Clinical trials: sponsored by Radboud University Medical Center
Diabetes Mellitus, Type 1, Cardiovascular Diseases
Activation Innate Immune System in Type 1 Diabetes
Hyperglycemia is a well-known cardiovascular risk factor. It has also been shown that episodes of hyperglycemia increase the risk for cardiovascular diseases despite return to normoglycemia, a phenomenon termed 'glycemic or…
- Conditions
- Diabetes Mellitus, Type 1, Cardiovascular Diseases, Innate Immune System, Inflammation
- Trial name
- NCT03441919
- Testing
- PET-CT (positron emission tomography - computer tomography), Blood drawn
- Where
- Netherlands
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Neuromuscular Block, Surgery
MRI Measurement of the Effects of Deep Neuromuscular Blockade on the Abdominal Working Space During Laparoscopy
During laparoscopy, a surgical working space is obtained by creation of a pneumoperitoneum. Optimal surgical conditions are essential to ensure the patient's safety.
- Trial name
- RELAX-2 (NCT03287388)
- Testing
- No Rocuronium, Rocuronium (moderate NMB), Rocuronium (deep NMB)
- Volunteers
- 8 people
- Sponsor
- Radboud University Medical Center
Atherosclerosis, Cardiovascular Diseases
The Role of Stem Cells on Immune Cells in the Development of Cardiovascular Diseases
An observational pilot proof-of-principle study. 15 patients with significant coronary artery disease and 15 matched controls. To investigate whether long-term activation of the innate immune system, named 'trained innate…
- Trial name
- ATHEROSTEM (NCT03172507)
- Where
- 2 sites in Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Psoriasis
Tight Control Dose Reductions of Biologics in Psoriasis Patients With Low Disease Activity
Rationale/hypothesis: Moderate-to-severe psoriasis can be treated with biologics. Objective To investigate whether the dose of biologics can be reduced in patients with psoriasis with stable disease.
- Trial name
- NCT02602925
- Testing
- Dose decrease, Usual care
- Where
- 6 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Radboud University Medical Center
Clear Cell Renal Carcinoma
89Zr-girentuximab ) Dosimetry in CCRC Study - ZIR-DOSE
The study is designed to explore the safety and tolerability as well as diagnostic 89Zr-girentuximab for imaging CCRC by PET/CT.
- Trial name
- NCT03556046
- Testing
- 89Zr-Girentuximab
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Cold Exposure, Hyperventilation
Effects of Cold Exposure and Breathing Techniques on Immune Response
Inflammatory cytokines play a pivotal role in rheumatoid arthritis (RA) and innovative non-pharmacological therapies aimed at limiting cytokine production are highly warranted.
- Conditions
- Cold Exposure, Hyperventilation, Inflammation, Endotoxemia
- Trial name
- EXPOCOL (NCT03240497)
- Testing
- Cold Exposure, Strength Ventilation
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Carcinoma, Renal Cell
Follow up After Cryoablation of Small Renal Masses.
Currently there is no consensus on post procedural follow up imaging following percutaneous cryoablation of renal tumors. Interpretation of conventional contrast enhanced imaging (CT and MRI) during follow up can be very…
- Trial name
- NCT02411968
- Testing
- 111In-Girentuximab DOTA SPECT
- Where
- Netherlands
- Volunteers
- 9 people
- Sponsor
- Radboud University Medical Center
HIV
Effects of Raltegravir Based Regimen on Platelet Reactivity, Platelet-monocyte Aggregation and Immune Activation
Cardiovascular disease (CVD) has emerged as a leading cause of morbidity and mortality in HIVinfected individuals. The precise mechanisms underlying this increased cardiovascular risk remain to be elucidated.
- Trial name
- RAPID (NCT02383355)
- Testing
- Raltegravir, Continuation of own regimen
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Uveal Melanoma
Messenger Ribonucleic Acid (mRNA) Transfected Dendritic Cell Vaccination in High Risk Uveal Melanoma Patients
1. Rationale Immunotherapy applying ex vivo generated and tumor antigen-loaded dendritic cells (DC) has now successfully been introduced in the clinic.
- Trial name
- NCT00929019
- Testing
- autologous dendritic cells electroporated with mRNA
- Where
- 2 sites in Netherlands
- Volunteers
- 23 people
- Sponsor
- Radboud University Medical Center
Breast Neoplasms
Influence of Exceptional Patient Characteristics on Everolimus Exposure
A study to determine whether everolimus pharmacokinetics in elderly and obese patients is different compared to control patients.
