Clinical trials: sponsored by RenJi Hospital
Rotator Cuff Tears
The Cross-sectional Area of the Long Head of the Biceps Tendon and the Rotator Cuff Tear Position
The main aim and scope of this study is making measurement and comparison of the cross-sectional area of the long head of the biceps tendon(LHBT) in the patients suffered form rotator cuff tear with different tear positions, and…
- Trial name
- NCT05477771
- Testing
- Arthroscopic rotator cuff repair
- Volunteers
- 38 people
- Sponsor
- RenJi Hospital
Knee Osteoarthritis
The Correlation Between Femoral Component Implanting Flexion Angle and Posterior Condyle Offset in Cruciate Retaining Total Knee Arthroplasty
The main aim and scope is making measurement and comparison about the femoral component posterior offset under different femoral component implanting flexion angle in cruciate retaining total knee arthroplasty.
- Trial name
- NCT05477745
- Testing
- total knee arthroplasty
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
COVID-19 Recurrence, Surface Contamination
Viral Excretion Among COVID-19 Omicron Recurrence Patients
The study analyzes the viral nucleic acid excretion and its influencing factors of SARS-COV-2 Omicron recurrence patients.
- Trial name
- NCT05470426
- Testing
- COVID-19 Omicron Recurrence
- Where
- China
- Volunteers
- 35 people
- Sponsor
- RenJi Hospital
Primary Sclerosing Cholangitis, IgG4-related Sclerosing Cholangitis
Multicenter Observational Study of PSC and IgG4-SC in China
The investigators aimed to collect demographic features and clinical outcomes in patients diagnosed with PSC and IgG4-SC by utilizing participants database from multiple medical centers across Mainland China.
- Trial name
- NCT05463445
- Testing
- Only observation
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- RenJi Hospital
Polycystic Ovary Syndrome, Metformin
Effects of Metformin on Metabolic and Reproductive Outcomes in Chinese PCOS Patients
Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease characterized by reproductive and metabolic abnormalities, which is a crucial cause of female infertility and an essential risk factor for type 2 diabetes.
- Trial name
- NCT05463627
- Testing
- Metformin
- Where
- China
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Pulmonary Arterial Hypertension
Efficacy and Safety Study of Ambrisentan in Chinese Patients With Pulmonary Arterial Hypertension
This multicenter, open label, single-arm study is aim at investigating the the efficacy and safety of china made ambrisentan in Chinese subjects with PAH.
- Trial name
- AMBLE (NCT05437224)
- Testing
- Ambrisentan
- Where
- China
- Volunteers
- 80 people
- Sponsor
- RenJi Hospital
Alzheimer Disease
Renji Alzheimer's Disease Neuroimaging Cohort Study
This study focuses on the population of Alzheimer disease (AD). Based on Aβ(A)-Tau(T)-Vascular(V)-Neurodegeneration(N) (ATV(N))-AD evaluation system of NIA-AA Association, it can accurately diagnose and predict early AD.
- Trial name
- NCT05433363
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Pulmonary Arterial Hypertension
Algorithms to Diagnose Pulmonary Arterial Hypertension
The investigators intend to evalute the value of radiomics signature of pulmonary vessels from chest computed tomography (CT) for dianosis and prognosis of pulmonary arterial hypertension.
- Trial name
- NCT05417373
- Testing
- calculated radscore
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Safety Issues
The Safety of Paxlovid in Hemodialysis Patients With Covid-19
Infection with SARS-CoV-2 continue to threaten global health. Persons with chronic kidney disease, including dialysis treatment are at hight risk for severe Covid-19 and associated adverse outcomes.
- Trial name
- SPHPS (NCT05366192)
- Testing
- Nirmatrelvir and ritonavir stage 1, Nirmatrelvir and ritonavir stage 2
- Where
- China
- Volunteers
- 18 people
- Sponsor
- RenJi Hospital
COVID-19, Vitamin D Deficiency
Calcitriol Supplementation in COVID-19 Patients
This is a randomized, open label study to evaluate the efficacy and safety of calcitriol supplementation in COVID-19 patients with vitamin D deficiency.
- Trial name
- NCT05415254
- Testing
- Calcitriol
- Where
- China
- Volunteers
- 86 people
- Sponsor
- RenJi Hospital
Kidney Injury
Epidemiological Study on Malignancy Complicated With Renal Injury
The epidemiological study of tumor complicated with kidney disease can clarify the prevalence and risk factors of renal injury when malignant tumor is diagnosed, and understand the impact of malignant tumor complicated with renal…
- Trial name
- NCT05392725
- Volunteers
- 30,000 people
- Sponsor
- RenJi Hospital
Peritoneal Dialysis
Faster Peritoneal Solute Transfer Rate and Survival in a Pre-APD and Icodextrin Peritoneal Dialysis Cohort
A fast peritoneal solute transfer rate (PSTR) has been linked to worse survival especially in continuous ambulatory peritoneal dialysis (PD) cohort.
