Clinical trials: sponsored by Samsung Medical Center
Gastric Cancer
Phase III Randomized Trial of Adjuvant Chemotherapy With S-1 vs S-1/Oxaliplatin ± Radiotherapy for Completely Resected Gastric Adenocarcinoma : The ARTIST II Trial
The optimal regimen for adjuvant treatment has not been established in GC yet. We plan to compare TS-1, TS-1/oxaliplatin with or without RT in D2 resected gastric cancer.
- Trial name
- ARTIST-II (NCT01761461)
- Testing
- TS-1, oxaliplatin
- Where
- South Korea
- Volunteers
- 547 people
- Sponsor
- Samsung Medical Center
Migraine
Longitudinal Changes of Brain Functional Connectivity in Migraine
The purpose of this study is to identify a core fMRI feature that determines migrainous brain and plastic fMRI features that changes with longitudinal courses of migraine.
- Trial name
- NCT03487978
- Testing
- resting-state functional MRI
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Cluster Headache, Disease Course
Long-term Prognosis of Cluster Headache: a Retrospective Cohort Study
Cluster headache is a syndrome characterized by disabling headache and accompanying autonomic symptoms. Despite cluster headache is called "suicide headache", its natural history has not been well investigated.
- Trial name
- NCT02895256
- Testing
- Any treatment for cluster headache
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Samsung Medical Center
Overactive Bladder
Interventions to Enhance Medication Persistence and Compliance in Patients With Overactive Bladder
Study Objectives: To explore the effectiveness of adjunctive intervention to enhance the medication compliance and persistence in patients with Overactive Bladder (OAB), thereby to improve treatment outcomes Study Hypothesis…
- Trial name
- NCT01515722
- Testing
- Health education intervention (HEI)
- Where
- 13 sites in South Korea
- Volunteers
- 692 people
- Sponsor
- Samsung Medical Center
Migraine Disorders
Resting-state Functional Connectivity Changes During Migraine Treatment
The purpose of this study is to determine whether reduced frequency of migraine attacks are associated with signal alternation and connectivity of cerebral cortex.
- Trial name
- NCT03484871
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Brain Tumor
High-dose Chemotherapy With Autologous Stem Cell Rescue in Pediatric High-risk Brain Tumors
Study No.: KSPNO-S-081 Reduced-dose Craniospinal Radiotherapy Followed by High-dose Chemotherapy and Autologous Stem Cell Rescue in Children with Newly Diagnosed High-risk Brain Tumor Study No.: KSPNO-S-082 High-dose Chemotherapy…
- Trial name
- NCT00798811
- Testing
- high-dose chemotherapy and autologous stem cell rescue
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Hyperthermia
Effectiveness of the Combined WLI and Hyperthermia for GI Cancer Liver Metastasis
The standard treatment of unresectable liver metastasis in gastrointestinal tract cancer is chemotherapy, but considerable portion of the patients progressed and most of the liver is converted to metastatic tumor lesions.
- Trial name
- NCT01963117
- Testing
- Combined hyperthermia and radiation therapy
- Where
- South Korea
- Volunteers
- 11 people
- Sponsor
- Samsung Medical Center
Relapsed Pediatric Solid Tumor, Refractory Pediatric Solid Tumor
Genomics-Based Target Therapy for Children With Relapsed or Refractory Malignancy
The purpose of this study is to evaluate the efficacy and feasibility of combination chemotherapy with target agents according to the result of targeted deep sequencing in pediatric patients with relapsed/refractory solid tumor…
- Conditions
- Relapsed Pediatric Solid Tumor, Refractory Pediatric Solid Tumor, Relapsed Pediatric AML, Refractory Pediatric AML
- Trial name
- NCT02638428
- Testing
- CancerSCAN™, Ifosfamide, Carboplatin
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Samsung Medical Center
Intracranial Non-germinomatous Germ Cell Tumor
Reduced Dose Radiotherapy Following High Dose Chemotherapy in Intracranial Non-germinomatous Germ Cell Tumor
The purpose of this study is to evaluate the outcome of intracranial non-germinomatous germ cell tumor (NGGCT) treated with reduced radiotherapy following high dose chemotherapy and autologous stem cell transplantation…
- Trial name
- NCT02784054
- Testing
- Carboplatin, Etoposide, Cyclophosphamide
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Samsung Medical Center
Stroke
Home-based Exercise Program With Smart Rehabilitation System
A lot of patients suffer the balance and gait disorders after stroke. Many rehabilitation therapies have been provided to improve the balance and gait function in stroke patients.
