Clinical trials: sponsored by Samsung Medical Center
One-Lung Ventilation, Postoperative Respiratory Complications
Driving Pressure and Postoperative Pulmonary Complications
This study aims to prove that driving pressure limited ventilation is superior in preventing postoperative pulmonary complications to existing protective ventilation.
- Conditions
- One-Lung Ventilation, Postoperative Respiratory Complications, Driving Pressure
- Trial name
- NCT02851238
- Testing
- Driving Pressure Limited Ventilation
- Where
- South Korea
- Volunteers
- 312 people
- Sponsor
- Samsung Medical Center
Small Cell Lung Cancer
Vistusertib (AZD2014) Monotherapy in Relapsed Small Cell Lung Cancer Patients Harboring RICTOR Amplification
[Study Design] This study is a single arm, multi-center phase II study of vistusertib monotherapy in patients with relapsed small cell lung cancer (SCLC) harboring RICTOR amplification.
- Trial name
- [SUKSES-D] (NCT03106155)
- Testing
- vistusertib (AZD2014)
- Where
- South Korea
- Volunteers
- 4 people
- Sponsor
- Samsung Medical Center
Small Cell Lung Cancer
Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients With MYC Family Amplification or CDKN2A Mutation Combined With TP53 Mutation
AZD1775 (previously known as MK-1775 in earlier studies) is an inhibitor of Wee1, a protein tyrosine kinase. Wee1 phosphorylates and inhibits cyclin-dependent kinases 1 (CDK1) and 2 (CDK2), and is involved in regulation of the…
- Trial name
- NCT02688907
- Testing
- AZD1775
- Where
- South Korea
- Volunteers
- 7 people
- Sponsor
- Samsung Medical Center
Relapsed Pediatric Solid Tumor, Refractory Pediatric Solid Tumor
Combination Chemotherapy With Pazopanib in Children and Adolescents With Relapsed/Refractory Solid Tumors
The purpose of this study is to evaluate the safety and efficacy of combination chemotherapy with Pazopanib in pediatric patients with relapsed/refractory solid tumor
- Trial name
- NCT03628131
- Testing
- Pazopanib, Ifosfamide, Carboplatin
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Samsung Medical Center
Type 2 Diabetes Mellitus
The Effect of Vildagliptin Based Treatment Versus Sulfonylurea on Glycemic Variability, Oxidative Stress, GLP-1, and Endothelial Function in Patients With Type 2 Diabetes
The effect of vildagliptin based treatment versus sulfonylurea based treatment on glycemic variability, oxidative stress, and endothelial function in patients with type 2 diabetes.
- Trial name
- NCT01404676
- Testing
- Add Vildagliptin, Add Glimepiride
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Samsung Medical Center
Neuroblastoma, Ewing Sarcoma
Haploidentical Stem Cell Transplantation and NK Cell Therapy in Patients With High-risk Solid Tumors
To evaluate feasibility and efficacy of haploidentical stem cell transplantation in patients with high-risk solid tumors who failed after tandem high-dose chemotherapy and autologous stem cell transplantation.
- Conditions
- Neuroblastoma, Ewing Sarcoma, Rhabdomyosarcoma, Osteosarcoma
- Trial name
- NCT01807468
- Testing
- haploidentical stem cell transplantation and NK cell therapy
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Samsung Medical Center
Neuroblastoma
Tandem High-dose Chemotherapy and Autologous Stem Cell Rescue in Patients With High-risk Neuroblastoma
The purpose of this study is to evaluate the efficacy and toxicity of tandem HDCT/ASCR in children with high-risk neuroblastoma. In the present study, a single arm trial of tandem HDCT/ASCR will be carried out.
- Trial name
- NCT00793845
- Testing
- Cyclophosphamide, Etoposide, Carboplatin
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
High Risk Neuroblastoma
Tandem High Dose Chemotherapy With 131I-MIBG Treatment in High Risk Neuroblastoma
The purpose of this study is to evaluate the efficacy and toxicity of tandem HDCT/ASCT including high-dose 131I-metaiodobenzylguanidine (MIBG) treatment.
