Clinical trials: sponsored by Radboud University Medical Center
Ischemia Reperfusion Injury, Cardiovascular Disease
Does Atorvastatin Reduce Ischemia-Reperfusion Injury in Humans in-Vivo?
To study the impact of 3 day exposure to atorvastatin 80mg on Annexin A5 targeting after ischemic exercise in the non-dominant forearm.
- Trial name
- NCT00441597
- Testing
- atorvastatin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Melanoma
Augmentation of Dendritic Cell-Based Vaccines in Melanoma Patients by Depletion of Regulatory T Cells in Stage IV Melanoma Patients
Dendritic cells (DC) are the professional antigen presenting cells of the immune system. Multiple distinct DC lineage's exist and it is now well appreciated that the DC subset and the maturation stage of the DC determines the…
- Trial name
- NCT00847106
- Testing
- Daclizumab, Dendritic cells
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Melanoma Stage III or IV
Dendritic Cell Vaccination in Melanoma Patients Scheduled for Regional Lymph Node Dissection
Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. As such they are currently used in clinical vaccination protocols in cancer patients, and both immunological and clinical responses have…
- Trial name
- NCT00243594
- Testing
- Peptide-pulsed dendritic cells
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Polycystic Liver Disease, Hepatomegaly
Lanreotide as Treatment of Polycystic Livers
To assess the efficacy of lanreotide in controling total liver volume in patients with polycystic livers this study will be performed.
- Conditions
- Polycystic Liver Disease, Hepatomegaly, Liver Diseases, Polycystic Kidney, Autosomal Dominant
- Trial name
- LOCKCYST (NCT00565097)
- Testing
- Lanreotide
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 38 people
- Sponsor
- Radboud University Medical Center
Parenteral Nutrition, Infection
The AOT (Acridine Orange and Taurolidine) Trial
Total parenteral (intravenous) nutrition in the home setting (Home TPN or HPN) is a life saving strategy in patients who suffer from severe intestinal failure.
- Conditions
- Parenteral Nutrition, Infection, Sepsis
- Trial name
- NCT00321165
- Testing
- taurolidine
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Cardiac Arrest, Post-Anoxic Encephalopathy
Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest
Survivors of a cardiac arrest frequently develop severe postanoxic encephalopathy. Derangements in cerebral blood after return of spontaneous circulation play an important role in the pathogenesis of postanoxic encephalopathy.
- Trial name
- NCT00441753
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Cancer, Neuralgia
Amitriptyline or Pregabalin to Treat Neuropathic Pain in Incurable Cancer
Rationale: Often, incurable cancer patients suffer from severe symptoms as (neuropathic) pain and fatigue with polypharmaceutic interventions as a consequence.
- Trial name
- Off-label (NCT00740571)
- Testing
- amitriptyline, pregabalin
- Where
- 2 sites in Netherlands
- Volunteers
- 130 people
- Sponsor
- Radboud University Medical Center
Pressure Ulcer, Urinary Tract Infection
SAFE or SORRY? Patient Safety Study of the Prevention of Adverse Patient Outcomes
The aim of SAFE or SORRY? is to develop and test an evidence based inpatient safety program for the prevention of three frequently occuring adverse events: pressure ulcers, urinary tract infections and falls.
- Conditions
- Pressure Ulcer, Urinary Tract Infection, Accidental Falls
- Trial name
- NCT00365430
- Testing
- safety program
- Where
- 10 sites in Netherlands
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Depressive Disorder, Depression
Detection and Treatment of Depression in Patients Admitted to the General Hospital
Depression is a common disorder among patients with a somatic illness admitted to the general hospital. Patients with depression do worse in terms of their somatic symptoms or functioning that those without depression.
- Trial name
- NCT00521911
- Testing
- Cognitive Behavioural Therapy
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Stress Urinary Incontinence
Value of Urodynamics Prior to Stress Incontinence Surgery 2
To test the value of preoperatively performed urodynamics with regard to outcome of surgery for stress urinary incontinence (SUI) and to examine whether not performing urodynamics preoperatively is more cost effective than…
- Trial name
- VUSIS 2 (NCT00814749)
- Testing
- midureteral sling, surgical therapy or conservative
- Where
- Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Polycystic Liver Disease, Hepatomegaly
Open-Label Extension of LOCKCYST Trial
Positive data originating from two polycystic liver patients treated with somatostatin analogues, showed a volume reduction of 38.3% and 14.9%.
