Clinical trials: sponsored by Radboud University Medical Center
Hereditary Spastic Paraplegia, Strumpell Disease
Improving Gait Adaptability in Hereditary Spastic Paraplegia
This study evaluates the effects of ten hours C-mill training on gait adaptability in participants with hereditary spastic paraplegia (HSP). Half of the participants start with five weeks of C-mill training (ten 1-hour sessions).
- Trial name
- Move-HSP (NCT04180098)
- Testing
- C-mill intervention, No intervention
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- Radboud University Medical Center
Usher Syndrome, Type 2A, Retinitis Pigmentosa
Characterizing Rate of Progression in USHer Syndrome (CRUSH) Study
Mutations in USH2A give rise to two phenotypes: Usher syndrome type 2a (USH2A) and nonsyndromic RP (USH2A associated nsRP). Usher syndrome is the most common form of congenital deafblindness.
- Conditions
- Usher Syndrome, Type 2A, Retinitis Pigmentosa, USH2A
- Trial name
- CRUSH (NCT04820244)
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- Radboud University Medical Center
Peripheral Arterial Disease
Genotype-guided Strategy for Antithrombotic Treatment in Peripheral Arterial Disease.
Rationale: Peripheral arterial disease (PAD) is a common presentation of atherosclerosis. For the prevention of adverse events related to arterial thrombosis in PAD patients, clopidogrel is recommended.
- Trial name
- GENPAD (NCT04619927)
- Testing
- Direct CYP2C19 genotyping, CYP2C19 genotyping at the end of the study, Poor metabolisers
- Where
- 11 sites in Netherlands
- Volunteers
- 2,276 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease
Trained Immunity by Dual-pathway Inhibition in Coronary Artery Disease
Coronary artery disease (CAD) is a manifestation of systemic atherosclerosis for which single antiplatelet therapy (SAPT) is indicated if patients are stable.
- Trial name
- DUALCAD (NCT05210725)
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Carotid Artery Plaque
Ultrasound Elastography for Individual Carotid Plaque Stratification
Ischemic strokes are a leading cause of death and disability worldwide. In 20% of cases they are caused by the rupture of atherosclerotic plaques in carotid arteries. Risk estimation of plaque rupture is currently suboptimal.
- Trial name
- Ultra-COMPASS (NCT05029661)
- Testing
- Carotid ultrasound
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Aortic Valve Disease, Aortic Valve Stenosis
Myeloid Cells in Aortic Valve Stenosis
Investigators plan to characterize systemic inflammation and circulating immune cells in participants with moderate and severe calcific aortic valve disease and matched healthy controls.
- Trial name
- MIRACLE (NCT04717219)
- Testing
- Blood drawing
- Where
- 3 sites in Netherlands
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Esophageal Cancer, Esophageal Neoplasms
TreatmENT of AnastomotiC Leakage After Esophagectomy
Rationale: Anastomotic leakage (0% - 30%) is a severe complication after esophagectomy with mortality rates approximately ranging from 2% - 12%. In addition, it is associated with a prolonged ICU treatment and hospital stay.
- Trial name
- TENTACLE (NCT03829098)
- Testing
- Intervantions for anastomotic leakage after esophagectomy
- Where
- Netherlands
- Volunteers
- 1,509 people
- Sponsor
- Radboud University Medical Center
Lithium Toxicities, Bipolar Disorder
Decline in Renal Concentration Ability in Lithium Treated Patients
Lithium therapy is cornerstone in therapy of bipolar disorders. A well known side-effect of lithium therapy is a urinary concentration defect which manifests in it's most severe form as nephrogenic diabetes insipidus.
- Conditions
- Lithium Toxicities, Bipolar Disorder, Concentration Ability Impaired, Nephrogenic Diabetes Insipidus
- Trial name
- NCT05307042
- Testing
- Deamino Arginine Vasopressin (dDAVP)
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- Radboud University Medical Center
Malaria,Falciparum, Plasmodium Falciparum
Safety and Protective Efficacy of Pb(PfCS@UIS4)
In the underlying study, a genetically modified P. berghei parasite is used. P. berghei is one of the four Plasmodium species that causes malaria in rodents. The hypothesis is that immunization of humans with P.
