Clinical trials: sponsored by Radboud University Medical Center
Aging, Aging Well
Early Variations in Immune Aging
Background: Despite an increase in lifespan over the last decades, our healthspan lags behind. In our aging population, it is pressing that we prevent age-related morbidities and associated burden on the health care system.
- Conditions
- Aging, Aging Well, Immuno Aging
- Trial name
- EVIA-NL (NCT06295354)
- Testing
- No intervention, we just study 'aging'
- Where
- Netherlands
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Anesthesia, Local
Soft Mist Nasal Administration Device for Topical Anaesthesia of the Nasal Cavity
Rationale: Effective and fast topical anesthesia of the nasal mucosa is of paramount importance for nasal instrumentation like nasal fiberoptic procedures, awake nasal fiberoptic intubation and placement of nasogastric tubes.
- Trial name
- NCT06205680
- Testing
- NAA for topical anaesthesia of the nasal cavity
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Lymphatic System Disorders Congenital, Lymphatic Diseases
Lymphatic Phenotype in Noonan Syndrome Spectrum Disorders
To get a better insight into the central conducting lymphatic system in adult volunteers with Noonan Syndrome (NS) without clinical symptoms or signs of lymphatic disease compared to NS and CardioFacioCutaan syndrome patients…
- Conditions
- Lymphatic System Disorders Congenital, Lymphatic Diseases, Noonan Syndrome, Lymphatic Disease
- Trial name
- LENS (NCT06267807)
- Testing
- Dynamic contrast-enhanced lymphangiography
- Where
- Netherlands
- Volunteers
- 9 people
- Sponsor
- Radboud University Medical Center
Arousal Disorders, Sexual
Neuromodulation of the Dorsal Genital Nerve in Persistent Genital Arousal Disorder
The goal of this clinical trial is to learn if neuromodulation of the dorsal genital nerve works to treat symptoms related to Persistent Genital Arousal Disorder in women.
- Trial name
- NemoPGAD (NCT06790563)
- Testing
- Neuromodulation
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Radboud University Medical Center
BCG Vaccination Reaction, Infections
Long Term Effects of BCG Vaccination on Infectious and Immune Mediated Diseases
Rationale: The effects of BCG vaccination have been only sporadically studied in the elderly, and the long-term effects of the vaccination have not been studied until now.
- Conditions
- BCG Vaccination Reaction, Infections, Inflammation, COVID-19
- Trial name
- BCG-LT (NCT05387655)
- Testing
- BCG
- Where
- Netherlands
- Volunteers
- 4,292 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Movement Disorders, Parkinson Disease
STEPWISE Parkinson: A Smartphone Based Exercise Solution for Patients With Parkinson's Disease
The aim of this study is to investigate whether a smartphone app can increase physical activity in patients with Parkinson's Disease in daily life for a long period of time (12 months).
- Trial name
- STEPWISE (NCT04848077)
- Testing
- Step count increase with the use of a motivational smartphone application
- Where
- Netherlands
- Volunteers
- 452 people
- Sponsor
- Radboud University Medical Center
Heart Failure
Fluid Restriction in Heart Failure Versus Liberal Fluid Uptake
Multi-centre open-label 1:1 randomized clinical trial in chronic heart failure patients on the effect of fluid restriction versus liberal fluid intake on quality of life.
- Trial name
- FRESH-UP (NCT04551729)
- Testing
- Lifestyle advice for liberal fluid intake
- Where
- 8 sites in Netherlands
- Volunteers
- 504 people
- Sponsor
- Radboud University Medical Center
Chronic Cluster Headache
LSD to Improve Cluster Headache Impact Trial
This study aims to investigate the efficacy and safety of LSD 25μg every 3 days for 3 weeks versus placebo in the treatment of chronic cluster headache (cCH).
- Trial name
- LICIT (NCT05477459)
- Testing
- LSD tartrate
- Where
- 2 sites in Netherlands
- Volunteers
- 65 people
- Sponsor
- Radboud University Medical Center
Cognitive Change
COgnitive Dynamics in Early Childhood
The goal of this accelerated longitudinal observational cohort study is to advance our understanding of cognitive variability in children aged 7 to 10 at first measurement.
- Trial name
- CODEC (NCT06330090)
- Where
- Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Recurrent Pregnancy Loss
Aerobe Cycling Training in Women With Unexplained Recurrent Pregnancy Loss
In 50% of women with recurrent pregnancy loss (RPL) miscarriages are unexplained, therefore no therapeutic intervention is possible.
