Clinical trials: sponsored by Samsung Medical Center
Sarcoma
Biomarker Analysis of Solid Cancers Such as Gastrointestinal Cancer
To prospectively collect ascites, pleural fluid, circulating tumor cells and derived primary cultures from metastatic cancer patients. The specimens will be analyzed using DNA/RNA/proteomic approaches.
- Trial name
- NCT01831609
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Samsung Medical Center
Advanced, Refractory Cancer
Patients With Refractory, Metastatic Cancer Harboring KIT Mutation or Amplification to Investigate the Clinical Efficacy and Safety of Imatinib Therapy
KIT is a receptor tyrosine kinase that binds to stem-cell factor (SCF), activating a series of downstream effector pathways. KIT is an established therapeutic target in cancer with activating mutations of KIT, such as…
- Trial name
- NCT02461849
- Testing
- Imatinib
- Where
- South Korea
- Volunteers
- 14 people
- Sponsor
- Samsung Medical Center
Stomach Neoplasms
Exploratory Study of Drug Sensitivity Prediction Software (IRCR-DReSS) With Patient-derived Tumor Cells of Metastatic Gastric Cancer
1. Metastatic gastric cancer patients who failed standard treatment will be enrolled in this study. 2. After consent form, patient-derived cancer cell will be collected and tested with 3 kinds of drugs (sunitinib, gefitinib…
- Trial name
- NCT03170180
- Testing
- Sunitinib, Gefitinib, Imatinib
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Samsung Medical Center
Refractory Solid Tumors
Study to Evaluate the Safety and Efficacy of Pazopanib, in Subject With Refractory Solid Tumors
This study is a single arm, pilot study of pazopanib in patient with FGFR2 amplification Refractory solid tumor and/or specific sensitivity to pazopanib by Avatar scan that has progressed following standard therapy or that has…
- Trial name
- NCT02691767
- Testing
- pazopanib
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Samsung Medical Center
Refractory Solid Tumors
Study to Evaluate the Safety and Efficacy of Sunitinib, in Subject With Refractory Solid Tumors
This study is a single arm, pilot study of Sunitinib in patient with RET fusion positive, FGFR2 fusion/FGFR mutation Refractory solid tumor and/or specific sensitivity to Sunitinib by Avatar scan that has progressed following…
- Trial name
- NCT02691793
- Testing
- Sunitinib
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Samsung Medical Center
Refractory Cancer
Study of AZD6738, DNA Damage Repair/Novel Anti-cancer Agent, in Combination With Paclitaxel, in Refractory Cancer
This study is a single center open label phase I study of AZD6738, DNA damage repair/novel cancer agent, in combination with paclitaxel in metastatic cancer patients who have failed standard chemotherapy.
- Trial name
- NCT02630199
- Testing
- AZD6738, Paclitaxel
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Samsung Medical Center
Biliary Tract Cancer
Gemcitabine+ Capecitabine Vs Capecitabine in Curatively Resected Biliary Tract Cancer
This clinical trial is an open-label, multicenter, phase 3 clinical trial to study the efficacy and safety of adjuvant gemcitabine + capecitabine combination treatment in patients with resectable biliary tract cancer according to…
- Trial name
- NCT04401709
- Testing
- Gemcitabine/Capecitabine, Capecitabine
- Where
- South Korea
- Volunteers
- 490 people
- Sponsor
- Samsung Medical Center
Stomach Neoplasms
The Screening Protocol for The VIKTORY Trial
This protocol is a screening protocol only. No drug intervention study will be included in this protocol. However, based on the molecular profiling, patients may be eligible for targeted agents.
- Trial name
- NCT02299648
- Testing
- Molecular profiling
- Where
- 2 sites in South Korea
- Volunteers
- 651 people
- Sponsor
- Samsung Medical Center
Advanced Gastric Adenocarcinoma
Phase Ib, Single-arm Study of AZD6094 (Volitinib) in Combination With Docetaxel, in Any Solid Cancer and Sequential Phase II, Single-arm Study of AZD6094 (Volitinib) in Combination With Docetaxel in Advanced Gastric Adenocarcinoma Patients With MET Amplification as a Second Line Treatment
Phase Ib/II, single-arm study of AZD6094 (Volitinib) in combination with docetaxel, in advanced gastric adenocarcinoma patients with MET amplification as a second-line treatment.
- Trial name
- NCT02447406
- Testing
- AZD6094, docetaxel
- Where
- South Korea
- Volunteers
- 7 people
- Sponsor
- Samsung Medical Center
Advanced Gastric Adenocarcinoma
Study of AZD6094 (Volitinib) in Advanced Gastric Adenocarcinoma Patients With MET Amplification as a Third-line Treatment
Volitinib is a potent and selective small molecule c-Met kinase inhibitor. Volitinib was found to inhibit c-Met kinase at the enzyme and cell levels with IC50s of 4 nM for both enzyme and Met phosphorylation in the cell.
