Clinical trials: sponsored by RenJi Hospital
Patients With an Abdominal Aortic Aneurysm of 39-49 mm in Diameter
Alpha-Ketoglutarate and Abdominal Aortic Aneurysm Progression and Rupture
The objective of this project is to define whether nutritional supplement (oral administration with alpha-ketoglutarate) capable of filling-up the citric acid cycle (anaplerotic therapy) can improve outcomes in patients with an…
- Trial name
- NCT04723888
- Testing
- alpha-ketoglutarate
- Where
- China
- Volunteers
- 300 people
- Sponsor
- RenJi Hospital
Esophageal Squamous Cell Carcinoma
Multimodal Functional Imaging Combined With Metabolomics in Predicting the Efficacy of nCRT for Locally Advanced ESCC
Esophageal cancer (EC) is the seventh most frequently diagnosed cancers and the sixth leading causes of cancer death worldwide .
- Trial name
- NCT04759235
- Testing
- Magnetic resonance imaging (MRI), 18F-Fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT), Blood and urine metabolic biomarker
- Where
- China
- Volunteers
- 118 people
- Sponsor
- RenJi Hospital
Acute Myocardial Infarction
Early Individualized-Exercise Based Cardiac Rehabilitation Programs in Patients With Acute Myocardial Infarction
Acute myocardial infarction (AMI) is a life-threatening condition and a cause of functional disability. After reperfusion therapies and pharmacological strategies, patients suffered great pain physically and mentally.
- Trial name
- NCT04511182
- Testing
- Exercise-based cardiac rehabilitation
- Where
- China
- Volunteers
- 160 people
- Sponsor
- RenJi Hospital
Brain Injuries, Hematoma of Head
Comparison of Cranioplasty With PEEK and Titanium
Decompressive craniectomy is suggested as an effective surgical intervention for patients with high intracranial pressure. Recently, various customized artificial materials are increasingly employed, e.g., titanium and…
- Conditions
- Brain Injuries, Hematoma of Head, Skull Defect
- Trial name
- NCT04707404
- Testing
- Cranioplasty
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
HBV, Liver Transplant Disorder
Tenofovir Alafenamide for HBV Prophylaxis in HBV(-) Liver Transplant Recipients With HBcAb+ Donors
Liver transplantation is currently the only effective way to treat end-stage liver disease.The shortage of donor liver is still the major problem. Incidence of HBcAb+ varies between different regions.
- Trial name
- NCT04703465
- Testing
- Tenofovir Alafenamide 25 MG
- Volunteers
- 30 people
- Sponsor
- RenJi Hospital
Hepatocellular Carcinoma
Effects of Anesthetic Methods on Hepatic Cancer Cell Function in Vitro
Numerous studies find that anesthetic methods may influence the recurrence of tumor and the overall survival of patients after primary cancer surgery.
- Trial name
- NCT04510935
- Testing
- general anesthesia, local anesthesia
- Where
- China
- Volunteers
- 35 people
- Sponsor
- RenJi Hospital
Total Knee Arthroplasty, Fracture of Head of Femur Articular Displaced
Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction
Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved.
- Conditions
- Total Knee Arthroplasty, Fracture of Head of Femur Articular Displaced, Protrusion of Intervertebral Disc
- Trial name
- NCT04423276
- Testing
- Donepezil
- Where
- China
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Neoadjuvant Therapy of Locally Advanced Upper Urinary Tract Urothelial Carcinoma
Neoadjuvant PD-1 Monoclonal Antibody Plus Cisplatin-based Chemotherapy in Locally Advanced Upper Tract Urothelial Carcinoma
This study is designed prospectively to investigate the safety and efficacy of neoadjuvant PD-1 monoclonal antibody combined with cisplatin-based chemotherapy in patients with locally advanced upper urinary tract urothelial…
- Trial name
- NCT04672317
- Testing
- Immunotherapy combined with chemotherapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Cardiovascular Diseases
Melatonin and Risk Of Cardiovascular Events And Malignant Tumors In The Elderly
Cardiovascular diseases and tumors seriously threaten human health. There are many risk factors that affect the occurrence and death of cardiovascular diseases and malignant tumors.
- Trial name
- NCT04631341
- Testing
- Melatonin
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Pancreatic Cancer
The Efficacy and Safety of K-001 in the Treatment of Advanced Pancreatic Cancer
No Standard therapy has been approved for third-line therapy of advanced pancreatic cancer. K001 is peptidoglycan prepared from the marine microorganism, with an anti-tumor activity.
