Clinical trials: sponsored by Radboud University Medical Center
Pneumoperitoneum, Neuromuscular Blockade
The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Innate Immune Homeostasis.
Substudy of the RECOVER trial (a randomised controlled trial comparing the effect of low pressure pneumoperitoneum with deep neuromuscular block versus normal pressure pneumoperitoneum with moderate neuromuscular block during…
- Conditions
- Pneumoperitoneum, Neuromuscular Blockade, Surgery, Immune Suppression
- Trial name
- RECOVER-PLUS (NCT03572413)
- Testing
- Low pressure pneumoperitoneum, Rocuronium bromide
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Pneumoperitoneum, Neuromuscular Blockade
The Effect of Low Pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery on Early Quality of Recovery
Randomised controlled trial comparing the effect of low pressure pneumoperitoneum with deep neuromuscular block versus normal pressure pneumoperitoneum with moderate neuromuscular block during laparoscopic colorectal surgery on…
- Conditions
- Pneumoperitoneum, Neuromuscular Blockade, Surgery
- Trial name
- RECOVER (NCT03608436)
- Testing
- Low pressure pneumoperitoneum, Rocuronium Bromide
- Where
- 3 sites in Netherlands
- Volunteers
- 178 people
- Sponsor
- Radboud University Medical Center
Critical Illness
Improving Sleep and Reducing External Stimuli With the Maya
Lack of sleep is a large problem for many patients in hospitals. Common causes are nuisances by light and sound. Especially with critically ill patients in the Intensive Care unit (ICU), Medium Care Unit (MCU) and Cardiac Care…
- Trial name
- NCT05078645
- Testing
- Maya
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Carcinoma, Renal Cell
Intraoperative Dual-modality Imaging in Renal Cell Carcinoma
Intraoperative tumor localization and resection can be enhanced using intraoperative fluorescence imaging and radiodetection. Girentuximab specifically recognizes carbonic anhydrase IX expressed on > 95% of renal cell carcinoma…
- Trial name
- NCT02497599
- Testing
- Indium-111-DOTA-Girentuximab-IRDye800CW, SPECT/CT, Intraoperative dual-modality imaging
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Back Pain Lower Back Chronic, Quality of Life
The Efficacy, Acceptability, Tolerability and Feasibility of a Therapeutic Virtual Reality Application
This study evaluates the effect of therapeutic Virtual Reality (VR) on quality of life of 60 patients with non-specific chronic low-back pain. 30 patients will be included in the intervention group.
- Trial name
- PijnVRij (NCT04042090)
- Testing
- Reducept, virtual reality
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Radboud University Medical Center
Pancreatic Cancer, Periampullary Cancer
Preoperative Detection of Lymph Node Metastases in Pancreatic and Periampullary Carcinoma Using USPIO MRI
Adenocarcinoma's of the pancreas and periampullary region (distal bile duct, ampulla of Vater and duodenum) are cancers with a poor survival.
- Trial name
- NANO-PANC (NCT04311047)
- Testing
- USPIO-enhanced MRI
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- Radboud University Medical Center
Acute Respiratory Distress Syndrome, SARS-CoV-2
Valsartan for Prevention of Acute Respiratory Distress Syndrome in Hospitalized Patients With SARS-COV-2 (COVID-19) Infection Disease
Rationale: The current SARS-CoV-2 pandemic has a high burden of morbidity and mortality due to development of the so-called acute respiratory distress syndrome (ARDS).
- Conditions
- Acute Respiratory Distress Syndrome, SARS-CoV-2, COVID, COVID-19
- Trial name
- NCT04335786
- Testing
- Valsartan (Diovan)
- Where
- 7 sites in Netherlands
- Volunteers
- 23 people
- Sponsor
- Radboud University Medical Center
Polycystic Liver Disease, Polycystic Kidney, Autosomal Dominant
Ursodeoxycholic Acid as Treatment for Polycystic Liver Disease
Rationale: Polycystic liver disease (PLD) is a rare disorder characterized by >20 fluid-filled hepatic cysts. Polycystic livers are present in the combination with renal cysts as a manifestation of autosomal dominant polycystic…
- Trial name
- CURSOR (NCT02021110)
- Testing
- Ursodeoxycholic Acid
- Where
- 3 sites in Netherlands, Spain
- Volunteers
- 34 people
- Sponsor
- Radboud University Medical Center
Tooth Wear, Dental Restoration Failure
Full Occlusal Rehabilitation for Patients With Severe Tooth Wear Using Indirect Composite Restorations
LAVA Ultimate composite restorations will be used as restorative material to reconstruct severely worn dentitions.
- Conditions
- Tooth Wear, Dental Restoration Failure, Dental Restoration Wear
- Trial name
- NTWP (NCT02957734)
- Testing
- Rehabilitation of severely worn dentitions
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Prostate Cancer
MRI-guided Focal Laser Ablation
Magnetic resonance imaging-guided focal laser ablation of prostate cancer.
