Clinical trials: sponsored by Radboud University Medical Center
Leg Ulcers, Varicose Ulcers
Legtest Multi Centre Testing of the Lively Legs Program for Promoting Compliance in Leg Ulcer Patients
Leg ulcers are often chronic or recurring complications of peripheral circulation disorders. Patients' lifestyles are known to influence leg ulcer occurrence and circulation disorders in general.
- Trial name
- NCT00184873
- Testing
- Health Counseling
- Where
- 11 sites in Netherlands
- Volunteers
- 180 people
- Sponsor
- Radboud University Medical Center
Infections, Total Parenteral Nutrition
Immune Modulation by Parenteral Lipids
Immune modulating properties of parenteral lipid emulsions seem to contribute to the increased risk for infections which remains associated with the use of total parenteral nutrition.
- Trial name
- NCT00734916
- Testing
- Parenteral lipid emulsion (Omegaven), Parenteral lipid emulsion (Intralipid), Parental lipid emulsion (Saline 0.9%)
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Type 2 Diabetes Mellitus Related Endothelial Dysfunction
Effects of Atazanavir Treatment on Type 2 Diabetes Mellitus Related Endothelial Dysfunction
The purpose of this study is to determine whether atazanavir use is of influence on the endothelial dysfunction associated with type 2 diabetes mellitus.
- Trial name
- DM2ATV (NCT00696722)
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Chronic Obstructive Pulmonary Disease, Health Status
Secondary Prevention of Problems in Health Status in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to determine the effectiveness of an intervention conducted by a pulmonary nurse in patients with COPD.
- Trial name
- NCT00940355
- Testing
- Intervention pulmonary nurse
- Where
- Netherlands
- Volunteers
- 303 people
- Sponsor
- Radboud University Medical Center
Delirium
Validating a Delirium Prediction Model for Critically Ill Patients
The objective of this study is to determine the incidence of delirium in adults patients who are admitted at the critical care unit of a Dutch University Hospital with the mapping of relevant delirium risk factors The primary aim…
- Trial name
- NCT00961389
- Where
- Netherlands
- Volunteers
- 650 people
- Sponsor
- Radboud University Medical Center
Stress Urinary Incontinence
Value of Urodynamics Prior to Stress Incontinence Surgery
To test the value of preoperatively performed urodynamics with regard to outcome of surgery for stress urinary incontinence (SUI) and to examine whether not performing urodynamics preoperatively is more cost effective than…
- Trial name
- VUSIS (NCT00509730)
- Testing
- Urodynamics
- Where
- Netherlands
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Endotoxemia
A Possible Therapeutic Role for Adenosine During Inflammation
The adenosine receptor is known for its anti-inflammatory actions and could therefore be a potential target in the treatment of sepsis and septic shock.
- Trial name
- NCT00513110
- Testing
- AMPD1 polymorphism, Caffeine infusion
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Handwashing
Helping Hands: Promoting Hand Hygiene in Hospital Nurses
Hand hygiene prescriptions are the most important measure in the prevention of hospital acquired infections. Yet compliance rates are generally below 50% of all opportunities for hand hygiene adherence.
- Trial name
- NCT00548015
- Testing
- state-of-the art strategy and extented strategy
- Where
- 3 sites in Netherlands
- Volunteers
- 900 people
- Sponsor
- Radboud University Medical Center
Atherosclerosis, Cardiovascular Disease
Is Augmentation of PORH by Rosuvastatin Adenosine-receptor Mediated?
Rationale: Statins form a class of drugs that is widely prescribed for hypercholesterolaemia, specifically to reduce the risk on atherosclerosis by lowering LDL-cholesterol.
- Trial name
- NCT00851175
- Testing
- rosuvastatin, caffeine
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Melanoma Stage III or IV
Peptide-pulsed vs. RNA-transfected Dendritic Cell Vaccines in Melanoma Patients
Dendritic cells (DCs)are the most potent antigen-presenting cells of the immune system, as such they are able to direct the immune system specifically against cancer cells.