- Trial name
- HMOVE (NCT06007560)
- Testing
- Exercise
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
FSHD - Facioscapulohumeral Muscular Dystrophy
Ten Year Follow-up in FSHD: the FOCUS 3 Study
This study aims to assess longitudinal data in 170 adult and 30 pediatric genetically and clinically well-defined facioscapulohumeral dystrophy (FSHD) patients.
- Trial name
- FSHD-FOCUS 3 (NCT06911190)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer
Dendritic Cell Vaccination in Patients With Lynch Syndrome or Colorectal Cancer With MSI
Objectives: In this Radboud University Nijmegen Medical Centre (RUNMC) initiated study our first objective is to investigate toxicity (safety and feasibility) of vaccination with frameshift-derived neoantigen-loaded DC of CRC…
- Trial name
- NCT01885702
- Testing
- DC vaccination
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sepsis, Neuroinflammatory Response
Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia
The goal of this clinical trial is to investigate the immunomodulatory effects of the drugs dexamethasone, tocilizumab and anakinra in healthy male subjects aged 18 to 35 undergoing experimental endotoxemia.
- Conditions
- Sepsis, Neuroinflammatory Response, Immunosuppresion, Endotoxemia
- Trial name
- DEDICATE-LPS (NCT06624436)
- Testing
- Dexamethasone, Tocilizumab, Anakinra
- Where
- Netherlands
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Lymphopenia Due to COVID-19, T-cell
CD8+ T-cell PET/CT Imaging in COVID-19 Patients
A subset of patients diagnosed with severe acute respiratory syndrome (SARS)-CoV2 infection present with lymphopenia. The degree of lymphopenia, and in particular reduced cluster of differentiation (CD)8+ T-cell numbers, is…
- Conditions
- Lymphopenia Due to COVID-19, T-cell, PET Imaging
- Trial name
- Tangelo (NCT04874818)
- Testing
- [89Zr]Df-IAB22M2C PET/CT scan
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease, Parkinsonian Disorders
The Personalized Parkinson Project De Novo Cohort
Currently, the Movement Disorders Society (MDS)-UPDRS scale remains the gold standard to document the outcomes in clinical trials for Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Parkinsonian Disorders, Basal Ganglia Diseases, Brain Diseases
- Trial name
- PPP-novo (NCT04985539)
- Testing
- Verily Study Watch
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease
The Personalized Parkinson Project (PPP)
Background Our understanding of PD has stagnated, partly due to the limited patient diversity and brief followup captured in most study cohorts.
- Trial name
- PPP (NCT03364894)
- Where
- Netherlands
- Volunteers
- 520 people
- Sponsor
- Radboud University Medical Center
Progressive Supranuclear Palsy, Brain Diseases
Personalized Parkinson Project PSP Cohort
There is an urgent need for the development of digital progression biomarkers, which are sensitive to detect small, but potentially clinically relevant changes in the disease course.
- Conditions
- Progressive Supranuclear Palsy, Brain Diseases, Neurodegenerative Diseases, Movement Disorders
- Trial name
- PPP-PSP (NCT05501431)
- Testing
- Verily Study Watch
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Carotid Artery Stenosis
Improved Image Quality for Assessment of Carotid Artery Stenosis by Ultrafast Ultrasound FLOW Imaging
Objective: To evaluate the technical performance of a novel cascaded wave imaging technique compared to plane wave imaging for blood flow imaging in patients with and without carotid artery stenosis.
- Trial name
- CAS-iFLOW (NCT06170580)
- Testing
- Conventional duplex, Ultrasound-based flow imaging using plane wave imaging, Ultrasound-based flow imaging using cascaded wave imaging
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Parkinson Disease, COPD
The ADAPT-study: Measuring Physical Performance Using Wearable Sensors in Parkinson's Disease and COPD (ADAPT)
The aim of this study is to investigate whether a smartwatch can measure the physical capacity of patients with Parkinson's Disease and COPD in the physiotherapy practice and at home.
- Trial name
- ADAPT (NCT05756075)
- Testing
- Aerobic exercise training
- Where
- 28 sites in Netherlands
- Volunteers
- 154 people
- Sponsor
- Radboud University Medical Center
Esophageal Cancer
Perioperative SDD to Prevent Infectious Complications After Esophagectomy
The primary aim of the PERSuaDER-trial is to evaluate the effect of SDD on infectious complications after esophagectomy, focussed on the prevention of pneumonia
- Trial name
- PERSuaDER (NCT05865743)
- Testing
- SDD
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 854 people
- Sponsor
- Radboud University Medical Center