Clinical trials: sponsored by Radboud University Medical Center
Cannabinoid, Tetrahydrocannabinol
Efficacy Study of Δ9-THC to Treat Chronic Abdominal Pain
The main goal of this trial is to study the efficacy of Namisol® after a single dose of Δ9-THC in the treatment of pain resulting from chronic pancreatitis. Objective measures of pain processing, e.g.
- Conditions
- Cannabinoid, Tetrahydrocannabinol, Chronic Pancreatitis, Abdominal Pain
- Trial name
- Delta-pain (NCT01318369)
- Testing
- Namisol, Diazepam
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Radboud University Medical Center
Cardiovascular Disease
Evaluation Research of a National Accreditation and Improvement Programme for General Practice
Objective: This study aims to determine the effectiveness and efficiency of a national accreditation and improvement programme for general practice, focusing on patients with established cardiovascular diseases.
- Trial name
- NCT00791362
- Testing
- National programme for accreditation and improvement of GP
- Where
- Netherlands
- Volunteers
- 1,685 people
- Sponsor
- Radboud University Medical Center
Endotoxemia, Inflammation
The Effects of Immunostimulation With GM-CSF or IFN-y on Immunoparalysis Following Human Endotoxemia
The human body knows a biphasic immunological reaction to sepsis. First, the pro-inflammatory reaction takes place, marked by the release of pro-inflammatory cytokines like TNF-α, as a reaction to the bacterial toxins.
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome, Sepsis
- Trial name
- NCT01374711
- Testing
- GM-CSF, IFN-Y, E.coli endotoxin
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Overall Functioning, Incremental Cost-effectiveness Ratio
The CareWell-programme for Community-dwelling Frail Elderly Persons.
The purpose of this study is to investigate the effect of the CareWell-programme on overall functioning of community-dwelling frail elderly persons.
- Trial name
- CareWell (NCT01499797)
- Testing
- The CareWell programme
- Where
- 10 sites in Netherlands
- Volunteers
- 536 people
- Sponsor
- Radboud University Medical Center
Neoplasms, Head and Neck
Normalcy of Food Intake in Head and Neck Cancer Patients
Background: Oral nutrition appears to be a challenge for patients with head and neck cancer after radiotherapy. Many patients desire to (their) 'normal food intake' and return to oral nutrition with normal consistency without…
- Trial name
- FOCISD (NCT01110980)
- Testing
- Swallow therapy in combination with individual dietary counselling, Individual dietary counselling
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Radboud University Medical Center
Ischemia Reperfusion Injury, Endothelial Function
The Metformin-FMD Trial
In acute myocardial infarction early restoration of coronary blood flow is the most effective strategy to limit infarct-size. Paradoxically, reperfusion itself also aggravates myocardial injury and contributes to final infarct…
- Trial name
- MetFMD (NCT01610401)
- Testing
- Metformin, Pretreatment with metformin in combination of infusion of caffeine., No pretreatment with metformin in combination with infusion of caffeine
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Familial Adenomatous Polyposis, Duodenal Neoplasms
Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis
Duodenal carcinomas are the leading cause of mortality in patients with Familial Adenomatous Polyposis (FAP) who underwent prophylactic colorectal surgery.
- Conditions
- Familial Adenomatous Polyposis, Duodenal Neoplasms, Duodenal Polyps
- Trial name
- PreDuoFAP (NCT00808743)
- Testing
- Celecoxib, Ursodeoxycholic acid
- Where
- 5 sites in Netherlands
- Volunteers
- 37 people
- Sponsor
- Radboud University Medical Center
Diabetes
Metformin-Dipyridamole Interaction Trial
The antihyperglycemic drug metformin and the thrombocyte aggregation inhibitor dipyridamole are often used concomitantly in patients with diabetes who have suffered a transient ischemic attack or stroke.
- Trial name
- MetDipy (NCT01613755)
- Testing
- Metformin, dipyridamole, Metformin
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria, Plasmodium Falciparum
Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine Versus Mefloquine Prophylaxis
Malaria is one of the major infectious diseases in the world with a tremendous impact on the quality of life, significantly contributing to the ongoing poverty in endemic countries.
- Trial name
- NCT01422954
- Testing
- Chloroquine prophylaxis, Mefloquine prophylaxis, Immunization
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus
Pharmacology of Insulin Injected With Jet-injection in Diabetes
A previous study showed that absorption and glucose-lowering action of rapid-acting insulin analogues occurred twice as fast when these analogues were administered by jet injection technology rather than by conventional insulin…
- Trial name
- NCT01438632
- Testing
- jet injection device
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Radboud University Medical Center
ADHD
Project Attention Deficit Hyperactivity Disorder (ADHD) and Electroencephalography (EEG)-Neurofeedback THERapy
Background: Electroencephalography (EEG)-neurofeedback has been shown to offer therapeutic benefits to patients with ADHD in several mostly uncontrolled studies with relatively small sample sizes.
- Trial name
- PANther (NCT00723684)
- Testing
- EEG-Neurofeedback
- Where
- 2 sites in Netherlands
- Volunteers
- 63 people
- Sponsor
- Radboud University Medical Center
Malaria, Falciparum
Re-exposure of Human Volunteers to a Heterologous Strain of P. Falciparum Sporozoites
In a previous study (NL33904.091.10) the investigators challenged 24 volunteers after Chloroquine Prophylaxis Sporozoites (CPS) immunization with 45, 30 or 15 infected mosquito-bites respectively.
- Trial name
- TIP4 (NCT01660854)
- Testing
- Heterologous challenge, Malarone treatment
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ischaemia Reperfusion Injury
Effect of Tea on Endothelial Function and Ischaemia-reperfusion Injury
Tea consumption may impact upon the decrease in endothelial function after IR-injury. However, no previous study directly examined the potential of tea to impact upon the change in endothelial function after IR-injury.
- Trial name
- NCT01660516
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Functional Decline and Complications of Frail Older Patients Admitted to Hospital
In Hospital Care and Welfare Standard
The current organization of hospital care for older patients with complex healthcare needs is of insufficient quality, safety and efficiency.
- Trial name
- CWSInHosp (NCT01273116)
- Testing
- CWS in Hospital
- Where
- Netherlands
- Volunteers
- 404 people
- Sponsor
- Radboud University Medical Center
Cardiovascular Disease, Ischemic Heart Disease
Can Dipyridamole Induce Protection Against Ischemia and Reperfusion Injury in Patients Undergoing Elective Coronary Artery Bypass Grafting (CABG)?
Rationale: Due to western lifestyle human coronary arteries are prone to develop atherosclerotic plaques. Hence the heart is an important target organ for atherothrombotic complications: myocardial ischemia, arrhythmias…
- Trial name
- NCT01295567
- Testing
- Dipyridamole
- Where
- Netherlands
- Volunteers
- 95 people
- Sponsor
- Radboud University Medical Center
Hypertension, Cancer
Bevacizumab and Endothelium Dependent Vasodilation
The introduction of angiogenesis inhibitors has remarkably improved treatment of patients with several types of cancer. One of the most reported side effects of angiogenesis inhibitors is hypertension.
- Conditions
- Hypertension, Cancer, Endothelial Dysfunction
- Trial name
- NCT01125943
- Testing
- Acetylcholine, Nitroprusside, Bevacizumab
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Idiopathic Membranous Nephropathy
Treatment With Synthetic ACTH in High Risk Patients With Membranous Nephropathy
The purpose of this study is to determine whether treatment with long-acting synthetic adrenocorticotropic hormone is in the treatment of patients with idiopathic membranous nephropathy and high for renal failure.
- Trial name
- ACTHiMeN (NCT00694863)
- Testing
- tetracosactide hexacetaat
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Urinary Bladder, Overactive, Pelvic Organ Prolapse
Study of Overactive Bladder in Women With Prolapse
Pelvic organ prolapse (POP) is a common problem. Symptoms of overactive bladder (OAB) are present in approximately 50% of patients with POP.
- Trial name
- SOAP (NCT01540214)
- Testing
- Pre- and postoperative evaluations
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Malaria
Reducing the Burden of Malaria by Targeting Hotspots of Malaria Transmission
In this study, the investigators propose to determine the value of rolling out four targeted malaria control efforts in reducing overall malaria transmission.
- Trial name
- REDHOT (NCT01575613)
- Testing
- Artemether-lumefantrine combination, Bacillus thuringiensis, Long lasting insecticide treated net (LLINs)
- Where
- Kenya
- Volunteers
- 17,506 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria
Comparison of Three Plasmodium Falciparum Isolates in a Controlled Human Malaria Infection
An effective vaccine against malaria is urgently needed to combat the scourge of this disease. Before candidate vaccines can be tested in endemic countries, they are first tested in human volunteers in so-called Controlled Human…
- Trial name
- TIP3 (NCT01627951)
- Testing
- NF54, NF135, NF166
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center