Clinical trials: sponsored by Radboud University Medical Center
Autoimmune Hepatitis
Mycophenolate Mofetil Versus Azathioprine in Treatment Naive Autoimmune Hepatitis
Rationale: Current standard therapy of autoimmune hepatitis consists of a combination of prednisolone and azathioprine. However, a significant proportion of patients does not respond to, or is intolerant for, azathioprine.
- Trial name
- CAMARO (NCT02900443)
- Testing
- Mycophenolate mofetil, Azathioprine
- Where
- 14 sites in Belgium, Netherlands
- Volunteers
- 70 people
- Sponsor
- Radboud University Medical Center
Distal Radius Fractures
A Clinical Comparison of Patient-specific 3D Printed Splints Versus Conventional Splints in the Treatment of Distal Radius Fractures.
The goal of this clinical trial is to assess patient reported outcome measures of adult patients who are diagnosed with a distal radius fracture and treated with a patient-specific 3D printed splint as compared to a control…
- Trial name
- 3DxSPLINT (NCT05902442)
- Testing
- 3DxSPLINT
- Volunteers
- 24 people
- Sponsor
- Radboud University Medical Center
Chronic Heart Failure, Heart Decompensation
Evaluating the Adherence Improving Self-Management Strategy Intervention in Chronic Heart Failure Patients
Patient non-adherence to treatment recommendations is common and decreases the effectiveness of Chronic Heart Failure (CHF) treatment.
- Conditions
- Chronic Heart Failure, Heart Decompensation, Myocardial Failure, Preserved Ejection Fraction
- Trial name
- AIMS-CHF RCT (NCT04698954)
- Testing
- Adherence Improving self-Management Strategy, Treatment-as-usual
- Where
- 3 sites in Netherlands
- Volunteers
- 86 people
- Sponsor
- Radboud University Medical Center
Distal Radioulnar Joint Sprain
4DCT Wrist Reference and DRUJ
The study will consist of 3 parts. First a reference study is performed with healthy volunteers to investigate the viability of 4DCT scanning of the wrist for evaluating wrist bones configurations and movements (translations and…
- Trial name
- NCT05886426
- Testing
- 4DCT wrist and standard CT wrist
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Cancer
Real World Pharmacokinetics of Immune Checkpoint Inhibitors
Rationale: Real-world pharmacokinetic data from cancer patients treated with immune checkpoint inhibitors (ICIs) are sparse. Moreover, pharmacokinetic parameters may be associated with response to ICI treatment and may act as a…
- Trial name
- ELICIT (NCT04833075)
- Testing
- blood sampling
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease
PERsonalized SPEeCh Therapy for actIVE Conversation
Background: Up to 70% of the patients with Parkinson's Disease (PD) experience speech problems, which cause a diminished intelligibility.
- Trial name
- PERSPECTIVE (NCT03963388)
- Testing
- Speech therapy
- Where
- Netherlands
- Volunteers
- 214 people
- Sponsor
- Radboud University Medical Center
Malaria,Falciparum, Controlled Human Malaria Infection
Safety and Efficacy of NF135 CPS Immunization
This is an open label, randomized, controlled clinical trial. The primary aim of this project is to determine the safety and tolerability of NF135.C10 sporozoite immunization under chemoprophylaxis against homologous and…
- Conditions
- Malaria,Falciparum, Controlled Human Malaria Infection, Immunization; Infection
- Trial name
- CPS135 (NCT03813108)
- Testing
- CPS-immunization, malaria challenge infection, P. falciparum NF135.C10, malaria challenge infection, P. falciparum NF54
- Where
- Netherlands
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Angiodysplasia, Vascular Malformations
Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anemia Due to Angiodysplasias
The purpose of this study is to determine whether 40 mg octreotide long-acting release intramuscular every 28 days is effective in the treatment of patients with refractory anemia due to gastrointestinal angiodysplasias.
- Conditions
- Angiodysplasia, Vascular Malformations, Gastrointestinal Hemorrhage, Anemia
- Trial name
- OCEAN (NCT02384122)
- Testing
- Octreotide
- Where
- 12 sites in Netherlands
- Volunteers
- 62 people
- Sponsor
- Radboud University Medical Center
Ischemic Stroke, Stroke in the Young
Observational Dutch Young Symptomatic StrokE studY - nEXT
BACKGROUND: Worldwide, 2 million patients aged 18-50 years suffer an ischemic stroke each year with an increasing trend over the past decade due to yet unknown reasons.
- Conditions
- Ischemic Stroke, Stroke in the Young, Cardiovascular Diseases, Cerebrovascular Disorders
- Trial name
- ODYSSEY-nEXT (NCT05853796)
- Where
- 6 sites in Netherlands
- Volunteers
- 280 people
- Sponsor
- Radboud University Medical Center
Salivary Gland Cancer, Salivary Duct Carcinoma
Lutetium-177-PSMA Radioligand Therapy in Advanced Salivary Gland Cancer Patients
Phase 2 pilot study, which evaluates the safety and efficacy of Lutetium-177-PSMA radioligand therapy in advanced salivary gland cancer patients.
