Clinical trials: sponsored by Radboud University Medical Center
Ischemia-Reperfusion Injury
Adenosine Receptors Influence Ischemia-Reperfusion Injury
Ischemic preconditioning is defined as the development of tolerance to ischemia-reperfusion injury by a previous short bout of ischemia resulting in a marked reduction in infarct size.
- Trial name
- NCT00184847
- Testing
- acetylcholine, twenty minutes of forearm ischemia, three 5-minute periods of forearm ischemia
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ischemia-Reperfusion Injury
Opioid Receptors Influence Ischemia-Reperfusion Injury
The most powerful protective mechanism against ischemia-reperfusion injury other than rapid reperfusion is ischemic preconditioning.
- Trial name
- NCT00184938
- Testing
- morphine, naloxone, Technetium-TC99m-labeled Annexin A5
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hyperemia, Hypoxia
Enhancement of Postocclusive Reactive Hyperaemia by Dipyridamole
The purpose of this study is to determine whether dipyridamole enhances postocclusive reactive hyperaemia by increasing extracellular adenosine concentrations during ischemia and reperfusion.
- Trial name
- NCT00268554
- Testing
- dipyridamole, caffeine
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pulmonary Hypertension of the Newborn (PPHN)
Circulatory Changes During Venovenous (VV)- and Venoarterial (VA) Extracorporeal Membrane Oxygenation (ECMO)
Rationale: Persistent pulmonary hypertension of the newborn (PPHN) is a life threatening disease with a high mortality rate. Extracorporeal Membrane Oxygenation (ECMO) with veno-arterial (V-A) or veno-venous (V-V) cannulation can…
- Trial name
- ECMO (NCT00622492)
- Testing
- echocardiography Doppler sonography, blood and urine sampling
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Tooth, Impacted
A Cluster Randomized Controlled Trial in Primary Oral Care
Background: Routine oral examination (ROE) refers to periodic monitoring of the general and oral health status of patients. In most developed Western countries a decreasing prevalence of oral diseases underpins the need for a…
- Trial name
- NCT00618215
- Testing
- peer group educational implementation strategy
- Where
- Netherlands
- Volunteers
- 1,161 people
- Sponsor
- Radboud University Medical Center
Dumping Syndrome
Treatment of the Dumping Syndrome With Lanreotide Autogel®
Background Somatostatin and octreotide LAR (long-acting analogue) exert a number of inhibitory effects: on gut hormones, but also on gastro-intestinal secretion and motility.
- Trial name
- NCT00543179
- Testing
- Somatuline (Lanreotide Autogel®)
- Where
- Netherlands
- Sponsor
- Radboud University Medical Center
Dyspepsia
Serotonin Effect in Functional Dyspepsia
The purpose of this study is to investigate whether Efexor (venlafaxine) is effective in the treatment of functional dyspepsia.
- Trial name
- NCT00115362
- Testing
- venlafaxine
- Where
- 6 sites in Netherlands
- Volunteers
- 300 people
- Sponsor
- Radboud University Medical Center
Colorectal Neoplasms
Evaluation of Metabolic Activity of Liver Metastases by FDG-PET Scanning
The purpose of this study is to evaluate the effect of primary tumor resection on the metabolic activity of metastases in patients with a colorectal primary tumor and synchronous liver metastases by positron emission tomography…
- Trial name
- NCT00184782
- Testing
- FDG-PET
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Heart Failure, Congestive
The Effect of Alfa-Adrenergic Receptor Blockade on Insulin-Stimulated Forearm Glucose Uptake and Metabolism in Chronic Heart Failure
The activity of the sympathetic nervous system seems to influence the uptake (and handling) of glucose by the skeletal muscle of the forearm.
- Trial name
- NCT00132106
- Testing
- phentolamine
- Where
- Netherlands
- Sponsor
- Radboud University Medical Center
Intermittent Claudication, Arterial Occlusive Diseases
Dacron vs Dardik for Fem-Pop Bypass
Clinical trial for the comparison of long-term patency of heparin-bonded Dacron and human umbilical vein vascular prostheses in above-knee femoro-popliteal bypass surgery.
- Conditions
- Intermittent Claudication, Arterial Occlusive Diseases, Atheroslerosis
- Trial name
- DaDa (NCT00523263)
- Testing
- heparin-bonded and collagen coated polyster, Human umbilical vein femoro-popliteal bypass
- Where
- Netherlands
- Sponsor
- Radboud University Medical Center
Dyspepsia, Gastrointestinal Diseases
Comparison of a "Step-Up" Versus a "Step-Down" Treatment Strategy for Patients With New Onset Dyspepsia in General Practice (The DIAMOND-Study)
The purpose of this study was to determine which treatment strategy, the step-up or the step-down treatment strategy, is the most cost-effective treatment for patients with new onset dyspepsia in primary care.
- Trial name
- NCT00247715
- Testing
- algeldrate/magnesium oxide, ranitidine, pantoprazole
- Where
- 3 sites in Netherlands
- Volunteers
- 664 people
- Sponsor
- Radboud University Medical Center
Falciparum Malaria
Study to Investigate the Induction of an Protective Immune Response to Malaria
The objective of the study is to induce a protective immune response against malaria in healthy human volunteers. The different parts of the immune response will then be studied.
- Trial name
- NCT00442377
- Testing
- exposure to malaria sporozoites
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Adenomatous Polyposis Coli
Influence of Sulindac and Probiotics on the Development of Pouch Adenomas in Patients With Familial Adenomatous Polyposis
The purpose of this study is to determine whether sulindac and VSL#3 - inulin, either combined or alone, are effective in treating or preventing adenoma development in the ileal anal pouch in patients with familial adenomatous…
- Trial name
- NCT00319007
- Testing
- Sulindac (drug), VSL#3 (probiotic), Inulin (probiotic)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Osteoarthritis, Knee
Randomised Controlled Trial PFC Versus CKS Total Knee Prostheses
The purpose of this study is to compare the functional outcome of two different total knee prostheses in a prospective randomised study.
- Trial name
- NCT00228137
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Radboud University Medical Center
Urinary Tract Infections
Prevention of Renal Failure in Children With Urinary Tract Infections
The aim of the study is to describe the current clinical management of young children with urinary tract infections in Dutch primary care and also to describe the possibilities for improvement and potential cost-efficiency of…
- Trial name
- NCT00316043
- Testing
- Written information for parents, Distance learning package for General Practitioners, Distance learning package for practice assistants
- Where
- Netherlands
- Volunteers
- 124 people
- Sponsor
- Radboud University Medical Center
Craniofacial Abnormalities, Maxillofacial Abnormalities
3D Imaging of Hard and Soft Tissue in Orthognathic Surgery
The primary objective of this clinical trial is to assess the influence of orthognathic surgery on facial soft tissue, such as changes (volume, linear, angular) of facial hard and soft tissue, in three dimensions, so enabling the…
- Conditions
- Craniofacial Abnormalities, Maxillofacial Abnormalities, Cleft Lip, Cleft Palate
- Trial name
- NCT00285714
- Testing
- 3D stereophotogrammetric imaging, 3D CT-imaging with cone-beam CT, Case report form
- Where
- 3 sites in Netherlands
- Volunteers
- 450 people
- Sponsor
- Radboud University Medical Center
Hyperthyroidism
Does Radioiodine Treatment Prevent Atrial Fibrillation and Bone Loss in Endogenous Subclinical Hyperthyroidism?
Subclinical hyperthyroidism is defined as the presence of serum free thyroxine (T4) and triiodothyronine (T3) levels within the reference range and a reduced serum thyrotrophin (TSH) level.
- Trial name
- NCT00151723
- Testing
- treatment with 131I
- Where
- 5 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Patient Centered Care, Postoperative Care
Outreach: A Programme for Timely Treatment of Critically Ill Patients in a University Hospital
The identification of patients with potential early organ failure is the key in preventing admission or readmission to a critical care facility.
- Conditions
- Patient Centered Care, Postoperative Care, Critical Illness
- Trial name
- NCT00306345
- Testing
- Outreach
- Where
- Netherlands
- Volunteers
- 1,500 people
- Sponsor
- Radboud University Medical Center
Head and Neck Neoplasms
The Role of CT-PET-MRI Image Fusion in Determining Radiation Treatment Volumes of Head-and-Neck Cancer Patients
Technical developments in radiation oncology are making it possible to deliver a prescribed radiation dose to radiation target volume with increasing accuracy.
- Trial name
- NCT00184860
- Testing
- PET-scan, MRI-scan
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Radboud University Medical Center
Dementia
Implementation Study of Dementia Guidelines in Primary Care
The purpose of this study is to determine whether a specially developed Dementia Training Program for duos of general practitioners and primary care nurses is able to increase the number dementia diagnoses in elderly people…
- Trial name
- NCT00459784
- Testing
- Dementia Training Program
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center