Clinical trials: sponsored by Samsung Medical Center
Lymphoma, Extranodal NK-T-Cell
Avelumab in Relapsed or Refractory Extranodal Natural Killer/T-cell Lymphoma[AVENT STUDY]
This study was conducted to evaluate the complete response rate of avelumab in patients with NK / T-cell lymphoma besides relapsed or refractory stage lymphoma.
- Trial name
- NCT03439501
- Testing
- avelumab
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- Samsung Medical Center
Pediatric Solid Tumor
A Prediction Model of Hematological Recovery After High-dose Chemotherapy in Pediatric Solid Tumor
This study aims to compare and evaluate the predicted values of the participants, and the algorithm predicted values of ANC level reduction periods after high-capacity chemotherapy in pediatric solid tumor patients.
- Trial name
- NCT05024331
- Where
- South Korea
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Lung Neoplasms
Practical Usability of EGFR Mutation Detection in ctDNA From Resectable NSCLC
The aim of the study is to assess the practical usability of EGFR mutation detection in ctDNA from early NSCLC.
- Trial name
- NCT04922073
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Samsung Medical Center
Heart Failure, Systolic
Sacubitril/Valsartan Versus Valsartan in Heart Failure With Improved Ejection Fraction
Heart failure (HF) is a chronic disease with weakened heart muscles or abnormal pressure within the heart chambers result in breathlessness, leg edema, or fatigue.
- Trial name
- PROSPER-HF (NCT04803175)
- Testing
- Sacubitril-Valsartan, Valsartan
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Salivary Gland Cancer
Weekly Docetaxel Plus Cisplatin as First-line Chemotherapy in Metastatic Salivary Gland Cancer Patients : a Multicenter Phase II Study
Cisplatin plus weekly docetaxel as first-line chemotherapy in metastatic salivary gland cancer patients : a multicenter phase II study
- Trial name
- NCT05008237
- Testing
- docetaxel plus Cisplatin
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Samsung Medical Center
Non-Small Cell Lung Cancer With EGFR T790M Mutation, With Brain and/or Leptomeningeal Metastasis
Study of AZD9291 in NSCLC Patients Harboring T790M Mutation Who Failed EGFR TKI and With Brain and/or LMS
AZD9291 is an oral potent irreversible EGFR TKI selective for sensitizing EGFR mutation and T790M resistance mutation but sparing wild-type EGFR.
- Conditions
- Non-Small Cell Lung Cancer With EGFR T790M Mutation, With Brain and/or Leptomeningeal Metastasis, Failed Tyrosine Kinase Inhibitors
- Trial name
- NCT03257124
- Testing
- AZD9291
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Head and Neck Squamous Cell Carcinoma
Durvalumab Plus Tremelimumab Combined With Proton Therapy for HNSCC
Clinical Phase: phase II single arm study Primary Objectives: Response rate Number of Subjects: 27 patients Study Population: recurrent or metastatic head and neck squamous cell carcinoma Investigational Product(s), Dose, and…
- Trial name
- NCT03450967
- Testing
- Durvalumab Plus Tremelimumab
- Where
- South Korea
- Volunteers
- 31 people
- Sponsor
- Samsung Medical Center
Stroke, Disability
Korean Stroke Cohort for Functioning and Rehabilitation
Korean Stroke Cohort for functioning and rehabilitation (KOSCO) is a large, multi-centre prospective cohort study for all acute first-ever stroke patients admitted to participating hospitals in nine distinct areas of Korea.
- Conditions
- Stroke, Disability, Function, Rehabilitation
- Trial name
- NCT03402451
- Volunteers
- 7,858 people
- Sponsor
- Samsung Medical Center
Alzheimer's Disease
Exploratory Efficacy Study of NEUROSTEM® in Subjects Who Control Group of NEUROSTEM®
This study is to evaluate of Exploratory Efficacy of NEUROSTEM® in Subjects who control group of NEUROSTEM® Phase-I/IIa Clinical Trial
- Trial name
- NCT04954534
- Testing
- human umbilical cord blood derived mesenchymal stem cells
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Samsung Medical Center
One-Lung Ventilation, Postoperative Complications
Driving Pressure and Postoperative Pulmonary Complications in Thoracic Surgery
Pulmonary complications are the most common complication in thoracic surgery and the leading cause of mortality.Therefore, lung protection is utmost important, and protective ventilation is strongly recommended in thoracic…
- Conditions
- One-Lung Ventilation, Postoperative Complications, Driving Pressure, Postoperative Pulmonary Complication
- Trial name
- NCT04260451
- Testing
- ventilation
- Where
- South Korea
- Volunteers
- 1,300 people
- Sponsor
- Samsung Medical Center
Sleep Disorder, Cardiac Arrythmias
DEvice-Detected CArdiac Tachyarrhythmic Events and Sleep-disordered Breathing (DEDiCATES)
This prospective multicenter registry study aims to determine whether device-detected sleep-disordered breathing events are associated increased risk of cardiac arrhythmias or other cardiovascular outcomes.
