Clinical trials: sponsored by RenJi Hospital
Gastric Ulcer, Gastric Cancer
Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients
Ciprofol is a new general anesthetic, which combine with γ- Aminobutyric acid-a (GABAA) receptor. Ciprofol has shown equivalent anesthetic efficacy of propofol at 1/4 to 1/5 of the dosage.
- Conditions
- Gastric Ulcer, Gastric Cancer, Gastrointestinal Polyp
- Trial name
- SpO2 (NCT05518929)
- Testing
- Ciprofol, Propofol
- Where
- 5 sites in China
- Volunteers
- 1,090 people
- Sponsor
- RenJi Hospital
Anesthesia; Adverse Effect, Biliary Tract Diseases
Ciprofol vs Propofol for Reducing Hypoxia Incidence in ERCP
Intravenous anesthesia has been widely used in endoscopic retrograde cholangiopancreatography (ERCP). In the past decade, many practices have been carried out under the propofol-based monitored anesthesia care without…
- Trial name
- NCT06015074
- Testing
- Propofol, Ciprofol
- Where
- China
- Volunteers
- 136 people
- Sponsor
- RenJi Hospital
Intracranial Hemorrhages
A Clinical Prospective Observational Study of Near Infrared Spectroscopy to Detect Subcranial Hematoma
This trial is a clinical prospective observational study. Cases meeting the entry criteria undergo near-infrared spectroscopy(NIRS）detection.
- Trial name
- NIRS-DETECT (NCT06404645)
- Testing
- Near-infrared spectroscopy detection
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Traumatic Brain Injury, Decompressive Craniectomy
Study on the Efficacy of Long-term Drainage of Subdural Effusion After Decompressive Craniectomy
Drilling or puncture drainage is commonly used in TBI patients with subdural effusion following decompressive craniectomy who fail to respond to conservative treatment, but there is no exact regulation or guideline recommendation…
- Conditions
- Traumatic Brain Injury, Decompressive Craniectomy, Subdural Effusion
- Trial name
- NCT06391203
- Testing
- Long-term Drainage, Short-term Drainage
- Where
- China
- Volunteers
- 160 people
- Sponsor
- RenJi Hospital
Diagnosis
Label-free Raman Spectroscopy for Discrimination Between Breast Cancer Tumor and Adjacent Tissues After Neoadjuvant Treatment
After neoadjuvant therapy, the primary lesion in breast cancer patients may experience tumor regression, which increases the difficulty of distinguishing between breast cancer and adjacent tissues.
- Trial name
- NCT06394050
- Testing
- Diagnostic Test
- Volunteers
- 150 people
- Sponsor
- RenJi Hospital
Pulmonary Complication
Supraglottic Airway vs Tracheal Intubation on PPCs Among High-risk Geriatric Patients
Postoperative pulmonary complications are serious threat to surgical patients, especially to high-risk geriatric patients. There is evidence that laryngeal mask airway is associated with postoperative pulmonary complications in…
- Trial name
- NCT06391333
- Testing
- laryngeal mask airway and endotracheal tube
- Volunteers
- 2,210 people
- Sponsor
- RenJi Hospital
Locally Advanced Cervical Carcinoma, Concurrent Chemoradiotherapy
Concurrent Chemoradiotherapy Followed by PD-1 Inhibitor in Advanced Cervical Cancer
To explore the safety and efficacy of Albumin-Bound Paclitaxel/Platinum based concurrent chemoradiotherapy Followed by PD-1 inhibitor (Sintilimab) in locally advanced cervical cancer
- Conditions
- Locally Advanced Cervical Carcinoma, Concurrent Chemoradiotherapy, Immunotherapy
- Trial name
- NCT06391190
- Testing
- Albumin-Bound Paclitaxel, cisplatin, Sintilimab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Obesity
Obesity Queue Database
To establish an obesity specific disease cohort database and form a special disease cohort, so as to provide guarantee for carrying out high-quality real-world clinical research and clinical research.
- Trial name
- NCT06391320
- Testing
- other
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Breast Cancer
Combination Neoadjuvant Chemotherapy With or Without Apatinib for HER2 Negative Breast Cancer
RATIONALE: The combination of anti-angiogenic targeted therapy with neoadjuvant chemotherapy has been shown to further improve the pathologic response rate for HER2-negative breast cancer patients.
- Trial name
- APP (NCT03982485)
- Testing
- Apatinib, Paclitaxel, Cisplatin
- Where
- China
- Volunteers
- 196 people
- Sponsor
- RenJi Hospital
Esophageal Squamous Cell Carcinoma
Accurate Diagnosis of the Invasion Depth in ESCC by a Deep Neural Network Analysis of NBI Endoscopy Data
The goal of this observational study is to accurate diagnose the stage of esophageal squamous cell carcinoma in order to help physicians to decide the appropriate clinical treatment.
- Trial name
- NCT06252974
- Volunteers
- 500 people
- Sponsor
- RenJi Hospital
Cardiovascular Diseases, Stroke
Cohort in Qianwan New District, Ningbo
Our objective is to carry out research on prevention and control of noncommunicable chronic diseases, and establish a risk prediction mechanism for chronic diseases to promote early detection, early diagnosis and early treatment…
- Conditions
- Cardiovascular Diseases, Stroke, Non-Communicable Chronic Diseases
- Trial name
- NCT06387875
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Locally Advanced Cervical Carcinoma, Concurrent Chemoradiotherapy
the Predictive Value of Immune Cell in Locally Advanced Cervical Cancer
To explore the predictive value of immune cells by single-cell sequencing on the outcome of locally advanced cervical cancer treated by concurrent chemoradiotherapy Followed by PD-1 inhibitor
- Conditions
- Locally Advanced Cervical Carcinoma, Concurrent Chemoradiotherapy, Immunotherapy
- Trial name
- NCT06378840
- Testing
- Nab-paclitaxel/Platinum, Sintilimab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Hepatoblastoma, Radiology
Evaluation of Lung Metastases Based on Ultrashort Echo Time MRI
Analyze the diagnostic efficiency (including performance, diameter, and location of nodules) of UTE-MRI in lung metastases of hepatoblastoma with chest CT as gold standard
- Trial name
- NCT05763173
- Where
- China
- Volunteers
- 65 people
- Sponsor
- RenJi Hospital
Delayed Graft Function, End Stage Renal Disease
Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations
Delayed graft function (DGF), delineated by the necessity for dialytic intervention within the initial week post-transplantation, afflicts approximately 20%-50% of recipients.
- Conditions
- Delayed Graft Function, End Stage Renal Disease, Kidney Transplantation
- Trial name
- NCT06367205
- Testing
- Goal-Directed Fluid Therapy (GDFT), Regular Fluid Therapy
- Where
- 3 sites in China
- Volunteers
- 380 people
- Sponsor
- RenJi Hospital
Progression Free Survival, Overall Survival
Id and Rd Maintenance Regimens After Induction of Remission in Multiple Myeloma.
Newly Diagnosed Myeloma Patients, who achieved efficacy above VGPR (very good PR)after initial treatment were enrolled. Patients were then randomly assigned to Id and Rd groups for maintenance treatment.
- Conditions
- Progression Free Survival, Overall Survival, Maintenance
- Trial name
- NCT05477797
- Testing
- Ixazomib DX/Lenalidomide DX
- Where
- China
- Volunteers
- 420 people
- Sponsor
- RenJi Hospital
Pancreatic Cancer Stage IV
SHR- 1210 Combined With Paclitaxel (Albumin Bound) and Gemcitabine as First-line Therapy in Patients With Metastatic Pancreatic Cancer
This is an open-label, single center, non-randomized, phase I trial to evaluate safety and efficacy of using the combination treatment of SHR-1210 with Paclitaxel-albumin and gemcitabine of metastatic PDAC.
- Trial name
- NCT04181645
- Testing
- Biological: SHR-1210 Drug: Gemcitabine Drug:Paclitaxel-albumin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Obesity, Chronic Kidney Diseases
Comparison of the Efficacy and Safety of SGLT2i and GLP-1 Receptor Agonists in Obese Patients With Kidney Disease
The goal of this clinical trial is to exploring the changes in 24-hour urinary protein and renal function in obese patients with kidney disease after the application of sodium glucose cotransporter 2 inhibitors (SGLT2i) and…
- Trial name
- NCT06344247
- Testing
- RAS inhibitors：Losartan®️/Valsartan®️, dapagliflozin：Forxiga®️, simagliptin：Forxiga®️
- Where
- China
- Volunteers
- 48 people
- Sponsor
- RenJi Hospital
Pancreatic Cancer Stage IV, Pancreatic Cancer Metastatic
A Prospective, Randomized, Double-blinded, Multi-center Clinical Trial to Evaluate the Efficiency and Safety of Anti-PD1 Antibody (Camrelizumab) Combined With Paclitaxel(Albumin Bound) and Gemcitabine as First-line Therapy in Patients With Metastatic Pancreatic Cancer
Aim：Evaluate the efficiency and safety of anti-PD1 antibody (Camrelizumab) combined with Paclitaxel(Albumin Bound) and Gemcitabine as first-line therapy in patients with metastatic pancreatic cancer.
- Trial name
- NCT04674956
- Testing
- Camrelizumab, Paclitaxel(Albumin Bound) and Gemcitabine
- Where
- 6 sites in China
- Volunteers
- 401 people
- Sponsor
- RenJi Hospital
Coma, Brain Injuries, Traumatic
Evaluation of EEG Power Spectrum in Patients With Traumatic Coma
Development of objective, reliable, and convenient assessment methods of disorders of consciousness is crucial. We aim to conduct multicenter prospective observational study and non-invasively collect EEG from patients with…
- Trial name
- EPIC (NCT06321146)
- Where
- 5 sites in China
- Volunteers
- 210 people
- Sponsor
- RenJi Hospital
Hypoxia, Gastric Cancer
Capnographic Monitoring in Gastrointestinal Endoscopy for Elderly Patients
Hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol and sufentanil, especially in elderly people.
- Conditions
- Hypoxia, Gastric Cancer, Gastric Polyp, Colon Polyp
- Trial name
- CapnoGI (NCT05030870)
- Testing
- Capnography monitoring, Standard monitoring
- Where
- 3 sites in China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital