Identification of Outcome Predictors and Stratification of Responder Profiles Implanted With Spinal Cord Stimulation. An AI-based-pathway & Algorithmic Approach to Treat Failed Back Surgery Syndrome Patients
Failed Back Surgery Syndrome is commonly defined as new, recurrent, or persistent pain in the back and/or leg(s) of at least 6-month duration following spinal surgery.
- Trial name
- PREDIBACK 2 (NCT04587674)
- Testing
- Spinal Cord Stimulation
- Where
- 7 sites in France
- Volunteers
- 110 people
- Sponsor
- Poitiers University Hospital
Knee Surgery, Rehabilitation
Optimization of the Role of Action Observation in the Post-operative Rehabilitation of the Total Knee Prosthesis: (LOARAL 2)
The LOARAL 2 project concerns patients who have undergone total knee arthroplasty to treat symptomatic osteoarthritis. Patient will be divided into three groups: a control group where patients will do standard rehabilitation…
- Conditions
- Knee Surgery, Rehabilitation, Point Light Display
- Trial name
- LOARAL 2 (NCT05297539)
- Testing
- Point light display
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Poitiers University Hospital
Diabetes, Diabetic Kidney Disease
Effect of Acute Hypoxia on Renal Hemodynamic in Healthy Volunteers, Patients With Diabetes and Patients With Diabetes and Kidney Disease
Diabetes mellitus is a non-transmissible disease whose incidence is growing worldwide . This pathology is defined by a chronic hyperglycaemia linked to a deficiency of either insulin secretion or its action or both.
- Conditions
- Diabetes, Diabetic Kidney Disease, Hypoxia, Healthy Volunteer
- Trial name
- DIAKIPOX (NCT06846034)
- Testing
- Hypoxia administration study group, Renal clairance study
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Type2 Diabetes, Diabetic Kidney Disease
Efficacy of a High-intensity Physical Activity Program on Renal Function in High Risk Patients With Type 2 Diabetes
Type 2 diabetes is a chronic condition whose prevalence is increasing globally. Kidney disease is a key complication of diabetes and is among the most common cause of end-stage renal disease, requiring renal replacement therapy.
- Trial name
- ACTIDIANE (NCT03184662)
- Testing
- HIPA, Counseling PA
- Where
- 20 sites in Belgium, France
- Volunteers
- 178 people
- Sponsor
- Poitiers University Hospital
Severe Asthma, Biotherapy
Impact of Respiratory Allergy on Response to Initiation of Biotherapy in Severe Asthma in Adult Severe Asthmatic Patients Followed at Poitiers University Hospital on Biotherapy
The aim of this study is to take stock of the situation of adult patients with severe asthma on biotherapy, followed up at Poitiers University Hospital, and in particular to increase our knowledge of factors predictive of…
- Conditions
- Severe Asthma, Biotherapy, Respiratory Allergy
- Trial name
- IARBASP (NCT06916104)
- Testing
- search for respiratory allergies
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Poitiers University Hospital
Obstructive Sleep Apnea, Fluid Retention
MOdification of Fluid Distribution in 90 Minutes
Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a cardiovascular risk factor due to intermittent hypoxia phenomena. Several etiological factors are involved in the pathogenesis of OSAS.
- Trial name
- NCT05786248
- Testing
- Impedancemetry
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Poitiers University Hospital
Weaning from Mechanical Ventilation
Impact of Gamma-OH on Sleep in ICU Patients
The Main objective of the trial is to assess sleep quality with Gamma-OH® in patients difficult to wean from mechanical ventilation in the ICU.
- Trial name
- GO-SLEEP (NCT04224246)
- Testing
- Gamma Hydroxybutyrate
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Poitiers University Hospital
Chronic Pulmonary Aspergillosis
Chronic Pulmonary Aspergillosis and Ambisome Aerosol with Itraconazole
This study compares the therapeutic (clinical and radiological) efficacy of a six-month treatment by itraconazole and nebulised Ambisome® (liposomal amphotericin B = LAmB) versus treatment by itraconazole alone, in non - or…
- Trial name
- NCT03656081
- Testing
- inhaled Ambisome®, Itraconazole
- Where
- France
- Volunteers
- 224 people
- Sponsor
- Poitiers University Hospital
Colorectal Cancer (CRC), Endocrine Disruptors
Effects of Endocrine Disruptors on the Gut Microbiota and Assessment of Their Impact on Colorectal Cancer Development (PERMICA)
Colorectal cancer is the third most common cancer worldwide, yet it was the second leading cause of cancer-related deaths in 2020. The average French population faces a colorectal cancer risk partly linked to lifestyle factors.
