Clinical trials: sponsored by RenJi Hospital
Traumatic Brain Injury
Multiomic Analysis of Serum in Acute Period of Traumatic Brain Injury
The goal of this experimental observation study is to figure out differently expressed biomarkers in serum in traumatic brain injury patients, compared with bone fracture patients. The main questions it aims to answer are: 1.
- Trial name
- MASTER-TBI (NCT05867992)
- Testing
- Type of trauma
- Where
- China
- Volunteers
- 80 people
- Sponsor
- RenJi Hospital
B-cell Tumors, Autoimmune Diseases
JWCAR201 for the Treatment of Hematology Malignancy and Autoimmune Diseases
JWCAR201 is a CD19/CD20 CAR-T product. This trial is intended to evaluate the safety, PK/PD and efficacy of JWCAR201 in patients with B cell driven hematology malignancy and autoimmune diseases
- Conditions
- B-cell Tumors, Autoimmune Diseases, Lupus Erythematosus, Systemic, Large B-cell Lymphoma
- Trial name
- NCT06567080
- Testing
- JWCAR201
- Where
- China
- Volunteers
- 15 people
- Sponsor
- RenJi Hospital
Localized Prostate Cancer
Clinical Study of HIFU for Localized Prostate Cancer
In this study, the safety and effectiveness data of Sonablate system, a transrectal high-intensity focused ultrasound therapeutic instrument, in the treatment of localized prostate cancer were collected, and the treatment…
- Trial name
- HIFU (NCT06362577)
- Testing
- EQ-5D-5L IPSS IIEF-5 EPIC-26 ECOG
- Where
- China
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Colorectal Cancer
A Study of Initiation Timing of VTE Prevention After Colorectal Cancer Surgery
This project intends to conduct a single-center, prospective, observational cohort study to explore the impact of the timing of drug prophylaxis on the risk of postoperative bleeding and the preventive effect of VTE in the…
- Trial name
- NCT06259149
- Testing
- Nardraparin calcium injection
- Where
- China
- Volunteers
- 914 people
- Sponsor
- RenJi Hospital
Primary Biliary Cholangitis, Cardiovascular Abnormalities
Early Identification of Myocardial Impairment in PBC
Primary biliary cholangitis (PBC) is a chronic inflammatory liver disease leading to cirrhosis. Researches reported patients with PBC may involve abnormalities on skeleton, thyroid and exocrine glands.
- Trial name
- EARLY-MYO-PBC (NCT03545672)
- Testing
- CMR examination
- Where
- China
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Liver Fibrosis, Pediatric Disorder
Pediatric Liver Transplantation-Liver Fibrosis Evaluation by Using Fibrosis Panel
Liver transplantation in children is highly successful with >80% having 20 years survival. Most pediatric liver diseases are potentially curable with liver transplantation and it is important to establish whether children who…
- Conditions
- Liver Fibrosis, Pediatric Disorder, Liver Transplant; Complications
- Trial name
- PT-LiFE (NCT05308628)
- Testing
- Liver Allograft Fibrosis by Using Fibrosis Panel(PRO-C3, PIIINP, TIMP-1, HA etc.)
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- RenJi Hospital
Hepatocellular Carcinoma
Prospective Real-World Study of HAIC With Raltitrexed or 5-Fluorouracil for the Treatment of Hepatocellular Carcinoma
This study is a prospective cohort study aimed at comparing the efficacy and safety of RALOX-HAIC and FOLFOX-HAIC in the treatment of hepatocellular carcinoma.
- Trial name
- NCT06519578
- Testing
- hepatic artery infusion chemotherapy
- Where
- 2 sites in China
- Volunteers
- 1,115 people
- Sponsor
- RenJi Hospital
ESCC, Biliary Tract Cancer
Surufatinib Combined With Serplulimab and Standard Chemotherapy as First-line Treatment in Advanced Solid Tumors With Neuroendocrine Differentiation
Currently, there are no standard treatment and relevant exploration for solid tumors patients with NED. The study aims to explore the efficacy and safety of surufatinib combined with serplulimab and standard chemotherapy in the…
- Conditions
- ESCC, Biliary Tract Cancer, Gastric Cancer, Pancreas Cancer
- Trial name
- NCT06531291
- Testing
- Surufatinib, Serplulimab, standard chemotherapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- RenJi Hospital
Arteriovenous Fistula, Angioplasty, Balloon
DRug-coAted Balloon Compared With cuttinG balloON in Treatment of Arteriovenous Fistula Stenosis
The purpose of this clinical trial is to compare the efficacy and safety of cutting balloons versus drug-coated balloons in treating venous stenosis of autologous arteriovenous fistulas.The main questions it aims to answer are…
- Conditions
- Arteriovenous Fistula, Angioplasty, Balloon, Hemodialysis Access Failure
- Trial name
- Dragon (NCT06527963)
- Testing
- Endovascular therapy
- Where
- 3 sites in China
- Volunteers
- 180 people
- Sponsor
- RenJi Hospital
Colorectal Cancer
A Study of Enhancing Drug Prophylaxis of Venous Thromboembolism in Chinese Colorectal Cancer Surgery
This project intends to conduct a multicenter, prospective, observational cohort study, aiming to explore the impact of the timing of pharmacological thromboprophylaxis initiation on postoperative bleeding risk and the…
- Trial name
- E-DISTANCE (NCT06513481)
- Testing
- Nardraparin calcium injection
- Volunteers
- 914 people
- Sponsor
- RenJi Hospital
Breast Cancer
Neoadjuvant Therapy With Weekly Utidelone Combined With Cisplatin for Patients With Breast Cancer (NeoURANIA)
This study is a prospective, multi-center, single-arm, two-cohort, exploratory study, aiming to explore the effectiveness and safety of neoadjuvant treatment with weekly utidelone combined with cisplatin in breast cancer patients.
