Clinical trials: open to volunteers, sponsored by Radboud University Medical Center
Thyroid Cancer Stage IV, Anaplastic Thyroid Cancer
Drug Repurposing in Thyroid Carcinoma: a Feasibility Trial
This is a phase Ib trial that studies personalized network pharmacology-based drug repurposing in patients with advanced thyroid cancer who have no other treatment options.
- Conditions
- Thyroid Cancer Stage IV, Anaplastic Thyroid Cancer, Differentiated Thyroid Cancer, Poorly Differentiated Thyroid Carcinoma
- Trial name
- REPOTHYROID-II (NCT07485569)
- Testing
- Personalised treatment
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Hepatocellular Carcinoma Non-Resectable
Overcoming Immunotherapy Resistance in Hepatocellular Carcinoma
Each year, approximately 1,000 patients in the Netherlands are diagnosed with liver cancer. When liver cancer can no longer be treated with surgery or thermal ablation, cure is no longer possible.
- Trial name
- OvercomeHCC (NCT07895342)
- Testing
- External beam radiotherapy, transarterial radioembolization
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Breast Cancer Detection, Breast Cancer
Screening and the Future of Enhanced MRI for Early Breast Cancer Detection
This study aims to recruit women aged 45 years in the Netherlands to participate in a one-time breast MRI screening examination and to evaluate their motivation for participation as well as the impact of screening on their…
- Conditions
- Breast Cancer Detection, Breast Cancer, Screening Strategy
- Trial name
- SAFE-MRI (NCT07878377)
- Testing
- Breast MRI Screening, Questionnaires
- Volunteers
- 2,628 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Parkinson Disease, Prodromal Stage
Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage
The goal of this clinical trial is two-fold. First to investigate the feasibility of whether a remotely administered smartphone app can increase the volume and intensity of physical activity in daily life in individuals with a…
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia Diseases
- Trial name
- Slow-SPEED (NCT06993142)
- Testing
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 600 people
- Sponsor
- Radboud University Medical Center
Mycobacterium Avium Complex Pulmonary Disease
A Prospective, Multicenter, Single-arm MAC-PD Cohort: a NTM-NET and ESGMYC Collaborative Study
To gain insight in the effectiveness of, adherence and adjustments to guideline-based three-drug antimycobacterial therapy in patients with Mycobacterium avium complex pulmonary disease (MAC-PD) during the first 6 months of…
- Trial name
- MAC-PD cohort (NCT05906316)
- Where
- 11 sites in United States, Belgium and 8 more
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Nontuberculous Mycobacterial Lung Disease, Mycobacterium Avium Complex
Hypertonic Saline Inhalation for Mycobacterium Avium Complex Pulmonary Disease
The SALINE trial will investigate the effect of Hypertonic Saline inhalation plus best supportive care on burden of symptoms, clearance of mycobacteria and functional capacities in participants with Mycobacterium avium complex…
- Trial name
- SALINE (NCT05192057)
- Testing
- Hypertonic Saline inhalation
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Diaphragm Dysfunction, Weaning Invasive Mechanical Ventilation
Diaphragm Hibernation and Its Driving Factors in Mechanically Ventilated ICU Patients
Rationale: Patients with invasive mechanical ventilation (IMV) frequently develop diaphragm dysfunction and experience difficult weaning.
- Conditions
- Diaphragm Dysfunction, Weaning Invasive Mechanical Ventilation, Respiratory Failure, ICU
- Trial name
- DISSECT (NCT07819864)
- Where
- Netherlands
- Volunteers
- 112 people
- Sponsor
- Radboud University Medical Center
Trauma (Including Fractures), Multiple Trauma/Injuries
Affordable, Tailored Therapy for Financially Vulnerable People With Trauma-related Injuries
Financially vulnerable people experience higher rates of trauma-related injuries and often face barriers to accessing physical therapy services.
- Conditions
- Trauma (Including Fractures), Multiple Trauma/Injuries, Rehabilitation
- Trial name
- AFTER-TRAUMA (NCT07819877)
- Volunteers
- 17 people
- Sponsor
- Radboud University Medical Center
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Chronic Fatigue
Modafinil for Debilitating Fatigue in Quiescent Inflammatory Bowel Disease MODIFI-IBD Trial)
The goal of this clinical trial is to learn if modafinil can treat severe fatigue in adults aged 18 to 75 years with quiescent inflammatory bowel disease (IBD).
- Trial name
- MODIFI-IBD (NCT07582458)
- Testing
- Modafinil
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
High Risk Localized Prostate Cancer, Synchronous Metastatic Hormone-Sensitive Prostate Cancer
Prospective Prostate Cancer Infrastructure
The goal of this observational study is to collect detailed long-term real-world data and biomaterials from men with high-risk localized prostate cancer and synchronous metastatic hormone-sensitive prostate cancer.
- Trial name
- ProPCI (NCT07560748)
- Where
- Netherlands
- Volunteers
- 700 people
- Sponsor
- Radboud University Medical Center
Carcinoma Nasal Vestibule
Brachytherapy (Interventional Radiotherapy) for Squamous Cell Carcinomas of the Nasal Vestibule: Optimization of Dose and Technique
Rationale: Primary brachytherapy (also known as Interventional Radiotherapy, IRT) achieves high cure rates in cancer of the nasal vestibule (CNV) while preserving nasal aesthetics and function.
- Trial name
- BRAVO (NCT07801690)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Radboud University Medical Center
Quality of Life, PROMs
Affordable, Tailored Physical Therapy for Financially Vulnerable People With Trauma-related Injuries (AFTER-TRAUMA)
SUMMARY Rationale: In the Netherlands, trauma-related injuries affect more than 700,000 people annually, and many require rehabilitation.
- Trial name
- AFTER-TRAUMA (NCT07795216)
- Testing
- Questionnaires
- Where
- Netherlands
- Volunteers
- 153 people
- Sponsor
- Radboud University Medical Center
Oncology
Promoting Response to IMmunotherapy by Exercise in Patients With Advanced Renal Cell Carcinoma
The primary aim of this study is to evaluate the feasibility of a supervised high intensity interval training (HIIT) program during first-line dual immune checkpoint inhibitor (ICI) therapy (nivolumab plus ipilimumab) in patients…
- Trial name
- PRIMER (NCT07680556)
- Testing
- HIIT
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Lyme Borreliosis, Nervous System
Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.
The goal of this clinical trial is to learn if hydroxychloroquine works to treat long-term complaints attributed to Lyme borreliosis in adults.
- Trial name
- DoBo (NCT07230028)
- Testing
- Hydroxychloroquin, Doxycycline
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease, Prodromal Stage
Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands
The goal of this clinical trial is to investigate the feasibility if a remotely administered smartphone app can increase the volume and intensity of physical activity in daily life in patients with isolated Rapid Eye Movement…
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Parkinsonian Disorders
- Trial name
- Slow-SPEED-NL (NCT06193252)
- Testing
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Radboud University Medical Center
Atrial Fibrillation (AF)
Pulsed Field Ablation for Atrial Fibrillation Using the VARIPULSE™ Catheter
Rationale: Effectiveness of thermal ablation techniques for pulmonary vein isolation, to treat atrial fibrillation (AF), are hampered by frequent pulmonary vein reconnection and risks of collateral tissue injury.
- Trial name
- VARI-POWER (NCT07779369)
- Testing
- Pulsed Field Ablation (PFA) with the VARIPULSE™ catheter
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Post-ERCP Acute Pancreatitis
An European Multi-centre Cohort Study for Unravelling Pharmacokinetic and Genetic Factors Underlying Post-ERCP Pancreatitis
Endoscopic retrograde cholangiopancreatography (ERCP) comes with a risk for post-ERCP pancreatitis (PEP), which accounts for considerable morbidity, high healthcare expenditure, and death.
- Trial name
- G-PEP (NCT05267379)
- Testing
- Take blood samples
- Where
- Netherlands
- Volunteers
- 700 people
- Sponsor
- Radboud University Medical Center
Agitation,Psychomotor
A Multicomponent Intervention Program to Prevent and Reduce ICU Agitation and Physical Restraint Use
Despite deleterious effects, physical restraints are still commonly used in (expected to become) agitated patients in Dutch ICUs (20-25%).
- Trial name
- PRAISE (NCT05783505)
- Testing
- Multicomponent intervention program
- Where
- 5 sites in Netherlands
- Volunteers
- 480 people
- Sponsor
- Radboud University Medical Center
Lynch Syndrome
Preventive Dendritic Cell Vaccination for Lynch Syndrome
The aim of this study is to assess safety, immunogenicity and feasibility of vaccination with neopeptide-loaded dendritic cells in Lynch Syndrome subjects who are known to be carrier of a germline MMR-gene mutation without signs…
- Trial name
- PREVENT-Lynch (NCT07412197)
- Testing
- DC vaccination
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Chronic Pulmonary Aspergillosis
Deposition of Inhaled Liposomal Amphotericin B in Chronic Pulmonary Aspergillosis (CPA)
This study evaluates and aims to optimize inhalation treatment with nebulized liposomal amphotericin B in patients with chronic pulmonary aspergillosis.
- Trial name
- NIMBUS (NCT07530263)
- Testing
- 12 mg of nebulised 99mTc-liposomal amphotericin B, 24 mg of nebulised 99mTc-liposomal amphotericin B, SPECT/CT scan
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Radboud University Medical Center