Clinical trials: sponsored by Radboud University Medical Center
Volatile Organic Compounds, Radiography
Tuberculosis Screening in Paraguayan Prisons
Two diagnostic tools for TB screening in high risk groups need additional assessment: the AeoNose™, an 'electronic nose device' for breath sampling, and digital chest X-ray (CXR) with computer aided detection with CAD4TB®…
- Trial name
- Prinose (NCT04407325)
- Testing
- electronic nose device, dig chest Xray with automated readings
- Where
- 2 sites in Paraguay
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Thyroid Cancer
Focus on Values to Stimulate Shared Decisions
Most patients with non-medullary thyroid carcinoma (TC) achieve remission after primary treatment. Nonetheless, 30% develop recurrent disease and/or distant metastases resulting in worse survival.
- Trial name
- NCT03905369
- Testing
- Decision aid and SDM booster, Deliberation training
- Where
- 11 sites in Netherlands
- Volunteers
- 128 people
- Sponsor
- Radboud University Medical Center
Postoperative Delirium, Postoperative Cognitive Dysfunction
Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Thoracic Aortic Aneurysm
- Trial name
- TURBO (NCT04523909)
- Testing
- Trajectory of neuroinflammatory proteins in CSF and blood
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Loneliness
Social Health Games: The Use of Online Games to Decrease Loneliness in Older Adults
This study examines whether social platform games are effective in expanding the social network and decreasing the experienced levels of loneliness in older adults.
- Trial name
- NCT04733898
- Testing
- SamenSpelen.app, FijnSpelen.app
- Where
- Netherlands
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Postoperative Cognitive Dysfunction, Coronary Artery Disease
Neuroinflammation in Cognitive Decline Post-cardiac Surgery
Major cardiovascular surgery is associated with postoperative cognitive decline (POCD), with a deterioration in memory, attention and speed of information processing.
- Conditions
- Postoperative Cognitive Dysfunction, Coronary Artery Disease, Pathophysiology
- Trial name
- FOCUS (NCT04520802)
- Testing
- 18F-DPA-714 PET/CT neuroimaging
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Polyp, Colonic, Bleeding
Clip Placement Following Colonic Endoscopic Mucosal Resection (EMR)
Study design: A national, multi-center, patient-blinded, randomized clinical trial. Study population: Patients undergoing EMR with a moderate to severe risk (right sided colon, ≥2cm) of developing Delayed Bleeding (DB).
- Trial name
- CLIPPER (NCT03309683)
- Testing
- Olympus Quick Clip Pro - Single Use Repositionable Clips
- Where
- 2 sites in Netherlands
- Volunteers
- 356 people
- Sponsor
- Radboud University Medical Center
Microvascular Angina, Coronary Vasospasm
Efficacy of Diltiazem to Improve Coronary Microvascular Dysfunction: a Randomized Clinical Trial
Rationale: Up to 40% of patients undergoing a coronary angiogram for symptoms/signs of ischemia do not have obstructive coronary artery disease (CAD).
- Conditions
- Microvascular Angina, Coronary Vasospasm, Microvascular Ischemia of Myocardium
- Trial name
- EDIT-CMD (NCT04777045)
- Testing
- Diltiazem Hydrochloride
- Where
- 3 sites in Netherlands
- Volunteers
- 85 people
- Sponsor
- Radboud University Medical Center
Malaria,Falciparum
Safety, Tolerability, and Pharmacokinetics and Pharmacodynamics of TB31F
This phase 1 study aims to assess the safety and tolerability of monoclonal antibody TB31F administered intravenously or subcutaneously at escalating dose levels in healthy, malaria naïve, adults.
- Trial name
- TB31F (NCT04238689)
- Testing
- TB31F
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Low Back Pain, Type of Leg Pain (Radicular, Non-radicular)
The Course of Low Back Pain
This study aims to research the possible associations of education level, sedentary lifestyle, and type of low back pain (radicular vs non-radicular) with the course of low back pain and recovery rate.
- Conditions
- Low Back Pain, Type of Leg Pain (Radicular, Non-radicular), Lifestyle (Sedentary Behavior and Physical Activity), Start Back Screening Tool
- Trial name
- NCT04419675
- Testing
- Observational Cohort, usual care = physical therapy
- Where
- 6 sites in Netherlands
- Volunteers
- 347 people
- Sponsor
- Radboud University Medical Center
Blunt Chest Trauma
The Effect of Virtual Reality on Pulmonary Recovery and Mobility in Patients With Blunt Chest Trauma
Blunt chest trauma comprises over 10% of all trauma patients presenting to emergency departments worldwide and is the most frequent injury in polytrauma patients.
