Clinical trials: sponsored by RenJi Hospital
Overweight and Obesity
Early Detection of Myocardial Work Impairment in Obesity II(EARLY-MYO-OBESITY-II)
This prospective study intends to explore the change of cardiac structure and function in the cohort of overweight or obesity patients, and determine the impact of clinical characteristics on cardiac remodeling and mechanics.
- Trial name
- NCT04933188
- Testing
- Myocardial work was estimated from left ventricular pressure-strain loop derived from speckle tracking echocardiography and non-invasive brachial artery cuff pressure
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Cognition
Effect on Early Cognition Under Sedation by Rimazole Toluenesulfonate in Old Patient Undergoing Colonoscopy
To investigate the effect on cognition under sedation by Rimazole toluenesulfonatein elderly patients undergoing colonoscopy
- Trial name
- NCT05255211
- Testing
- Remimazolam tosilate, Propofol, saline solution
- Where
- China
- Volunteers
- 90 people
- Sponsor
- RenJi Hospital
Multiple Myeloma, Bone Diseases
Narlumosbart Compared With Denosumab in Patients With Multiple Myeloma Bone Disease
The purpose of this study is to determine if narlumosbart is non-inferior to denosumab in the treatment of bone diseases from multiple myeloma (MM).
- Trial name
- NCT06314698
- Testing
- Narlumosbart, Denosumab
- Volunteers
- 478 people
- Sponsor
- RenJi Hospital
Systemic Lupus Erythematosus, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Safety and Efficacy Study of CD19-CAR-DNT Cells in Autoimmune Diseases
To evaluate the safety and efficacy of CD19-CAR-DNT cells in subjects with relapsed/refractory autoimmune diseases
- Conditions
- Systemic Lupus Erythematosus, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Idiopathic Inflammatory Myopathies, Systemic Sclerosis
- Trial name
- NCT06316076
- Testing
- CD19-CAR-DNT cells
- Where
- China
- Volunteers
- 48 people
- Sponsor
- RenJi Hospital
Diffuse Large B-cell Lymphoma Recurrent, Diffuse Large B Cell Lymphoma Refractory
Zanubrutinib+Lenalidomide+R-ICE in Relapsed/Refractory DLBCL
This is a prospective, single center, single arm, open label study of zanubrutinib, lenalidomide in combination with Rituximab-ICE for treatment of relapsed/refractory diffuse large B-cell lymphoma.
- Trial name
- NCT06033820
- Testing
- ZR2-ICE
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Decompensated Cirrhosis
A Clinical Trial Evaluating the Safety, Tolerability, and Preliminary Efficacy of HCL001 Cell Injection (Homologous Allogeneic Hepatocytes) in Patients With Decompensated Cirrhosis
This study protocol is designed to evaluate the clinical efficacy, safety, and tolerability of HCL001 cell injection in the treatment of decompensated cirrhosis.
- Trial name
- NCT06306781
- Testing
- HCL001 cell (homologous allogeneic hepatocytes) injection
- Volunteers
- 18 people
- Sponsor
- RenJi Hospital
Idiopathic Inflammatory Myopathies
Clinical Study Cohort of Idiopathic Inflammatory Myositis
Idiopathic inflammatory myositis (IIM), also known as myositis, are a heterogeneous group of diseases characterized by chronic inflammation of striated muscles and skin, with different clinical manifestations, treatment…
- Trial name
- NCT06306547
- Testing
- no interventions were involved
- Volunteers
- 1,000 people
- Sponsor
- RenJi Hospital
Somatization Disorder
Assessment of Somatic Symptom Burden
The Patient Health Questionnaire-15 (PHQ-15) is a frequently used questionnaire to assess somatic symptom burden. The Somatic Symptom Scale China (SSS-CN) was recently developed as a comprehensive self-report instrument in…
- Trial name
- NCT03321409
- Testing
- The general population, Patients with suspected CAD
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Cardiovascular Diseases, Non-Communicable Chronic Diseases
Intervention and Effect of Sleep Pattern on Cardio-cerebrovascular Disease
Because of the growing population of older people, cardio-cerebrovascular diseases has been the most important aging-related chronic disease, studying the pathogenesis and early warning mechanisms of cardio-cerebrovascular…
- Trial name
- NCT06294964
- Testing
- sleep education, behavioral education
- Where
- China
- Volunteers
- 12,800 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Bladder Pain Syndrome
fMRI for BPS: A Descriptive Study of Findings and Symptoms
The goal of this observational study is to investigate the relationship between functional magnetic resonance imaging (fMRI) findings of the brain and symptom presentation in patients with bladder pain syndrome (BPS).
- Trial name
- NCT06294951
- Testing
- fMRI
- Where
- China
- Volunteers
- 120 people
- Sponsor
- RenJi Hospital
Biliary Tract Diseases, Gallbladder Cancer
Construction of Multicenter Retrospective Registry Cohort Database for Gallbladder Cancer
The aim of the study is to establishing a standardized clinical information database for patients with malignant tumors of gallbaldder.
- Conditions
- Biliary Tract Diseases, Gallbladder Cancer, Gallbladder Neoplasms
- Trial name
- CRGGCext (NCT06276153)
- Testing
- no interventions
- Volunteers
- 5,000 people
- Sponsor
- RenJi Hospital
Thromboelastography, Hemodialysis
Preliminary Exploration of Thromboelastography in the Monitoring of Anticoagulation in Maintenance Hemodialysis Patients
Objectives: To investigate the role of thromboelastography parameters (R, K, Angle, MA) in monitoring anticoagulation in maintenance hemodialysis (MHD) patients. Subjects: Two hundred stable MHD patients.
- Conditions
- Thromboelastography, Hemodialysis, Anticoagulation
- Trial name
- NCT06272708
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Acute Ischemic Stroke
Sodium Valproate in Patients With Acute Ischemic Stroke
The purpose of this pilot trial is to investigate the feasibility, safety, and efficacy of sodium valproate in patients with acute ischemic stroke, and also explore the mechanism: whether valproate increases peripheral…
- Trial name
- NCT06020898
- Testing
- Sodium valproate, Normal saline
- Where
- China
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Recurrent Miscarriage
The Analysis of Risk Factors for Recurrent Pregnancy Loss and Prediction of Pregnancy Loss Risk
Based on the comprehensive etiological screening results of patients with recurrent pregnancy loss, including basic characteristics, coagulation function indicators, autoimmune indicators, endocrine indicators, and gynecological…
- Trial name
- NCT06249230
- Testing
- Hematologic features, Ultrasound indices of uterine artery blood flow, Demographic characteristics
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- RenJi Hospital
Hypothermia; Anesthesia
A Risk Prediction Model for Hypothermia After Laparoscopic Gastrointestinal Tumor Surgery
The incidence of postoperative hypothermia in patients with laparoscopic gastrointestinal tumors is high. Hypothermia increases the risk of postoperative complications and medical costs.
- Trial name
- NCT05958550
- Testing
- The tympanic membrane temperature of patients was measured.
- Volunteers
- 480 people
- Sponsor
- RenJi Hospital
Cerebral Hemorrhage
Retrospective Study on the Direction of Artificial Intelligence in Identifying Cranial Trauma CT Imaging
The goal of this observational retrospective study is to evaluate artificial intelligences (AI)'s proficiency in identifying and annotating brain bleeds in computed tomography (CT) images.
- Trial name
- NCT06230419
- Where
- China
- Volunteers
- 208 people
- Sponsor
- RenJi Hospital
Peripheral Arterial Disease
Development and Validation of the Modified Version of VascuQol Scale in Patients With Lower Extremity Peripheral Arterial Disease.
The purpose of this study is to assess the utility of the Modified version of VascuQol Scale as an effective biopsychosocial assessment tool for patients suffering from lower extremity peripheral arterial disease.
- Trial name
- NCT06223217
- Testing
- Surveys and Questionnaires
- Where
- China
- Volunteers
- 480 people
- Sponsor
- RenJi Hospital
Stroke Volume Variation, SVV-FloTrac
A Comparison of Stroke Volume Variation for Prediction of Fluid Responsiveness
Stroke volume variation (SVV) is an indicator used to assess the patient's volume status. The FloTrac system (Edwards Lifesciences, Irvine, CA) continuously monitors cardiac output (CO) and SVV (SVV-FloTrac) by analyzing the…
- Conditions
- Stroke Volume Variation, SVV-FloTrac, Thoracic Electrical Bioimpedance, Fluid Responsiveness
- Trial name
- NCT06215157
- Testing
- Flotrac Group, BioZ Group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- RenJi Hospital
Autoimmune Diseases
F01 in the Treatment of Autoimmune Diseases
This is a multicenter, open lable clinical study to evaluate the safety and tolerability of F01 in autoimmune diseases.
- Trial name
- NCT06208280
- Testing
- After preconditioning with Fludarabine and Cyclophosphamide, F01 will be evaluated.
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Upper Tract Urothelial Carcinoma Receiving Kidney-sparing Therapy
Prognosis of Patients With Upper Tract Urothelial Carcinoma Receiving Kidney-sparing Therapy
Upper tract urothelial carcinoma (UTUC) is a rare malignant disease which accounts for 5-10% of urothelial carcinoma in the western world and 9%-30% in China.
- Trial name
- NCT06204406
- Testing
- Observational
- Where
- China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital