Clinical trials: sponsored by Poitiers University Hospital
Mild Traumatic Injury, Pre-hospital Dispatching
Non-severe Traumatic Injuries Evaluation Using smartPhone Camera for Extra-hospital Regulation
Photography teletransmission allow a better and optimized dispatching of patients calling an Emergency Medical Call Center (EMCC) for a mild traumatic injury.
- Conditions
- Mild Traumatic Injury, Pre-hospital Dispatching, Visioconference
- Trial name
- NIEPCE (NCT05404425)
- Testing
- Visioconference: live visual injury evaluation, Control
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Poitiers University Hospital
Diuresis in Incontinent Patients
Evaluation of a Non-invasive Urinary Collection Technique for the Adaptation of Diuretic Treatment in Incontinent Heart Failure Patient Over 75 Years of Age in the Acute Phase
Heart failure is a general disease affecting many organs and regulatory systems with a prevalence of 10% after 75 years of age, leading to significant hospitalization in the elderly.
- Trial name
- ATIICA (NCT05186428)
- Testing
- carrying out standard care, adult diaper
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Poitiers University Hospital
Memory Complaint, Alzheimer Disease
Study of Phosphorylated Metabolism Profile as Predictive Biomarker of Cognitive Decline in Memory Complaint.
Alzheimer disease is a frequent disease in the late ages that results in global alteration of cognitive functions. In which memory complaint can be isolated in the early stages.
- Conditions
- Memory Complaint, Alzheimer Disease, Phosphorylated Metabolism Profile, Magnetic Resonance Spectroscopy
- Trial name
- NCT03863041
- Testing
- Additional sequence performed during MRI scan
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Poitiers University Hospital
Pelvic Organ Prolapse, Rectal Prolapse
Materiovigilance After Urinary Incontinence or Prolapse Surgery
Observatory of Materiovigilance After Surgery of Urinary Incontinence or Prolapse in Women Implantable medical devices (meshes) used in pelvic organ prolapse surgery (genital prolapse, rectal prolapse), or incontinence surgery…
- Conditions
- Pelvic Organ Prolapse, Rectal Prolapse, Urinary Stress Incontinence
- Trial name
- VIGI-MESH (NCT03052985)
- Testing
- urinary incontinence, pelvic organ or rectal prolapse surgery
- Where
- 31 sites in France
- Volunteers
- 19,000 people
- Sponsor
- Poitiers University Hospital
Transthyretin Cardiac Amyloidosis
Imaging for the Evaluation of Transthyretin Cardiac Amyloidosis Prevalence of Patients Over 65 Hospitalized in Cardiology Wards (the IMPACT Study)
Heart failure with preserved ejection and hypertrophic cardiomyopathy are common diseases and often associated with transthyretin cardiac amyloidosis (TTR-CM), especially in elderly people.
- Trial name
- IMPACT (NCT05064839)
- Testing
- Bony scintigraphy
- Where
- France
- Volunteers
- 553 people
- Sponsor
- Poitiers University Hospital
Meningococcal Infections
Epidemiological, Clinical and Biological Caracteristics of Patients Presenting With Invasive Meningococcal Disease
An unusual increase in cases of invasive meningococcal infection between late 2022 and early 2023. These cases sometimes had atypical presentations (large numbers of bacteremias without meningitis).
- Trial name
- CARACIIM (NCT05981599)
- Testing
- There is no intervention
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Chronic Myeloid Leukemia
Innate T Cells and TKI Discontinuation
After more than a decade of treating chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKI), the discontinuation of treatment represents the expected new revolution.
- Trial name
- TIBIOP-LMC (NCT04645706)
- Testing
- Characteristics of innate T cells
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Poitiers University Hospital
Fetal Anomaly, Ultrasound
Trial Observationnal
The aim of this retrospective longitudinal study was to describe a key factor in the prenatal diagnosis of isolated cleft palate on the axial transverse view, in order to provide better understanding, detection and diagnosis of…
- Trial name
- CLEFTPALATDIAG (NCT05785338)
- Testing
- Posterior angle of the hard palate
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Poitiers University Hospital
Infection
Population Pharmacokinetic-pharmacodynamic (PK-PD) Study of 9 Broad-Spectrum Anti-infective Agents in the Cerebro Spinal Fluid (CSF) of Brain Injured Patients With an External Ventricular Drainage (EVD).
Nosocomial Central Nervous System infections are difficult to treat and an early appropriate therapy can improve prognosis. The two main reasons for treatments failure are the difficulty to reach high concentrations of…
- Trial name
- NCT03481569
- Testing
- Blood and cerebrospinal fluid pharmacocinetic samples on one of the nine antibiotics prescribed in routine use
- Where
- France
- Volunteers
- 176 people
- Sponsor
- Poitiers University Hospital
Obesity, Neostigmine
Observational Study in Bariatric Surgery
Obesity in the world represents a growing share of the general population. At hospital, the management of these patients could be problematic especially when calculating the drug dosage.