- Conditions
- Malaria,Falciparum, Plasmodium Falciparum, Plasmodium Berghei, Controlled Human Malaria Infection (CHMI)
- Trial name
- PbVac (NCT03138096)
- Testing
- Pb(PfCS@UIS4)-infected mosquitoes, Challenge infection P. falciparum
- Where
- 2 sites in Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Type 1 Diabetes Mellitus
Visualizing Beta Cells After Islet Transplantation
In patients with type 1 diabetes (T1D) that have undergone islet of Langerhans transplantation or are on the waiting list for transplantation, Ga-68-exendin PET imaging is performed to study the visualization of transplanted…
- Trial name
- GLP1-transpl (NCT03785236)
- Testing
- 68Ga-NODAGA-exendin PET/CT
- Where
- 2 sites in Netherlands, Sweden
- Volunteers
- 13 people
- Sponsor
- Radboud University Medical Center
Type 1 Diabetes Mellitus
Beta Cell Imaging in T1D Patients With a Different Glycemic Control
The primary aim of this study is to measure (residual) beta cell mass in type 1 diabetes (T1D) patients with stable near-normal and unstable glucose control using PET/CT imaging, to improve the understanding of the relation…
- Trial name
- GLP1-reg (NCT03785275)
- Testing
- gallium-68-exendin PET/CT
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Thyroid Cancer
Myeloid Cell Reprogramming in Thyroid Carcinoma
This study investigates the reprogramming of myeloid cells in patients with thyroid carcinoma. The investigators hypothesize that tumor-derived factors change the function of myeloid cells (peripheral blood and bone…
- Trial name
- NCT03397238
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
COVID, Vascular; Damage
Influence of COVID-19 on Vascular Endothelial Function
Rationale: Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) 2 could result in endothelial dysfunction with increased risk of arterial thrombotic events by downregulating the expression of angiotensin…
- Trial name
- COVAS (NCT04468412)
- Testing
- Carotid Artery Reactivity Testing
- Where
- Netherlands
- Volunteers
- 203 people
- Sponsor
- Radboud University Medical Center
Peripheral Artery Disease
DUAL Pathway Inhibition to Improve Endothelial Function in Peripheral Artery Disease
Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis, causing patients to be at high risk of major adverse cardiovascular and limb events.
- Trial name
- DUAL-PAD (NCT04218656)
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet
- Where
- 2 sites in Netherlands
- Volunteers
- 159 people
- Sponsor
- Radboud University Medical Center
Hip Osteoarthritis, Physical Inactivity
Total Hip Arthroplasty and Physical Activity in Patients Younger Than 50 Years
Rationale: THA is a widely applied procedure for osteoarthritis of the hip. After THA, one can expect an increase in physical activity due to the reduction of pain and increased range of motion of the hip joint, especially in…
- Trial name
- THA&PA (NCT05189964)
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Radboud University Medical Center
Head and Neck Cancer
PD-L1 ImagiNg to prediCt Durvalumab Treatment Response in HNSCC
Non-invasive imaging of tumor PD-L1 expression with 89Zr-labeled durvalumab PET/CT predicts response to durvalumab.
- Trial name
- PINCH (NCT03829007)
- Testing
- PD-L1 imaging, Durvalumab
- Where
- 4 sites in Netherlands
- Volunteers
- 33 people
- Sponsor
- Radboud University Medical Center
Non Small Cell Lung Cancer
PD-L1 Imaging in Non Small Cell Lung Cancer' (PINNACLE)
In this feasibility study, a zirconium-89 (89Zr)-avelumab positron emission tomography (PET) scan will be performed in 37 patients prior to treatment with avelumab to: 1.
- Trial name
- PINNACLE (NCT03514719)
- Testing
- 89Zr-avelumab PET, Avelumab
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Radboud University Medical Center
Clear-cell Metastatic Renal Cell Carcinoma, Kidney Neoplasms
IMaging PAtients for Cancer Drug selecTion - Renal Cell Carcinoma (IMPACT-RCC)
Rationale. In part of the patients with good and intermediate risk metastatic renal cell carcinoma (mRCC) the disease course is indolent and immediate start of systemic therapy is not necessary.
- Trial name
- IMPACT-RCC (NCT02228954)
- Testing
- Molecular imaging
- Where
- 3 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Parkinson's Disease
Real-PD Trial: Development of Clinical Prognostic Models for Parkinson's Disease
Background: Long-term management of Parkinson's disease (PD) does not reach its full potential due to lack of knowledge about disease progression.
- Trial name
- NCT02474329
- Testing
- Clinical assessment, Fox Insight self-monitoring android app and falls detector
- Where
- Netherlands
- Volunteers
- 304 people
- Sponsor
- Radboud University Medical Center
Secondary Caries
Effectiveness of Adhesive Containing MDPB
9 general practices in the Netherlands were provided with two composite resin adhesives, each for a period of 9 months. One contained MDPB (Adhesive P), and the other one was used as a control (Adhesive S).
- Trial name
- NCT05118100
- Testing
- Clearfil Protect Bond, Clearfil SE Bond
- Volunteers
- 5,102 people
- Sponsor
- Radboud University Medical Center