Clinical trials: sponsored by Radboud University Medical Center
Fasciitis
Treatment With High Dose Methotrexate in Patients With Eosinophilic Fasciitis
Evaluate the effect of high dose MTX on skin induration in patients with eosinophilic fascia.
- Trial name
- NCT00441961
- Testing
- methotrexate
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Radboud University Medical Center
Otitis Media
Host-pathogen Interaction in Otitis Media
Otitis Media (OM) is one of the most frequent diseases in childhood and the primary reason for children to visit a physician. In many countries it is the most common reason to prescribe antibiotics leading to increased…
- Trial name
- OMVac (NCT00847756)
- Testing
- questionnaire, blood sample, collection of middle ear fluid
- Where
- 2 sites in Netherlands
- Volunteers
- 179 people
- Sponsor
- Radboud University Medical Center
Type 2 Diabetes Mellitus, Weight Gain
Determinants of Insulin-induced Weight Gain in Type 2 Diabetes Mellitus
The purpose of this study is to find determinants of insulin-induced weight gain in type 2 diabetes mellitus Primary objective: To find an association between weight gain after start of insulin therapy and physical activity…
- Trial name
- NCT00781495
- Testing
- Sensewear Bodymedia armband
- Where
- 3 sites in Netherlands
- Volunteers
- 75 people
- Sponsor
- Radboud University Medical Center
Chronic Obstructive Pulmonary Disease, Cardiovascular Disease
Interaction in Chronic Obstructive Pulmonary Disease Experiment
The final purpose of this study is to determine whether bronchodilation and cigarette smoking in Chronic Obstructive Pulmonary Disease (COPD) patients interact, resulting in an increase of cardiovascular disease.
- Conditions
- Chronic Obstructive Pulmonary Disease, Cardiovascular Disease, Smoking, Bronchodilation
- Trial name
- ICE (NCT00981851)
- Testing
- Tiotropium (Spiriva) + Salbutamol (Ventolin)
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Innate Immune Response
The Effects of Concentration/Meditation on the Innate Immune Response During Human Endotoxemia
The innate immune response is the first line of defense against invading pathogens. Ideally, the inflammatory response is tightly regulated leading to both adequate protection to invading pathogens as well as limitation of an…
- Trial name
- NCT01352871
- Testing
- Concentration / meditation, lipopolysaccharide
- Where
- Netherlands
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Endotoxemia
Anti-inflammatory Effects of Enriched Enteral Nutrition During Human Experimental Endotoxemia
During sepsis and septic shock the immune response can be overwhelming leading to excessive tissue damage, organ failure and death.
- Trial name
- VIHE (NCT01100996)
- Testing
- control enteral nutrition, enriched enteral feeding
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
One-lung Ventilation
EZ Blocker Versus Left Sided Double-lumen Tube
Lung isolation is used to achieve one lung ventilation to facilitate thoracic surgery. Two methods are commonly used, a double lumen tube (DLT) or a bronchial blocker introduced through a single lumen tube.
- Trial name
- NCT01073722
- Testing
- Placement of double lumen tube for one-lung ventilation, Placement of EZ- Blocker for one-lung ventilation
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Endotoxemia, Inflammation
In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia
Excessive inflammation is associated with tissue damage caused by over-activation of the innate immune system. This can range from mild disease to extreme conditions such as multiple organ failure (MOF).
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome
- Trial name
- VECTOR (NCT00785018)
- Testing
- C1-esterase inhibitor, Endotoxin administration
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus
Effect of Anakinra on Insulin Sensitivity in Type 1 Diabetes Mellitus
The purpose of this study is to test whether anakinra is able to reduce insulin resistance. This will be tested in overweighted type I diabetes mellitus patients, which have no residual beta-cell function.
- Trial name
- NCT01285245
- Testing
- kineret
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Parkinson's Disease
Feasibility of a Trial Evaluating the Effectiveness of Occupational Therapy in Parkinson's Disease
The purpose of this study is to determine the feasibility of a RCT evaluating the effectiveness of occupational therapy in Parkinson's disease.
