Clinical trials: sponsored by RenJi Hospital
Systemic Lupus Erythematosus
Safety and Efficacy of SM934 Compared to Placebo in Adult Subjects With Active Systemic Lupus Erythematosus
This is a single-center, randomized, double-blind, placebo-controlled, phase 2 study. The purpose of the study is to initially evaluate the safety and efficacy of SM934 combined with steroids compared to placebo in adult subjects…
- Trial name
- NCT03951259
- Testing
- SM934
- Where
- China
- Volunteers
- 32 people
- Sponsor
- RenJi Hospital
Epithelial Ovarian Cancer
Individualized Health Management of Epithelial Ovarian Cancer: A Retrospective Study
The purpose of this study is to identify the demographic and sociological characteristics of epithelial ovarian cancer in a cohort, identify the risk factors of epithelial ovarian cancer, effectively identify the high-risk…
- Trial name
- NCT06085456
- Testing
- Hematologic features
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- RenJi Hospital
HCC, Liver Cirrhosis
SALT for Liver Cirrhosis With HCC
HCC is the third leading cause of cancer deaths worldwide. Although surgical treatment may be effective in patients with HCC, the five-year survival rate is only 50-70%.
- Trial name
- NCT06069947
- Testing
- sequential adult left lateral lobe liver transplantation (SALT)
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Colon Cancer Liver Metastases
SALT for Unresectable Colorectal Liver Metastases
Colon cancer is a common malignancy with a low survival rate worldwide, and unresectable colon cancer liver metastases (ICRLM) have a worse prognosis.
- Trial name
- NCT06069960
- Testing
- sequential adult left lateral lobe liver transplantation (SALT)
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
End Stage Liver DIsease
SALT in Adolescents With End-stage Liver Disease
End-stage liver disease is synonymous with advanced liver disease, liver failure, and decompensated cirrhosis, and their disease progression is generally irreversible.
- Trial name
- NCT06069050
- Testing
- sequential adolesent left lateral lobe liver transplantation (SALT)
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Acute-On-Chronic Liver Failure
SALT for Treatment of Patients With Early ACLF
ACLF is a syndrome characterized by rapid deterioration of liver function in chronic liver disease or undiagnosed chronic liver disease, with a high risk of short-term death.
- Trial name
- NCT06069037
- Testing
- sequential adult left lateral lobe liver transplantation (SALT)
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Obesity, Type 2 Diabetes
The Effect of Henagliflozin and Metformin on Myocardial Tissue-level Characteristics
This is a prospective, randomized, open-label, active drug controlled clinical trial that aims to compare the effects of henagliflozin or metformin on myocardial tissue level characteristics in type 2 diabetes patients with…
- Conditions
- Obesity, Type 2 Diabetes, Sodium-glucose Co-transporter-2 Inhibitor, Myocardial Fibrosis
- Trial name
- NCT06059287
- Testing
- Henagliflozin, Metformin
- Volunteers
- 64 people
- Sponsor
- RenJi Hospital
Diabetic Kidney Disease, Extracellular Matrix Alteration
The Influence of the Thickening of Bowman's Capsule on the Clinical Prognosis of Patients With Diabetic Kidney Disease
Diabetic kidney disease (DKD) is the leading cause for renal replacement therapy in developed country. DKD is also the primary cause of ESKD among middle-aged and elderly people in China.
- Trial name
- NCT06049550
- Testing
- no intervention
- Volunteers
- 250 people
- Sponsor
- RenJi Hospital
Postoperative Delirium, Stroke
Cyclopofol Versus Propofol for Postoperative Delirium in Elderly Patients Having Orthopedic Surgery
Postoperative delirium (POD) is common in elderly patients recovering from surgery and anesthesia. POD has adverse effects on early and long-term prognosis.
- Trial name
- NCT06046638
- Testing
- Cyclopofol, Propofol
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Coronary Artery Disease, Multi Vessel Coronary Artery Disease
Influence of Risk Factors on ISR and Nonintervened Lesions
This study enrolled patients who used to received PCI therapy with nonintervened coronary lesions. Baseline characteristics and laboratory testing were collected to find out the risk factor difference between ISR and…
- Trial name
- NCT06039059
- Where
- China
- Volunteers
- 510 people
- Sponsor
- RenJi Hospital
Deep Learning,Lumbar Magnetic Resonance Imaging
Application of Artificial Intelligence Deep Learning Technology in Magnetic Resonance Lumbar Imaging
To study the comparative analysis of artificial intelligence deep learning technology in the image quality of under-artificial intelligence (AI) reconstruction images and the original acquisition images of magnetic resonance…
- Trial name
- NCT06037057
- Testing
- no intervention name
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Hemodialysis Access Failure
Exploratory Research of PCSK9 Inhibitor on Patency of aAVF After PTA With PCB
Autologous arteriovenous fistula (AVF) is the preferred vascular pathway type for maintenance hemodialysis (MHD) patients. The K/DOQI guidelines suggest that the use of percutaneous transluminal angioplasty (PTA) as the primary…
- Trial name
- NCT06034691
- Testing
- pcsk9 inhibitor
- Where
- China
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Delirium, Cognitive Dysfunction
Prediction Model of Long-term Cognitive Dysfunction and Delirium After Cardiac Surgery
Delirium is a clinical syndrome caused by normal dysfunction of the brain, characterized by reduced awareness and responsiveness to the environment, as well as orientation disorders, incoherent thinking and memory disorders.
