Clinical trials: sponsored by Radboud University Medical Center
BRCA Mutation, Serous Tubal Intraepithelial Carcinoma
International Registration of Isolated STIC: to Report and Investigate the Risk of Serous Peritoneal Carcinomatosis
To prospectively assess the incidence of peritoneal carcinomatosis for women with isolated STIC (serous tubal intraepithelial carcinoma).
- Conditions
- BRCA Mutation, Serous Tubal Intraepithelial Carcinoma, Ovarian Carcinoma, Peritoneal Carcinoma
- Trial name
- STICRISC (NCT06393543)
- Testing
- No intervention, only registration
- Volunteers
- 600 people
- Sponsor
- Radboud University Medical Center
Drug Drug Interaction Study
Rivaroxaban Sotorasib Interaction Study
Venous thromboembolic Events (VTEs) are common in lung cancer patients with an incidence of >15%, requiring anticoagulant treatment or prophylaxis.
- Trial name
- ROSIE (NCT06314763)
- Testing
- Rivaroxaban 20mg, Sotorasib 960mg
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sensory Processing Sensitivity
Mindfulness-Based Stress Reduction (MBSR) for People High on the Personality Trait Sensory Processing Sensitivity: A Mixed Methods Study
This study investigates the efficacy of MBSR training in alleviating stress-related symptoms among individuals with high sensory processing sensitivity.
- Trial name
- MindSens (NCT06390020)
- Testing
- MBSR
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- Radboud University Medical Center
Barrett Esophagus, Esophageal Cancer
Early Detection of Barrett's Esophagus in Participants With Reflux Symptoms in Primary Care
In the Netherlands, the incidence of esophageal adenocarcinoma (EAC) is increasing. In addition, EAC has a dismal prognosis. Therefore, screening for Barrett's Esophagus (BE) has stimulated interest.
- Trial name
- ELECTRONIC (NCT04656392)
- Testing
- Breath test (eNose) followed by uTNE.
- Where
- Netherlands
- Volunteers
- 449 people
- Sponsor
- Radboud University Medical Center
Pain, Acute
Virtual Reality Therapy for Pain Management at the Emergency Department
Rationale: Prescriptions of analgesics, especially opioids, have doubled in the Emergency department (ED) over the past decades in response to frequently reported undertreatment of pain in ED patients.
- Trial name
- VRxOPUS-2 (NCT06089642)
- Testing
- Virtual reality
- Where
- Netherlands
- Volunteers
- 124 people
- Sponsor
- Radboud University Medical Center
Burns, Burn Scar
Dermal Substitution in Pediatric Burns
The standard treatment of deep dermal to full thickness burns is surgical removal of the burn followed by skin transplantation. Dermal substitutes are increasingly used in the treatment of deep burns to replace lost dermis.
- Trial name
- GlyPeB (NCT05309720)
- Testing
- Glyaderm
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Pancreas Cancer
Intratumoral Holmium Microspheres Brachytherapy for Patients With Pancreatic Cancer
This is a feasibility study in which patients with pancreatic cancer are treated with intratumoral holmium microsphere injections.
- Trial name
- SLOTH-1 (NCT05191498)
- Testing
- QuiremSpheres®
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- Radboud University Medical Center
Post-extubation Dysphagia
Post-extubation Dysphagia
Mechanical ventilation is a widely used treatment on the Intensive Care Unit (ICU). Swallowing dysfunction (dysphagia) after extubation may cause aspiration, and is associated with poor outcomes: pneumonia, reintubation, a…
- Trial name
- NCT03761823
- Where
- Netherlands
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Chronic Central Serous Chorioretinopathy
Steroid Eye Drops in Chronic Central Serous Chorioretinopathy
In this pilot study the effect and safety of the use of steroid eye drops in chronic central serous chorioretinopathy (cCSC) will be evaluated. The study is conducted as a randomized single-blind placebo-controlled trial.