- Trial name
- OTiP pilot (NCT01010529)
- Testing
- occupational therapy
- Where
- 4 sites in Netherlands
- Volunteers
- 43 people
- Sponsor
- Radboud University Medical Center
Malaria, Schistosomiasis
Correlating Protection Against Malaria With Serum Profiles Against Plasmodium Falciparum Antigen Repertoires
A longitudinal study on immune responses in relation to protection against clinical malaria episodes will be conducted in Apac District, Uganda.
- Conditions
- Malaria, Schistosomiasis, Hiv Infection
- Trial name
- NCT01214876
- Where
- Uganda
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Dementia
Comparison of Effectiveness and Costs of Post-diagnosis Treatment in Dementia
In the Netherlands a rapidly increasing number of multidisciplinary memory clinics (MMC) currently diagnose 25% of the patients with dementia.
- Trial name
- AD-Euro (NCT00554047)
- Testing
- Multidisciplinary Memory Clinic, General Practitioners
- Where
- 9 sites in Netherlands
- Volunteers
- 220 people
- Sponsor
- Radboud University Medical Center
Postoperative Adhesion, Peritoneal Adhesion, Nos
Efficacy of Sprayable PEG Barrier in Gynecologic Laparoscopy
The purpose of the study is to investigate whether sprayable PEG barrier is effective in reducing adhesions in laparoscopic gynecologic surgery.
- Trial name
- NCT01187680
- Testing
- Spraygel, Control
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Type 2, Insulin Resistance
Interleukin-1 Receptor Antagonist and Insulin Sensitivity
Obesity is characterized by continuous low-grade inflammation. This is an important link between obesity and insulin resistance.
- Trial name
- NCT00928876
- Testing
- Anakinra (Kineret)
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Liver Metastases
Carcinoembryonic Antigen-loaded Dendritic Cells in Advanced Colorectal Cancer Patients
Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. As such they are currently used in clinical vaccination protocols in cancer patients.
- Trial name
- NCT00228189
- Testing
- CEA-loaded dendritic cell vaccine
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus
Sugarsquare. Focus on the Adolescent: Digital Treatment of Type 1 Diabetes Through the Internet
Background The treatment of diabetes is multidisciplinary. Alignment of care of the various professional disciplines is, however, not always optimal.
- Trial name
- NCT01249742
- Testing
- Internet intervention
- Where
- Netherlands
- Volunteers
- 65 people
- Sponsor
- Radboud University Medical Center
Parkinson's Disease
Reduction of Falls in the Elderly - Parkinson's Disease
The REFINE-PD study is a controlled trial embedded within a larger cluster controlled study (the IMPACT study). The study aims to investigate the efficacy of a multifactorial falls prevention program for patients with Parkinson's…
- Trial name
- REFINE-PD (NCT00518648)
- Testing
- Multifactorial fall prevention program, Usual care
- Where
- 6 sites in Netherlands
- Volunteers
- 187 people
- Sponsor
- Radboud University Medical Center
Plasmodium Falciparum, Malaria
Comparison of Three Plasmodium Falciparum Isolates in an Experimental Human Malaria Infection
Plasmodium falciparum isolates display a wide genetic diversity with possibly different properties to induce immune responses. These properties could directly influence the ability to induce protective efficacy.
- Trial name
- TIP1 (NCT01002833)
- Testing
- Exposure to Plasmodium falciparum infected mosquitoes
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
P. Falciparum Malaria
Re-exposure of EHMI-8 Human Volunteers to Live Malaria Sporozoites
In the EHMI-8 study (CMO 2006/207) the investigators induced sterile protection against P. falciparum challenge in healthy Dutch volunteers by repeated exposure to infected mosquitoes whilst under chloroquine prophylaxis.
- Trial name
- NCT00757887
- Testing
- Exposure to 5 P. falciparum infected mosquitoes
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Renal Cell Cancer
Influence of Sutent on Tumor Vascularization and Necrosis in Patients With Renal Cell Carcinoma
The purpose of the study is to assess the effect of Sunitinib on tumor vascularization and necrosis in patients with metastatic renal cell cancer.
- Trial name
- NCT00509704
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center