- Trial name
- Unicorn (NCT04379362)
- Testing
- Focal laser ablation
- Where
- Netherlands
- Volunteers
- 53 people
- Sponsor
- Radboud University Medical Center
Pancreatic Neoplasms
Contrast-enhanced Diffusion-weighted MRI to Detect Liver Metastases in Patients With Pancreatic Cancer
Given the dismal prognosis of pancreatic cancer, detecting liver metastases early can avoid inappropriate therapy with the associated substantial risks, long-term hospital admissions and high costs, but without survival benefit.
- Trial name
- DIA-PANC (NCT03469726)
- Testing
- Contrast-enhanced Diffusion-weighted MRI
- Where
- 7 sites in Greece, Netherlands and 2 more
- Volunteers
- 465 people
- Sponsor
- Radboud University Medical Center
Melanoma
myDC/pDC in Stage III Melanoma Patients
This is an interventional study to test the immunogenicity of combined adjuvant myDC and pDC vaccination versus adjuvant myDC or pDC vaccination alone in stage III melanoma patients.
- Trial name
- NCT02574377
- Testing
- A: myDC vaccination, B: pDC vaccination, C: combined myDC/pDC vaccination
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Myocardial Infarction, Acute Coronary Syndrome
Identification of Risk Factors for Acute Coronary Events by OCT After STEMI and NSTEMI in Patients With Residual Non-flow Limiting Lesions
The objective of this study is to compare the clinical outcome of Non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) patients with non-obstructive, non-culprit coronary lesions and…
- Conditions
- Myocardial Infarction, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- PECTUS-obs (NCT03857971)
- Testing
- Coronary Optical Coherence tomography
- Where
- Netherlands
- Volunteers
- 438 people
- Sponsor
- Radboud University Medical Center
Pain, Post-surgical Pain
The Effect of Virtual Reality on Post-surgical Pain and Recovery.
This study evaluates the effect of Virtual Reality (VR) on pain and recovery in 100 post-operative patients. 60 patients will be included in the intervention group; they will use VR minimal 3 times a day on day 2-4 after surgery…
- Conditions
- Pain, Post-surgical Pain, Pain Management
- Trial name
- VIRTUAL (NCT03933124)
- Testing
- Virtual Reality
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Cardiovascular Diseases, HMG COA Reductase Inhibitor Adverse Reaction
Exercise-induced Muscle Damage in Statin Users
Rationale: Combining statin treatment and physical activity is very effective for the prevention of cardiovascular diseases. Statins are well-tolerated by most patients, but may cause statin-associated muscle symptoms (SAMS) and…
- Conditions
- Cardiovascular Diseases, HMG COA Reductase Inhibitor Adverse Reaction, Muscle Damage
- Trial name
- NCT05011643
- Testing
- Moderate-intensity exercise
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Tuberculosis
Phenotyping of High Dose Rifampicin
Higher doses of rifampicin as a means of more efficient use of this pivotal TB drug has shown promising results and might become standard in future.
- Trial name
- PHENORIF (NCT04525235)
- Testing
- phenotyping cocktail, rifampicin
- Where
- 2 sites in South Africa
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Castrate Resistant Prostate Cancer, Bone Metastases
Health-related Quality of Life, Psychological Distress and Fatigue in Metastatic CRPC Patients Treated With Radium-223
The aim of the current prospective multicenter study is to evaluate cancer-specific and bone metastases related HR-QoL, psychological distress and fatigue in mCRPC patients before, during and after treatment with radium-223 in…
- Trial name
- NCT04995614
- Testing
- Radium-223
- Where
- 11 sites in Netherlands
- Volunteers
- 122 people
- Sponsor
- Radboud University Medical Center
Malignant Hyperthermia, Rhabdomyolysis
Multisystem Features of Malignant Hyperthermia or Rhabdomyolysis Related to RYR1 Variants
Rationale: Malignant hyperthermia and rhabdomyolysis are phenotypes that have long been considered to occur only in response to external stimuli (trigger anaesthesia and physical exhaustion) show several features of a continuous…
- Conditions
- Malignant Hyperthermia, Rhabdomyolysis, RYR1 Variant
- Trial name
- NCT04610619
- Testing
- Immunological challenge
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Fluconazole, Candidiasis
Fluconazole Pharmacokinetics, Including Bioavailability, in Obese Subjects After an Intravenous and Oral Administration
The pharmacokinetics of fluconazole are expected to be different in obese patients compared to non-obese patients. The investigators will determine fluconazole and free fluconazole concentrations in 16 obese patients and 8…
- Conditions
- Fluconazole, Candidiasis, Invasive Fungal Infections, Obesity
- Trial name
- FOLIA (NCT04122560)
- Testing
- Fluconazole 200mg tab, Fluconazole 2 MG/ML
- Where
- 2 sites in Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
COVID-19
Lanadelumab for Treatment of COVID-19 Disease
So far little is very few drugs have demonstrated positive results for treatment of COVID19. Recently the researchers have shown that the use of icatibant in COVID-19 results in a potent decrease in oxygen use.
- Trial name
- COVID_LAN (NCT04422509)
- Testing
- lanadelumab, regular care
- Where
- 4 sites in Netherlands
- Volunteers
- 43 people
- Sponsor
- Radboud University Medical Center