- Trial name
- PICS (NCT05633576)
- Testing
- steroid eye drops
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Non-Medullary Thyroid Carcinoma
Digoxin for the Reinduction of Radioiodine Uptake in Metastatic or Locally Advanced Non-medullary Thyroid Carcinoma
Non-medullary thyroid carcinoma has a good prognosis in most patients. However, a small subset of patients nevertheless develop metastatic or locally advanced and unresectable disease which in some cases also becomes radioiodine…
- Trial name
- DIGUP-TC (NCT05507775)
- Testing
- Digoxin tablet
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- Radboud University Medical Center
Anxiety, Anxiety State
Virtual Reality to Reduce Periprocedural Anxiety During Invasive Coronary Angiography
Introduction Patients undergoing invasive coronary angiography experience anxiety due to various factors. This can lead to physiological and psychological complications, compromising patient comfort and overall procedural…
- Trial name
- VR InCard (NCT06215456)
- Testing
- Virtual reality therapy
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
NSCLC
Dose Tapering and Early Discontinuation to InCreAse cosT-effectIveness Of Immunotherapy for NSCLC
Rationale: Immune checkpoint inhibitors have shown to improve the overall survival for patients with metastasized non-small cell lung carcinoma (NSCLC) but the optimal dosing and patient selection are still a matter of…
- Trial name
- DEDICATION-1 (NCT04909684)
- Testing
- Pembrolizumab
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- Radboud University Medical Center
Pancreatic Cancer, Cholangiocarcinoma
Bile Duct Drainage After ERCP Failure: EUS-BD vs PTBD
The vast majority of patients with distal biliary, pancreatic head or uncinate process cancer have jaundice caused by distal malignant obstruction (DMO) of the common bile duct.
- Conditions
- Pancreatic Cancer, Cholangiocarcinoma, Biliary Obstruction
- Trial name
- BESTDRAIN (NCT05519605)
- Where
- Netherlands
- Volunteers
- 61 people
- Sponsor
- Radboud University Medical Center
Trained Immunity, BCG Vaccine
BCG-induced Epigenetic Modifications in the NEXT Generation
Non-specific protective effects resulting from the BCG vaccine appear to be paternally inheritable. Since the BCG vaccine is known to induce trained immunity, epigenetics might explain the fathers' contribution to the immune…
- Conditions
- Trained Immunity, BCG Vaccine, Epigenetics
- Trial name
- NEXT (NCT05766345)
- Testing
- BCG-Vaccine SSI [Statens Serum Institut]) Danish strain 1331
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Primary Glioblastoma
Effectiveness of MR-guided LITT Therapy in Irresectable Glioblastoma (EMITT)
The aim of this study is to investigate the (cost-)effectiveness of LITT (Laser Interstitial Thermal Therapy) in primary irresectable glioblastoma.
- Trial name
- EMITT (NCT05318612)
- Testing
- Laser Interstitial Thermal Therapy (LITT), Biopsy
- Where
- 7 sites in Netherlands
- Volunteers
- 238 people
- Sponsor
- Radboud University Medical Center
Infectious Complications, Postoperative Pain
Early Postoperative Pain and 30-day Complications Following Major Abdominal Surgery: an Observational Study
In this retrospective cohort study, we assess the relationship between the intensity of early postoperative pain and the risk of infectious- and non-infectious complications within 30 days after major abdominal surgery.
- Conditions
- Infectious Complications, Postoperative Pain, Acute Pain, Postoperative Complications
- Trial name
- NCT05244655
- Where
- Netherlands
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Vaccination; Infection, COVID-19
Intradermal Administration of a COVID-19 mRNA Vaccine in Elderly
Respiratory tract infections, e.g. caused by SARS-CoV-2, disproportionately affect elderly. Vaccination has shown to be the most cost-effective approach to prevent infections.
- Trial name
- HVaNa (NCT05977127)
- Testing
- Comirnaty
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease
Remote 3-week Booster Intervention to Reduce Sedentary Time in Patients With Coronary Artey Disease
The goal of this clinical trial is to learn about the effect of a booster program aiming to lower daily sitting time (SIT LESS Booster program) compared to usual care in patient with coronary heart problems.
- Trial name
- BOOSTSITLESS (NCT06038188)
- Testing
- SIT LESS Booster
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Radboud University Medical Center
Time Restricted Feeding, Myocardial Infarction
Time Restricted Eating and Innate Immunity
The goal of this cross over study is to investigate the effect of short term time restricted eating (TRE) on the innate immune system in patients with a history of myocardial infarction.
- Conditions
- Time Restricted Feeding, Myocardial Infarction, Atherosclerotic Cardiovascular Disease
- Trial name
- SIGNATURE (NCT05639244)
- Testing
- Time restricted eating (TRE), Regular diet
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- Radboud University Medical Center
Gastric Content, Healthy Volunteers
Nurses' Competence in Gastric Ultrasound
The goal of this observational cohort study is to investigate gastric ultrasound skills in surgical nurses. The main question it aims to answer is: how much training is required for surgical nurses to obtain competency in…
- Trial name
- SKILLS-1 (NCT06320574)
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center