- Trial name
- NCT03061656
- Testing
- Cyclophosphamide, Carboplatin, Etoposide
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Unresectable Localized Soft Tissue Sarcoma
Response Based Treatment for Children With Unresectable Localized Soft Tissue Sarcoma
To evaluate the treatment outcome of unresectable soft tissue sarcoma using response based treatment
- Trial name
- NCT02784015
- Testing
- Cisplatin, Etoposide, Doxorubicin
- Where
- South Korea
- Volunteers
- 41 people
- Sponsor
- Samsung Medical Center
Chemotherapy Induced Neutropenia, Pediatric Solid Tumor
Pegteograstim in Children With Solid Tumors
To evaluate the efficacy and safety of pegteograstim on chemotherapy-induced neutropenia in children with solid tumors
- Trial name
- NCT02787876
- Testing
- Pegteograstim
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Samsung Medical Center
Diabetes Mellitus, Prediabetic State
Effect of Pravastatin in the Subjects With Prediabetes or Early Diabetes
An increased risk of incident diabetes with statin therapy have been reported in several studies. However, it is not recommended to limit the use of statin for this reason since the absolute risk increase was small, and the…
- Trial name
- NCT02754739
- Testing
- Pravastatin, Nutritional education only
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Samsung Medical Center
Non-Hodgkin Lymphoma
Brentuximab Vedotin for Relapsed/Refractory CD30-positive Non-Hodgkin Lymphomas
Brentuximab vedotin is an antibody-drug conjugate targeting CD30, one of surface antigens expressed in lymphoma cells. Fanale MA, et al.
- Trial name
- BRAN (NCT02280785)
- Testing
- Brentuximab vedotin
- Where
- 4 sites in South Korea
- Volunteers
- 33 people
- Sponsor
- Samsung Medical Center
T-cell Lymphoma
Bendamustine, Carboplatin and Dexamethasone (BCD) for Refractory or Relapsed Peripheral T-cell Lymphoma
BCD (Bendamustine, carboplatin and dexamethasone)chemotherapy regimen is proposed as the salvage treatment for relapsed or refractory PTCLs in this study protocol, which would be expected to show more promising clinical outcomes…
- Trial name
- NCT02424045
- Testing
- BCD chemotherapy (Bendamustine, Carboplatin, Dexamethasone)
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Polypoidal Choroidal Vasculopathy Without Active Polyp
Efficacy and Safety of Intravitreal Vascular Endothelial Growth Factor Trap-eye in Patients With Polyploidal Choroidal Vasculopathy
The purpose of this study is to evaluate the efficacy and safety of aflibercept for treatment of polypoidal choroidal vasculopathy without active polyp.
- Trial name
- NCT02072408
- Testing
- aflibercept
- Where
- 3 sites in South Korea
- Volunteers
- 46 people
- Sponsor
- Samsung Medical Center
Alopecia
EValuation of the Impact of a TOpical Lotion on Permanent Chemotherapy Induced Hair Disorders in Cancer Survivors
This study aims to evaluate the Impact of a topical Lotion, CG428, on permanent chemotherapy induced hair and scalp disorders in Cancer survivors.
- Trial name
- VOLUME (NCT02605629)
- Testing
- CG428
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Alopecia, Chemotherapy Effects
A 6-month Post-interventional Follow-up Extension of VOLUME Study (VOLUME-2)
We would suggest to conduct "VOLUME-2" study, as an extension of the ongoing "VOLUME" study with all subjects already included. After completion of VOLUME study, the study will be directly extend with an "open-label design".
- Trial name
- VOLUME2 (NCT02986412)
- Testing
- CG428
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- Samsung Medical Center
Esophageal Cancer
Bispectral Index Throughout Esophageal Cancer Operation
The investigators try to conduct a study to assess the impact of changing patients' lateral decubitus position on BIS readings during esophageal cancer operation.
- Trial name
- NCT03397745
- Testing
- BIS
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Samsung Medical Center
Non Small Cell Lung Cancer
Atezolizumab Monotherapy and Consequent Therapy With Atezolizumab Plus Bevacizumab for NSCLC
This is a single-arm phase II trial to evaluate the efficacy and safety of atezolizumab and bevacizumab combination therapy (stage 2) after radiologic progression of atezolizumab monotherapy (stage 1) in Korean patients with…
- Trial name
- NCT03616691
- Testing
- Atezolizumab, Bevacizumab
- Volunteers
- 46 people
- Sponsor
- Samsung Medical Center
Mild Cognitive Impairment
Effects of the Cognitive Enhancing ICT Contents in Patients With Mild Cognitive Impairment
The purpose of this study is to investigate the effect of cognitive rehabilitation program on the improvement of cognitive functions in patients with mild cognitive impairment(MCI).
- Trial name
- NCT03405857
- Testing
- Cognitive rehabilitation program
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Pediatric Disorder, Femoral Artery Injury
The Optimal Leg Angulation of Femoral Central Catheterization in Pediatrics
Evaluation for the range of smallest leg angulation with femoral artery and vein overlap with femoral central catheterization in pediatrics.
- Conditions
- Pediatric Disorder, Femoral Artery Injury, Emergencies
- Trial name
- NCT03358446
- Testing
- A group, S group
- Where
- South Korea
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center