- Trial name
- NeoURANIA (NCT06510465)
- Testing
- utidelone, Cisplatin, Trastuzumab
- Where
- 2 sites in China
- Volunteers
- 143 people
- Sponsor
- RenJi Hospital
Septic Shock, Abdominal Sepsis
OXiris for Abdominal SEptic Shock (OASES Study)
This study innovatively utilizes multi-modal hemodynamic monitoring (Norepinephrine equivalence, NEE+Pulse indicator Continuous Cariac output, PiCCO) to investigate the optimal timing of initiation of oXiris in abdominal…
- Conditions
- Septic Shock, Abdominal Sepsis, Multi Organ Failure, Blood Purification
- Trial name
- OASES (NCT06504316)
- Testing
- CRRT filter
- Where
- China
- Volunteers
- 192 people
- Sponsor
- RenJi Hospital
Hemodialysis Access Failure
Effectiveness of Endoluminal Treatment of Autologous Arteriovenous Endovascular Fistula Failure
This study was aimed at comparing the efficacy and safety of cutting balloons versus drug-coated balloons in treating venous segment stenosis of autologous arteriovenous fistulas.This is a prospective, multi-center cohort study.
- Trial name
- NCT06493292
- Testing
- Endovascular therapy
- Where
- 3 sites in China
- Volunteers
- 180 people
- Sponsor
- RenJi Hospital
Post-operative Cognitive Dysfunction
Effects of TEAS on POCD
Patients undergoing elective orthopedics, urology, and general surgery will be included and randomly allocated to TEAS group or control group .
- Trial name
- NCT04338555
- Testing
- Transcutaneous electrical acupoint stimulation
- Where
- China
- Volunteers
- 110 people
- Sponsor
- RenJi Hospital
Systemic Lupus Erythematosus
Efficacy and Safety of Telitacicept for Prevention of Flares in SLE Patients
This study is a randomized, double-blind, placebo-controlled single-center clinical trial. The aim of this study is to investigate the efficacy and safety of low-dose telitacicept for prevention of flares in SLE patients with low…
- Trial name
- NCT06394063
- Testing
- Telitacicept
- Where
- China
- Volunteers
- 176 people
- Sponsor
- RenJi Hospital
Acute Ischemic Stroke, Endovascular Thrombectomy
Effects of Post-Operative Sedation for Endovascular Thrombectomy
Studies from our lab indicated that long-term sedation is protective in mice with midbrain infarct. To assess whether post-operative sedation has protective effects on clinical outcomes in patients with ischemic stroke undergoing…
- Trial name
- POSET (NCT04517383)
- Testing
- post-operative sedation, routine recovery
- Where
- China
- Volunteers
- 1,286 people
- Sponsor
- RenJi Hospital
Anticoagulation
Efficacy and Safety of Rivaroxaban in the Early Postoperative Period for Patients With Bioprosthetic Valves
this study aims to comprehensively evaluate the efficacy and safety profiles of rivaroxaban and warfarin during the initial postoperative period following surgical bioprosthetic valve in patients.
- Trial name
- NCT06476301
- Testing
- Rivaroxaban
- Volunteers
- 250 people
- Sponsor
- RenJi Hospital
Tumor Pancreas
Evaluate the Safety and Efficacy of BGT007H Cell Therapy in Patients With Relapsed/Refractory Pancreatic Cancer
The primary objective of this study is to evaluate the safety and tolerability of BGT007H cell therapy in patients with recurrent/refractory pancreatic cancer.
- Trial name
- NCT06478225
- Testing
- BGT007H Cell Injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- RenJi Hospital
Hemodialysis Access Failure
Effectiveness and Health Economics of Endoluminal Treatment of Arteriovenous Graft Fistula.
This study is a prospective, single-center real-world research, aiming to understand the clinical intervention effects and health economics value of various endovascular treatment methods for arteriovenous graft fistula failure…
- Trial name
- NCT06470646
- Testing
- Endovascular therapy
- Where
- China
- Volunteers
- 240 people
- Sponsor
- RenJi Hospital
Hemodialysis Access Failure
Effectiveness and Health Economics of Endoluminal Treatment of Autologous Arteriovenous Endovascular Fistula Failure
This study was aimed at evaluating the efficacy of different endovascular treatments for early and mid-stage clinical interventions in patients with autologous arteriovenous fistulae loss of function and the corresponding health…
- Trial name
- NCT06454396
- Testing
- Endovascular therapy
- Where
- China
- Volunteers
- 480 people
- Sponsor
- RenJi Hospital