- Trial name
- NCT04183478
- Testing
- K-001
- Where
- China
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
Complications, Surgery
A Multi-center Randomized Clinical Trial About Using LMA or ETI in Elderly Patients
Perioperative airway management is a top priority of anesthesiologists in daily work, and endotracheal intubation (ETI) is considered as the gold standard for providing safe glottic seal,effective ventilation and oxygen…
- Trial name
- LMA;ETI (NCT02240901)
- Testing
- Laryngeal mask airway（LMA）, Endotracheal intubation（ETI）
- Where
- China
- Volunteers
- 2,900 people
- Sponsor
- RenJi Hospital
COVID-19
Long-term Outcomes in Patients With COVID-19
Long-term outcomes from coronavirus disease 2019 (COVID-19) are currently unknown. This study will collect daily living status of survivors of COVID-19.
- Trial name
- NCT04508712
- Where
- China
- Volunteers
- 900 people
- Sponsor
- RenJi Hospital
Bowel Preparation
The Effect of Antiemetics on Bowel Preparation Before Colonoscopy
Polyethylene glycol (PEG) is one of the most common laxatives used in colonoscopy. However, 5 - 15% of patients can not complete the preparation due to its poor taste and large volume.
- Trial name
- NCT04583111
- Testing
- Domperidone, sulpiride
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Rheumatoid Arthritis, Pregnancy Related
Treatment of Pregnancy RA
It is important to control the disease of pregnant women with rheumatoid arthritis to ensure the fetal and maternal health. Frequent disease flare can increase the risk of adverse pregnancy outcomes, including abortion, premature…
- Trial name
- NCT04569890
- Testing
- Certolizumab Pegol 200 MG/ML [Cimzia], Hydroxychloroquine, Prednisone
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Liver Carcinoma, Liver Transplant; Complications
Durvalumab and Lenvatinib in Participants With Locally Advanced and Metastatic Hepatocellular Carcinoma ( Dulect2020-1 )
This study will evaluate the safety and efficacy of durvalumab in combination with lenvatinib in participants with locally advanced hepatocellular carcinoma before liver transplant and metastatic unresectable HCC.The primary…
- Trial name
- Dulect2020-1 (NCT04443322)
- Testing
- Durvalumab Injection, Lenvatinib 4 MG
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Rheumatoid Arthritis
Role of L-Arginine Supplementation in the Treatment of Rheumatoid Arthritis
To investigate the role of L-arginine supplementation in the treatment of DMARDs-refractory moderate to severe rheumatoid arthritis
- Trial name
- NCT04535427
- Testing
- L-arginine
- Where
- China
- Volunteers
- 144 people
- Sponsor
- RenJi Hospital
Pulmonary Arterial Hypertension
Pilot Study of the Safety and Efficacy of Sulfasalazine in Pulmonary Arterial Hypertension
Under placebo control, the investigators intend to evaluate the effectiveness and safety of anti-inflammatory therapy and/or targeted drug therapy for early treatment of patients with pulmonary arterial hypertension.
- Trial name
- NCT04528056
- Testing
- Sulfasalazine, Ambrisentan
- Where
- China
- Volunteers
- 80 people
- Sponsor
- RenJi Hospital
Osteoporotic Pain
Immunotherapy for Elderly Patients With Chronic Osteoporotic Pain
Osteoporotic pain is the most common clinical symptom in elderly patients. The course of pain is prolonged and the effect of clinical treatment is limited.
- Trial name
- NCT04524169
- Testing
- Thymosin Alpha1
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Systemic Sclerosis, Diffuse
Iguratimod in Systemic Sclerosis
The purpose of this study is to evaluate the safety, tolerability and efficacy of iguratimod in adult subjects with diffuse cutaneous systemic sclerosis.
- Trial name
- NCT04515706
- Testing
- Iguratimod
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Sepsis
EARLY-MYO-SEPSIS Registry
The diagnosis and pathophysiology of sepsis-induced cardiac dysfunction remain unknown. This registry is to evaluate characteristics of sepsis patients by multi-modalities imaging, including echocardiography, cardiovascular…
- Trial name
- NCT04513795
- Volunteers
- 300 people
- Sponsor
- RenJi Hospital