Clinical trials: sponsored by Radboud University Medical Center
Breast Cancer
Minimal Invasive Breast Cancer Excision Using Vacuum Assisted Biopsy Under Ultrasound Guidance
This study will assess whether it is feasible to remove small breast cancers completely using the Vacuum Assisted Biopsy (VAB) system System under Ultrasound guidance.
- Trial name
- MINIVAB (NCT04107636)
- Testing
- Vacuum assisted biopsy, conventional lumpectomy
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Radboud University Medical Center
Lynch Syndrome
Preventive Dendritic Cell Vaccination for Lynch Syndrome Carriers
The primary objective is to assess the effect of vaccination with neopeptide-loaded dendritic cells on disease-free survival (DFS) compared to placebo in LS subjects who are known to be carrier of a germline MMR-gene mutation…
- Trial name
- PROTECT-Lynch (NCT07609901)
- Testing
- Arm A: DC vaccination
- Where
- Netherlands
- Volunteers
- 372 people
- Sponsor
- Radboud University Medical Center
Depressive Disorder, Major
Prospective Assessment of Cost-effectiveness and Side-effects of Depressive Patients Treated With ECT or TCA
Prospective observational cohort study to determine cost-effectiveness of ECT compared to medication in the treatment of major depressive disorder (MDD) in the Netherlands.
- Trial name
- PROSPECT (NCT05306184)
- Testing
- Electroconvulsive therapy (ECT)
- Where
- 2 sites in Netherlands
- Volunteers
- 220 people
- Sponsor
- Radboud University Medical Center
Hiv
Study on PhArmacokinetics of First liNe Antiretrovirals in Healthy Breastfeeding Volunteers
No to little data exists on penetration of antiretroviral drugs in breastmilk. Too high concentrations may lead to infant toxicity and too low concentrations may lead to development of resistance in case the infant inadvertently…
- Trial name
- PANNA-B PK (NCT05648201)
- Testing
- Doravirine 100Mg Tab, Biktarvy 50/200/25 Tab
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Endometrial Cancer, Radiotherapy, Adjuvant
MR-guided Adaptive Stereotactic Radiotherapy for Endometrial Cancer
Rationale: External beam radiotherapy (EBRT) is an important cornerstone in treatment to reduce locoregional relapse in high(-intermediate) risk endometrial cancer (EC) patients.
- Trial name
- MASTEC (NCT07514325)
- Testing
- MR-guided adaptive radiotherapy (MGART) with reduced PTV margins, including 5 times 6Gy to the vaginal vault and pelvic nodal areas, 2 times a week
- Volunteers
- 61 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease
An Integrated and Personalized Lifestyle Approach for People With Parkinson's Disease
The goal of this study is to investigate the effects of a combined lifestyle program on the quality of life in people with Parkinson's Disease.
- Trial name
- SENSS (NCT06669455)
- Testing
- Personalized and combined lifestyle approach
- Where
- Netherlands
- Volunteers
- 256 people
- Sponsor
- Radboud University Medical Center
Parkinson's Disease
The Effects of Mindfulness-based Cognitive Therapy in People With Parkinson's Disease
Parkinson's disease (PD) is a debilitating neurodegenerative disorder occurring in 7 million patients worldwide. PD is caused by progressive loss of nigro-striatal dopamine cells, which causes motor symptoms such as slowness of…
- Trial name
- MIND-PD (NCT05779137)
- Testing
- MBCT
- Where
- Netherlands
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Parkinson&Amp;#39;s Disease, Action Tremor
Effectiveness of STIL Orthosis in PD
Parkinson's disease is a neurodegenerative condition that leads to uncontrollable shaking (tremor), which can substantially impair everyday activities.
- Trial name
- STIL-PD (NCT06886178)
- Testing
- STIL Orthosis
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Psoriasis, Psoriasis Vulgaris
Dose Reduction of IL17 and IL23 Inhibitors in Psoriasis
The main objective of this study is to investigate whether controlled dose reduction of IL17 or IL23 inhibiting biologics is not inferior compared to usual care in psoriasis patients.
- Trial name
- BeNeBio (NCT04340076)
- Testing
- Secukinumab, Ixekizumab, Brodalumab
- Where
- 19 sites in Belgium, Netherlands
- Volunteers
- 244 people
- Sponsor
- Radboud University Medical Center
Acute Myeloid Leukemia Refractory, Acute Myeloid Leukemia, Relapsed, Adult
Natural Killer-cell Therapy for Acute Myeloid Leukemia
This study investigates an innovative treatment for relapsed or refractory acute myeloid leukemia exploiting administration of ex vivo-generated allogeneic natural killer (NK) cells with preceding non-myeloablative conditioning…
- Trial name
- NK4AML (NCT04347616)
- Testing
- UCB-NK cells, IL-2
- Where
- Netherlands
- Volunteers
- 9 people
- Sponsor
- Radboud University Medical Center
Freezing of Gait
Tackling Anxiety-related Freezing of Gait in People With Parkinson's Disease
The purpose of this study is to investigate whether personalized strategies that target anxiety and stress surrounding freezing of gait can alleviate freezing of gait in people with Parkinson's Disease.
- Trial name
- TACKLING-FOG (NCT06302309)
- Testing
- Psychological intervention
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Radboud University Medical Center
Colorectal Polyp
Optical Diagnosis Versus Laser Measurement of Polyps' Size During Colonoscopy and Implications for Surveillance
Recent updates of the guidelines on polyp surveillance of the American Society of Gastrointestinal Endoscopy (ASGE) and European Society of Gastrointestinal Endoscopy (ESGE) increasingly focus on size of polyps as an important…
- Trial name
- NCT05489380
- Testing
- AccuMeasure
- Where
- 3 sites in United States, Netherlands
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Prostate Cancer
Lutetium-177-PSMA-617 in Oligo-metastatic Hormone Sensitive Prostate Cancer
Radioligand therapy (RLT) using Lutetium-177 labelled PSMA is a promising new therapeutic approach to treat metastatic prostate cancer.
- Trial name
- Bullseye (NCT04443062)
- Testing
- 177Lu-PSMA-617
- Where
- 4 sites in Cyprus, Netherlands
- Volunteers
- 58 people
- Sponsor
- Radboud University Medical Center
Parkinson's Disease (PD), Freezing of Gait
Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: a Multi-centre and Multi-modal Approach
The goal of this clinical trial is to learn if the medication atomoxetine can reduce freezing of gait in people with Parkinson's disease.
- Conditions
- Parkinson's Disease (PD), Freezing of Gait, Freezing of Gait Symptoms in Parkinson Disease
- Trial name
- AnTi-FREEZE (NCT07316296)
- Testing
- Atomoxetine
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Covid19, Severe Acute Respiratory Syndrome
Safety and Tolerability of COVID-19 Vaccine (ABNCoV2)
This phase 1 trial aims to assess the safety and tolerability of two doses of ABNCoV2, formulated with and without the adjuvant MF59, in healthy adult volunteers and to identify the dosage and formulation that optimizes the…
- Conditions
- Covid19, Severe Acute Respiratory Syndrome, SARS-CoV-2 Infection
- Trial name
- COUGH-1 (NCT04839146)
- Testing
- ABNCoV2 Vaccine
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Dietary Protein Intake
App-based Protein Support for Older Adults; Coaching Towards Healthy Ageing
Rationale: Sufficient dietary protein intake helps to preserve muscle mass and strength and is a key factor in healthy ageing. Achieving an increased protein intake with regular food products has shown to be a challenge for many…
- Trial name
- APPROACH (NCT07415408)
- Testing
- Nutritional coaching via an app, Exercise recommendations
- Where
- Netherlands
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria,Falciparum
Safety, Pharmacokinetics, and Plasmodium Falciparum Transmission-reducing Activity of Monoclonal Antibody TB31F in Mali
Mali faces a significant challenge with malaria, particularly among its younger population. While existing measures like seasonal chemoprevention and vaccination have shown efficacy, further innovations are necessary to combat…
- Trial name
- NCT06413108
- Testing
- TB31F, Normal saline
- Where
- Mali
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Tuberculosis, Pulmonary
Pragmatic Optimized Rifampicin Trial
The goal of this clinical trial is to compare an optimized dose (1800 mg) of rifampicin to standard dose (450 mg if patient <50 kg and 600 mg if patient >50kg) of rifampicin in tuberculosis patients.
- Trial name
- PORT (NCT06057519)
- Testing
- Optimised dose rifampicin, Standard dose rifampicin
- Where
- 2 sites in Italy, Netherlands
- Volunteers
- 164 people
- Sponsor
- Radboud University Medical Center
Dementia, Dementia Caregivers
SOCAV: a Nurse-led Support Programme for Self-direction in People With Dementia
In this study, we tested whether a support program could help people living at home with dementia keep making their own everyday choices for as long as possible, with help from a family caregiver and a home-care nurse.
- Trial name
- SOCAV-program (NCT07347639)
- Testing
- SOCAV-Home Care (self-directed care support for home-dwelling people with dementia)
- Where
- Netherlands
- Volunteers
- 85 people
- Sponsor
- Radboud University Medical Center
Prostate Cancer
Detection of Minimal Residual Disease Post-prostatectomy
The clinical objective for this pilot study is to determine whether minimal residual disease (MRD) detection in high-risk prostate cancer, utilizing a custom-made prostate-specific circulating tumor DNA (ctDNA) panel, may lead to…
- Trial name
- MiRaDE (NCT07334275)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center