- Trial name
- NCT05972057
- Testing
- cardiac surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Venous Cannulation Pain, Total Knee Arthroplasty
Feasibility Study of Peripheral Venous Cannulation Pain in Predicting Acute Pain After Total Knee Arthroplasty
The goal of this prospective observational study is to explore the feasibility of preoperative peripheral venous cannulation pain score in predicting acute pain after total knee arthroplasty, including resting pain and…
- Conditions
- Venous Cannulation Pain, Total Knee Arthroplasty, Movement-evoked Pain, Acute Pain
- Trial name
- NCT06002724
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Non-Muscle Invasive Bladder Cancer, HER2
RC48 Combined With Tislelizumab for Bladder Sparing Treatment in NMIBC With BCG Treatment Failure and HER2 Expression
This is a prospective, open, single-center clinical study of anti-HER2-ADC combined with PD-1 monoclonal antibody for bladder sparing treatment in non-muscular invasive bladder cancer (NMIBC) patients with HER2-expressing.
- Trial name
- NCT05957757
- Testing
- RC48, Tislelizumab
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
FH-Deficient RCC, Systemic Treatments
Molecular Markers in Predicting Response to Treatment in FH-deficient RCC Patients
Fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) is a rare subtype of RCC characterized by germline/somatic mutation of the fumarate hydratase (FH) gene, and is an extremely aggressive tumor, with a propensity…
- Conditions
- FH-Deficient RCC, Systemic Treatments, Biomarkers
- Trial name
- NCT05535829
- Testing
- Laboratory analysis of samples
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Renal Tumor Histology, Kidney Cancer
Frequency, Clinical Phenotype and Genetic Analysis of Heritable Kidney Cancer Syndromes
This study will investigate the frequency, clinical phenotype, management and molecular genetic defects of heritable kidney cancer syndromes. Families with kidney cancer with known or suspected genetic basis will be enrolled.
- Conditions
- Renal Tumor Histology, Kidney Cancer, Renal Cell Carcinoma, Familial Renal Cancer
- Trial name
- NCT05534854
- Testing
- Gene test
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Muscle Invasive Bladder Cancer, HER2 Expression
RC48 Combined With Toripalimab and Radiotherapy for Bladder Sparing Treatment in MIBC
This is a prospective, open, single-center clinical study of RC48 combined with PD-1 and radiotherapy as bladder-preserving therapy in patients with muscular invasive bladder uroepithelial carcinoma with high HER-2 expression…
- Conditions
- Muscle Invasive Bladder Cancer, HER2 Expression, Radiotherapy, PD-1
- Trial name
- NCT05979740
- Testing
- Disitamab Vedotin and Toripalimab
- Where
- China
- Volunteers
- 6 people
- Sponsor
- RenJi Hospital
Stomach Neoplasms
Efficacy and Safety of Fruquintinib With Sintilimab as First-line Therapy in Gastric Cancer
The goal of this clinical trial is to explore the efficacy and safety in patients with gastric adenocarcinoma or adenocarcinoma of esophagogastric junction.
- Trial name
- NCT05795296
- Testing
- Fruquintinib, Sintilimab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- RenJi Hospital
Tubular Breast Cancer, Mucinous Breast Cancer
Weekly Paclitaxel and Cisplatin to Treat Hormone Receptor Positive and Triple Negative Breast Cancer Patients
The investigators hypothesize that paclitaxel combined with cisplatin in a weekly-based regimen as neoadjuvant chemotherapy is effective and tolerable for locally advanced breast cancer.
- Conditions
- Tubular Breast Cancer, Mucinous Breast Cancer, Invasive Ductal Breast Cancer, Inflammatory Breast Cancer
- Trial name
- SHPD002 (NCT02221999)
- Testing
- Paclitaxel, Cisplatin, Gonadotropin-releasing hormone agonist
- Where
- 12 sites in China
- Volunteers
- 250 people
- Sponsor
- RenJi Hospital