- Conditions
- Sleep Disorder, Cardiac Arrythmias, Cardiac Event, Cardiac Implantable Electronic Device
- Trial name
- DEDiCATES (NCT03614377)
- Testing
- Device interrogation
- Where
- 15 sites in South Korea
- Volunteers
- 600 people
- Sponsor
- Samsung Medical Center
Heart Failure
Reduction or Extension of COnduction Time With Ventricular Electromechanical Remodeling (RECOVER)
This prospective multicenter registry study aims to detect the serial changes in ventriculo-ventricular conduction times according to cardiac-resynchronization therapy response.
- Trial name
- RECOVER (NCT04397224)
- Testing
- Device interrogation
- Where
- 6 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
NSCLC Stage IV, NSCLC Stage IIIB
Comparison of Genomic and Transcriptomic Patterns Between CTC and Metastatic Tumormetastatic Tumor
This study aims to understand the metastasis in advanced NSCLC through comparing genomic and transcriptomic patterns between the circulating tumor cells and metastatic tumor cells by single cell sequencing analysis.
- Trial name
- NCT04932343
- Testing
- cohort study
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Samsung Medical Center
Sanfilippo Syndrome A
Natural History Observational Study of MPS IIIa in SMC
To characterize the clinical course of mucopolysaccharidosis type IIIA (MPS IIIA), and identify potential endpoints for future treatment trials.
- Trial name
- NCT04918641
- Testing
- assessment
- Volunteers
- 25 people
- Sponsor
- Samsung Medical Center
Stomach Neoplasms
Study of Vismodegib in Advanced Gastric Adenocarcinoma Patients With SMO Overexpression
There is no accepted standard therapy for patients with advanced gastric cancer who have progressed during or after second-line therapy. The role of 3rd line treatment in advanced gastric cancer has not been proven.
- Trial name
- NCT03052478
- Testing
- Vismodegib 150 mg
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Samsung Medical Center
Deep Vein Thrombosis
The Learning Curve of Emergency Physicians Performed Lower-extremity Ultrasonography in the Diagnosis of DVT
If deep vein thrombosis (DVT) is suspected among patients who have symptoms such as pain or swelling of the lower extremities, duplex ultrasound of the lower limb is the first-line imaging modality to diagnose DVT.
- Trial name
- NCT04913688
- Testing
- bedside ultrasound performed group
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Samsung Medical Center
Emergencies
Comparison of Hands-on Versus Online Learning About Ocular Ultrasound
In patients who visit an emergency room with ocular symptoms, point-of-care ultrasound can quickly identify several emergency diseases.
- Trial name
- NCT04834700
- Testing
- online group
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Cardiopulmonary Arrest
Comparison of Tracheal Ultrasound With Capnography for Intubation Confirmation During CPR Wearing PPE
It is very important to ensure the tube placement in patients with cardiac arrest and unrecognized misplacement of endo-tracheal tube can lead to morbidity and mortality.
- Trial name
- NCT04690517
- Testing
- tracheal ultrasound
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Samsung Medical Center
Non-small Cell Lung Cancer
Cell Free DNA for the Diagnosis and Treatment in Early NSCLC
The aim of the study is to evaluate whether peripheral circulating cell-free tumor DNA (cfDNA) can aid screening of recurrence after complete resection of early stage non-small cell lung cancer.
- Trial name
- NCT03791034
- Where
- South Korea
- Volunteers
- 700 people
- Sponsor
- Samsung Medical Center
Gait
Correlation Between Cardiopulmonary Metabolic Cost and Lower Limb Muscle Activity
The purpose of this study was to determine the effect of lower extremity muscle activity on the increase of cardiopulmonary metabolic cost during inclined treadmill gait in the elderly.
- Trial name
- NCT04614857
- Testing
- Inclined treadmill gait
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center