Clinical trials: sponsored by Radboud University Medical Center
Paraganglioma
Exendin PET/CT for Imaging of Paragangliomas
Functional imaging of paragangliomas (PGLs) is not unequivocal. Existing functional imaging modalities show good but variable results in PGLs, warranting the search for additional molecular imaging targets.
- Trial name
- ENTRAP (NCT05418907)
- Testing
- 68Ga-NODAGA-exendin-4 PET/CT
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus
A GLP-1 Receptor PET Imaging Substudy Within the VER-A-T1D Trial Investigating the Effects on Beta Cell Mass
The goal of the trial is to measure pancreatic uptake of 68Ga-NODAGA-exendin by PET/CT for detection of intra-individual differences in beta cell mass before and after treatment with Verapamil.
- Trial name
- Ver-A-image (NCT04615910)
- Testing
- 68Ga-NODAGA-exendin-4 PET/CT
- Where
- 2 sites in Austria, France
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Type 2 Diabetes Mellitus
Visualizing Beta Cells After Bariatric Surgery
In order to evaluate the difference in beta cell mass in patients with and without complete resolution of type 2 diabetes mellitus (T2DM) after Roux en Y gastric bypass (RYGB) investigators aim to compare quantitative PET imaging…
- Trial name
- GLP1-bar (NCT02542059)
- Testing
- 68Ga-exendin PET/CT
- Where
- 2 sites in Netherlands
- Volunteers
- 24 people
- Sponsor
- Radboud University Medical Center
HIV Infections
2000 HIV Human Functional Genomics Partnership Program
Background Chronic HIV infection leads to a dysregulated immune system, even when full viral suppression is achieved. HIV causes persistent immune activation, relating to an array of common non-AIDS-related diseases such as…
- Trial name
- 2000HIV (NCT03994835)
- Where
- 4 sites in Netherlands
- Volunteers
- 1,910 people
- Sponsor
- Radboud University Medical Center
Hiv
Relative Bioavailability Study to Investigate a Potential Interaction Between DTG DT and F/TAF TOS.
This relative bioavailability (RBA) study will be conducted to investigate whether there is a potential pharmacokinetic effect when paediatric DTG and F/TAF are taken together as dispersible formulations.
- Trial name
- UNIVERSALRBA (NCT05489406)
- Testing
- DTG DT (6 x 5 mg), F/TAF TOS (3 x 60/7.5 mg)
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Kidney Transplant Failure
A Clinical Practice Snapshot on Pediatric Kidney Transplantation
The aim is to create an overview of the similarities and differences in daily practice among the different centers performing pediatric kidney transplantation in Europe.
- Trial name
- NCT05619679
- Testing
- Kidney Transplantation
- Where
- Netherlands
- Volunteers
- 410 people
- Sponsor
- Radboud University Medical Center
Kidney Transplant; Complications, Kidney Transplant Infection
Pediatric Kidney Transplantation, Ureteroneocystostomy Techniques
In this study the researchers want to retrospectively compare non-refluxing ureteroneocystostomy (UNC techniques to reflux UNC techniques in paediatric kidney recipients with regard to urinary tract infections and uteral…
- Conditions
- Kidney Transplant; Complications, Kidney Transplant Infection, Kidney Transplant Failure and Rejection
- Trial name
- TUIKIT (NCT05397821)
- Testing
- UNC technique
- Where
- Netherlands
- Volunteers
- 398 people
- Sponsor
- Radboud University Medical Center
Atherosclerosis
Effect of Statins on Trained Immunity
In this study, the investigators will determine whether patients with elevated levels of LDL are characterized by specific epigenetic changes in circulating cells of the innate immune system, compared to control subjects with…
- Trial name
- NCT02817230
- Testing
- Statin
- Where
- 3 sites in Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Turner Syndrome, Infertility, Female
Turner Syndrome Minipuberty Study
Rationale: Due to accelerated germ cell loss, infertility is a major problem in girls with Turner syndrome (TS). Therefore, cryopreservation of ovarian tissue or oocytes before exhaustion of the ovarian reserve may preserve…
- Conditions
- Turner Syndrome, Infertility, Female, Premature Ovarian Failure, Gonadal Dysgenesis
- Trial name
- Minipuberty (NCT04189406)
- Testing
- Venapunction
- Where
- 13 sites in Denmark, Germany and 3 more
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Perceived Stress, Persistent Poverty
Pathways to Empowerment for Persons Living in Persistent Poverty
The general purpose of this feasibility study is to evaluate the potential impact of Pathways to Empowerment (PTE) on the four constitutional conditions of social quality for persons living in persistent poverty.
