Clinical trials: sponsored by Radboud University Medical Center
Parkinson's Disease
Integrated Multidisciplinary Care for Parkinson's Disease: a Controlled Trial
The aim of the present study is to evaluate the (cost) effectiveness of a new health care system in which an individualised multidisciplinary assessment is given to patients with Parkinson's Disease(PD)in combination with…
- Trial name
- NCT00518791
- Testing
- Multidisciplinary Care, Usual Care
- Where
- 6 sites in Netherlands
- Volunteers
- 301 people
- Sponsor
- Radboud University Medical Center
Endotoxemia, Sepsis
Anti-inflammatory Effects of GTS-21 After LPS
Rationale: The vagus nerve exerts an anti-inflammatory effect in in vitro and animal experiments. This 'vagal anti-inflammatory pathway' is mediated by the nicotinergic α7nACh receptor that can be selectively stimulated by…
- Conditions
- Endotoxemia, Sepsis, Vagal Activity
- Trial name
- NCT00783068
- Testing
- GTS-21, [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], Lipopolysaccharide E. Coli 113:H 10:K negative
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Type 2 Diabetes, Endothelial Dysfunction
Vildagliptin and Endothelium-dependent Vasodilatation
Rationale: Cardiovascular complications in type 2 diabetes are the leading cause of morbidity and mortality associated with the disease. Endothelial dysfunction is regarded as an important factor in these vascular complications.
- Trial name
- NCT01000688
- Testing
- vildagliptin + acarbose, acarbose + vildagliptin
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Endotoxemia
The Effects of Oral Dipyridamole Treatment on the Innate Immune Response During Human Endotoxemia
During sepsis and septic shock the immune response can be overwhelming leading to excessive tissue damage, organ failure and death.
- Trial name
- NCT01091571
- Testing
- Dipyridamole, LPS
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
COPD
Implementation of an Evidence Based Smoking Cessation Strategy (SMOCC) for Patients With COPD in Primary Care
A controlled study demonstrated that a smoking cessation protocol in routine primary care, specifically targeted at patients with COPD (SMOCC), doubled the quit rates.
- Trial name
- NCT00294905
- Testing
- Implementation of a combined smoking cessation strategy
- Where
- Netherlands
- Volunteers
- 2,700 people
- Sponsor
- Radboud University Medical Center
Delirium
Incidence of Delirium in Critically Ill Patients in a Dutch University Hospital
The objective of this study is to determine the incidence of delirium in adults patients who are admitted at the critical care unit of a Dutch University Hospital.
- Trial name
- NCT00604773
- Where
- Netherlands
- Volunteers
- 700 people
- Sponsor
- Radboud University Medical Center
Fluid Responsiveness
The Distribution of Pressure in the Thorax During Mechanical Ventilation and Its Effects on the Circulation
Fluid administration is a daily intervention on the intensive care unit to improve cardiac output (CO) and stabilize circulation in critically ill patients.
- Trial name
- NCT01113073
- Testing
- ventilatory protocol, Elastic band, passive leg raising test
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Insulin Resistance
The Influence of Rosiglitazone on the Diuretic Effect of Furosemide and Amiloride
Thiazolidinedione derivates (TZD's) are Peroxisome-Proliferator-Activated-Receptor-γ agonists (PPARγ-agonists) and enhance insulin sensitivity.
- Trial name
- NCT00285805
- Testing
- response (sodium excretion) to amiloride infusion, response (sodium excretion) to furosemide infusion
- Where
- Netherlands
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ischemia-Reperfusion Injury, The Metabolic Syndrome
The Effect of Rosiglitazone on Ischemia-reperfusion-injury Using Annexin A5 Scintigraphy.
Cardiovascular disease is the leading cause of death in diabetic patients due to both a high event rate and a worse outcome. A pharmacological intervention that reduces ischemia-reperfusion-injury would improve the outcome of…
- Trial name
- NCT00405015
- Testing
- rosiglitazone
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Radboud University Medical Center
Critical Illness
Effects of Daily Interruption of Sedatives in Critically Ill Children
Critically ill children are often sedated in order to relieve them from anxiety and discomfort, and to facilitate their care. There is little information on the effects of prolonged and continuous use of sedatives and analgesic…
- Trial name
- NCT00441506
- Testing
- daily interruption of sedatives
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Accidental Falls
Trial to Reduce Falls Incidence Rate in Frail Elderly
Background: Approximately 750,000 elderly Dutch people fall at least once a year, which often results in physical injuries and a fear of falling, with high costs and far-reaching consequences on functionality, physical activity…
- Trial name
- CP (NCT00512655)
- Testing
- Fall prevention course
- Where
- 3 sites in Netherlands
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Preeclampsia
Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia
A history of preeclampsia is associated with a low plasma volume and higher sympathetic activity. Methyldopa will suppress sympathetic activity to normal values.