- Trial name
- NCT05381051
- Volunteers
- 430 people
- Sponsor
- RenJi Hospital
COVID-19
Echocardiographic Manifestation in Patients With Omicron Variant of COVID-19
The cardiovascular scenario associated with omicron, the new variant of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19), remains unclear.
- Trial name
- NCT05379543
- Testing
- Echocardiography
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Hemodialysis Complication
The Safety of Dapagliflozin in Hemodialysis Patients With Heart Failure
SGLT2 inhibitor is a new type of sugar-lowering medicine and is recommended to treat heart failure. eGFR lower than 30ml/min/1.73M2 is contraindication of SGLT2 inhibitor.
- Trial name
- SDHF (NCT05141552)
- Testing
- Dapagliflozin 10Mg Tab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Cerebral Small Vessel Diseases, Long Term Adverse Effects
Functional Prognosis of Post-operative Patients With Cerebral Small Vascular Disease(CSVD)
The investigators perform a retro-prospective exploratory cohort study among patients 65 to 85 years old with pre-operative head MRI result after thoracic surgery in Renji Hospital Affiliated to Shanghai Jiaotong University from…
- Trial name
- NCT05359588
- Where
- China
- Volunteers
- 212 people
- Sponsor
- RenJi Hospital
Necrosis of Femoral Head, Knee Osteoarthritis
Probiotics Attenuate Postoperative Cognition Decline
The aim of this study was to evaluate whether perioperative probiotics can reduce the incidence of postoperative cognitive dysfunction and postoperative delirium.
- Conditions
- Necrosis of Femoral Head, Knee Osteoarthritis, Fracture of Neck of Femur, Lumbar Disc Herniation
- Trial name
- NCT04017403
- Testing
- Bifidobacterium triple live capsule
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- RenJi Hospital
Locally Advanced Breast Cancer, Circulating Tumor Cell
CTC in Predicting Neoadjuvant Chemotherapy Among LABC Patients: a Single-center, Prospective, Exploratory Clinical Trial
The GILUPI CellCollector® is the first in vivo CTC isolation product worldwide, which is CE approved. The purpose of this clinical trial is to evaluate the predictive value of CTC in neoadjuvant chemotherapy among locally…
- Trial name
- CTCNeoBC (NCT03732339)
- Testing
- GILUPI CellCollector®
- Where
- China
- Volunteers
- 29 people
- Sponsor
- RenJi Hospital
Liver Cancer, Liver Transplant; Complications
IMRT Plus PD-1 Blockade and Lenvatinib for HCC With PVTT (Vp3) Before Liver Transplantation
This is a parallel assigned, open-label, perspective trial studying the safety and efficacy of intensity-modulated radiotherapy (IMRT) combined with PD-1 Blockade and Lenvatinib for Hepatocellular Carcinoma (HCC) with Vp3 Portal…
- Conditions
- Liver Cancer, Liver Transplant; Complications, Hepatocellular Carcinoma, Portal Vein Thrombosis
- Trial name
- iPLENTY-pvtt (NCT05339581)
- Testing
- intensity-modulated radiotherapy, Pembrolizumab, Sintilimab
- Where
- China
- Volunteers
- 78 people
- Sponsor
- RenJi Hospital
Unresectable Locally Advanced Pancreatic Cancer
A Prospective, Single-arm, Exploratory Clinical Study of Sintilimab Injection in Combination With Paclitaxel (Albumin-bound) and Gemcitabine in Translational Therapy in Patients With Unresectable Locally Advanced Pancreatic Cancer.
Pancreatic cancer is a common malignant tumor of digestive tract, and its morbidity and mortality are increasing worldwide. Few clinical data have been published on immunotherapy for pancreatic cancer.
- Trial name
- NCT05346146
- Testing
- Sintilimab; Gemcitabine; Albumin-paclitaxel
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Transitional Cell Tumor, Hepatoblastoma
Sequential PD-1/PD-L1 Inhibitor and LENvatinib in TLCT and Refractory Hepatoblastoma After Chemotherapy
This is a single arm, open-label trial studying the combination of PD-1/PD-L1 Inhibitor (e.g.pembrolizumab, Sintilimab,Duvarizumab，Camrelizumab )and lenvatinib given at the recommended dose in pediatric and young adolescent…
- Conditions
- Transitional Cell Tumor, Hepatoblastoma, Liver Cancer, Pediatric Solid Tumor
- Trial name
- sPLENTY-pc (NCT05322187)
- Testing
- PD-1 inhibitor
- Where
- China
- Volunteers
- 15 people
- Sponsor
- RenJi Hospital