Clinical trials: open to volunteers, sponsored by RenJi Hospital
Autosomal Dominant Polycystic Kidney
GBP-213 in Patients With Autosomal Dominant Polycystic Kidney Disease
This study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of GBP-213 in patients with autosomal dominant polycystic kidney disease (ADPKD).
- Trial name
- NCT07891364
- Testing
- GBP-213
- Where
- China
- Volunteers
- 24 people
- Sponsor
- RenJi Hospital
Renal Cell Carcinoma, Benign Renal Mass
Plasma DNA Methylation for Preoperative Classification of Renal Masses
METH-RENAL is a prospective observational diagnostic development and threshold-setting study in adults with a renal mass scheduled for partial or radical nephrectomy.
- Trial name
- NCT07874542
- Where
- China
- Volunteers
- 240 people
- Sponsor
- RenJi Hospital
Deep Vein Thrombosis
PROfunda Femoris Vein Thrombosis Evaluation and Clearance to Improve Outcomes of Endovascular Treatment for Acute Iliofemoral Deep Vein Thrombosis
Patients with iliofemoral vein thrombosis are prone to developing post-thrombotic syndrome (PTS). The profunda femoris vein (PFV) is an important inflow of the iliofemoral vein.
- Trial name
- NCT07622199
- Testing
- Endovascular treatment with profunda femoris vein thrombosis clearance (Endovascular treatment with PFV-TC), Percutaneous mechanical thrombectomy without profunda femoris vein thrombosis clearance (PMT without PFV-TC)
- Where
- China
- Volunteers
- 140 people
- Sponsor
- RenJi Hospital
Prostate Biopsy, Sedation Complication
Effect of Remimazolam on Hypoxemia and/or Hypotension in Prostate Biopsy
This study aims to investigate whether remimazolam, a novel benzodiazepine sedative, can reduce the composite incidence of hypotension and hypoxemia during prostate biopsy in elderly patients compared with propofol.
- Trial name
- NCT07854197
- Testing
- Using remimazolam for sedation during prostate biopsy, Administer 1.5mg/kg of propofol for sedation
- Volunteers
- 1,146 people
- Sponsor
- RenJi Hospital
Multiple Myeloma
Long-term Follow-up Study in Subjects With Multiple Myeloma Previously Treated With GC012F Injection
This is an open-label, multicenter, observational study (non-interventional study) to evaluate the long-term safety, efficacy, and in vivo pharmacokinetic persistence of CAR-T cells in subjects treated with GC012F Injection
- Trial name
- NCT07833046
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Tirzepatide, Frozen Embryo Transfer
Dual GIP/GLP-1 Receptor Agonist in Obese Women Before Frozen Embryo Transfer
To evaluate the efficacy and safety of Dual GIP/GLP-1 receptor agonist pretreatment on reproductive outcomes in obese women before frozen embryo transfer.
- Conditions
- Tirzepatide, Frozen Embryo Transfer, Obesity
- Trial name
- NCT07811895
- Testing
- Dual GIP/GLP-1 receptor agonist
- Where
- China
- Volunteers
- 1,510 people
- Sponsor
- RenJi Hospital
Central Nervous System Infections
Safety and Efficacy of Ventricular Irrigation for Ventriculitis
Ventriculitis is a severe infectious disease of the central nervous system with diverse etiologies. Currently, the treatment for ventriculitis is challenging, with poor prognosis.
- Trial name
- NCT06358209
- Testing
- Ventricular irrigation
- Where
- 35 sites in China
- Volunteers
- 310 people
- Sponsor
- RenJi Hospital
Esophageal Squamous Cell Cancer
Retlirafusp Alfa Combined With Chemoradiotherapy in Unresectable ESCC
The goal of this clinical trial is to evaluate the efficacy and safety of retlirafusp alfa combined with radical chemoradiotherapy in the treatment of locally advanced unresectable esophageal squamous cell carcinoma.
- Trial name
- NCT07769866
- Testing
- Induction chemo-immunotherapy, Concurrent chemoradiotherapy (cCRT), maintenance immunotherapy
- Where
- China
- Volunteers
- 68 people
- Sponsor
- RenJi Hospital
Hip Fractures (i.e. Femoral Neck or Intertrochanteric Hip Fractures), Postoperative Pain
FICB for Hip Fracture Pain in Elderly
Hip fracture is a common injury in elderly patients, often requiring surgical treatment. However, these patients frequently experience severe postoperative pain, which can delay mobility and recovery, and increase the risk of…
- Conditions
- Hip Fractures (i.e. Femoral Neck or Intertrochanteric Hip Fractures), Postoperative Pain, QoR-15, Fascia Iliaca Block
- Trial name
- FICB-PREP (NCT07762846)
- Testing
- Ultrasound-Guided Fascia Iliaca Compartment Block
- Where
- China
- Volunteers
- 144 people
- Sponsor
- RenJi Hospital
Prostate Cancer
CytoREductive prostAtectomy for Poly-metastatic Hormone sensiTIVE Prostate Cancer
The goal of this clinical trial is to compare systemic therapy combined with cytoreductive prostatectomy with standard of care (SOC) in de novo poly-metastatic hormone sensitive prostate cancer (de novo pmHSPC).