- Trial name
- NCT00243529
- Testing
- autologous dendritic cell vaccine
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- Radboud University Medical Center
Abdominal Injuries, Thoracic Injuries
TRACT Study: Evaluation of the Value of Routine Thoraco-abdominal CT in Blunt Trauma Patients
The aim of this study is to establish the additional effectiveness and costs of routine thoraco-abdominal computed tomography (CT) in blunt trauma patients versus conventional radiological imaging and to determine which clinical…
- Trial name
- NCT00228111
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Radboud University Medical Center
Alcohol Drinking
Engaging General Practice in the Prevention of Patients With Alcohol Problems
The aim of the study is to test whether or not a tailored multi-component intervention program to increase the activity of general practice teams in the prevention of hazardous and harmful alcohol consumption results in increase…
- Trial name
- NCT00298220
- Testing
- Feedback about patients at risk, Dissemination guideline and patient information letters, Tailored educational training
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Advanced Solid Tumor, Refractory to Standard Therapies
Phase 1 Study With Sorafenib and Sirolimus
The purpose of the trial is to identify the recommended dose of sorafenib and sirolimus for combination therapy in subsequent phase 2 trials.
- Trial name
- NCT00509613
- Testing
- Sorafenib, Sirolimus
- Where
- Netherlands
- Sponsor
- Radboud University Medical Center
Hypertension
The Effects of Blood Pressure Reduction on Cerebral Perfusion and Cognition in the Elderly Population
The purpose of this study is to determine if a reduction in systolic blood pressure induced by anti-hypertensive medication results in changes in cerebral perfusion and cognition in hypertensive elderly.
- Trial name
- MBRACE (NCT00966199)
- Testing
- anti-hypertensive medication
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Respiratory Tract Diseases, Pulmonary Disease, Chronic Obstructive
Feedback Reports and e-Learning in Primary Care Spirometry
Spirometry is a biomedical test to measure lung function in subject who (may) have a chronic respiratory condition. Performing the test requires a certain level of training and experience from the health care professional who…
- Conditions
- Respiratory Tract Diseases, Pulmonary Disease, Chronic Obstructive, Asthma
- Trial name
- FRESCO (NCT00962455)
- Testing
- e-learning & performance feedback, usual practice
- Where
- Netherlands
- Volunteers
- 1,135 people
- Sponsor
- Radboud University Medical Center
Low Back Pain
Guideline Implementation in Physiotherapy
The purpose of this study is 1) to develop an intervention strategy to increase physiotherapists' adherence to evidence-based practice guidelines, 2) to try out this intervention on a small scale to determine what efficacy may be…
- Trial name
- GIPhT (NCT00962169)
- Testing
- Behavioral and managerial, Behavioral and IT
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Benzodiazepines Therapeutic Use
Implementation Strategies for a Simple Intervention to Reduce Longterm Benzodiazepine Use in Dutch Community Pharmacies
The purpose of this study is to compare the effect of two implementation strategies for a simple patient-directed intervention to reduce long-term benzodiazepine use in Dutch community pharmacies.
- Trial name
- NCT00268775
- Testing
- training and follow-up of pharmacists, patient-directed discontinuation letter
- Where
- 90 sites in Netherlands
- Volunteers
- 20,000 people
- Sponsor
- Radboud University Medical Center
Leukemia, Myeloid, Leukemia, Lymphocytic
T-cell and B-cell Depletion in Allogeneic Peripheral Blood Stem Cell Transplantation
T-cell and B-cell depletion in allogeneic peripheral blood stem cell transplantation by using immunomagnetic negative and positive selection procedures Background: Removal of T-cells from the donor graft (T-cell depletion) offers…
- Conditions
- Leukemia, Myeloid, Leukemia, Lymphocytic, Myelodysplastic Syndrome, Leukemia, Myeloid, Chronic
- Trial name
- NCT00306332
- Testing
- T-cell and B-cell depletion
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Radboud University Medical Center
Amyotrophic Lateral Sclerosis
The Effect of Intensive Controlled Exercise in the Early Stages of Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurological disorder characterized by amongst others asymmetric muscle weakness, respiratory insufficiency and spasticity.
- Trial name
- NCT00160004
- Testing
- Intensive Controlled Exercise
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Mild Hyperhomocysteinemia
Does B Vitamin Supplementation Decrease Homocysteine Concentrations in Newborns
The purpose of this study is to determine whether supplementation with folinic acid, a B vitamin, lowers the concentrations of total homocysteine in newborns.
- Trial name
- NCT00877227
- Testing
- 5-formyltetrahydrofolate (10 mg/ml) (Pharmachemie bv)
- Where
- Netherlands
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center