Clinical trials: sponsored by Poitiers University Hospital
Neuromuscular Residual Curarization
Comparison of the TOFScan and the WiTOF During Recovery of Neuromuscular Function
The purpose of this study is to compare two neuromuscular blockade monitors on recovery from an ATRACURIUM intra veinous injection for surgery. The TOFscan, a wired connected monitors and the WiTOF, a wireless connected monitor.
- Trial name
- NCT05231525
- Testing
- WiTOF, TOFscan
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Acute Right Heart Failure, Pulmonary Hypertension
Assessment of Peripheral Veins Doppler Ultrasound for Diagnosis of Acute Right Heart Failure in Suspicion or Follow-up of Pulmonary Hypertension
Occurrence of acute right heart failure (ARHF) remains common during pulmonary hypertension (PH). Right atrial pressure (RAP) invasive measurement is the gold standard to diagnose ARHF in order to improve diuretic treatment…
- Conditions
- Acute Right Heart Failure, Pulmonary Hypertension, Peripheral Veins Doppler Ultrasound
- Trial name
- CODOVEIN (NCT04792879)
- Testing
- Peripheral veins Doppler ultrasound
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Poitiers University Hospital
Mast Cell Activation Disease, Mast Cell Activation Syndrome
Ocular and Palpebral Manifestations of Mastocytosis (MOOMA)
Mastocytosis is a rare condition characterized by an accumulation of mast cell cells in one or more organs such as the liver, bone marrow, spleen and intestines. Its prevalence in the general population is 1 in 10,000.
- Conditions
- Mast Cell Activation Disease, Mast Cell Activation Syndrome, Mast Cell Disease, Urticaria Pigmentosa
- Trial name
- NCT04978740
- Testing
- Ophthalmological examination
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Poitiers University Hospital
Intrauterine Growth Retardation (IUGR)
Reproducibility of the Measurement of the Right Portal Vein Diameter
Although routine ultrasound is offered during the third trimester of pregnancy, less than a quarter of newborns with intrauterine growth retardation (IUGR) are suspected antenatally.
- Trial name
- PORTALGROWTH1 (NCT04617964)
- Testing
- Ultrasound
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Intensive Care Unit, Antibiotic Therapy
Therapeutic Monitoring of Antibiotics in Intensive Care Patients: a Cohort Study PopTDM-ICU
Intensive care patients are exposed to serious infections. Mortality linked to these infections remains high and antibiotic therapy treatment optimization is one of the key points of therapeutic success .
- Conditions
- Intensive Care Unit, Antibiotic Therapy, Pharmacokinetic
- Trial name
- NCT05367011
- Volunteers
- 2,500 people
- Sponsor
- Poitiers University Hospital
Dysphagia
Influence of Oesophageal Contractile Reserve in High Resolution Manometry on Post Operative Dysphagia After Anti-reflux Surgery
The main objective of this study is to evaluate, in a prospective cohort, the link between preoperative contractile reserve of oesophagus evaluated by high resolution manometry (HRM) and the occurrence of post operative dysphagia…
- Trial name
- NCT03374930
- Testing
- Multiple rapid swallows test
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Poitiers University Hospital
Cholangiocarcinoma, Interventional Imaging
Pilot Study on the Evaluation of Irreversible Electroporation Technique in Infiltrating Perihilar Cholangiocarcinoma
The aim of the study is to evaluate the feasibility of irreversible electroporation in the treatment of locally advanced cholangiocarcinoma.
- Trial name
- HOPE (NCT04717687)
- Testing
- Irreversible electroporation
- Sponsor
- Poitiers University Hospital
Identification of the Mother or Fetus Contamination by SARS Cov-2, Research the Presence of Viruses at Different Sites of the Mother and the Fetus or Father
Study of Late Fetal Loss in Poitou-Charentes. GYNE-COVID
Maternal-fetal transmission in the second or third trimester of pregnancy of the SARS-COV-2 virus could explain some late fetal losses. Finding a cause in the context of fetal loss is essential for parents and caregivers.
- Conditions
- Identification of the Mother or Fetus Contamination by SARS Cov-2, Research the Presence of Viruses at Different Sites of the Mother and the Fetus or Father, The Survey Builds on a Network Work Already Organized Around the CPDPN of Poitou-Charentes, Analysis Laboratories of the Poitiers CHU
- Trial name
- NCT04387253
- Testing
- Identification by PCR of the SARS-COV-2 virus in samples taken from the fetus
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Exposure, Health Behavior
Advancing Tools for Human Early Lifecourse Exposome Research and Translation- Adolescence Follow-up of the HELIX Subcohort
ATHLETE will set up a prospective Europe-wide exposome cohort covering the first 2 decades of the life course, which will integrate data on the external, chemical, physical,behavioral, and social domains of the exposome, as well…
- Conditions
- Exposure, Health Behavior, Environment
- Trial name
- ATHLETE (NCT05158010)
- Testing
- HELIX's follow-up
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Rheumatic Disease, Rheumatic Disorder
Survey About Diet in Chronic Inflammatory Rheumatic Diseases
A French Survey on patients' practices, knowledge and beliefs about diet in chronic inflammatory rheumatic diseases (rheumatoid arthritis, psoriatic arthritis, spondylarthritis) Use of a questionnaire about what patients have…
- Conditions
- Rheumatic Disease, Rheumatic Disorder, Inflammatory Rheumatism, Rheumatoid Arthritis
- Trial name
- NCT05283096
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 203 people
- Sponsor
- Poitiers University Hospital
Cardiac Surgery in Adult Patient
Randomized Trial of 2% Chlorhexidine-70% Isopropanol vs 5% Povidone Iodine-69% Ethanol for Skin Antisepsis in Reducing Surgical-site Infection After Cardiac Surgery
Despite completion of more than 9 million procedures each year in France, the best antiseptic solution to be used for preparing the skin to reduce risk of surgical site infection (SSI) remains unknown.