- Trial name
- NCT05336097
- Testing
- Pathways to Empowerment
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Innate Inflammatory Response, Osteoarthritis, Hip
The Immunomodulatory Effect of Sugammadex After Total Hip Replacement Surgery Under Neuraxial Anaesthesia: a Pilot Study
Monocenter randomized controlled proof of principle study to investigate the effect of sugammadex at the end of total hip replacement surgery on the postoperative innate immune function
- Trial name
- MAGIC (NCT05723406)
- Testing
- Sugammadex 100 MG/ML [Bridion]
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
HIV-1-infection
2000HIV Trained Innate Immunity in HIV Elite Controllers
Some individuals are able to spontaneously control HIV replication, the so-called 'elite controllers' (ECs). ECs are crucial for our understanding of HIV infection.
- Trial name
- 2000HIVTrained (NCT04968717)
- Where
- 3 sites in Netherlands
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Parkinson Disease
Cost-effectiveness of Nursing Interventions for Patients With PD
Background: Current guidelines recommend that every person with Parkinson's disease (PD) should have access to Parkinson's Disease Nurse Specialist (PDNS) care.
- Trial name
- NICE-PD (NCT03830190)
- Testing
- Parkinson's disease nurse specialist care
- Where
- Netherlands
- Volunteers
- 242 people
- Sponsor
- Radboud University Medical Center
Proton Pump Inhibitor, Inappropriate Drug Use
Patient Journey Application for Discontinuing Inappropriate PPI Use: a Randomized Controlled Trial
Rationale/objective: This study hypothesizes that offering patient-tailored and dosed information on PPI discontinuation in patients with inappropriate chronic PPI use will result in an increased discontinuation rate when…
- Conditions
- Proton Pump Inhibitor, Inappropriate Drug Use, Discontinuation, E-health
- Trial name
- SUPPORT (NCT05348252)
- Testing
- Patient Journey App, Information folder
- Where
- Netherlands
- Volunteers
- 163 people
- Sponsor
- Radboud University Medical Center
Inflammatory Bowel Diseases, Colorectal Neoplasms
Back-to-back Endoscopy Versus Single-pass Endoscopy and Chromoendoscopy in IBD Surveillance
The current international guidelines for CRC surveillance in IBD recommend as first choice the use of chromoendoscopy, and as an alternative high-definition white light endoscopy (HDWLE) for optimal dysplasia detection, based on…
- Trial name
- HELIOS (NCT04291976)
- Testing
- Back-to-back high-definition white light endoscopy, single-pass high-definition white light endoscopy, chromoendoscopy
- Where
- 4 sites in Netherlands
- Volunteers
- 563 people
- Sponsor
- Radboud University Medical Center
Prostate Cancer
Artificial Intelligence and Radiologists at Prostate Cancer Detection in MRI: The PI-CAI Challenge
The PI-CAI challenge aims to validate the diagnostic performance of artificial intelligence (AI) and radiologists at clinically significant prostate cancer (csPCa) detection/diagnosis in MRI, with respect to histopathology and…
- Trial name
- NCT05489341
- Testing
- Histopathology and Magnetic Resonance Imaging with Follow-Up, Histopathology and Magnetic Resonance Imaging
- Where
- Netherlands
- Volunteers
- 10,207 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Adolescent Idiopathic Scoliosis
Comparing Use of Radiographs Versus Patient Empowerment (CURVE)
Objective: To evaluate the (cost-)effectiveness of a new patient-empowered follow up (FU) protocol in patients with Adolescent idiopathic Scoliosis (AIS) that is based on patient-reported outcome measures (PROMs), self-assessment…
- Trial name
- CURVE (NCT05379127)
- Testing
- Patient-empowered follow up, Standard follow-up
- Where
- 23 sites in Netherlands
- Volunteers
- 812 people
- Sponsor
- Radboud University Medical Center
Rectal Neoplasms, Neoplasm Recurrence, Local
Incidence, Risk Factor, Treatment and Overall Survival of Locally Recurrent Rectal Cancer
Data on disease recurrence was collected for all primary rectal cancer patients diagnosed in the Netherlands over the first six months of 2015.
- Trial name
- NCT05475301
- Volunteers
- 1,431 people
- Sponsor
- Radboud University Medical Center
Cardiovascular Diseases, HMG COA Reductase Inhibitor Adverse Reaction
Physical Activity Levels and Statin Therapy
Rationale: Combining statin treatment and physical activity is very effective for the prevention of cardiovascular diseases. Statins are well-tolerated by most patients, but may cause statin-associated muscle symptoms (SAMS).
- Conditions
- Cardiovascular Diseases, HMG COA Reductase Inhibitor Adverse Reaction, Muscle Pain
- Trial name
- NCT05625945
- Testing
- Physical activity monitoring
- Where
- Netherlands
- Volunteers
- 196 people
- Sponsor
- Radboud University Medical Center
MDC1A, SELENON-related Myopathy
The Natural History of Patients With Mutations in SEPN1 (SELENON) or LAMA2
SEPN1 (SELENON) is a rare congenital myopathy due to mutations in the SELENON gene. MDC1A is a rare congenital muscle dystrophy due to mutations in the LAMA2 gene.
- Trial name
- NCT04478981
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Radboud University Medical Center