Clinical trials: sponsored by Radboud University Medical Center
Rectal Neoplasms, Neoplasm Recurrence, Local
Incidence, Risk Factor, Treatment and Overall Survival of Locally Recurrent Rectal Cancer
Data on disease recurrence was collected for all primary rectal cancer patients diagnosed in the Netherlands over the first six months of 2015.
- Trial name
- NCT05475301
- Volunteers
- 1,431 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Chemotherapeutic Toxicity
Aerobic Fitness or Muscle Mass Training to Improve Colorectal Cancer Outcome
Evidence from randomized controlled trials shows that exercise during cancer treatment benefits physical fitness, fatigue and quality of life.
- Conditions
- Colorectal Cancer, Chemotherapeutic Toxicity, Survivorship, Lifestyle
- Trial name
- AMICO (NCT04754672)
- Testing
- Continuous aerobic and resistance exercise intervention, Continuous aerobic and aerobic interval exercise intervention
- Where
- 13 sites in Netherlands
- Volunteers
- 228 people
- Sponsor
- Radboud University Medical Center
Primary Liver Cancer, Non-Resectable Hepatocellular Carcinoma
MRI-guided Holmium-166 Radioembolization
To investigate the safety and feasibility of a personalized Ho-166-PLLA-MS TARE approach by using MRI guidance in inoperable patients with HCC.
- Trial name
- EMERITUS-2 (NCT05609448)
- Testing
- MRI-guided radioembolization
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
MDC1A, SELENON-related Myopathy
The Natural History of Patients With Mutations in SEPN1 (SELENON) or LAMA2
SEPN1 (SELENON) is a rare congenital myopathy due to mutations in the SELENON gene. MDC1A is a rare congenital muscle dystrophy due to mutations in the LAMA2 gene.
- Trial name
- NCT04478981
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Radboud University Medical Center
Prostate Cancer
Artificial Intelligence and Radiologists at Prostate Cancer Detection in MRI: The PI-CAI Challenge
The PI-CAI challenge aims to validate the diagnostic performance of artificial intelligence (AI) and radiologists at clinically significant prostate cancer (csPCa) detection/diagnosis in MRI, with respect to histopathology and…
- Trial name
- NCT05489341
- Testing
- Histopathology and Magnetic Resonance Imaging with Follow-Up, Histopathology and Magnetic Resonance Imaging
- Where
- Netherlands
- Volunteers
- 10,207 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
LAMA2-related Muscular Dystrophy, SELENON-related Myopathy
A 5-year Natural History Study in LAMA2-related Muscular Dystrophy and SELENON-related Myopathy.
SELENON-related myopathy (SELENON-RM) and LAMA2-related muscular dystrophy (LAMA2-MD) are congenital neuromuscular disorders presenting with slowly, progressive axial muscle weakness, spinal rigidity, scoliosis and respiratory…
- Trial name
- NCT06132750
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Dyspepsia
Low-value Chronic Prescription of Acid Reducing Medication Among Dutch General Practitioners
Dyspepsia is a commonly encountered clinical condition in Dutch general practice, which is often treated through the prescription of acid-reducing medication (ARM).
- Trial name
- NCT06108817
- Testing
- Information material, No Intervention
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pain, Pain, Acute
Opioid Use and Predicting Factors at the Emergency Department
Background: Increasing opioid misuse is a worldwide problem. About 10% of opioid misusers are primarily exposed to opioids at the Emergency Department (ED).
- Trial name
- VRxOPUS-1 (NCT06072950)
- Testing
- Usual care
- Where
- Netherlands
- Volunteers
- 149 people
- Sponsor
- Radboud University Medical Center
Hiv
Optimizing Counceling on Feeding Options of Babies From Mothers Living With HIV
Semi structured interviews will be performed to determine attitudes and experiences of people living with HIV and health care providers on counseling on feeding options of babies from mothers living with HIV in order to optimize…
- Trial name
- ROMI (NCT06067646)
- Testing
- Semistructured interview
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Mental Disorders, Severe
Transmural Collaborative Care Model for CVRM and Medication Review for Patients Using Antipsychotics
Currently, monitoring of usage and effects of antipsychotic treatment and cardiovascular risk screening in patients with severe mental illness or antipsychotic treatment is not sufficient.
- Trial name
- TACTIC (NCT05647980)
- Testing
- TACTIC
- Where
- Netherlands
- Volunteers
- 480 people
- Sponsor
- Radboud University Medical Center
Chronic Condition, Chronic Conditions, Multiple
EMBOSS A Person-centred Integrated-care for Chronic Diseases in Patients of Low Socio Economic Status
People of low socio economic status (SES) more often than others suffer from chronic diseases like diabetes mellitus, chronic obstructive pulmonary disease (COPD), or coronary diseases.
- Trial name
- EMBOSS (NCT05972031)
- Testing
- Person-centred integrated care intervention
- Where
- Netherlands
- Volunteers
- 540 people
- Sponsor
- Radboud University Medical Center
Nontuberculous Mycobacterial Diseases
Pharmacokinetic Study With a Loading Dose of Clofazimine in Adult Patients With Nontuberculous Mycobacterial Disease
Clofazimine (CFZ) is a promising drug for the treatment of NTM diseases. CFZ is highly active in vitro against M. abscessus and M. avium, the most common NTM pathogens, and shows synergy with macrolides and amikacin.
- Trial name
- C-LOAD (NCT05294146)
- Testing
- Clofazimine
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease, Effect of Drug
Multiple N-of-1 Trials of (Intermittent) Hypoxia Therapy in Parkinson's Disease
In recent years, mitochondrial dysfunction and oxidative stress have been implicated in PD pathophysiology. Intermittent hypoxia therapy (IHT) is an upcoming treatment used by elite athletes as well as fragile individuals in…
- Trial name
- TALISMAN (NCT05214287)
- Testing
- Hypoxic Gas Mixture
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus
Quantitative GLP-1 Receptor Imaging Correlated to ex Vivo Distribution of In-111-exendin
The main goal is to study the correlation of pancreatic uptake of In-111-DTPA-exendin-4 (measured by ex vivo counting) with the beta cell mass determined in the pancreatic specimens obtained after surgery.
- Trial name
- GLP1-ex-vivo (NCT03889496)
- Testing
- indium-111-exendin SPECT/CT
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Radboud University Medical Center
Deafness, Bilateral, Deafness Neurosensory
Auditory Diagnostics and Error-based Treatment
The main objective of this study is to assess the effectiveness of an integrated program of fitting and training interventions aimed at reducing unexpected variability and addressing the specific error patterns of each recipient.
- Conditions
- Deafness, Bilateral, Deafness Neurosensory, Deafness Permanent
- Trial name
- AuDiET (NCT05307952)
- Testing
- Tone Audiometry, Spectrotemporal Assessment, Phoneme and Speech Perception
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Patent Ductus Arteriosus
Early Treatment Versus Expectative Management of PDA in Preterm Infants
Much controversy exists about the optimal management of a patent ductus arteriosus (PDA) in preterm infants, especially in those born at a gestational age <28 weeks and/or a birth weight ≦1000 grams due to a lack of evidence for…
- Trial name
- BeNeDuctus (NCT02884219)
- Testing
- Ibuprofen, Expectative Management, Indomethacin
- Where
- 13 sites in Belgium, Netherlands
- Volunteers
- 273 people
- Sponsor
- Radboud University Medical Center
Cancer, Systemic Treatment
Systemic Treatment Related Toxicity Identified With a Smartphone APPlication Measuring Step Count
The goal of this observational study is to investigate whether daily physical activities measured with a smartphone are related to the possible side effects or other physical complaints that arise as a result of cancer treatment.
- Conditions
- Cancer, Systemic Treatment, Physical Activity, Toxicity Due to Chemotherapy
- Trial name
- STAPPS (NCT05927636)
- Where
- 3 sites in Netherlands
- Volunteers
- 411 people
- Sponsor
- Radboud University Medical Center
Impact of Advanced Hemodynamic Monitoring
Early Detection of Neonatal Shock
The purpose of this study is to evaluate the hypothesis that advanced hemodynamic monitoring results in an earlier detection of circulatory failure in newborn infants
- Trial name
- Edscini (NCT01550198)
- Testing
- Advanced hemodynamic monitoring
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Influenza, Herpes Zoster
Age Differences in Influenza and Herpes Zoster Vaccine Responses (INFLUENZA-SHINGRIX)
Vaccines are used to prevent infectious diseases worldwide. Unfortunately, many vaccines, like the flu vaccine, are less effective in older adults.
- Trial name
- NCT05082688
- Testing
- Herpes zoster vaccination (Shingrix, GSK), Influenza Vaccine (Fluarix Tetra Northern Hemisphere 2021 or 2022, GSK)
- Where
- Netherlands
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Major Depressive Disorder
Cognition in Mindfulness: Negativity and Depression
Mindfulness-Based Cognitive Therapy (MBCT) is effective in reducing relapse rates and (residual) symptoms in major depressive disorder (MDD). However, the mechanisms underlying those MBCT-induced effects are far from clear.
- Trial name
- CogMiND (NCT05802966)
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center