- Trial name
- INPRES (NCT01948960)
- Testing
- everolimus dose escalation
- Where
- 7 sites in Netherlands
- Volunteers
- 56 people
- Sponsor
- Radboud University Medical Center
Congenital Hyperinsulinism
GLP-1 Receptor Expression in CHI
The primary objective is the in vivo and ex vivo investigation of the expression and distribution of the GLP-1R in the pancreas of CHI patients.
- Trial name
- GLP-1-CHI (NCT03768518)
- Testing
- 68Ga-exendin-4 PET/CT
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Rectal Neoplasms, Breast Neoplasms
Nano MRI on 7 Tesla in Rectal and Breast Cancer
This study evaluates the diagnostic accuracy of an USPIO contrast agent (ferumoxtran-10) in combination with 7 Tesla MRI to detect lymph node metastases in rectal and breast cancer.
- Trial name
- NCT02751606
- Testing
- ferumoxtran-10, 7 Tesla MRI, 3 Tesla MRI
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Pulmonary Tuberculosis (TB)
Safety, Tolerability, Extended Early Bactericidal Activity and PK of Higher Doses Rifampicin in Adults With Pulmonary TB
This is the first trial in a series of clinical trials that aim to bring the concept of high dose rifampicin beyond phase II of clinical development.
- Trial name
- HR1 (NCT01392911)
- Testing
- Rifampicin
- Where
- 2 sites in South Africa
- Volunteers
- 128 people
- Sponsor
- Radboud University Medical Center
Type1diabetes, Hypoglycemia Unawareness
The Effect Lactate Administration on Cerebral Blood Flow During Hypoglycemia
It is thought that altered brain lactate handling is involved in the development of impaired awareness of hypoglycemia (IAH), i.e. the inability to timely detect hypoglycemia in people with type 1 diabetes (T1DM).
- Trial name
- NCT03730909
- Testing
- Sodium Lactate, Sodium chloride
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Bacterial Infections
Pharmacokinetics of Flucloxacillin Given by Continuous or Intermittent Infusion to ICU Patients
The pharmacokinetics of flucloxacillin are expected to be different in ICU patients compared to non-ICU patients. The investigators will determine total and free flucloxacillin concentrations in 30 ICU patients, who will get…
- Trial name
- FANATIC (NCT02993575)
- Testing
- Flucloxacillin
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Neuropathic Pain, Orofacial Pain
Bilateral TMS vs. Unilateral TMS
Rationale: In 2016, Henssen et al. discuss that orofacial pain may be conducted in a bilateral fashion, inducing activation of both thalami [1].
- Conditions
- Neuropathic Pain, Orofacial Pain, Trigeminal Neuropathy
- Trial name
- biTMSvsuniTMS (NCT03710967)
- Testing
- Transcranial magnetic stimulation
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Radboud University Medical Center
Dementia, Empowerment
Empowerment Intervention for Persons With Young Onset Dementia
The purpose of this study is to evaluate the effects of an empowerment intervention for community-dwelling persons with young onset dementia and their informal caregivers.
- Trial name
- NCT02937883
- Testing
- Empowerment intervention
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Chronic Pain
Effectiveness of Buprenorphine/Naloxone
Long-term use of opioids for chronic pain is a growing health and social problem, mainly because of the risk of dependence. Buprenorphine/naloxone is used as substitution therapy for opioid dependence.
- Trial name
- NCT02882412
- Testing
- observational
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Vaccine Reaction, Anemia
Non-specific Effects of Vaccination on Mortality and Morbidity
It has long been recognized that the positive effects of vaccination on childhood mortality cannot be solely attributed to a decline in the disease targeted by the vaccine.
- Conditions
- Vaccine Reaction, Anemia, Malaria,Falciparum, Salmonella Bacteraemia
- Trial name
- NOVAC (NCT03176719)
- Testing
- Venipuncture
- Where
- Burkina Faso
- Volunteers
- 1,005 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Self-management for Mobility Improvement in the Elderly
The Senior Step Study How Elderly Help Themselves Maximally Forward
The Senior Step Study investigates whether feedback given by a mobility feedback device in combination with an instruction book containing every day exercises, motivates elderly to exercise more.
- Trial name
- SSS (NCT01792180)
- Testing
- Mobility feedback device with use of instruction book
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Radboud University Medical Center