Clinical trials: completed, sponsored by Samsung Medical Center
Charcot-Marie-Tooth Disease, Type 1
Evaluate the Safety and Potential Efficacy of Human Wharton's Jelly-derived Mesenchymal Stem Cells With Charcot-Marie-Tooth Disease Type 1E
Charcot-Marie-Tooth disease (CMT) is a hereditary peripheral nerve disease that causes causes muscle atrophy, muscle weakness, sensory loss, balance disorder, gait disorder, blindness, hearing disorder, breathing disorder, vocal…
- Trial name
- NCT06218134
- Testing
- human Wharton's jelly-derived mesenchymal stem cells
- Where
- South Korea
- Volunteers
- 3 people
- Sponsor
- Samsung Medical Center
Cardiogenic Shock, Frailty
Prognostic Impact of Frailty in Cardiogenic Shock
The goal of this observational study is to show prognostic impact of frailty in cardiogenic shock according to age. The main questions it aims to answer are: Can frailty successfully predict outcomes in cardiogenic shock? Whether…
- Conditions
- Cardiogenic Shock, Frailty, Age
- Trial name
- NCT07260084
- Volunteers
- 207,419 people
- Sponsor
- Samsung Medical Center
Healthy
Remimazolam Versus Midaszolam for Sedation in Diagnostic Upper Gastrointestinal Endoscopy
The goal of this clinical trial is to compare the efficacy of remimazolam with midazolam in patients undergoing gastrointestinal endoscopy.
- Trial name
- NCT05836545
- Testing
- Remimazolam, Midazolam
- Where
- South Korea
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Oesophageal Squamous Cell Carcinoma
A Retrospective Cohort Study of Patients Who Underwent Curative-intent Esophagectomy for ESCC at a Tertiary Referral Center in South Korea
This retrospective cohort study was conducted using the Registry for Thoracic Cancer Surgery at Samsung Medical Center (Seoul, South Korea), which has included all patients who underwent thoracic surgery
- Trial name
- NCT07201571
- Volunteers
- 3,131 people
- Sponsor
- Samsung Medical Center
Breast Cancer Related Lymphedema
Factors Associated With Health-related Quality of Life in Patients With Breast Cancer-Related Lymphedema Undergoing Prospective Surveillance
Breast cancer-related lymphedema (BCRL) is a chronic condition that affects more than 1 in 5 breast cancer survivors. It causes swelling, pain, and reduced arm function, which can significantly impact quality of life.
- Trial name
- NCT07165275
- Where
- South Korea
- Volunteers
- 203 people
- Sponsor
- Samsung Medical Center
Acute Respiratory Failure
Asymmetric High-flow Nasal Cannula (HFNC) vs Standard HFNC for Post Extubation High-risk Group
Background The exacerbation of respiratory failure that occurs after endotracheal intubation often occurs in patients who have received mechanical ventilation therapy, and when it occurs, it emerges as an important issue to…
- Trial name
- NCT06301035
- Testing
- Asymmetric High flow nasal cannula, Standard(symmetric) High flow nasal cannula
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Gallbladder Cancer
Artificial Intelligence-based Tumor Microenvironment Analysis for Prognosis Prediction in Gallbladder Cancer
This retrospective study aims to investigate the prognostic significance of artificial intelligence (AI)-powered analysis of tumor-infiltrating lymphocytes (TILs) and the tumor microenvironment (TME) in patients with resected…
- Trial name
- NCT07092397
- Where
- South Korea
- Volunteers
- 266 people
- Sponsor
- Samsung Medical Center
Interstitial Cystitis
Therapeutic Effects of Endoscopic Ablation of Hunner Lesions in Interstitial Cystitis/ Bladder Pain Syndrome Patients
efficacy of endoscopic ablation of Hunner lesions in patients with IC/BPS and the characteristics of HLs based on a long-term follow-up
- Trial name
- NCT03468530
- Testing
- Transurethral ablation
- Where
- South Korea
- Volunteers
- 442 people
- Sponsor
- Samsung Medical Center
Diabetes (DM), Physical Activity
Effect of Regular Physical Activity in Normal-Weight Individuals With Type 2 Diabetes and Abdominal Obesity
Individuals with T2DM accompanied by abdominal obesity tend to experience worse clinical outcomes. To identify modifiable factors that may improve these outcomes, the investigators conducted a retrospective cohort study using…
- Trial name
- PA-NormalWtDM (NCT07071545)
- Testing
- Regular physical activity, No regular physical activity
- Volunteers
- 249,247 people
- Sponsor
- Samsung Medical Center
Disabilities, Type 2 Diabetes
The Impact of Medication Adherence in Patients With Type 2 Diabetes and Disabilities
Individuals with disabilities and type 2 diabetes tend to have worse clinical outcomes. To identify modifiable factors that may improve these outcomes, the investigators evaluated the role of medication adherence.