- Trial name
- NCT00117546
- Testing
- alpha methyldopa
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Radboud University Medical Center
Uncomplicated Malaria
Treatment Efficacy and Malaria TRANSmission After Artemisinin Combination Therapy (TRANSACT)
Artemisinin combination therapy (ACT) with artemether lumefantrine (AL) is currently the first line treatment policy in Tanzania. AL is an efficacious drug that also has the capacity to reduce malaria transmission to mosquitoes.
- Trial name
- TRANSACT (NCT00868465)
- Testing
- Artemether-Lumefantrine, Dihydroartemisinin-piperaquine
- Where
- 2 sites in Kenya, Tanzania
- Volunteers
- 600 people
- Sponsor
- Radboud University Medical Center
Hypertension, Cancer
Bevacizumab and Vasoconstriction
Rationale: The introduction of angiogenesis inhibitors has remarkably improved treatment of patients with several types of cancer. One of the most common side effects of angiogenesis inhibitors is hypertension.
- Trial name
- BVZ1 (NCT00929058)
- Testing
- Bevacizumab
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ischemia Reperfusion Injury, Endothelial Dysfunction
Short Term Statin Treatment and Endothelial Dysfunction Due to Ischemia and Reperfusion Injury
Rationale: Apart from their cholesterol lowering effects, statins have cholesterol-independent pleiotropic actions, such as upregulation of 5'-ectonucleotidase and up-regulation of NO-synthase that may increase tolerance against…
- Trial name
- NCT00987974
- Testing
- rosuvastatin, atorvastatin 3 days, rosuvastatin 7 days
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Breast Cancer
Sequential vs Upfront Intensified Neoadjuvant Chemotherapy in Patients With Large Resectable or Locally Advanced Breast Cancer.
2 different treatment schedules may be used for neoadjuvant chemotherapy in breast cancer using adriamycin, cyclophosphamide and taxotere. The most optimal sequence- concurrent or sequential- is however unclear.
- Trial name
- INTENS (NCT00314977)
- Testing
- Doxorubicin, Cyclophosphamide, Docetaxel
- Where
- 24 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Renal Cell Carcinoma, GIST
Study of the Immunoresponse in Patients Treated With a Tyrosine Kinase Inhibitor
In this study the researchers investigate the influence of the tyrosine kinase inhibitors sunitinib and sorafenib, on the normal humoral and cellular immuno response to influenza vaccination in patients with metastases of renal…
- Trial name
- NCT00979381
- Testing
- influenza vaccine
- Where
- Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
COPD on Primary Care Treatment (COOPT)
The aim of this family practice based study is to determine the long-term treatment effects of two drugs that are presumed to modify the course and progression of chronic obstructive pulmonary disease (COPD), oral…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive, Bronchitis, Chronic
- Trial name
- NCT00184977
- Testing
- N-acetylcysteine, fluticasone propionate
- Where
- 2 sites in Netherlands
- Volunteers
- 270 people
- Sponsor
- Radboud University Medical Center
Lung Diseases, Obstructive, Asthma
Monitoring Asthma and COPD in Primary Care
The purpose of this study is to determine the clinical effectiveness and cost-effectiveness of a written expert advice for GPs on additional diagnostic, treatment, and referral of patients based on half-yearly monitoring routines…
- Trial name
- Monaco (NCT00542061)
- Testing
- half-yearly monitoring routine
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Healthy
Safety and Efficacy Study of Plasmodium Falciparum LSA-3 Malaria Vaccine
Malaria is responsible for over 2 million deaths each year. The development of an efficient vaccine would present by far the best solution for solving this disastrous situation.
- Trial name
- LSA-3-rec (NCT00509158)
- Testing
- arm I: PfLSA-3-rec with aluminium hydroxide as adjuvant, arm 2: PfLSA-3-rec with Montanide Isa 720 as adjuvant
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center