- Conditions
- Obesity, Neostigmine, Residual Neuromuscular Blockade
- Trial name
- NEOCURE (NCT04244266)
- Testing
- NO INTERVENTION, it is an observational study
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Covid19
Description of Immunologic, Enzymatic and Metabolic Biomarkers Associated to the Severity of COVID-19 (SARS-CoV-2) and Its Resolution
Prospective study to describe the immunological, metabolic and serologic profile in the acute and post acute phases of Coronavirus disease (COVID-19)
- Trial name
- BIOMARK-COVID (NCT04664023)
- Testing
- Blood collection at Day 8, Day 16, Day 24, Month 6 and Month 12 after first symptoms from SARS-CoV-2 infection., Blood collection at 1st injection of vaccine against COVID-19, at at second injection of vaccine, at Month 1, Month 2, Month 6 and Month 12 after second injection of vaccine for volunteers
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Chronic Low Back Pain
Evaluation of Therapeutic Management in Chronic Low Back Pain Patients
Seventy-eight percent of the population declares being concerned by pain, directly or indirectly. Chronic pain, defined as pain that has lasted for more than three months, affects more than one third of the French population.
- Trial name
- PREDIPAIN (NCT05209854)
- Where
- France
- Volunteers
- 613 people
- Sponsor
- Poitiers University Hospital
Non Small Cell Lung Cancer, PET/CT
Radiomics for prEdiction of lunG cAncer biologY
Therapeutic progress for subgroups of Non Small Cell Lung Cancer can largely be attributed to the accumulation of molecular knowledge and the development of new drugs that specifically target molecular abnormalities.
- Conditions
- Non Small Cell Lung Cancer, PET/CT, PD-L1, Gene Mutation-Related Cancer
- Trial name
- NCT05819905
- Testing
- PET/CT
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Poitiers University Hospital
Neuromuscular Blockade
Interest of the Automated Management of Deep Neuromuscular Blockade Monitoring (CURATP)
Neuromuscular blockade (NMB) recommendations updated in 2018 by the Société Française d'Anesthésie et Réanimation (SFAR) recommend the use of NMB agents to facilitate surgical procedure during abdominal surgery by laparotomy or…
- Trial name
- CURATP (NCT05784610)
- Testing
- Monitorage by TOF/PTC, Monitorage by ATP
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Postoperative Residual Curarization
Comparison of Train of Four, Tetanus 50 and 100 Hz Recovery After Rocuronium Block Reversed by Neostigmine
Despite neuromuscular transmission monitoring and pharmacological reversal allowing a train of four ratio recovery higher than 0.9, patients receiving neuromuscular blocking agent during general anesthesia have a high risk of…
- Trial name
- DECURATOF 2 (NCT05224648)
- Testing
- TOF scan train of four ratio monitoring, ITF device tetanus stimulation monitoring
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Poitiers University Hospital
Pain, Neuropathic
Comparative Study in Patients With Refractory Chronic Lower Limb Neuropathic Pain and/or Back Neuropathic Pain.
Neuropathic pain is described as a "pain initiated or caused by a primary lesion or dysfunction in the nervous system". It is thus often a chronic affection, as a difficult-to-treat condition.
- Trial name
- BOOST DRG (NCT04852107)
- Testing
- Spinal Cord Stimulation, association of both (DUAL), Dorsal Root Ganglion stimulation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Poitiers University Hospital
Multiple Myeloma in Relapse, Multiple Myeloma, Refractory
Multicenter Open Label Phase 2 Study of Isatuximab Plus Pomalidomide and Dexamethasone With Carfilzomib in Relapsed or Refractory Multiple Myeloma
Study a quadruplet-based regimen with Minimal Residual Disease (MRD) 10-5 negative rate as primary end point in patients with early Relapsed or Refractory Multiple Myeloma.
- Trial name
- NCT04287855
- Testing
- Isatuximab, Carfilzomib, Pomalidomide
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Poitiers University Hospital
Cardiogenic Pulmonary Edema
HIgh Flow Versus NIV for Acute Cardiogenic PuLmonary Oedema With Acute Respiratory Failure in an ED
The purpose of this study is to compare non invasive ventilation to high flow nasal cannula oxygen for the management of patients admitted with an acute respiratory failure due to an acute cardiogenic pulmonary edema.
- Trial name
- NCT04971213
- Testing
- Non invasive ventilation, High-flow nasal cannula heated and humidified oxygen
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Circulating Tumor DNA, Endometrial Cancer
Reliability and Interest of Circulating Tumor DNA in Endometrial Cancers.
The recent histo-prognostic molecular discoveries of the TCGA (The Cancer Genome Atlas) have shed new light on the classification of endometrial carcinomas.
- Trial name
- NCT04456972
- Testing
- One arm only
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Poitiers University Hospital
Diurnal Variations of Cerebral Metabolite
Diurnal Variations of Brain Metabolite Concentrations in 1H-MRS
Proton Magnetic Resonance Spectroscopy (1H-MRS) is a magnetic resonance imaging (MRI) technique. It allows the quantification of cerebral metabolite concentrations.
- Trial name
- Dyn24 (NCT03497832)
- Testing
- magnetic resonance spectroscopy (MRI)
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital