Clinical trials: sponsored by Royal Marsden NHS Foundation Trust
Prostate Cancer
Multifunctional Magnetic Resonance (MR) for Radiotherapy Planning in Prostate Cancer
To determine if functional MRI methods will aid planning of a radiation dose boost within the prostate in patients with prostate cancer potentially improving safety and efficacy.
- Trial name
- NCT01006564
- Testing
- Imaging Investigations (not radiation), Other
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Non-small Cell Lung Cancer
Evaluation of Stents to Open Restricted Airways in Patients With Centrally Placed Non-small Cell Lung Cancer
To investigate whether the use of airways stents (metal tubes to open and keep open narrowed airways) together with the standard treatment increases the proportion of patients who can complete a 6min walking distance (6MWD) test…
- Trial name
- RESTORE-AIR (NCT01003522)
- Testing
- Arterial puncture, Venepuncture, General anaesthetic
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Malignant Melanoma
The Identification of Novel Prognostic Markers in Melanoma
The purpose of this project is to analyze tumour tissue from a group of subjects with malignant melanoma, who have been treated at the Royal Marsden Hospital.
- Trial name
- NCT01002560
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Bladder Cancer
Adaptive Planning in Bladder Cancer
To demonstrate that radiotherapy treatments for bladder cancer can be delivered with greater accuracy using a new planning method and that this method can be used simply and effectively by those delivering treatment.
- Trial name
- APPLY (NCT01000129)
- Testing
- Adaptive-Planning Organ Localisation (A-POLO) (Planning CT scan), Cone beam CT acquisition
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Prostate Cancer
An Exploration of Genetic Testing for Prostate Cancer Susceptibility
Study of the factors that affect interest in - and uptake of - genetic testing for variants that predispose to prostate cancer from the perspective of the patient.
- Trial name
- NCT00997464
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Head and Neck Cancer
Functional Imaging in HNC Undergoing Chemoradiation
The purpose of the study is to generate a library of functional imaging and anatomical imaging for patients with head and neck cancers for evaluation of new radiotherapy strategies and planning techniques including IMRT.
- Trial name
- NCT00837980
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Thyroid Carcinoma, Metastatic Sites Lung Bone Nodal
Radioiodine Dosimetry Protocol for Thyroid Cancer Metastases
The main purpose of the study is to establish a relationship between the administered activity of the radioiodine and absorbed dose in the tumor sites.
- Trial name
- NCT00749697
- Testing
- SPECT scan
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Multiple Myeloma, Acute Lymphoblastic Leukemia
A Randomized Trial of Human Growth Hormone (hGH) vs Placebo in Intensively Treated Haemato-Oncology Patients.
About 90% of patients with haemato-oncologic malignancy lose their body muscle mass and also lose weight either due to chemotherapy induced nausea/vomiting or the high catabolic state due to fever, sepsis or chemotherapy.
- Conditions
- Multiple Myeloma, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Myelodysplastic Syndrome
- Trial name
- NCT00300664
- Testing
- Human Growth hormone
- Volunteers
- 150 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Hodgkin's or Non-Hodgkin's Lymphoma
Dual Time Point PET Imaging in Lymphoma
Comparison of single time point with dual time point PET imaging in the accuracy of diagnosing active lymphoma. Biopsy results or clinical/radiological progression will be used in conjunction with the PET data.
- Trial name
- NCT00297557
- Sponsor
- Royal Marsden NHS Foundation Trust
Multiple Myeloma
A Phase II Trial Comparing the Quality of Life, Tolerability and Toxicity of PEG Intron With INTRON® A in Patients With Multiple Myeloma
Multiple myeloma is a rare form of malignancy in which neoplastic plasma cells accumulate in the bone marrow. Most malignant plasma cells continue to produce immunoglobulin.
- Trial name
- NCT00323505
- Testing
- Pegylated Interferon, Interferon-alpha2a
- Where
- United Kingdom
- Sponsor
- Royal Marsden NHS Foundation Trust
Multiple Myeloma
Assessing Free Immunoglobulin Light Chains in Patients With Myeloma
Multiple myeloma is a disorder in which malignant plasma cells accumulate in the bone marrow. These plasma cells produce an abnormal protein called paraprotein / M spike in the serum which can be serially monitored to assess the…
- Trial name
- NCT00301275
- Where
- United Kingdom
- Sponsor
- Royal Marsden NHS Foundation Trust
Peripheral T Cell Lymphoma (PTCL)
A Multicenter, Open-Label Continuation Trial Evaluating the Tolerability and Activity of Depsipeptide (FK228) in Patients That Have Completed a Prior Clinical Study With Depsipeptide.
To evaluate the safety and tolerability of extended treatment with depsipeptide in patients who have at least demonstrated stable disease on prior Gloucester-sponsored depsipeptide clinical trials, and in the opinion of their…
- Trial name
- NCT00299351
- Testing
- Depsipeptide
- Volunteers
- 8 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Gynaecological, Urological or Rectal Cancer
Prospective Study in Pelvic Radiotherapy Patients
Symptoms such as diarrhoea and abdominal discomfort are common side effects of radiotherapy for tumours in the pelvis and usually occur within 2 weeks of starting treatment.
- Trial name
- NCT00220181
- Volunteers
- 100 people
- Sponsor
- Royal Marsden NHS Foundation Trust