- Trial name
- NCT02449551
- Testing
- Volitinib
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Samsung Medical Center
Biliary Tract Cancer
FOLFIRI as Salvage Treatment in Metastatic Biliary Tract Cancer (BTC) Patients Who Were Failed After Gemcitabine Containing Chemotherapy: A Phase II Single Arm Prospective Study
FOLFIRI as a salvage treatment in metastatic biliary tract cancer (BTC) patients who failed gemcitabine containing chemotherapy
- Trial name
- NCT03110510
- Testing
- Fluorouracil, Irinotecan Hydrochloride, leucovorin calcium
- Where
- South Korea
- Sponsor
- Samsung Medical Center
Refractory Solid Tumors
Single-arm Study to Evaluate the Safety and Efficacy of Pazopanib, in Subjects With FGFR2 Amplification, FGFR2 Mutation Refractory Solid Tumors
This is a pilot study of Pazopanib in patients with FGFR2 Amplification or FGFR2 mutation Refractory solid tumors. This study is a single-arm, pilot study of Pazopanib in subjects with Refractory solid tumors harboring FGFR2…
- Trial name
- NCT02450136
- Testing
- pazopanib
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Samsung Medical Center
Biliary Tract Cancer
Pemetrexed in Combination With Erlotinib as a Salvage Treatment in Patients With Metastatic Biliary Tract Cancer (BTC) Who Failed Gemcitabine Containing Chemotherapy: A Phase II Single Arm Prospective Study
Pemetrexed in combination with erlotinib as a salvage treatment in patients with metastatic biliary tract cancer (BTC) who failed gemcitabine containing chemotherapy
- Trial name
- NCT03110484
- Testing
- Pemetrexed 500 MG, Erlotinib
- Where
- 2 sites in South Korea
- Volunteers
- 44 people
- Sponsor
- Samsung Medical Center
Preterm, Extreme Prematurity
Effectiveness of Home Based Early Intervention of Extremely Premature Infant by Parent
This study is to prove the effectiveness of home based early intervention of extremely premature infant by Parent.
- Conditions
- Preterm, Extreme Prematurity, Early Intervention, Developmental Delay
- Trial name
- NCT05334550
- Testing
- Home Based Early Intervention by Parent
- Volunteers
- 110 people
- Sponsor
- Samsung Medical Center
Metastatic Lung Non-Small Cell Carcinoma, EGFR T790M
Lazertinib Real-world Observational Study of in Pre-treated EGFR T790M Mutant With Advanced Non-small Cell Lung Cancer
It is to evaluate the safety and effectiveness of a lasertinib(LECLAZA) single drug in a actual medical environment for patients 1. Primary Purpose: Progression-free survival (PFS) 2.
- Trial name
- NCT05377788
- Testing
- Lazertinib
- Where
- South Korea
- Volunteers
- 900 people
- Sponsor
- Samsung Medical Center
Meibomian Gland Dysfunction
Effects and Prognostic Factors of Intensive Pulse Light Treatment for Meibomian Gland Dysfunction
The investigators are going to Investigate the comparative efficacy of intense pulsed light therapy alone with that of intense pulsed light plus meibomian gland expression for meibomian gland dysfunction.
- Trial name
- NCT03950115
- Testing
- Intense Pulsed Light (IPL)
- Where
- South Korea
- Volunteers
- 81 people
- Sponsor
- Samsung Medical Center
Dry Eye Syndromes
Clinical Efficacy of Intense Pulsed Light(IPL) Procedure in Dry Eye Patient
Clinical efficacy of Intense Pulsed Light(IPL) procedure in dry eye patients with meibomian gland dysfunction prior to cataract surgery.
- Trial name
- NCT04391907
- Testing
- IPL
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Cataract
Comparing the Visual Outcome, Visual Quality, and Satisfaction Among Three Types of Multi-focal Intraocular Lenses
The investigators are going to Investigate the comparative efficacy of the patients who underwent cataract surgery with three different multifocal IOLs.
- Trial name
- NCT04019691
- Testing
- Mix-and-Match, EDOF, Trifocal
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Dry Eye Syndromes
The Effect of Cyclosporin Before Cataract Surgery
To evaluate the effect of cyclosporine eye drop before cataract surgery for the prevention of post cataract surgery dry eye syndrome.
- Trial name
- NCT04426240
- Testing
- Cyclosporine microemulsion
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Presbyopia
Clinical Outcome of Extended-depth-of-focus Trifocal Intraocualr Lens (Triumf) Implantation
Clinical outcome of extended-depth-of-focus trifocal intraocualr lens (Triumf) implantation
- Trial name
- NCT04392024
- Testing
- Triumf
- Where
- South Korea
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center