Clinical trials: sponsored by RenJi Hospital
Polycystic Ovary Syndrome
Research of Intensive Lifestyle Intervention for PCOS Patients With IGT
Compare the efficacy between intensive lifestyle intervention and drugs (GLP-1 Receptor Agonists, metformin and acarbose) for PCOS patients with early onset diabetes in their metabolic and reproductive abnormalities treatment…
- Trial name
- NCT02446834
- Testing
- intensive lifestyle intervention, GLP-1 Receptor Agonists, Metformin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Hypoxia, Gastric Cancer
Efficacy and Safety of Remimazolam Tosylate for Sedation in Gastroscopy
Propofol is the most commonly used intravenous anesthetic for painless gastroscopy, but propofol significantly inhibits the respiratory and circulatory systems.
- Conditions
- Hypoxia, Gastric Cancer, Sedation Complication, Propofol Adverse Reaction
- Trial name
- NCT04727034
- Testing
- Remimazolam tosylate, Propofol
- Where
- 5 sites in China
- Volunteers
- 1,800 people
- Sponsor
- RenJi Hospital
COVID-19
Analysis of Clinical Characteristics of Hemodialysis Patients With Omicron Infection
By collecting the clinical data of hemodialysis patients with Omicron infection in RenJi Hospital from April 7, 2022 to June 10, 2022, the clinical characteristics of this population were analyzed.
- Trial name
- NCT05559138
- Testing
- no intervention
- Where
- China
- Volunteers
- 260 people
- Sponsor
- RenJi Hospital
COVID-19, Patient Discharge
Symptom Clusters and Risk Factors of COVID-19 Patients
Aim and objectives: To clarify the types, composition, distribution characteristics and risk factors of symptom clusters experienced by discharged patients with COVID-19, to lay the foundation for effective symptom management.
- Conditions
- COVID-19, Patient Discharge, Symptoms and Signs
- Trial name
- NCT05556707
- Where
- China
- Volunteers
- 384 people
- Sponsor
- RenJi Hospital
Fracture of Neck of Femur (Hip), Femoral Head Necrosis
Mortality and Related Risk Factors After Hip Arthroplasty
The patients who underwent hip arthroplasty in our hospital from January 2017 to December 2020 were reviewed. The perioperative data were collected, and then the mortality was calculated and the risk factors were analyzed.
- Conditions
- Fracture of Neck of Femur (Hip), Femoral Head Necrosis, Dislocation of Hip Joint, Dysplasia of Hip Joint
- Trial name
- NCT05548257
- Volunteers
- 900 people
- Sponsor
- RenJi Hospital
Postoperative Cognitive Dysfunction
Assessment of POCD After Steep Trendelenburg Position and CO2 Pneumoperitoneum With Cerebral Oxygen
Postoperative cognitive decline (POCD) is a common and impactful outcome of surgical procedures in older adults. The pathophysiology and causative mechanisms for POCD are poorly understood.
- Trial name
- NCT03372135
- Where
- China
- Volunteers
- 147 people
- Sponsor
- RenJi Hospital
Polymyalgia Rheumatica, Effect of Drug
Tofacitinib as a GC Sparing Agent for Polymyalgia Rheumatica
Glucocorticoids are the cornerstone treatment for polymyalgia rheumatica but induce adverse events. The efficacy of the candidate drug Tofacitinib has not yet been demonstrated in controlled studies.
- Conditions
- Polymyalgia Rheumatica, Effect of Drug, Safety Issues
- Trial name
- NCT04799262
- Testing
- Tofacitinib 5 MG
- Where
- China
- Volunteers
- 14 people
- Sponsor
- RenJi Hospital
Vaccine Hesitancy
Investigation on the Hesitancy of COVID-19 Vaccination Among Liver Transplant Recipients in China
On WeChat platform, through a point-to-point connection, and carry on the questionnaire survey to collect information of liver transplant recipients followed-up by the department of Liver Surgery, Renji Hospital Shanghai Jiao…
- Trial name
- NCT05532592
- Testing
- Perceptions and attitudes towards COVID-19 and COVID-19 vaccine
- Where
- China
- Volunteers
- 449 people
- Sponsor
- RenJi Hospital
Efficacy and Safety
Efficacy and Safety of the Treatment of Primary Membranous Nephropathy: A Randomized Clinical Trial
1. Main purpose: To evaluate the efficacy and safety of rituximab combined with tacrolimus in the treatment of intermediate and high-risk primary membranous nephropathy 2.
- Trial name
- NCT05532111
- Testing
- Rituximab combined with tacrolimus induction + rituximab maintenance, Rituximab combined with tacrolimus induction + tacrolimus maintenance, Glucocorticoid combined with cyclophosphamide induction + maintenance
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Rheumatoid Arthritis of Knee, Osteoarthritis of the Knee
Exploratory Study on Safety of PEEK Knee Prosthesis
In this study, 10 subjects will be underwent total knee arthroplasty with PEEK knee prosthesis and be followed up 3, 6, and 12 months after surgery.
