Clinical trials: sponsored by Radboud University Medical Center
Adhesions Abdominal, Adhesions Pelvic
Natural Course of Pain Following Surgery Through an Abdominal Incision
Chronic abdominal pain is highly prevalent in patients undergoing abdominal surgery. Adhesions are reported to be one of the most common causes of chronic pain after surgery.
- Conditions
- Adhesions Abdominal, Adhesions Pelvic, Surgery Induced Tissue Adhesions, Chronic Pain
- Trial name
- Pain Trac (NCT04088838)
- Testing
- Pain tracking app
- Where
- 7 sites in Netherlands
- Volunteers
- 650 people
- Sponsor
- Radboud University Medical Center
Colon Cancer
PRE- MISTIC: MRI and Cine Imaging to Improve Staging of Tumors in the Colon
At this moment, we use CT and endoscopy to clinically stage colon tumours. Unfortunately, the combination of these imaging techniques is highly inaccurate.
- Trial name
- PRE-MISTIC (NCT06216743)
- Testing
- MRI and CT
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease
Neural Control of Breathing in Parkinson's Disease
Breathing is a complex process, which can be controlled through voluntary command or neural control. Parkinson's disease (PD) is a progressive neurological disorder.
- Trial name
- NEURON-PD (NCT06074614)
- Testing
- Hypercapnic ventilatory response, Respiratory related evoked potential, Transcranial magnetic stimulation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Squamous Cell Carcinoma of the Nasal Vestibule
Sentinel NOSE Study: Prospective Registration Study on the Sentinel Node Procedure for Bulky Squamous Cell Carcinoma of the Nasal Vestibule.
Management of the neck in Wang cT1-T2N0 nasal vestibule carcinoma (NVC) has been an ongoing point of discussion. As the disease is rare publications are scarce and published regional recurrence rates vary widely between 0% up to…
- Trial name
- NCT05637307
- Testing
- Sentinel node procedure
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Non Small Cell Lung Cancer, Mesothelioma
Dose Individualization of Pemetrexed - IMPROVE-I
Rationale: Pemetrexed is a multi-targeted folate antagonist, which is primarily indicated for the treatment of advanced non-small cell lung cancer (NSCLC) and mesothelioma.
- Trial name
- IMPROVE-I (NCT03656549)
- Testing
- Pemetrexed + oral folinic acid rescue
- Where
- 6 sites in Netherlands
- Volunteers
- 6 people
- Sponsor
- Radboud University Medical Center
Internalizing Problems
Promoting Resilience in Youth Through Mindfulness mEditation
The aim of this randomized controlled trial (RCT) is to assess whether mindfulness training reduces early stage internalizing problems such as anxiety, worrying, and low mood in help-seeking youth.
- Trial name
- PRYME (NCT05916651)
- Testing
- Learning to Offset Stress (LOS) (in Dutch: Leren Omgaan met Stress) training, Care as usual
- Where
- 2 sites in Netherlands
- Volunteers
- 155 people
- Sponsor
- Radboud University Medical Center
Chronic Total Occlusion (CTO), Percutaneous Coronary Intervention (PCI)
Remodeling of Distal Coronary Vessel in Chronic Total Occlusions: Prediction Based on Hemodynamic Coronary Parameters
Background Revascularization of a chronic total occlusion (CTO) has gained popularity last decade. After recanalization there is an acute gain in vessel diameter, as well as a late lumen gain distal to the stent as a result of…
- Conditions
- Chronic Total Occlusion (CTO), Percutaneous Coronary Intervention (PCI), Fractional Flow Reserve, Quantitative Coronary Analysis
- Trial name
- CTO-VR (NCT06728384)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Nemaline Myopathy, Inspiratory Muscle Training
Inspiratory Muscle Training in Nemaline Myopathy
Nemaline myopathy is a rare congenital myopathy. Respiratory failure is the main cause of death in these patients. The primary objective of this study is to determine the effect of a 8-week inspiratory muscle training program on…
- Trial name
- NEMTRAIN (NCT03728803)
- Testing
- Threshold IMT, Philips Respironics, Murrysville, PA, USA
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Radboud University Medical Center
FSHD
Testing a Tailored Home Exercise Program to Reduce Pain and Fatigue in Patients with FSHD.
The goal of this intervention study is to determine the effect of a tailored exercise program (with aerobic, strength and balance training) in patients with FSHD.
- Trial name
- GRIPonFSHD (NCT06712043)
- Testing
- Personalised Exercise, Historical control group
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
NSCLC
Immuno-pet IMaging ResPonses AdministeRed Immune CheckpoiNt InhibiTor
This study investigates whether a single subcutaneous administration of anti-PD-1 antibody can induce CD8+ T-cell tumor-infiltration that can be non-invasively monitored with [89Zr]crefmirlimab berdoxam PET imaging as an imaging…
- Trial name
- IMPRINT (NCT06218069)
- Testing
- Sasanlimab, non-ablative radiotherapy, [89Zr]Zr-crefmirlimab berdoxam
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Osteoarthritis, Hip
HXLPE Vs CPE Cups Under 50 Years
This randomized controlled trial evaluated the long-term wear of cemented highly cross-linked polyethylene (HXLPE) versus conventional polyethylene (CPE) acetabular cups in patients under 50 years undergoing primary total hip…
- Trial name
- NCT06706193
- Testing
- Total hip arthroplasty using CPE, Total hip arthroplasty using HXLPE
- Volunteers
- 59 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Colonic Polyp
Effect of Low-volume (1L) vs Intermediate-volume (2L) Bowel Preparation on Cost-effectiveness and Quality of Life
Adequate bowel preparation for colonoscopy is paramount for optimal diagnostic accuracy and safety. However, the need for high volumes to clean the colon often makes it difficult for patients to adhere to.
- Trial name
- RESULT (NCT05242562)
- Testing
- Plenvu, Moviprep
- Where
- Netherlands
- Volunteers
- 509 people
- Sponsor
- Radboud University Medical Center
Intracerebral Hemorrhage, Minimally Invasive Surgical Procedures
Dutch Intracerebral Hemorrhage Surgery Trial
Background: Intracerebral hemorrhage (ICH) accounts for 16-19% of all strokes in Western Europe and contributes profoundly to mortality and disability.
- Conditions
- Intracerebral Hemorrhage, Minimally Invasive Surgical Procedures, Endoscopic Surgical Procedures
- Trial name
- DIST (NCT05460793)
- Testing
- Minimally invasive endoscopy-guided surgery
- Where
- 11 sites in Netherlands
- Volunteers
- 600 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Colonic Adenoma
Bowel Cleansing Performance of the Pure-Vu System in Patients With a History of Poor Bowel Preparation
The diagnostic accuracy and safety of colonoscopy highly depends on the quality of the pre-procedural bowel preparation. A past history of poor bowel preparation is the most important risk factor of inadequate bowel cleansing at…
- Conditions
- Colorectal Cancer, Colonic Adenoma, Bowel Preparation
- Trial name
- NCT04700410
- Testing
- Pure-Vu System
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 44 people
- Sponsor
- Radboud University Medical Center
Gitelman Syndrome
Salt Supplementation in Gitelman Syndrome
The purpose of this study is to determine the effect of salt (NaCl) supplementation on serum potassium and clinical signs and symptoms in patients with Gitelman syndrome.
- Trial name
- NCT04995627
- Testing
- Salt (NaCl)
- Where
- 3 sites in Italy, Netherlands
- Volunteers
- 21 people
- Sponsor
- Radboud University Medical Center
Pheochromocytoma, Paraganglioma
Hereditary Pheochromocytoma Assessment of Tumour Immunologies
In this study, the investigators are examining the role of the immune system in pheochromocytoma and paraganglioma. The investigators aim to examine the differences in the immune system between people who have these tumors with…
- Trial name
- HEPHESTOS (NCT06444607)
- Testing
- Venepuncture
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Polyp of Colon
Breath Analysis as an Additional Test for Colorectal Cancer Screening to Reduce the Number of Unnecessary Colonoscopies
In the past decade, the demand for colonoscopy procedures has increased significantly since the introduction of population-based colorectal cancer (CRC) screening in many western countries.
- Conditions
- Colorectal Cancer, Polyp of Colon, Colorectal Neoplasms
- Trial name
- SCREENER (NCT04357158)
- Testing
- AeonoseTM
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- Radboud University Medical Center
Inpatient Endoscopy Delay, Readmission
Inpatient Endoscopy Procedure Planning Delays and Impact on Length of Stay and 30-day Readmission
Single center retrospective cohort study of all inpatient endoscopy procedures to asses factors associated with inpatient endoscopy delays and impact on length of stay and 30-day readmission
- Conditions
- Inpatient Endoscopy Delay, Readmission, Prolonged Hospital Stay
- Trial name
- Impatience (NCT05798065)
- Testing
- Inpatient gastrointestinal endoscopy
- Where
- Netherlands
- Volunteers
- 3,700 people
- Sponsor
- Radboud University Medical Center
Multiple Myeloma
Anakinra: Efficacy in the Management of Fever During Neutropenia and Mucositis in ASCT - A Randomized Controlled Trial
Oral and intestinal mucositis are major risk factors for the occurrence of fever during neutropenia and bloodstream infections after intensive chemo- and radiotherapy.
- Trial name
- AFFECT-2 (NCT04099901)
- Testing
- Anakinra
- Where
- 3 sites in Netherlands
- Volunteers
- 88 people
- Sponsor
- Radboud University Medical Center
Coronary Spasm
Efficacy of Endothelin Receptor Antagonism in Coronary Artery Spasm
The goal of this randomized clinical trial is to assess if adjunctive bosentan therapy, in comparison to placebo, can reduce the rate of epicardial vasospasm at follow-up spasm provocation CFT (fuCFT) in patients with previously…
- Trial name
- EDIT-CAS (NCT06432452)
- Testing
- Endothelin Receptor Antagonist
- Where
- 4 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center