Clinical trials: sponsored by Radboud University Medical Center
Tissue Adhesions
The Effect of Adhesiolysis During Elective Abdominal Surgery on Per- and Postoperative Complication, Quality of Life and Socioeconomic Costs
Official title: LAPAD - A prospective study on the effect of adhesiolysis during elective laparotomy or laparoscopy on per- and postoperative complication, quality of life and socioeconomic costs Background: With improved…
- Trial name
- LAPAD (NCT01236625)
- Testing
- Adhesiolysis
- Where
- Netherlands
- Volunteers
- 752 people
- Sponsor
- Radboud University Medical Center
Rheumatoid Arthritis
Pharmacogenomics of Anti-TNF (Anti-tumor Necrosis Factor) Treatment in Patients With Rheumatoid Arthritis
The main aim of this study is to identify genetic markers (at DNA and RNA level) which are involved in the response to treatment with monoclonal antibodies against TNF in patients with rheumatoid arthritis.
- Trial name
- NCT00321217
- Where
- 3 sites in Netherlands
- Volunteers
- 700 people
- Sponsor
- Radboud University Medical Center
Delirium
Evaluation of Delirium Prevention in Critically Ill Patients
Haloperidol is prescribed in high risk ICU patients concerning delirium (50% or more chance to develop delirium detected with the delirium prediction model PRE-DELIRIC, or patients with history of dementia or alcohol abuse)since…
- Trial name
- NCT01187667
- Where
- Netherlands
- Volunteers
- 650 people
- Sponsor
- Radboud University Medical Center
Delirium
International Validation of a Delirium Prediction Model for ICU Patients
Recently our ICU research group developed and validated a delirium prediction model in the NetherlandsThis. This model has a high predictive value.
- Trial name
- NCT01249755
- Volunteers
- 2,000 people
- Sponsor
- Radboud University Medical Center
Cardiovascular Disease
Exercise Test and Cardiac Injury
Strenuous exercise in apparent healthy individuals increases plasma (high sensitive) troponin levels. The underlying mechanism is not yet elucidated, but could be explained by changes due to a mismatch in oxygen demand and supply…
- Trial name
- NCT01660828
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Postcancer Fatigue, Chronic Fatigue Syndrome
Humoral and Cellular Immune Responses After Influenza Vaccination in Patients With Postcancer Fatigue and in Patients With Chronic Fatigue Syndrome
Postcancer fatigue (PCF) is a frequently occurring, severe and invalidating problem, impairing quality of life. Patients with chronic fatigue syndrome (CFS) also suffer from severe fatigue symptoms.
- Trial name
- NCT01651754
- Testing
- Seasonal influenza vaccination
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Overactive Bladder Syndrome
Overactive Bladder (OAB) Drink Advice Study
The researchers want to investigate how fluid intake influences the symptoms of OAB. The researchers will recruit 45 patients with OAB and randomize them (blind) in 3 groups (low/normal/high fluid intake).
- Trial name
- NCT00982241
- Testing
- water
- Where
- Netherlands
- Sponsor
- Radboud University Medical Center
Overactive Bladder, Urinary Frequency or Urgency Adverse Event
Urgent-SQ in Treatment of Overactive Bladder Syndrome: 9-yr Follow up
Long term open label study on safety and durability of the Urgent-SQ tibial implant device for refractory overactive bladder syndrome (OAB).
- Conditions
- Overactive Bladder, Urinary Frequency or Urgency Adverse Event, Urinary Incontinence, Urge
- Trial name
- NCT01644409
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- Radboud University Medical Center
Postcancer Fatigue
An Explorative Study on Physiological and Neurophysiological Determinants of Fatigue in Cancer Survivors
Postcancer fatigue is a severe and invalidating problem, impairing quality of life. About 20 to 40% of the patients remain fatigued, at least one year after successful cancer treatment.
- Trial name
- NCT01096641
- Testing
- immediate CBT, Delayed CBT
- Where
- Netherlands
- Volunteers
- 57 people
- Sponsor
- Radboud University Medical Center
Acromegaly
Prospective Study on Changes in Acromegaly
Rationale: Acromegaly is the clinical syndrome that results from an excess of growth hormone (GH). Craniofacial and hand disproportions due to soft tissue swelling and new bone formation are highly prevalent in patients with…
- Trial name
- NCT01612624
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetic Nephropathy
Eplerenone, ACE Inhibition and Albuminuria
The purpose of this study is to determine whether eplerenone is more effective than doubling the dose of ACE inhibitor in reducing urinary protein (albumin) loss in diabetes mellitus
- Trial name
- NCT00315016
- Testing
- eplerenone, fosinopril
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Schnitzler Syndrome
Efficacy and Safety of Canakinumab in Schnitzler Syndrome
Schnitzler syndrome is a disabling inflammatory disease, characterized by chronic urticaria, fever, arthralgia, bone pain and gammopathy, which can so far only be effectively treated with anakinra, an interleukin-1 receptor…
- Trial name
- NCT01276522
- Testing
- Canakinumab
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- Radboud University Medical Center
Dyslipidemias, Hypertension
Cardiovascular Effects of Salvia Miltiorrhiza Extract (Danshen)
Rationale: Extracts of the plant Salvia miltiorrhiza (Danshen) have been used as traditional Chinese medicine in the treatment of cardiovascular diseases, such as angina pectoris and myocardial infarction.
- Conditions
- Dyslipidemias, Hypertension, Vasodilation, Oxidative Stress
- Trial name
- NCT01563770
- Testing
- Salvia miltiorrhiza extract
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Nontuberculous Mycobacterial Diseases
PK and PD of Drugs for Nontuberculous Mycobacterial Diseases in Dutch Patients
A prospective observational study in which pharmacokinetic and pharmacodynamic parameters are evaluated in a cohort of patients with NTM diseases.
- Trial name
- NTM (NCT01051752)
- Where
- 2 sites in Netherlands
- Volunteers
- 26 people
- Sponsor
- Radboud University Medical Center
Irresectable Squamous Cell or Adenocarcinoma of the Oesophagus
Radio-chemotherapy With or Without Panitumumab (Vectibix®) in Irresectable Squamous Cell Carcinoma or Adenocarcinoma of the Oesophagus
For esophageal cancer that can not be removed by surgery, the choice of treatment is a combination of chemotherapy and radiotherapy. We call this combination- (or concurrent) chemoradiotherapy.
- Trial name
- PANORAMIC (NCT01262183)
- Testing
- CRT + Panitumumab, Concurrent chemoradiation therapy without panitumumab
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- Radboud University Medical Center
Renal Cell Cancer
Temsirolimus-RCC-imaging
This study uses one trialdrug: Temsirolimus (sometimes called Torisel ® ). Temsirolimus is an mTOR inhibitor. It is an agent that is specifically aimed at disrupting cell division (needed for cancer cell growth).
- Trial name
- NCT01246817
- Testing
- Temsirolimus
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- Radboud University Medical Center
Head and Neck Cancer
TPF Induction With Concomitant Chemoradiation to Treat Patients With Head and Neck Cancer
The purpose of this trial is to compare two different treatments for fit patients with head and neck cancer: All patients are given induction-chemotherapy (docetaxel, cisplatin, 5-FU).
- Trial name
- Condor (NCT00774319)
- Testing
- conventional radiotherapy with 'high' dose cisplatin, accelerated radiotherapy with 'low' dose cisplatin
- Where
- 2 sites in Netherlands
- Volunteers
- 70 people
- Sponsor
- Radboud University Medical Center
Advanced/Recurrent Breast Cancer, Endometrial Cancer
A Study of Combination of Temsirolimus (Torisel®) and Pegylated Liposomal Doxorubicin (PLD, Doxil®/Caelyx®) in Advanced or Recurrent Breast, Endometrial and Ovarian Cancer
A study to examine the combination of temsirolimus and Caelyx® (chemotherapeutic) in advanced or recurrent breast, endometrial and ovarian cancer.
- Conditions
- Advanced/Recurrent Breast Cancer, Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT00982631
- Testing
- Temsirolimus/PLD
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Plasmodium Falciparum Malaria
Immunization With Different Doses of Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis
Malaria is one of the major infectious diseases in the world with a tremendous impact on the quality of life significantly contributing to the ongoing poverty in endemic countries.
- Trial name
- ZonMw1 (NCT01218893)
- Testing
- Chloroquine prophylaxis, Immunization, Plasmodium falciparum challenge
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Glucose Intolerance, Impaired Insulin Secretion
The Effect of Anakinra on Insulin Secretion
Rationale: Once diabetes develops, β-cell function progressively deteriorates and therapeutic approaches that prevent of delay loss of β-cell function are needed in the treatment of type 2 diabetes mellitus.
- Conditions
- Glucose Intolerance, Impaired Insulin Secretion, Diabetes Mellitus Type 2
- Trial name
- NCT01285232
- Testing
- Anakinra
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center