- Trial name
- NCT04927104
- Testing
- PEEK Knee Prosthesis
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Gastric Cancer, Gastric Ulcer
HFNO Combined With NPA Reduces Hypoxia During Sedated Gastrointestinal Endoscopy In Obese Patients
Obesity is associated with adverse airway events including desaturation during deep sedation. Previous studies have suggested that high-flow nasal oxygenation may be superior to regular (low-flow) nasal cannula for prevention of…
- Conditions
- Gastric Cancer, Gastric Ulcer, Intestinal Cancer, Intestinal Polyps
- Trial name
- NCT05526339
- Testing
- High-flow nasal oxygenation combined with nasopharyngeal airway, Regular nasal cannula combined with nasopharyngeal airway
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
Haemodialysis, Uremic Pruritus
A Study of Thalidomide in the Treatment of Refractory Uremic Pruritus
The purpose of this study is to evaluate the safety and efficacy of thalidomide in the treatment of refractory uremic pruritus in maintenance hemodialysis patients.
- Conditions
- Haemodialysis, Uremic Pruritus, Thalidomide
- Trial name
- NCT05525234
- Testing
- Thalidomide
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
In-stent Restenosis
In-stent Restenosis and Pericoronary Fat Attenuation Index
This study aims to investigate the predictive value of fat attenuation index (FAI) and related radiomics characteristics of pericoronary fat in patients after percutaneous coronary intervention (PCI) for the occurrence of…
- Trial name
- NCT05512832
- Where
- China
- Volunteers
- 126 people
- Sponsor
- RenJi Hospital
Gastric Cancer, Intestinal Cancer
HFNO Reduces Hypoxia During Sedated Gastroscopy or Colonoscopy in High Risk Patients
The objective of this study is to observe the preventive effects of high flow nasal oxygenation on the incidence of hypoxia during gastroscopy or colonoscopy sedated with propofol in high-risk patients.
- Conditions
- Gastric Cancer, Intestinal Cancer, Intestine Adenoma, Gastritis
- Trial name
- HRISK (NCT05510388)
- Testing
- High-flow nasal cannula oxygenation, Regular nasal cannula oxygenation
- Where
- 2 sites in China
- Volunteers
- 450 people
- Sponsor
- RenJi Hospital
Urothelial Carcinoma Bladder, PD-1 Inhibitor
Bladder Sparing Treatment of Tislelizumab, Gemcitabine and Cisplatin for Patients With PD-L1 Positive Muscle Invasive Bladder Cancer
This is a phase II open label single-arm prospective study aiming to investigate the efficacy of PD-1 inhibitor Tislelizumab combined with conventional gemcitabine and cisplatin as bladder sparing treatment for patients with…
- Trial name
- NCT05401279
- Testing
- Tislelizumab, Gemcitabine, Cisplatin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Metabolomics, Renal Cell Carcinoma
Biomarkers of Response to Systemic Treatments in FH-deficient RCC
Fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) is a rare subtype of RCC characterized by germline/somatic mutation of the fumarate hydratase (FH) gene, and is an extremely aggressive tumor, with a propensity…
- Conditions
- Metabolomics, Renal Cell Carcinoma, FH-Deficient RCC, Systemic Treatments
- Trial name
- NCT05243173
- Testing
- Sequencing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Pulmonary Nodule, Multiple, Pulmonary Nodule, Solitary
Comparative Study on the Efficacy and Safety of Microwave Ablation and Lobectomy in the Treatment of Ground Glass Nodules Located in the Pulmonary Hilar Region
GGO is a characteristic focus of early lung cancer. Due to the abundant peripheral blood vessels and bronchial tissues around the GGO lesions located in pulmonary hilar, only lobectomy could be used for the surgical treat of…
- Trial name
- NCT05477251
- Testing
- microwave ablation, lobectomy
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Functional Gastrointestinal Disorders, Dyspepsia
Stigma and Efficacy of Zhizhu Kuanzhong Capsules
Antidepressants are effective in patients with functional dyspepsia (FD), however, the stigma related with FD and antidepressants could affect treatment adherence and efficacy.
- Conditions
- Functional Gastrointestinal Disorders, Dyspepsia, Psychosomatic Disorder
- Trial name
- NCT05107999
- Testing
- Zhizhu Kuanzhong capsules (ZZKZ), Doxepin Hydrochloride (Doxepin)
- Where
- China
- Volunteers
- 76 people
- Sponsor
- RenJi Hospital
Arthropathy of Knee
Alteration of Thrombelastography and Coagulation Function in Patients Undergoing Total Knee Arthroplasty With Intra-articular Tranexamic Acid Administration
The main aim and scope of this study is making comparison about the thrombelastography and coagulation function in patients before and after the total knee arthroplasty with intra-articular tranexamic acid administration.
- Trial name
- NCT05490160
- Testing
- Tranexamic acid
- Volunteers
- 54 people
- Sponsor
- RenJi Hospital
Rotator Cuff Tears
Relationship Between the Arthroscopic Anatomy of the Middle Glenohumeral Ligament and the Rotator Cuff Tear Position
The main aim and scope of this study is making observation and comparing the difference in the tear position in the patients suffered form rotator cuff tear with different arthroscopic anatomy of the middle glenohumeral ligament.
- Trial name
- NCT05484271
- Testing
- Rotator cuff repair
- Volunteers
- 125 people
- Sponsor
- RenJi Hospital