Clinical trials: sponsored by Radboud University Medical Center
Renal Cell Cancer, Colorectal Cancer
Study on the Influence of Sunitinib and Sorafenib on Fatigue, QoL, Depression in Patients With Metastatic RCC or GIST
The purpose of this study is to assess the influence of Sunitinib and Sorafenib on fatigue, quality of life and depression in patients with metastatic renal cell or colorectal cancer or GIST.
- Conditions
- Renal Cell Cancer, Colorectal Cancer, GIST
- Trial name
- NCT00979329
- Testing
- Questionnaires
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Atherosclerosis
The Effect of Statin Treatment on Trained Innate Immunity
The innate immune system plays a pivotal role in the development and progression of atherosclerosis. Recently, it was reported that monocytes can develop a long-lasting immunological memory after stimulation with various…
- Trial name
- SIMPEL (NCT03354156)
- Testing
- statin treatment
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Neuromuscular Diseases
Effectiveness and Cost-effectiveness of the Energetic Program
Fatigue is present in at least 60% of the patients with a muscle disease and can be the most disabling symptom. In combination with other impairments, this often results in low levels of physical activity and decreased social…
- Trial name
- NCT02208687
- Testing
- Energetic, Control group
- Where
- Netherlands
- Volunteers
- 53 people
- Sponsor
- Radboud University Medical Center
Pulmonary Embolism
Iodine Mapping Using Subtraction in Pulmonary Embolism CT Versus Dual-Energy CT
Comparing two techniques (Subtraction and Dual Energy CT) for functional Chest CT for patients with suspected with pulmonary embolism.
- Trial name
- InSPECT-DECT (NCT02890706)
- Testing
- Iodine Mapping using Subtraction in Pulmonary Embolism Computed Tomography versus Dual Energy Computed Tomography
- Where
- Netherlands
- Volunteers
- 295 people
- Sponsor
- Radboud University Medical Center
Breast Cancer, Renal Cell Carcinoma
Dried Blood SPOT Analysis of Everolimus in Cancer Patients (SPOT-study)
Everolimus shows a large interpatient variability with fixed dose administration. These very different exposure levels between individuals can result in supratherapeutic or subtherapeutic exposure levels and consequently in over…
- Trial name
- SPOT (NCT02809404)
- Testing
- Everolimus
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Radboud University Medical Center
Primary Hyperaldosteronism
Primary Hyperaldosteronism and Ischemia-reperfusion Injury
Patients with primary hyperaldosteronism experience more cardiovascular events compared to patients with primary hypertension, independent of the blood pressure level.
- Trial name
- PHA-FMD (NCT01978132)
- Testing
- forearm ischemia and reperfusion
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Chronic Central Serous Chorioretinopathy
Prospective Randomized Controlled Treatment Trial for Chronic Central Serous Chorioretinopathy
Chronic central serous chorioretinopathy (CSC) is a relatively frequent eye disease that often occurs in patients in the professionally active age range.
- Trial name
- PLACE (NCT01797861)
- Testing
- Half-dose photodynamic therapy (PDT), Micropulse laser (ML) treatment
- Where
- 5 sites in France, Germany and 2 more
- Volunteers
- 140 people
- Sponsor
- Radboud University Medical Center
Shock
PICU Admission Lactate and Central Venous Oxymetry Study
Observational multicentre cohort study. Children admitted to a Dutch PICU are studied for lactate levels and ScvO2. Children instrumented with arterial and central venous catheters are included within the first 12 hours after…
- Trial name
- PALVOS (NCT01696175)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Sepsis, Septic Shock
The Effects of Interferon-gamma on Sepsis-induced Immunoparalysis
The primary aim of this study is to assess the effects of adjunctive therapy with Interferon (IFN)-gamma on immune function in patients with septic shock in a placebo-controlled manner.
- Trial name
- NCT01649921
- Testing
- Interferon-gamma, Recombinant, Saline 0.9%
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- Radboud University Medical Center
Type 1 Diabetes Mellitus With Hypoglycemia
The Effect of Intravenous Lactate on Brain Lactate Concentrations During Hypoglycemia
Patients with type 1 diabetes (T1DM) who are unable to perceive symptoms of hypoglycemia, referred to as impaired awareness of hypoglycemia (IAH), are at very high risk of severe hypoglycemia.
