Clinical trials: sponsored by Radboud University Medical Center
Attention Deficit Disorder With Hyperactivity
Working Memory Training in Young ADHD Children
The purpose of this study is to investigate whether working memory training improves behavioral symptoms, neurocognitive performance, and neural functioning in young children with ADHD.
- Trial name
- NCT00819611
- Testing
- Cogmed Working memory training, Control version of Cogmed working memory training
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- Radboud University Medical Center
Healthy
Ticagrelor and Adenosine
Preclinical studies have shown that the P2Y12 receptor antagonist ticagrelor can increase the extracellular concentration of the endogenous nucleoside adenosine by inhibiting the cellular uptake of adenosine via the equilibrative…
- Trial name
- NCT01996735
- Testing
- Ticagrelor 180 mg single dose
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pharmacodynamics
Eplerenone and Extracellular Adenosine Formation
Various studies have reported cardioprotective effects of mineralocorticoid receptor (MR) antagonists in the setting of an acute myocardial infarction.
- Trial name
- eplerenone01 (NCT01837108)
- Testing
- Eplerenone
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Anemia
The Immunomodulatory Effects of Phlebotomy
Although phlebotomy is routinely performed in blood donors, and seemingly does not have significant health risks, it is highly relevant to know what the effect of phlebotomy is on immunity.
- Trial name
- NCT02031614
- Testing
- Phlebotomy
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Drug Safety
Safety and Tolerability of Namisol in the Elderly
The results of phase I Namisol® study (Klumpers et al. Br J Clin Pharmacol, 2012), implicate that Namisol® may have a favorable PK and PD characteristics and is safe to use in people.
- Trial name
- THC (NCT01740960)
- Testing
- delta-9-tetrahydrocannabinol
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Unexplained Subfertile Couples With a Good Prognosis.
FertiScreen: an Online Application to Improve the Quality of Fertility Care
Objectives The investigators present an online application to empower and inform patients and improve guideline adherence in unexplained subfertility.
- Trial name
- NCT01820039
- Testing
- FertiScreen
- Where
- Netherlands
- Volunteers
- 152 people
- Sponsor
- Radboud University Medical Center
Clear Cell Renal Cell Carcinoma
Effect of Sorafenib on ccRCC Uptake of Radiolabeled Bevacizumab or cG250
Sorafenib is a tyrosine kinase inhibitor that is registered for the treatment of metastasized clear cell Renal Cell Carcinoma (ccRCC).
- Trial name
- NCT00602862
- Testing
- Sorafenib, 111Indium-bevacizumab, 111Indium-cG250
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- Radboud University Medical Center
Cardiovascular Disease
The Impact of Age and Fitness on Reperfusion Injury and Ischemic Preconditioning to Prevent This Injury
Rationale: Ischaemic preconditioning (IP) refers to the reduction of ischemia-reperfusion injury induced by a brief preceding period of ischemia. Also the arterial endothelium can be protected by IP.
- Trial name
- NCT01606410
- Testing
- IPC
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Arthroplasty, Replacement, Knee
Functional Evaluation of a Standard and a High-flexion Knee Prosthesis Using Thigh-calf Contact Force Measurements
The purpose of this study is to investigate whether subjects receiving a high-flexion knee prosthesis show a better knee function than patients receiving a standard knee prosthesis.
- Trial name
- NCT00899041
- Testing
- Total Knee Arthroplasty (TKA)
- Where
- Netherlands
- Volunteers
- 67 people
- Sponsor
- Radboud University Medical Center
Lung Cancer
Treatment of Early Stage Lung Cancer by VATS Versus OPEN Lobectomy
In patients with early stage lung cancer surgical lobectomy is the treatment of choice. A resection by Video-assisted Thoracic Surgery (VATS) is probably superior to an open procedure by thoracotomy for patients with early stage…
- Trial name
- SCOPE (NCT01933828)
- Testing
- OPEN lobectomy, VATS lobectomy, ROBOT-assisted lobectomy
- Where
- Netherlands
- Volunteers
- 176 people
- Sponsor
- Radboud University Medical Center
Pain
Perioperative Δ9-THC for Postsurgical Pain
Adequate treatment of postsurgical pain leads to better mobilization, shorter hospital stay, lower costs and higher patient satisfaction. In its treatment, frequent use is made of opioids. However, opioids have many side-effects.