- Trial name
- NCT07052708
- Testing
- No adherence group, Adherence group
- Volunteers
- 365,295 people
- Sponsor
- Samsung Medical Center
Neuromyelitis Optica Spectrum Disorder (NMOSD)
Efficacy and Safety of Conventional Immunosuppressant Therapies in Elderly Patients With Neuromyelitis Optica Spectrum Disorder
Newly diagnosed NMOSD patients
- Trial name
- NCT07032337
- Volunteers
- 2,985 people
- Sponsor
- Samsung Medical Center
Gastric Cancer Stage IV
Conversion Surgery After Target Therapy or Immunotherapy in Stage IV Gastric Cancer
In this retrospective study, investigators conducted a comprehensive investigation of the factors influencing postoperative prognosis in patients with stage IV gastric cancer undergoing conversion surgery.
- Trial name
- NCT07009600
- Testing
- immune check point inhibitors (PD-1 inhibitors), target therapy (trastuzumab)
- Volunteers
- 124 people
- Sponsor
- Samsung Medical Center
Breast Cancer
Association of Breast Reconstruction Method With Long-term Risk of Psychiatric Disorders
Female breast cancer patients who underwent total mastectomy followed by breast reconstruction
- Trial name
- NCT06981689
- Volunteers
- 24,930 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Hyperlipidemias
Optimal Attained LDL-Cholesterol Levels in Patients Who Achieved ≥50% LDL Reduction After PCI
For the management of low-density lipoprotein-cholesterol (LDL-C), some guidelines recommend initial statin treatment with high-intensity statins to achieve at least a 50% reduction in LDL-C levels.
- Trial name
- Lipid-PCI (NCT06338956)
- Testing
- LDL reduction therapy
- Where
- South Korea
- Volunteers
- 135,877 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Switching to E-cigarette After PCI
Despite the increasing popularity of electronic cigarettes (E-cigarettes), the prognostic impact of switching to E-cigarettes in smokers with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI)…
- Trial name
- E-cig-PCI (NCT06338761)
- Testing
- Smoking cessation, Switching to E-cigarette
- Where
- South Korea
- Volunteers
- 17,973 people
- Sponsor
- Samsung Medical Center
Non-small Cell Lung Cancer
Pembrolizumab With Standard Cytotoxic Chemotherapy in Treatment Naive NSCLC Patients With Asymptomatic Brain Metastases
This is a Phase II single center, open-label, single arm study in patients with advanced non-small cell lung cancer (stage IV) with brain metastases.
- Trial name
- PHOEBS (NCT04967417)
- Testing
- Pemetrexed, Carboplatin, Pembrolizumab, Paclitaxel, Carboplatin, Pembrolizumab
- Where
- South Korea
- Volunteers
- 13 people
- Sponsor
- Samsung Medical Center
Cerebral Palsy, Spastic Hemiplegic
Effects of Constraint-induced Movement Therapy With Home-based Hand-arm Bimanual Intensive Therapy in Children With Unilateral Cerebral Palsy
This study evaluates the therapeutic effects of constraint-induced movement therapy (CIMT) with home-based hand-arm bimanual intensive therapy (H-HABIT) with unilateral cerebral palsy.
- Trial name
- NCT04904796
- Testing
- CIMT, H-HABIT
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Samsung Medical Center
Colorectal Cancer, Anesthesia
Effects of Dexmedetomidine/Lidocaine/Intrathecal Morphine on Cancer Metastasis Biomarker After Colorectal Surgery
This is a prospective randomized controlled trial. Investigators aimed to compare the effect of three different anesthetic adjuvants (continuous infusion of lidocaine or dexmedetomidine, intrathecal morphine injection) on the…
- Conditions
- Colorectal Cancer, Anesthesia, Cancer Metastatic, Inflammation
- Trial name
- NCT05742438
- Testing
- Lidocaine IV, Dexmedetomidine IV, intrathecal morphine
- Where
- South Korea
- Volunteers
- 114 people
- Sponsor
- Samsung Medical Center
Intraoperative Hypotension, General Anesthesia
Deep Learning Models for Prediction of Intraoperative Hypotension Using Non-invasive Parameters
The investigators aimed to investigate the deep learning model to predict intraoperative hypotension using non-invasive monitoring parameters.
- Trial name
- NCT05762237
- Where
- South Korea
- Volunteers
- 5,175 people
- Sponsor
- Samsung Medical Center
Chronic Coronary Syndrome, Coronary Artery Bypass Graft CABG
Antiplatelet Strategy for CCS Patients Undergoing CABG
To evaluate the long-term outcomes of different antiplatelet strategies, including DAPT, aspirin monotherapy, and clopidogrel monotherapy, in CCS patients undergoing CABG.
- Trial name
- CABG_DAPT_SAPT (NCT06881901)
- Volunteers
- 29,898 people
- Sponsor
- Samsung Medical Center