- Trial name
- CREATIVE (NCT06306612)
- Testing
- Systemic Chemohormonal Therapy, Systemic Hormonal Therapy, Cytoreductive Prostatectomy
- Where
- China
- Volunteers
- 192 people
- Sponsor
- RenJi Hospital
Prostate Cancer (Diagnosis)
miRNA Panel for PCa Diagnosis
This is a single-center, prospective diagnostic accuracy trial conducted at Renji Hospital, Shanghai Jiao Tong University School of Medicine, led by a team of urology and molecular medicine researchers.
- Trial name
- NCT07755592
- Testing
- Serum microRNA panel detection for prostate lesion differentiation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- RenJi Hospital
Prostate Cancer, Circulating Tumor Cell
A Trial to Evaluate the Effect of Applying Leukapheresis to Enrich CTCs in mPCa Patients
The goal of this observational study is to compare the number of CTCs enriched by both sampling methods, leukapheresis and collection of peripheral blood in metastatic prostate cancer patients.
- Conditions
- Prostate Cancer, Circulating Tumor Cell, Leukapheresis
- Trial name
- NCT06469710
- Testing
- leukapheresis
- Where
- China
- Volunteers
- 50 people
- Sponsor
- RenJi Hospital
Breast Cancer
Pre-operative Therapy in Breast Cancer
This is a prospective and retrospective study to evaluate the effect of pre-operative therapy on response and survival, and compare the difference in response and survival by pre-operative regimen or by patient's…
- Trial name
- NCT05621564
- Testing
- pre-operative therapy
- Where
- China
- Volunteers
- 6,032 people
- Sponsor
- RenJi Hospital
Prostate Cancer, Prostate
Efficacy and Safety of Darolutamide Combined With Docetaxel and ADT as Neoadjuvant Therapy for Locally Advanced Prostate Cancer.
The goal of this study is to evaluate the efficacy and safety of darolutamide combined with docetaxel and ADT compared to docetaxel combined with ADT in treating locally advanced prostate cancer patients scheduled for radical…
- Conditions
- Prostate Cancer, Prostate, Prostate Cancer Patients
- Trial name
- NCT07730151
- Testing
- Darolutamide, docetaxel, ADT
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Colorectal Carcinoma
COLORECTUM+ Digital System for Postoperative Quality Improvement in Colorectal Cancer
This is a single-center, prospective, interventional study. A total of 236 colorectal cancer patients who underwent surgery will be enrolled and followed for 52 weeks.
- Trial name
- NCT06685497
- Testing
- Mobile application follow-up
- Where
- China
- Volunteers
- 236 people
- Sponsor
- RenJi Hospital
Hemodynamic Stability, Ischemic Strokes
Ciprofol vs Propofol for Hemodynamic Stability in Patients Having General Anesthesia for Endovascular Thrombectomy After Ischemic Stroke
Endovascular therapy (EVT) improves the prognosis of patients with acute ischemic stroke (AIS). EVT has been established as a standard of care for AIS caused with large vessel occlusion based on numerous randomized controlled…
- Trial name
- NCT07696208
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 124 people
- Sponsor
- RenJi Hospital
Primary Biliary Cholangitis (PBC), Primary Sclerosing Cholangitis (PSC)
The Safety and Efficacy of Upadacitinib in Refractory Autoimmune Related Cholangitis and Atopic Dermatitis With Moderate to Severe Itching
Cholestatic liver diseases are characterized by jaundice, pruritus, and elevated levels of alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT).
- Conditions
- Primary Biliary Cholangitis (PBC), Primary Sclerosing Cholangitis (PSC), Atopic Dermatitis (AD)
- Trial name
- NCT07678645
- Testing
- Upadacitinib 15 MG
- Where
- China
- Volunteers
- 44 people
- Sponsor
- RenJi Hospital
Deep Vein Thrombosis
Comparison Of Different Mechanical Thrombectomy Devices in Endovascular Treatment of Acute Iliofemoral Venous Thrombosis
A head-to-head comparison of two different types of percutaneous mechanical thrombectomy (PMT) - ClotTriever System versus aspiration thrombectomy (including rheolytic thrombectomy) - in patients with acute iliofemoral deep vein…
- Trial name
- NCT07622212
- Testing
- Percutaneous mechanical thrombectomy by ClotTriever System, Percutaneous mechanical thrombectomy by aspiration or rheolytic thrombectomy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- RenJi Hospital
CAR-T Cell Therapy
Dual Target CAR-T Cell Treatment for Refractory Systemic Lupus Erythematosus (SLE) Patients
This is an early exploratory phase, single arm, non-randomized, open label, treatment study trial to determine the maximum tolerated dose of GC012F injection (CD19-BCMA CAR-T cells) in patients with refractory systemic lupus…
- Trial name
- NCT05858684
- Testing
- GC012F injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- RenJi Hospital
Solid Tumor, Solid Carcinoma
Trop2-targeted immunoPET Imaging of Solid Tumors
This study aims to establish and optimize the trophoblast cell surface antigen 2 (Trop2)-targeted immuno-positron emission tomography/computed tomography (immunoPET/CT) imaging method and its physiological and pathological…
- Conditions
- Solid Tumor, Solid Carcinoma, Uroepithelial Carcinoma, Bladder Cancer
- Trial name
- NCT06851663
- Testing
- [68Ga]Ga-NOTA-T4, [68Ga]Ga-NOTA-RT4, [18F]F-RESCA-T4
- Where
- China
- Volunteers
- 400 people
- Sponsor
- RenJi Hospital