- Trial name
- NamiSur (NCT01790555)
- Testing
- Namisol
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Tuberculosis
Pharmacokinetics and Pharmacodynamics of High Versus Standard Dose Rifampicin in Patients With Pulmonary Tuberculosis
In this phase II clinical trial, the pharmacokinetics, safety and (short-term) efficacy of higher than standard doses rifampicin will be studied during the intensive phase of tuberculosis (TB) treatment.
- Trial name
- High RIF (NCT00760149)
- Testing
- Rifampicin in higher doses
- Where
- Tanzania
- Volunteers
- 150 people
- Sponsor
- Radboud University Medical Center
Cardiovascular Disease, Aging
Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function
Healthy but sedentary aging leads to increased morbidity and mortality of cardiovascular disease. This is partly due to the accumulation of Advanced Glycation Endproducts (AGEs) and the stiffening of the myocardium and arteries.
- Conditions
- Cardiovascular Disease, Aging, Endothelial Dysfunction, Physical Activity
- Trial name
- NCT01417663
- Testing
- Alt-711, Physical exercise training
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ossification, Heterotopic
Prevention of Heterotopic Ossification With Arcoxia After Total Hip Replacement
The purpose of the study is to determine whether Arcoxia is effective in preventing heterotopic ossification after total hip arthroplasty.
- Trial name
- Arcoxia (NCT01022190)
- Testing
- Etoricoxib (Arcoxia)
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Radboud University Medical Center
Type 2 Diabetes Mellitus
Liraglutide and Insulin Therapy in Patients With Type 2 Diabetes
Insulin therapy is frequently needed to achieve adequate glycaemic control in type 2 diabetes. Although insulin is an effective treatment modality, this is often at the expense of significant weight gain.
- Trial name
- ELEGANT (NCT01392898)
- Testing
- liraglutide, Insulin
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Complex Regional Pain Syndrome, Type I
Pain Exposure Physical Therapy (PEPT) Versus CBO in Patients With Complex Regional Pain Syndrome Type I (CRPS-1)
The current Dutch CBO guideline treatment of Complex Regional Pain Syndrome Type I (CRPS-1) is very disappointing with chronification, disability and subsequent high medical costs and personal suffering.
- Trial name
- PEPTOC (NCT00817128)
- Testing
- PEPT, CBO standard
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Radboud University Medical Center
Autoimmune Diseases
Concentration/Meditation Limits Inflammation
Auto-immune diseases are characterized by an inappropriate inflammatory response against tissues in the body and represent a major health care burden.
- Trial name
- NCT01835457
- Testing
- Lipopolysaccharide, Concentration/meditation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Head and Neck Cancer
Efficacy of Prophylactic Treatment With Antibiotics During Concomitant Chemoradiotherapy in Patients With Head and Neck Cancer to Prevent Aspiration Pneumonia
Patients with locally advanced head and neck cancer treated with chemo-radiotherapy have (during and shortly after this treatment) a high risk of developing pneumonia by aspiration.
- Trial name
- PANTAP (NCT01598402)
- Testing
- amoxicillin/clavulanic acid suspension
- Where
- 6 sites in Netherlands
- Volunteers
- 106 people
- Sponsor
- Radboud University Medical Center
Malignant Ascites, Malignant Pleural Effusion
Cediranib as Palliative Treatment in Patients With Symptomatic Malignant Ascites or Pleural Effusion
In some patients with cancer there are also cancer cells in the abdominal cavity or between the lung membranes. These cancer cells create too much moisture in the abdominal cavity or between the lung membranes.
- Trial name
- NCT01262612
- Testing
- immediate cediranib, Start cediranib after 28 days Best Supportive Care
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Radboud University Medical Center
Locally Advanced Non-Small Cell Lung Cancer, NSCLC
Study of Combination Therapy of Carboplatin -Gemcitabine Plus Bevacizumab Beyond Progression in Patients With Locally Advanced and/or Metastatic Non-small Cell Lung Cancer (NSCLC) Who Have Not Received Prior Systemic Therapy
A phase II study of combination therapy of carboplatin -gemcitabine plus bevacizumab beyond progression in patients with locally advanced and/or metastatic non-small cell lung cancer (NSCLC) who have not received prior…
- Trial name
- NCT00702975
- Testing
- Paclitaxel, Carboplatin and Bevacizumab,Erlotinib
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Radboud University Medical Center