Clinical trials: sponsored by Radboud University Medical Center
Kidney Transplantation
Rituximab for Prevention of Rejection After Renal Transplantation
Our standard immunosuppressive treatment after renal transplantation is a combination of tacrolimus, mycophenolate mofetil, and prednisolone.
- Trial name
- NCT00565331
- Testing
- Rituximab
- Where
- Netherlands
- Volunteers
- 280 people
- Sponsor
- Radboud University Medical Center
Autoimmune Diseases
Increasing Plasma Adrenaline Levels Through Breathing Techniques - an Explorative Study
Inflammatory cytokines play a pivotal role in rheumatoid arthritis (RA) and innovative non-pharmacological therapies aimed at limiting cytokine production are highly warranted.
- Trial name
- INADRI (NCT02417155)
- Testing
- Hyper/hypoventilation, Strength ventilation
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Adhesions
Adhesions After Open Versus Laparoscopic Resection of Colorectal Malignancies Detected During Liver Resection
Rationale: Adhesion formation is a frequent complication after abdominal surgery. Adhesion formation might be reduced by laparoscopic surgery, however sound evidence is lacking.
- Trial name
- ALIVE (NCT01720966)
- Testing
- Liver resection
- Where
- 6 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- Radboud University Medical Center
Cardiovascular Disease, Ischemia-reperfusion Injury
Effect of Ischemic Postconditioning on Targeting of Annexin A5 After Forearm Exercise
To adjust our forearm model for ischemia reperfusion injury, in order to used it for assessment of ischemia reperfusion damage in elderly and patients.
- Conditions
- Cardiovascular Disease, Ischemia-reperfusion Injury, Postconditioning
- Trial name
- NCT00441714
- Testing
- repetitive short ischemia and reperfusion of non dominant fore arm after 10 minute ischemic exercise
- Where
- Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Stage III Non-small Cell Lung Cancer, Individualized Radiation Dose Escalation
Individualized Dose Prescription in Advanced Stage Lung Cancer Patients Using Modern (Chemo)Radiotherapy
The aim of this present study is to test the feasibility and toxicity of individualized hypofractionated radiotherapy, and to report outcome data.
- Trial name
- IDEAL-VMAT (NCT01577212)
- Testing
- Individualized dose escalation
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Radboud University Medical Center
Hypertension, Renal Function
The Vascular and Metabolic Effects of Sunitinib in Patients With Metastatic Renal Cell Carcinoma
Rationale: The introduction of angiogenesis inhibitors, like sunitinib and bevacizumab, has improved the outcome of patients with several types of cancer remarkably.
- Conditions
- Hypertension, Renal Function, Insulin Sensitivity, Renal Cell Carcinoma
- Trial name
- NCT01227213
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Coronary Heart Disease, Percutaneous Transluminal Coronary Angioplasty
Persantin Preceding Elective PCI
In this study the investigators will investigate whether a short pretreatment (3-7 days) with dipyridamole 200mg twice daily will protect patients against myocardial injury sustained during an elective dotter operation of the…
- Conditions
- Coronary Heart Disease, Percutaneous Transluminal Coronary Angioplasty, Atherosclerosis
- Trial name
- P3 (NCT00767663)
- Testing
- dipyridamole
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus
Reliability of Insulin by Jet Injection
Using a specific jet injector for the administration of a rapid-acting insulin analogue has been shown to advance the absorption of insulin from the subcutaneous area into the bloodstream by 40-50%, when compared to conventional…
- Trial name
- NCT02272296
- Testing
- jet injector, Conventional pen (NovoPen IV)
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Lung Cancer
Mindfulness for Lung Cancer Patients and Partners
The aim of the current study is to examine the (cost)effectiveness of mindfulness based stress reduction (MBSR) in comparison with treatment as usual for patients with lung cancer and their partners.
- Trial name
- NCT01494883
- Testing
- Mindfulness Based Stress Reduction
- Where
- Netherlands
- Volunteers
- 107 people
- Sponsor
- Radboud University Medical Center
Cancer, Fatigue
Implementation of Physical Cancer Rehabilitation Programmes in a European Healthcare System.
