Clinical trials: sponsored by Radboud University Medical Center
Melanoma
Timing of Immunotherapy in Melanoma
The TIME-NL trial is a multicenter, randomized, open-label clinical trial in the Netherlands to assess the effect of the timing of the first administration of standard-of-care intravenous combination immunotherapy (early morning…
- Trial name
- TIME-NL (NCT07696715)
- Testing
- Timing of first administration (early morning), Timing of immunotherapy (afternoon)
- Where
- 5 sites in Netherlands
- Volunteers
- 170 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease, Atherosclerosis
Measuring Athlete's Risk of Cardiovascular Events 3 (MARC-3)
Regular endurance exercise is widely known to improve cardiovascular health and reduce the risk of heart disease. Yet several imaging studies have shown that male endurance athletes have a higher prevalence of coronary artery…
- Trial name
- MARC-3 (NCT07625488)
- Where
- 2 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Type 1, Inflammation
The Role of the Adrenergic System in Hypoglycaemia Induced Inflammatory Response in People With Type 1 Diabetes and People Without Type 1 Diabetes-RAID-II
The goal of this trial is to study the effect that adrenaline has on the immune reaction seen during a low blood sugar. People with type 1 diabetes do not produce their own insulin.
- Trial name
- RAID-II (NCT06422494)
- Testing
- hyperinsulinaemic hypoglycaemic clamp, Propranolol Hydrochloride 1 MG/ML, Phentolamine
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Palliative Care
Contextualizing Care for Patients With a Serious Illness
When people become seriously ill, healthcare decisions are influenced not only by their medical condition, but also by their personal situation, values, wishes, and daily life circumstances.
- Trial name
- SVPII-TRAIN (NCT07764263)
- Testing
- Contextualized Care Communication Training
- Where
- Netherlands
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Chronic Pain, Acute Pain
Pain Predict Genetics
Pain is the most frequent cause of suffering and disability in society. Despite considerable involvement of genetic factors in pain sensation and sensitivity, the individual genes involved remain largely unidentified.
- Trial name
- PPG (NCT02383342)
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- Radboud University Medical Center
Wear Comfort, Retention
3D Printed vs. Milled Occlusal Splints in Dentistry
This crossover study aims to evaluate the wear comfort, retention, and stability of 3D-printed and milled occlusal splints in healthy subjects.
- Conditions
- Wear Comfort, Retention, Stability
- Trial name
- Splints (NCT07236294)
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Bacterial Infections
TDM-optimized Teicoplanin Dosing Versus Standard of Care
Value of TDM for teicoplanin is not well defined. In this single-center low-interventional randomized trial the investigators aim to investigate the superiority of teicoplanin TDM-optimized using Model-Informed-Precision-Dosing…
- Trial name
- PLATO-3 (NCT05914467)
- Testing
- Teicoplanin
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- Radboud University Medical Center
Risk of Malnutrition
Plant-based Versus Animal-based Oral Nutritional Supplements
Background information: Many people who are admitted to the hospital are at risk of malnutrition. In some patient groups, this can be as high as 40%.
- Trial name
- PAVOS (NCT07399886)
- Testing
- Fresubin Plant-based drink vanilla©, Fresubin Yodrink raspberry©
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Bariatric Surgery, Fat Free Mass
Protein Supplementation and Resistance Training to Prevent Fat-Free Mass Loss Following Metabolic-Bariatric Surgery
The goal of this clinical trial is to investigate the effects of daily protein supplementation and participation in a weekly supervised resistance training program on the prevention of excessive muscle mass loss following…
- Trial name
- ENRICHED (NCT07156552)
- Testing
- Resistance exercise training and protein supplementation
- Where
- 2 sites in Netherlands
- Volunteers
- 400 people
- Sponsor
- Radboud University Medical Center
Kbg Syndrome, ADHD - Combined Type
Methylphenidate in KBG Syndrome: N-of-1 Series
The goal of this clinical trial] is to learn about the effect of methylphenidate in children and adolescents with KBG syndrome. The main question it aims to answer is: What is the effectiveness of methylphenidate on attention…
- Trial name
- KBGS_N_of_1 (NCT06465641)
- Testing
- Methylphenidate Hydrochloride
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Delirium - Postoperative
Intranasal Insulin to Prevent Intensive Care Unit Delirium
This study aims to assess the feasibility, tolerability, and exploratory efficacy of intranasal insulin to prevent delirium in ICU patients aged ≥65 years after complex elective cardiac surgery with cardiopulmonary bypass
- Trial name
- INSPIRE (NCT07532577)
- Testing
- Intranasal insulin-40U, Intranasal sodium chloride 0.9%
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Endometrial Cancer
Individualised Endometrial Cancer Risk Stratification by Bayesian Prediction Model (ENDORISK), Optimizing Clinical Implementation
Rationale: Preoperative identification of patients at risk for lymph node metastasis (LNM) is challenging in endometrial cancer (EC).
- Trial name
- ENDORISK-I (NCT07200466)
- Testing
- ENDORISK personalized risk assesment for lymph node metastases in endometrial cancer.
- Where
- 14 sites in Netherlands
- Volunteers
- 735 people
- Sponsor
- Radboud University Medical Center
Occlusion, Occlusal Splints
Clinical Performance of CAD/CAM Occlusal Splints Fabricated With or Without a Wax Bite Registration in Healthy Adults
Occlusal splints are commonly used to manage sleep bruxism, temporomandibular disorders, and tooth wear. Traditionally, a wax bite registration is used during the fabrication of CAD/CAM occlusal splints to determine the vertical…
- Conditions
- Occlusion, Occlusal Splints, Occlusal Analysis, Comfort
- Trial name
- Splint (NCT07720453)
- Testing
- Occlusal splint fabricated using a virtual increase of the vertical dimension, Occlusal splint fabricated using a conventional wax bite registration
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Melanoma (Skin) Stage IV, Melanoma (Skin Cancer)
Dietary Fiber to Induce Gut Microbiota-mediated Response to Immunotherapy in Melanoma.
Previous research has shown that a higher fiber intake may have a beneficial effect on the intestinal health and improve the effectiveness of immunotherapy, but this is not certain.
- Conditions
- Melanoma (Skin) Stage IV, Melanoma (Skin Cancer), Melanoma Metastatic, Melanoma Advanced
- Trial name
- FIGURE-IM (NCT07686835)
- Testing
- Dried chicory roots
- Where
- 2 sites in Netherlands
- Volunteers
- 70 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease
A Physical Activity Programme Focussed on Step Volume and Intensity for People With Cardiovascular Disease: Getting Active and Staying Active After Cardiac Rehabilitation
The goal of this clinical trial is to learn about the effect of a physical activity program, focussing on increasing step volume and step intensity (STEP COACH program), compared to usual care in patients with coronary heart…
- Trial name
- STEP COACH RCT (NCT07723274)
- Testing
- STEP COACH intervention group
- Where
- 4 sites in Netherlands
- Volunteers
- 334 people
- Sponsor
- Radboud University Medical Center
Cardiac Output
Validation of CardioQ Versus PiCCO in Children
To compare the less invasive Oesophageal Doppler cardiac output Monitor (ODM) to the invasive (standard of care) Transpulmonary Thermodilution cardiac output monitor (TPTD) in children.
- Trial name
- CQPiCCO (NCT03172689)
- Testing
- CardioQ
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Radboud University Medical Center
Polypharmacy, Medication Review
Less Is More: Optimized Pharmacotherapy With Improved coNtinuity of CarE in hospitaLized oLder peOple
The goal of this cluster randomized controlled trial is to compare transitional multidisciplinary pharmacotherapeutic care (TMPC) with usual care in patients aged 70 years or older with polypharmacy, admitted to the hospital via…
- Trial name
- LIMONCELLO (NCT05899114)
- Testing
- Transitional Multidisciplinary Pharmacotherapeutic Care
- Where
- 16 sites in Netherlands
- Volunteers
- 1,241 people
- Sponsor
- Radboud University Medical Center
Hemophilia A, Anticoagulant Therapy
Home Monitoring in Hemophilia A
Rationale: A novel point-of-care device capable of measuring factor VIII (FVIII) activity and thrombin generation (TG) is currently under development.
- Conditions
- Hemophilia A, Anticoagulant Therapy, Monitoring, Point of Care Testing
- Trial name
- NCT06702579
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Radboud University Medical Center
Candidemia
Safety and Efficacy of Interferon-Gamma 1b in Patients With Candidemia
A multi-center open label adaptive randomized interventional phase 2 study to evaluate safety and efficacy of rIFN-y treatment in patiens with candidemia.
- Trial name
- HDM-FUN Cand (NCT04979052)
- Testing
- Interferon Gamma-1B
- Where
- 6 sites in United States, Germany and 4 more
- Volunteers
- 65 people
- Sponsor
- Radboud University Medical Center
Influenza With Pneumonia, Pulmonary Aspergillosis
Prospective Observational Trial of IAPA
A prospective multi-center observational study to assess the incidence of influenza-associated pulmonary aspergillosis (IAPA) in ICU patients and to identify host- and pathogen related risk factors for IAPA in EORTC negative ICU…
- Trial name
- IAPAFLU (NCT04530799)
- Testing
- Identification of biomarkers for IAPA via patient sampling
- Where
- 12 sites in Belgium, France and 1 more
- Volunteers
- 241 people
- Sponsor
- Radboud University Medical Center