- Conditions
- Salivary Gland Cancer, Salivary Duct Carcinoma, Adenoid Cystic Carcinoma
- Trial name
- LUPSA (NCT04291300)
- Testing
- Lutetium-177-PSMA-I&T
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Radboud University Medical Center
Hypotension During Surgery
Post Anaesthesia Care Hypotension Prevention
The goal of this clinical trial is to investigate if the use of the hypotension prediction index during the perioperative period leads to a decrease in hypotension both during and after surgery (24 hrs) in adults undergoing major…
- Trial name
- PACH-1 (NCT05844774)
- Testing
- HPI (using HemoSphere) - guided algorithm, Treatment of hypotension following standard of care
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
PDAC - Pancreatic Ductal Adenocarcinoma
Defining a Vascular Phenotype of Pancreatic Ductal Adenocarcinoma With CT Perfusion Using Quantitative Radiomics
With CT-perfusion(CTP) it is possible to visualize the enhancement pattern of the tumor. The perfusion CT, interleaved with a routine contrast enhanced CT (CECT) will be performed at diagnosis in all patients (goal: n=125…
- Trial name
- NCT05669287
- Testing
- CT Perfusion
- Where
- Netherlands
- Volunteers
- 125 people
- Sponsor
- Radboud University Medical Center
Intracranial Aneurysm, Subarachnoid Hemorrhage
Deferoxamine in Aneurysmal Subarachnoid Hemorrhage Trial
Aneurysmal subarachnoid hemorrhage (SAH) is a form of stroke in which secondary neurological deterioration is an important cause of mortality and morbidity.
- Trial name
- DASH (NCT02875262)
- Testing
- Deferoxamine
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Recurrent Depression
Mindfulness Based Compassionate Living in Recurrent Depression
Since a few years, Mindfulness Based Cognitive Therapy (MBCT) has been used as treatment for patients suffering from recurrent depression.
- Trial name
- MBCL-RD (NCT02059200)
- Testing
- Mindfulness Based Compassionate Living
- Where
- Netherlands
- Volunteers
- 122 people
- Sponsor
- Radboud University Medical Center
Bipolar Disorder
Mindfulness Based Cognitive Therapy for Bipolar Disorder
The current study will be a randomized controlled trial (RCT) investigating the clinical and cost-effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) as an adjunct to usual care, versus usual care alone, in reducing…
- Trial name
- MBCT-BD (NCT03507647)
- Testing
- Mindfulness Based Cognitive Therapy, Usual Care
- Where
- 4 sites in Netherlands
- Volunteers
- 144 people
- Sponsor
- Radboud University Medical Center
Intensive Care Unit Syndrome, Patient Engagement
Improving Shared-Decision Making in the Intensive Care Unit Using Patient-reported Outcome Information
The aim of this study is to evaluate the effect of incorporation of outcome information in the Intensive Care Unit (ICU) decision-making process on patient and family reported outcomes and experiences of patients, relatives and…
- Trial name
- NCT05155150
- Testing
- Providing patient-reported outcome
- Where
- 2 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Radboud University Medical Center
Liver Cyst, Polycystic Liver Disease
Assessment of Treatment With Laparoscopic Fenestration or Aspiration Sclerotherapy for Large Symptomatic Hepatic Cysts
Patients with large hepatic cysts (> 5cm) may develop symptoms. These can be captured with the polycystic liver disease questionnaire (PLD-Q).
- Conditions
- Liver Cyst, Polycystic Liver Disease, Autosomal Dominant Polycystic Kidney, Autosomal Dominant Polycystic Liver Disease
- Trial name
- ATLAS (NCT05500157)
- Testing
- aspiration sclerotherapy versus laparoscopic fenestration
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Radboud University Medical Center
Barrett Esophagus, Barrett Adenocarcinoma
Public's Intended Uptake and Views on Organization of Esophageal Cancer Screening
Rationale: Research on novel methods to screen for esophageal adenocarcinoma (EAC) has expanded. Insight into individuals' drivers and barriers to attend screening is essential to tailor a potential new screening policy to their…
- Conditions
- Barrett Esophagus, Barrett Adenocarcinoma, Esophageal Adenocarcinoma
- Trial name
- ACCEPT-survey (NCT05690958)
- Testing
- Survey
- Where
- Netherlands
- Volunteers
- 2,088 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Parkinson Disease
Bringing Parkinson Care Back Home
SUMMARY Rationale: For persons with Parkinson's disease (PD), medical decisions are based almost exclusively on periodic in-clinic evaluations by a neurologist or a nurse.
- Trial name
- NCT04288583
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Type 1 Diabetes
BetaFIT Study: Beta Cell Imaging After Faecal mIcrobiota Transplantation
The main goal is to investigate whether beta cell mass is correlated to beta cell function after autologous faecal microbial transplantation (FMT) in patients with newly diagnosed type 1 diabetes
- Trial name
- BetaFIT (NCT05622123)
- Testing
- 68Ga-NODAGA-Exendin-4
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center