- Conditions
- Polycystic Liver Disease, Hepatomegaly, Liver Diseases, Polycystic Kidney
- Trial name
- LOCKCYST-ext (NCT00771888)
- Testing
- lanreotide
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 54 people
- Sponsor
- Radboud University Medical Center
Head and Neck Cancer
Validation of FDG-PET Segmentation Tools for Tumor Delineation by Correlation of CT- and FDG-PET Volume Measurements With Histopathology of Nodal Metastases of Head and Neck Carcinomas.
Various methods of FDG-PET signal segmentation will be validated by correlation of histopathologically measured tumor dimensions in lymph node dissection specimens of head-and-neck cancer patients.
- Trial name
- NCT00782691
- Testing
- CT-FDG/PET scan of the head-and-neck region
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Male Infertility, Female Infertility
'SPRING'-Study: "Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists"
The purpose of this study is to compare two different strategies to implement the existing Guideline programme on Subfertility, as issued by the Dutch Society of Obstetrics and Gynaecology (NVOG).
- Conditions
- Male Infertility, Female Infertility, Ovarian Hyperstimulation Syndrome, Premature Ovarian Failure
- Trial name
- NCT00119925
- Testing
- patient education, professional audit and feedback (guideline adherence), professional education (communication/shared decision making)
- Where
- 16 sites in Netherlands
- Volunteers
- 5,200 people
- Sponsor
- Radboud University Medical Center
Male Infertility, Female Infertility
Patient-Centered Implementation Trial for Single Embryo Transfer
Background: The number of multiple pregnancies is considered to be the most important adverse effect of in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI).
- Conditions
- Male Infertility, Female Infertility, Pregnancy
- Trial name
- NCT00315029
- Testing
- evidence based decision aid, Possible reimbursement 4th IVF/ICSI cycle when necessary
- Where
- 2 sites in Netherlands
- Volunteers
- 230 people
- Sponsor
- Radboud University Medical Center
Endotoxemia
Blockade of Vascular Potassium Channels During Human Endotoxemia
Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine.
- Trial name
- NCT00185003
- Testing
- endotoxin, Potassium channel blockers: TEA, Quinin, Tolbutamide, L-NMMA
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Osteoarthritis, Knee, Osteoarthritis, Hip
Functional Evaluation of the Total Knee Prostheses:Rising From a Chair
In this study, a functional evaluation of total knee arthroplasty (TKA) patients is performed. The patients are measured prior to surgery and 6 and 12 months after surgery.
- Trial name
- NCT00163228
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Heart Failure
Does Ascorbic Acid Reduce Sympathoexcitation in CHF?
In CHF central sympathetic activity is increased. ROS formation seems to play a role in this process. This study analyzes the effect of vitamin C as an antioxidant on central sympathetic activity in CHF
- Trial name
- NCT00550121
- Testing
- vitamin C
- Where
- Netherlands
- Sponsor
- Radboud University Medical Center
Dementia, Vascular, Dementia
Systematic Care for Informal Caregivers of Dementia Patients: An Efficient Approach?
The objective is to ascertain the potential efficiency of a systematic care programme for caregivers of dementia patients. The research questions are: What are the costs and benefits of the Systematic Care Programme - Dementia…
- Conditions
- Dementia, Vascular, Dementia, Alzheimer Disease, Lewy Body Disease
- Trial name
- NCT00147693
- Testing
- Diagnosis of caregivers' problems, Professional service: treatment of problems by counseling or practical support
- Where
- Netherlands
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hypertension
Does Statin Therapy Reduce Sympathoexcitation in Hypertension?
A number of patients with hypertension have increased central sympathetic activity. Statins seem to inhibit central sympathetic output.
- Trial name
- NCT00497016
- Testing
- atorvastatin 80 mg
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Radboud University Medical Center
Adenosine Metabolism
The Effect of Rosuvastatin on Adenosine Metabolism
The aim of this study is to show whether rosuvastatin influences adenosine metabolism. Therefore we will determine whether rosuvasatin increases dipyridamole-induced vasodilation by increased adenosine receptor stimulation.
- Trial name
- NCT00554138
- Testing
- rosuvastatin
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center