- Trial name
- NCT03286816
- Testing
- SodiumChloride, Sodium Lactate
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Radboud University Medical Center
Distress, Anxiety
(Cost-)Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) in Cancer Patients
Mindfulness-based cognitive therapy has been demonstrated to be effective in reducing anxiety, depression and fatigue in cancer patients. As this intervention can be offered in groups, costs are relatively low.
- Conditions
- Distress, Anxiety, Depression
- Trial name
- BeMind (NCT02138513)
- Testing
- Mindfulness Based Cognitive Therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 245 people
- Sponsor
- Radboud University Medical Center
Esophagus Cancer
TTS Esophageal HILZO Stent: A Safety and Feasibility Study
A multicenter non-randomized prospective clinical study assessing the safety and feasibility of the esophageal through-the-scope HILZO Covered self-expandable metal stent placement for palliation of malignant dysphagia
- Trial name
- HILZO (NCT03269903)
- Testing
- HILZO esophageal stent
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Chronic Obstructive Pulmonary Disease (COPD)
Exacerbation Self-management in COPD: The ACCESS Study
Aim is to test the effect of ACCESS ("Adaptive Computerized COPD Exacerbation Self-management Support"), a software application designed to support patients with COPD in self-management of exacerbations.
- Trial name
- ACCESS (NCT02553096)
- Testing
- ACCESS
- Where
- Netherlands
- Volunteers
- 87 people
- Sponsor
- Radboud University Medical Center
Prostate Cancer, Lymph Node Metastases
Accuracy of Lymph Node Imaging in Prostate Cancer: PSMA PET-CT and Nano-MRI
Following curative intended therapy in prostate cancer patients, a high proportion of patients (approx. 25%) relapse with local and/or distant recurrence.
- Trial name
- MAGNIFY (NCT03223064)
- Testing
- Ferumoxtran-10 enhanced MRI; MRI contrast agent, 68Ga PSMA PET-CT
- Where
- 3 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Myotonic Dystrophy Type 1
Observational Prolonged Trial in Myotonic Dystrophy Type 1
Myotonic dystrophy type1 (DM1) is a rare, inherited, chronic progressive disease as well as an autosomal dominant multisystemic disorder.
- Trial name
- OPTIMISTIC (NCT02118779)
- Testing
- Behavioural change intervention
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 255 people
- Sponsor
- Radboud University Medical Center
Pelvic Organ Prolapse
Performance of Tension Free Vaginal Mesh (Prolift) Versus Conventional Vaginal Prolapse Surgery in Recurrent Prolapse.
Pelvic organ prolapse is a common problem. A lot of women have surgery for prolapse. The recurrence rate op pelvic organ prolapse after surgical treatment is high.
- Trial name
- NCT00372190
- Testing
- Tensionfree vaginal mesh kit (Prolift), classic vaginal prolapse surgery (fascia plication)
- Where
- 13 sites in Netherlands
- Volunteers
- 194 people
- Sponsor
- Radboud University Medical Center
Malnutrition
Novel Meal Service Improves Nutritional Intake
This study aims to investigate whether a novel meal service FoodforCare (FfC), comprising 6-protein-rich meals a day following proactive advice from a nutritional assistant, improves dietary intake and patient satisfaction…
- Trial name
- NCT03195283
- Testing
- Meal service
- Volunteers
- 637 people
- Sponsor
- Radboud University Medical Center
Renal Cell Carcinoma
Zirconium-89-girentuximab PET/CT Imaging in Renal Cell Carcinoma
Girentuximab is an antibody against Carbonic Anhydrase IX (CAIX), an antigen that is expressed on the cell surface of 95% of clear cell RCC (ccRCC).
- Trial name
- NCT02883153
- Testing
- Zirconium-89 girentuximab PET/CT
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Benign Esophageal Stricture
Progressive Esophageal Dilation for Benign Strictures: a Randomized Controlled Trial
A randomized controlled prospective clinical trial assessing the efficacy and safety of progressive esophageal dilation compared to conservative esophageal dilation in patients with severe benign esophageal strictures.
- Trial name
- DILATE (NCT03192098)
- Testing
- Savary bougie dilation
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Radboud University Medical Center
Benign Esophageal Stricture
BD-Covered Stent for Benign Esophageal Strictures: a Safety and Feasibility Study
A non-randomized prospective clinical, pilot study in a single centre assessing the safety and feasibility of the esophageal biodegradable covered stent for refractory benign esophageal strictures with or without fistulae
- Trial name
- BIDARCA (NCT03189927)
- Testing
- BD-Covered esophageal stent
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center