- Trial name
- CLEAN2 (NCT03560193)
- Testing
- 2%Chlorhexidine-70%Isopropanol, 5%Povidone Iodine- 69%Ethanol
- Where
- 8 sites in France
- Volunteers
- 3,316 people
- Sponsor
- Poitiers University Hospital
Heart; Surgery, Heart, Functional Disturbance as Result, Anxiety
Combination of Music and Relaxing Light on the Patient's Anxiety After Cardiac Surgery in the Intensive Care Unit
Cardiac surgery is not trivial. It requires opening the thorax in certain indications: coronary artery bypass grafting, valve replacements or plasties, aortic dissection, etc.
- Conditions
- Heart; Surgery, Heart, Functional Disturbance as Result, Anxiety, Pain, Postoperative, Delirium
- Trial name
- RéaRelax (NCT05178680)
- Testing
- relaxation session combining music and soft light
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Poitiers University Hospital
Weaning From Mechanical Ventilation, Extubation
T-piece Versus Pressure-support for the Spontaneous Breathing Trial
The main objective will be to compare the number of ventilator-free days within the 28 days following the first spontaneous breathing trial between strategies of extubation performing spontaneous breathing trials with T-piece…
- Trial name
- TiP-Ex (NCT04227639)
- Testing
- T-piece trial, Pressure-support trial
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Poitiers University Hospital
Antenatal Management of the Fetal Gastrointestinal Atresia
Prenatal Diagnosis of the Fetal Esophageal or Intestinal Atresia
Aim- to investigate how prenatal diagnosis of fetal esophageal or intestinal atresia impacts obstetric and neonatal outcomes. Methods- This was a retrospective cohort study at a single center.
- Trial name
- DANATRESIA (NCT05362604)
- Testing
- scheduled delivery at a tertiary center
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Poitiers University Hospital
Pancreatic Adenocarcinoma, Interventional Imaging
Irreversible Electroporation (NanoKnife) for the Treatment of Pancreatic Adenocarcinoma
The aim of the study is to evaluate the use of irreversible electroporation in the treatment of locally advanced cancers of the head of pancreas with vascular spread.
- Trial name
- NCT03105921
- Testing
- NanoKnife
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Poitiers University Hospital
Accumbo Frontal Tract
Accumbofrontal Tract Study in 2 Populations of Patients With Anorexia Nervosa and Obsessional Compulsive Disorder and Healthy Volunteer
Restrictive anorexia nervosa and TOCs are psychiatric diseases which shares a common pathophysiological substrate We hypothesize that anorexia patients and patients with OCD have structural and functional changes in the…
- Trial name
- ACCUMBENS (NCT03496285)
- Testing
- Multimodal MRI with diffusion sequence for anorexia nervosa patient, Multimodal MRI with diffusion sequence for obsessional compulsive disorder patient, Multimodal MRI with diffusion sequence for healthy volunteer
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Febrile Neutropenia
Amoxicillin-clavulanate Alone or in Combination With Ciprofloxacin in Low-Risk Febrile Neutropenic Adult Patients: A Prospective, Double-blind, Randomized, Non-Inferiority Multicenter, Phase III Clinical Trial.
In low risk neutropenic fever in cancer, standard of care is the association of amoxicillin clavulanate and ciprofloxacin. But in this population, the rate of fever related to infection is very low, leading to a overtreatment of…
- Trial name
- ACACIA (NCT04698057)
- Testing
- Amoxicillin Clavulanate, Ciprofloxacin
- Sponsor
- Poitiers University Hospital
Trauma, Telemedicine
AmbulaNCE Teletransmited PHOtography for Trauma REgulation
Physicians in charge of medical regulation within French SAMU have to take difficult decisions regarding patient's orientation (in or out-of hospital care) but suffer from lack of information.
- Trial name
- NiCEPHORE (NCT04034797)
- Testing
- Photography teletransmission, No photo
- Where
- France
- Volunteers
- 179 people
- Sponsor
- Poitiers University Hospital
MRI, PTX
MR7T-Healthy-PTX : Brain Exploration in Magnetic Resonance Imaging in Parallel Transmission Mode (pTX) at 7 Tesla
Magnetic resonance imaging (MRI) is a non-invasive imaging modality used in routine clinical practice for clinical diagnosis by visualizing the anatomical structure and in vivo function of certain organs.
- Conditions
- MRI, PTX, BRAIN, 7 TESLA
- Trial name
- NCT04369755
- Testing
- MRI
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Perineal Tear
Descriptive Evaluation of Expulsive Efforts During Pregnancy in Term Nulliparous Women by Measurement of Intra Bladder Pressure: Pilot Observational Study.
Severe complications of childbirth are common. Many factors have been studied to assess their imputability in the occurrence of perineal tears.
- Trial name
- ACCOUPIV (NCT04544488)
- Testing
- Recording of expulsive efforts by connection of a pressure sensor to the women's bladder probe
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital