Clinical trials: sponsored by Radboud University Medical Center
Colorectal Neoplasms
Study of Pretargeted Radioimmunotherapy of a Anti-CEA Bispecific Antibody and Lu177-labeled Peptide in Colorectal Cancer
This study will investigate the toxicity, safety and pharmacokinetics of pretargeted radioimmunotherapy with anti-CEA x anti-hapten bispecific antibody TF2 and Lu-177-labeled di-HSG-DOTA peptide IMP-288.
- Trial name
- PRIT2008 (NCT00860860)
- Testing
- TF2, IMP-288 labeled with In111 and Lu177
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Cardiovascular Disease
Evaluation of Non-invasive Measurements of Atherosclerosis in Cardiovascular Risk Stratification
Multiple risk factors contribute to atherosclerosis, which ultimately results in clinical manifestation of cardiovascular disease.
- Trial name
- NIMA (NCT01555294)
- Where
- Netherlands
- Volunteers
- 1,960 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Candidemia
Efficacy of Interferon-gamma in Combination With Anidulafungin for the Treatment of Candidemia
The purpose of this study is to assess the feasibility and preliminary efficacy of interferon-gamma in combination with anidulafungin for the treatment of candidemia
- Trial name
- NCT01270490
- Testing
- Interferon-gamma, Recombinant
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Primary Hypertension
Nijmegen Antihypertensive Management Improvement Study
High blood pressure is an important risk factor for diseases of heart and blood vessels like myocardial infarction and stroke. Many patients are not treated to target blood pressures, even though good blood pressure lowering…
- Trial name
- NAMIS (NCT00457483)
- Testing
- hydrochlorothiazide, valsartan, 80 mg once-a-day
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer
Capiri-sutent Phase-1 in Advanced Colo-rectal Cancer
The primary objective of this Phase 1 study is to identify the recommended dose of capiri and of sunitinib for combination therapy subsequent phase II trials.
- Trial name
- sutent-capiri (NCT00777478)
- Testing
- capiri-sutent
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Radboud University Medical Center
Parkinson's Disease
Effectiveness of an Active Lifestyle Promotion Program for Patients With Parkinson's Disease
Patients with Parkinson's disease (PD) are heavily inclined towards a sedentary lifestyle. This is caused by a combination of physical impairments and cognitive dysfunction.
- Trial name
- ParkFit (NCT00748488)
- Testing
- Physical therapy aimed to move safely, Physical Therapy aimed to improve Physical Activity
- Where
- 32 sites in Netherlands
- Volunteers
- 700 people
- Sponsor
- Radboud University Medical Center
Breast Cancer, BRCA Mutation
Patient Empowerment by Group Medical Consultations
Carriers of a BRCA mutation have a significantly increased risk to develop breast cancer in the course of their lives . They face a difficult choice: either a preventive removal of the breast(s) or an intensive inspection…
- Trial name
- GMC (NCT01329068)
- Testing
- individual consult, group medical consult
- Where
- Netherlands
- Volunteers
- 320 people
- Sponsor
- Radboud University Medical Center
Breast Cancer
Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients
Hydroxychloroquine is a drug that has been used to treat malaria and rheumatism. It is recently discovered that Hydroxychloroquine increases 'autophagy'.
- Trial name
- NCT01292408
- Testing
- Hydrochloroquine
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Head and Neck Neoplasms
Value of FLT-PET Before and During Radiotherapy in Head and Neck Tumors
Tumor cell proliferation and repopulation contribute to resistance to radiotherapy in head and neck cancer. Up to now, this characteristic is mostly assessed using biopsies acquired during inspection under general anaesthesia…
- Trial name
- NCT00163176
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Lung Diseases, Obstructive
Costs and Effects of Three Modes for Disease Management of Chronic Obstructive Pulmonary Disease in General Practice
In this randomized controlled trial, three contemporary modes for chronic obstructive pulmonary disease (COPD) management in Dutch general practices are compared for costs and effects: usual general practitioner (GP) care (at…
- Trial name
- NCT00128765
- Testing
- an integrated self-management education program, regular practice nurse review (monitoring controls), care at initiative of the patient (usual GP care)
- Where
- Netherlands
- Volunteers
- 165 people
- Sponsor
- Radboud University Medical Center
Community Occupational Therapy, Dementia Patients
Effects of Community Occupational Therapy in Older Patients With Dementia and Their Caregivers.
The purpose of this study is to determine the effects of community occupational therapy in older patients with mild ot moderate dementia and their primary caregivers.
- Conditions
- Community Occupational Therapy, Dementia Patients, Primary Caregivers of Dementia Patients
- Trial name
- NCT00295152
- Testing
- community occupational therapy in dementia
- Where
- Netherlands
- Volunteers
- 135 people
- Sponsor
- Radboud University Medical Center
Metastatic Renal Cell Cancer, GIST
Evaluation of Cognitive Function of Patients With Sunitinib or Sorafenib
Patients with advanced kidney cancer or GIST (Gastro Intestinal Stromal Tumor: this is a tumor of the intestines) may be eligible for treatment with one of the following drugs: sunitinib (Sutent ®) or sorafenib (Nexavar ®).
- Trial name
- NCT01246843
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Anesthesia Recovery Period
Street Fitness in Surgical Patients Undergoing General Anesthesia After Reversal of Neuromuscular Blockade
Rationale: Recovery from outpatient anesthesia includes dissipation of anesthetics agents, normalization of physiological function, observation for medical or surgical complications, treatment of immediate side effects of…
- Trial name
- SFINX (NCT01453530)
- Testing
- Sugammadex, Neostigmine/Glycopyrrolate
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Renal Cell Carcinoma, Gastrointestinal Stromal Tumor
Study to the Optimal Duration of Therapy With Oral Angiogenesis Inhibitors
The purpose of this study is to determine if and how often an unexpected fast increase of disease and complaints shows after stopping the anti-angiogenetic therapy
- Trial name
- NCT00777504
- Testing
- usage oral angiogenesis inhibitor, stop oral angiogenesis inhibitor
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Colorectal Neoplasms, Liver Neoplasms
Neo-adjuvant Therapy and the Effect on Synchronous Metastatic Growth
Study Hypothesis As well as in animal models as in patients with colorectal cancer resection of the primary tumor resulted in increase in vascular density, metabolism and secondary tumor growth of the distant metastases.
- Trial name
- NCT00659022
- Testing
- immediate surgery (resection of primary colorectal tumor), neo-adjuvant treatment with bevacizumab, neoadjuvant treatment with capecitabine and oxaliplatin
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Breast Cancer
MIBG Scintigraphy and Strain Echocardiography in the Detection of Subclinical Cardiovascular Effects One Year After (Neo)Adjuvant Breast Cancer Treatment With Docetaxel, Doxorubicin and Cyclophosphamide (TAC): a Pilot Study
Many patients with breastcancer in the past, were treated with TAC. These last years, there is more and more focus on the effects of chemotherapy, particularly in children treated with this.
- Trial name
- TOXTAC (NCT01246856)
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer
Multi-modality Imaging in the Prediction of Response to Systemic Treatment in Colorectal Cancer
Because of metastatic liver cancer of the colon or rectum, patients will be treated with cytotoxic drugs (chemotherapy). In the Radboud University Nijmegen Medical Centre the investigators investigate whether the imaging…
- Trial name
- NCT01292681
- Testing
- Multi-modality imaging
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Colorectal Neoplasms, Liver Neoplasms
The Role of Fluorothymidine Positron Emission Tomography (FLT-PET) in Proliferation of Colorectal Liver Metastases
The aim of the study is to obtain information on FLT used in a PET-scan as a marker for the proliferation of colorectal liver metastases, so that the risk of recurrence can be identified in a noninvasive way, concerning patients…
- Trial name
- NCT00145665
- Testing
- FLT-PET scan
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Type 1
Pharmacology of Insulin Injected With Jet-Injection
The purpose of this study is to compare the pharmacological profile of insulin administered with jet-injection with that of insulin injected with a conventional insulin pen.
- Trial name
- NCT00983775
- Testing
- jet injector (SQ pen/Novopen III)
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Fasciitis
Treatment With High Dose Methotrexate in Patients With Eosinophilic Fasciitis
Evaluate the effect of high dose MTX on skin induration in patients with eosinophilic fascia.
- Trial name
- NCT00441961
- Testing
- methotrexate
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Radboud University Medical Center