- Trial name
- Smart-Rehab (NCT03282734)
- Testing
- Home-based exercise program with smart rehabilitation system ((Uincare®, D-gate Co.), Conventional home rehabilitation exercise
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Lymphoma, Large B-Cell, Diffuse
Genomic Evaluation in Patients With Diffuse Large B Cell Lymphoma After First Relapse/Progression
DLBCL has the highest frequency out of all lymphoid malignancies. With the recent development of antitumor agents targeting intracellular/extracellular cell signaling pathways, patients have access to various treatment options…
- Trial name
- COGET-B (NCT03977623)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Stroke, Biomarker
Serum BDNF Role as a Biomarker for Stroke Rehabilitation
This study aims to develop the quantitative biomarker to establish the individualized strategy in stroke rehabilitation. Brain-derived neurotrophic factor (BDNF) acts on certain neurons of the central nervous system (CNS) helping…
- Conditions
- Stroke, Biomarker, Rehabilitation, BDNF
- Trial name
- BDNF (NCT03164798)
- Testing
- Conventional inpatient rehabilitation
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Samsung Medical Center
Mantle Cell Lymphoma
Bendamustine Plus Rituximab for Mantle Cell Lymphoma: a Multicenter Retrospective Analysis(BR-MCL)
This study with retrospective data collection does not entail sample size calculation. The study will involve patients who received bendamustine + rituximab for relapsed/refractory mantle cell lymphoma and meet the…
- Trial name
- NCT04127916
- Testing
- Bendamustine
- Where
- 2 sites in South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Unrecognized Condition
Interaction of Genetic and Environmental Factors for Body Fat Mass Control
Although the effect of interaction between genetic and environmental factors on body fat mass (BFM) has been proposed, how lifestyle changes affect body weight with regard to the genetic composition needs to be verified.
- Trial name
- NCT04299698
- Testing
- lifestyle
- Where
- South Korea
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Small Cell Lung Cancer
Chemoradiation With Durvalumab Followed by Durvalumab Maintenance for Limited Disease Small Cell Lung Cancer
This is a single arm Phase II study, in which 4 cycles of chemotherapy (Etoposide and Cisplatin) and durvalumab with thoracic radiotherapy (52.2Gy, 2.1Gy/Fx) start at the 3rd cycle of chemotherapy and durvalumab for limited…
- Trial name
- NCT03585998
- Testing
- Durvalumab
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Samsung Medical Center
Healthy
Real-time Monitoring of Motor Cortical Activity Induced by Low-frequency Repetitive Transcranial Magnetic Stimulation
In this study, we investigated the effect of low-frequency repetitive trans cranial magnetic stimulation, one of the noninvasive brain stimuli, on the functional changes of the bilateral motor cortical activity in normal subjects…
- Trial name
- NCT04019028
- Testing
- low frequency rTMS + Navigation System, only low frequency rTMS
- Where
- South Korea
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Hemodialysis Access Failure
Prospective, Multicenter, Non-randomized, Single Arm Clinical Trial to Evaluate the Safety and Efficacy of e-PTFE Grafts Inner Surface-treated With Paclitaxel as an Access for Hemodialysis in Patients With End-stage Renal Disease.
This prospective, multicenter, non-randomized, single-arm Clinical trial aims to evaluate the safety and effectiveness of the use of paclitaxel-coated arteriovenous graft (AVG) on the inner wall of ePTFE graft, which is designed…
- Trial name
- NCT04285073
- Testing
- Paclitaxel-eluting graft
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Samsung Medical Center
HER2-positive Breast Cancer, Chemotherapy Effect
Genetic Characteristics of HER2 Positive Breast Cancer With Neoadjuvant TCHP Chemotherapy
Locally advanced breast cancer (LABC) is defined as breast cancer (BC) larger than 5 centimeters or with lymph node metastasis. Usually, LABC is treated with neoadjuvant chemotherapy (NAC) followed by curative surgery to reduce…
- Conditions
- HER2-positive Breast Cancer, Chemotherapy Effect, Circulating Tumor DNA
- Trial name
- NCT04276337
- Testing
- LiquidSCAN(Trade Mark) / CancerSCAN(Trade Mark)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Samsung Medical Center
Mild to Moderate Alzheimer Disease
Study on the Effect of Transcranial Magnetic Stimulation in Mild to Moderate Alzheimer's Disease
The investigators will compare cognitition, mood (depression), ADL, and brain structural and functional MRI before and after 4-week transcranial magnetic stimulation in patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT04260724
- Testing
- TMS
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Metastatic Breast Cancer
Genetic Characteristics of Metastatic Breast Cancer Patients
Genomic analysis for metastatic breast cancer(MBC) patients Participant (Inclusion criteria) 1. Patients who diagnosed metastatic/stage IV breast cancer 2.
- Trial name
- NCT04258735
- Testing
- Genomic analysis
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Samsung Medical Center