- Trial name
- VIREX PURE (NCT05194176)
- Testing
- Virtual Reality
- Where
- Netherlands
- Volunteers
- 27 people
- Sponsor
- Radboud University Medical Center
Streptococcus Pneumoniae Infection
A Controlled Human Pneumococcal Infection Model (PIM) Study
Infection with Streptococcus pneumoniae (the pneumococcus) is the leading cause of pneumonia, bacterial meningitis and bacteraemia worldwide in the very young and the elderly.
- Trial name
- PIM (NCT05361499)
- Testing
- Sp_6B, Amoxicillin 500 mg
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Airway, Anesthesia, Local
Soft Mist Spray Device for Airway Anaesthesia During Awake Videolaryngoscopy
Rationale: Effective and fast topical anaesthesia of the upper airway is of paramount importance in awake (conscious) videolaryngoscopy of the airway in order to avoid patient discomfort.
- Trial name
- CT2Trachospray (NCT05478122)
- Testing
- Trachospray for awake videolaryngoscopy
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Inflammatory Bowel Diseases
The Effects of Combined Lifestyle Intervention (CLI) in Patients With Inflammatory Bowel Disease (IBD)
A single-center observational study to investigate the effects of combined lifestyle intervention (CLI, in Dutch: gecombineerde leefstijlinterventie, GLI) in patients with Inflammatory Bowel Disease.
- Trial name
- GLI-IBD (NCT05725369)
- Testing
- Combined Lifestyle Intervention (CLI)
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Oncology
ExeNTrO: Exercise During Neoadjuvant Chemoradiation Treatment to Improve Rectal and Esophageal Cancer Outcome - Pilot Trial
The goals of this study is to 1) evaluate feasibility and fidelity of a three-arm RCT containing a twice-weekly exercise intervention supervised by a first-line (oncology) physiotherapist and a 5-day weekly in-hospital exercise…
- Trial name
- ExeNTrO (NCT05686213)
- Testing
- combined aerobic exercise + resistance exercise intervention (AE + RE), Aerobic exercise prior to daily radiotherapy sessions (ExPR)
- Where
- Netherlands
- Volunteers
- 39 people
- Sponsor
- Radboud University Medical Center
Pulmonary Disease, Chronic Obstructive
(In)Voluntary Assessed Quadriceps Muscle Endurance in COPD
The primary objective is to assess the relation between involuntary and voluntary assessed quadriceps muscle endurance in patients with COPD. We hypothesized a good correlation (>0.8) between the measurements.
- Trial name
- Bionic (NCT05427773)
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus Type 2 in Obese
The GATE Trial: Endoscopic Sutured Gastroplasty in Type 2 Diabetic, Obese Patients Using the Endomina Device
Rationale: Diabetes mellitus is a chronic disease that is often associated with long-term macrovascular and microvascular complications and decreased life expectancy.
- Trial name
- GATE (NCT05711043)
- Testing
- Endoscopic sutured gastroplasty with endomina
- Where
- Netherlands
- Volunteers
- 58 people
- Sponsor
- Radboud University Medical Center
Bacterial Infections
Pharmacokinetics of Teicoplanin in Intensive Care and Haematology Patients
Characterize teicoplanin PK in critically ill patients with a specific focus on alterations of exposure due to variability in renal function.
- Trial name
- PLATO (NCT04096092)
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Gastro Esophageal Reflux
Gastroesophageal Reflux Disease in the Dutch Population
Rationale: Screening for esophageal adenocarcinoma (EAC) precursors and treating them may help to decrease mortality of this malignancy.
- Trial name
- REFLUX (NCT05689918)
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 4,719 people
- Sponsor
- Radboud University Medical Center
Post-Traumatic Osteoarthritis of Knee, Knee Injuries
Changes in the Immunomodulatory Properties of Adipose Stromal Cells Due to Hemarthrosis After Knee Injury
The goal of this observational study is to gain insight in the natural course of pro-inflammatory factors and hemarthrosis in patients older than 18 with a recent knee trauma.
- Conditions
- Post-Traumatic Osteoarthritis of Knee, Knee Injuries, Hemarthrosis
- Trial name
- CASH (NCT05687331)
- Testing
- knee arthrocentesis, venipuncture, MRI-scan
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Endometrial Cancer Stage III, Endometrial Cancer Stage IV
PROMOTE Study: Prediction of Response Of HorMOnal Treatment in Advanced and Recurrent Endometrial Cancer
The PROMOTE study aims at optimising use of hormonal therapy in advanced stage and recurrent endometrial cancer analysing tumor tissue taken before start of hormonal therapy
- Conditions
- Endometrial Cancer Stage III, Endometrial Cancer Stage IV, Endometrial Cancer Recurrent
- Trial name
- PROMOTE (NCT03621904)
- Testing
- Hormonal Antineoplastics
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Radboud University Medical Center