The aim of this study is to develop and identify the most effective strategy to implement PCRPs into daily care. We want to assess the added value of a multi-faceted strategy compared with a single-faceted patient-directed…
- Trial name
- NCT02205853
- Testing
- The patient-directed (PD) strategy, The multi-faceted (MF) strategy
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Medically Unexplained Symptoms, Psychosomatic Therapy
Psychosomatic Therapy, Feasibility and Cost Analysis
Medically unexplained symptoms (MUS) are a common and important problem in primary care. Patients repeatedly presenting MUS to their general practitioner (GP) suffer from their symptoms, are functionally impaired, and are at risk…
- Trial name
- PsySom (NCT01935258)
- Testing
- Psychosomatic therapy, care as usual
- Where
- 8 sites in Netherlands
- Volunteers
- 42 people
- Sponsor
- Radboud University Medical Center
Endotoxemia, Inflammation
The Effects of Atazanavir-induced Hyperbilirubinemia During Human Endotoxemia
Excessive inflammation, production of free radicals and vascular injury are considered the main contributors to the development of organ dysfunction in patients with severe infections and sepsis.
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome, Sepsis
- Trial name
- NCT00916448
- Testing
- Atazanavir, E. coli endotoxin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Metastatic Clear Cell Renal Cell Carcinoma
Phase II Study of Lutetium-177 Labeled Girentuximab in Patients With Advanced Renal Cancer
To determine the efficacy of multiple doses Lutetium-177-DOTA-girentuximab in patients with advanced clear cell renal cell carcinoma using RECIST criteria.
- Trial name
- NCT02002312
- Testing
- Lu-177-DOTA-girentuximab
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Radboud University Medical Center
Breast Cancer, Metastatic Castration-resistant Prostate Carcinoma
Lean Body Mass as a Determinant of Docetaxel Pharmacokinetics and Toxicity
Docetaxel is used as a first line anti-cancer drug in the treatment of several cancers, mainly breast- and metastatic castration-resistant prostate carcinoma.
- Trial name
- LEANDOC (NCT01621425)
- Testing
- Lean body mass, Total body weight, bloodsampling
- Where
- 2 sites in Netherlands
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Malaria
Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis
Malaria, a disease caused by the parasite Plasmodium, is one of the world's major infectious diseases. With approximately 627.000 deaths a year, there is desperate need for an effective vaccine.
- Trial name
- BMGF1 (NCT02080026)
- Testing
- CPS-immunization, Controlled Human Malaria Infection, chloroquine
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hypomagnesemia, Intestinal, With Secondary Hypocalcemia, Drug Induced Hypomagnesemia
Prevalence and Intervention of Hypomagnesemia in Users of Proton-pump Inhibitors
Hypomagnesemia is a severe side effect of longterm use of all available proton-pump inhibitors (PPIH). It develops due to intestinal malabsorption of Mg2+.
- Trial name
- Privet (NCT02518659)
- Testing
- Inulin
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hyperaldosteronism
SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.
Rationale: Primary hyperaldosteronism (PA) is the most frequent form of secondary hypertension. In PA autonomous hypersecretion of aldosterone by one or both adrenal glands causes hypertension that is often refractory to…
- Trial name
- SPARTACUS (NCT01096654)
- Testing
- Ct-scan or adrenal vein sampling
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Polycystic Liver Disease
Everolimus and LongActing Octreotide Trial in Polycystic Livers
The aim of this study is to reduce polycystic liver volume by treating with octreotide, whether or not combined with everolimus; to assess whether combination therapy of everolimus and octreotide gives a bigger reduction of…
- Trial name
- ELATE (NCT01157858)
- Testing
- Everolimus, Octreotide LAR
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Radboud University Medical Center
Hypoxia, Normoxia
Effects of Oxygen Status on Endotoxemia Induced Inflammation and Hypoxia Inducible Factor-1α
Oxygen is a widely available gas that is cheap, easy to get and extensively used in medicine. From animal studies it has become apparent that increasing or lowering the degree of oxygen in the blood, the inflammatory response can…
- Conditions
- Hypoxia, Normoxia, Hyperoxia
- Trial name
- NCT01978158
- Testing
- Lipopolysaccharide
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Substitution of Care
A Multicenter Research on the Effects of Substitution of Hospital Ward Care From Medical Doctors to Physician Assistants
Reallocation of healthcare is one solution to the problems healthcare is facing. In the Netherlands reallocation of care to Physician Assistants (PAs) hasn't adequately been studied.
- Trial name
- NCT01835444
- Testing
- PA/MD model
- Where
- 24 sites in Netherlands
- Volunteers
- 2,382 people
- Sponsor
- Radboud University Medical Center