- Conditions
- Colorectal Cancer (CRC), Endocrine Disruptors, Microbiota, Dysbiosis
- Trial name
- PERMICA (NCT06809660)
- Testing
- Collection of biological samples and clinical data
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Surgical Site Infection
Pharmacokinetic Study of Vancomycin, Clindamycin And/or Gentamicin Administration During Surgery Using a Microdialysis Procedure
The surgical site infection is one of the most important causes of postoperative morbidity. The appropriate antibiotic prophylaxis is one of the most effective way to prevent surgical site infections.
- Trial name
- NCT03845790
- Testing
- Blood and microdialysis samples
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Poitiers University Hospital
Diabetic Nephropathies
MRI Biomarkers in Diabetic Kidney Disease
Diabetic kidney disease is one of the most severe and frequent complications of diabetes. Few preclinical markers are available apart from plasma creatinine and microalbuminuria.
- Trial name
- MR3T - DKD (NCT04570735)
- Testing
- MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Virtual Reality, Pediatrics
Impact of Virtual Reality in Hematology and Oncology During Invasive Procedures in Children, Adolescents and Young Adults, from 7 to Less Than 25 Years Old
This pilot study will be testing the feasibility of medical hypnosis through virtual reality during invasive médical procédures in children and young adults with cancer.
- Conditions
- Virtual Reality, Pediatrics, Cancer, Pain
- Trial name
- NCT05275881
- Testing
- Virtual Reality, Usual Practices
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Giant Cell Arteritis
Validation of a Diagnostic Algorithm of Giant Cell Arteritis
Giant cell arteritis (GCA or temporal arteritis or cranial arteritis) or Horton disease is a vasculitis that occurs in older adults, affecting vessels of medium and large caliber.
- Trial name
- ECHORTON (NCT02703922)
- Testing
- color Doppler ultrasound and TAB in case of CDU negative
- Where
- 6 sites in France
- Volunteers
- 165 people
- Sponsor
- Poitiers University Hospital
Salpingography, Virtual Reality Exposure Therapy
Assessment of Patients' Pain and Anxiety During a Hysterosalpingography Narratified by a Virtual Reality Helmet (Daphné)
Compare the maximum pain and anxiety experienced between the group using a virtual reality headset and the control group in an adult woman during a hysterosalpingography examination
- Conditions
- Salpingography, Virtual Reality Exposure Therapy, Virtual Reality, Pain
- Trial name
- Daphné (NCT05036772)
- Testing
- Virtual reality
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Schatzker Type 2 or 3 Tibial Plateau Fracture
Comparative Evaluation of Minimally Invasive "tibial Tuberoplasty" Surgical Technique Versus Conventional Open Surgery for Tibial Plateau Fractures
PMSI (French Medico-Administrative Database) data shows more than 10000 proximal tibial fractures diagnosed in 2014 and 4055 lateral tibial plateau fractures operated in 2013 in France.
- Trial name
- TUBERIMPACT (NCT03444779)
- Testing
- Tibial Tuberoplasty, Open technique
- Where
- 12 sites in France, Martinique
- Volunteers
- 137 people
- Sponsor
- Poitiers University Hospital
Heart Failure
HeartLogic France Study: Heart Failure Patients Managed with the HeartLogic Algorithm
Heart Failure (HF) is a chronic disease that leads to numerous rehospitalisations and affects more than one million people in France.
- Trial name
- NCT04619888
- Testing
- HeartLogic
- Where
- 10 sites in France
- Volunteers
- 310 people
- Sponsor
- Poitiers University Hospital
Chronic Myeloid Leukemia (CML)
Long-term Risk of Second Primary Malignancies for Chronic Myeloid Leukaemia in the French Imatinib-based SPIRIT Trial
Imatinib is a tyrosine kinase inhibitor that has improved the prognosis of patients with chronic myeloid leukemia (CML). CML has become a chronic disease requiring long-term administration of imatinib.
- Trial name
- K2SPIRIT (NCT06646978)
- Testing
- Imatinib (STI571)
- Where
- France
- Volunteers
- 787 people
- Sponsor
- Poitiers University Hospital
Sleep Quality, Critically Ill Patient
Assessment of Sleep Quality of Hospitalized Patients Treated With EEG-guided Protection Procedures: Application in Intensive Care Unit
Sleep of critically ill patients is highly disturbed with a high sleep fragmentation; patients spend most of their sleep in very short sleep episodes, lasting less than 10 minutes.
- Conditions
- Sleep Quality, Critically Ill Patient, Intensive Care Unit
- Trial name
- SleepScan (NCT05963672)
- Testing
- EEG-guided sleep protection, Control condition
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Poitiers University Hospital