Clinical trials: sponsored by Samsung Medical Center
Sepsis-associated AKI
Oxiris in Septic AKI
Sepsis is a leading cause of acute kidney injury (AKI) in critically ill patients, with sepsis-associated AKI accounting for approximately 50% of all AKI cases in the intensive care unit.
- Trial name
- NCT07641660
- Testing
- Oxiris, Standard CRRT
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)
Livalozet Versus High-intensity Statin in Older Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention
Acute myocardial infarction is one of the leading causes of death in elderly patients, and the importance of lipid-lowering therapy as a secondary prevention strategy to reduce cardiovascular events is emphasized.
- Trial name
- SMARTDECISION2 (NCT07626840)
- Testing
- Pitavastatin/ezetimibe, Atorvastatin or Rosuvastatin
- Volunteers
- 5,000 people
- Sponsor
- Samsung Medical Center
Ambient AI System, Emergency Department
Evaluation of a Generative AI-Based Voice Documentation System for Patient-Clinician Communication in the Emergency Department and Its Impact on Clinical Workflow Efficiency and Usability
This research study at Samsung Medical Center evaluates the impact of Ambient AI system, a Generative AI-based communication and documentation system developed by NAVER, on the efficiency and quality of medical record-keeping…
- Conditions
- Ambient AI System, Emergency Department, Generative ai
- Trial name
- CLOVA Charty (NCT07637591)
- Testing
- VoiceEMR
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Gastric Cancer
Pembrolizumab Plus Ramucirumab in Metastatic Gastric Cancer
1. Objective 1) Primary Objective: To estimate preliminary overall response rate (ORR) of combination therapy of Ramucirumab and Pembrolizumab in patients with metastatic gastric or GEJ adenocarcinoma 2)Secondary Objectives: To…
- Trial name
- NCT04632459
- Testing
- pembrolizumab plus ramucirumab
- Where
- 2 sites in South Korea
- Volunteers
- 26 people
- Sponsor
- Samsung Medical Center
Duchene Muscular Dystrophy
Home-Based Tele-Rehabilitation for Respiratory Function in Children With Duchenne Muscular Dystrophy
This study evaluates the feasibility and preliminary clinical effects of a home-based tele-rehabilitation program aimed at improving respiratory function in children with Duchenne Muscular Dystrophy (DMD).
- Trial name
- NCT07629284
- Testing
- Home-Based Respiratory Telerehabilitation Program
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Samsung Medical Center
Borderline Intellectual Functioning (BIF), Intellectual Disability
Co-design of an AI Rehabilitation Program for Children With Borderline Intellectual Disorder
Co-design of an AI Rehabilitation Program for Children With Borderline Intellectual Disorder
- Trial name
- NCT07625592
- Testing
- Tablet-Based AI Cognitive and Language Rehabilitation Program
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Atrial Fibrillation (AF), Tricuspid Regurgitation (TR)
Efficacy of Early Rhythm Control in AF With TR Patients
Atrial fibrillation is frequently accompanied by tricuspid regurgitation and may contribute to right atrial and tricuspid annular remodeling, leading to progression of tricuspid regurgitation and adverse clinical outcomes.
- Trial name
- TRAF (NCT07607093)
- Testing
- Anti-arrhythmic drugs for rhythm control, DC cardioversion, catheter ablation for rhythm control, Usual care
- Where
- South Korea
- Volunteers
- 5,800 people
- Sponsor
- Samsung Medical Center
Gastric Adenocarcinoma, Stomach Neoplasms
PULSAR Combined With Immunotherapy for Unresectable Locally Advanced Gastric Cancer
The purpose of this prospective, single-center, phase II study is to evaluate the clinical efficacy and safety of combining first-line systemic therapy plus immunotherapy with personalized ultrafractionated stereotactic adaptive…
- Conditions
- Gastric Adenocarcinoma, Stomach Neoplasms, Locally Advanced Gastric Cancer, Unresectable Gastric Cancer
- Trial name
- NCT07607119
- Testing
- PULSAR (Personalized Ultrafractionated Stereotactic Adaptive Radiation Therapy), PULSAR
- Where
- South Korea
- Volunteers
- 53 people
- Sponsor
- Samsung Medical Center
Esophagectomy, Dumping Syndrome
Dumping Syndrome After Esophagectomy
Background: Dumping syndrome is a common complication for patients who have undergone surgery for esophageal cancer. It occurs when food moves too quickly from the stomach (or the reconstructed gastric tube) into the small…
- Conditions
- Esophagectomy, Dumping Syndrome, Continous Glucose Measurement
- Trial name
- NCT07605481
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Aortic or Mitral Valve Replacement, Valvular Heart Disease Patients
Association of Prosthesis Types for Aortic or Mitral Valve Replacement With Long-term Risk of Mental Disorders
Patients were enrolled if the patients aged 60 to 70 years who underwent surgical aortic or mitral valve replacement. The age range was restricted to 60 to 70 years to ensure comparability in surgical indications between…
- Trial name
- NCT07489313
- Volunteers
- 1,811 people
- Sponsor
- Samsung Medical Center
NSCLC, Neoadjuvant Chemoimmunotherapy
Imaging-based PRediction of Eligibility for ChemoImmunotherapy in reSEctable NSCLC, iPRECISE
This study is for adults with resectable non-small cell lung cancer who are scheduled to receive neoadjuvant chemoimmunotherapy before surgery.
- Conditions
- NSCLC, Neoadjuvant Chemoimmunotherapy, CT
- Trial name
- iPRECISE (NCT07559123)
- Testing
- High-resolution deep learning-based CT reconstruction
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Samsung Medical Center
Atrial Fibrillation (AF), Cardiac Amyloidosis
Early Detection of Concealed Cardiac Amyloidosis Using AI-ECG and CT-Derived Extracellular Volume in Patients With Atrial Fibrillation
This study investigates the clinical efficacy of a non-invasive screening protocol using AI-ECG and CT-ECV analysis for cardiac amyloidosis. The study targets on atrial fibrillation(AF) patients with "red-flag" indicators.
- Trial name
- SEARCH-AF (NCT07567508)
- Testing
- AI-ECG analysis, CT-ECV analysis, Atrial fibrillation treatment
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
Asthma, Immunogenicity
Real-world Immunogenicity of Anti-IL5/5a Antibody
This study aims to evaluate the immunogenicity of the drug by measuring anti-drug antibody (ADA) formation and titers. The presence of ADAs will be assesses to determine their potential impact on the drug's efficacy and safety.
- Conditions
- Asthma, Immunogenicity, Biologics
- Trial name
- NCT07567690
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Heart Failure, Bradycardia
Impact of Optimized Pacing Strategies on Clinical and Hemodynamic Outcomes in Heart Failure Patients With Pacemaker
This study aims to evaluate the clinical impact of an optimized pacing strategy in patients with heart failure. Intervention: Adjustment of the pacemaker lower rate limit to an individualized, hemodynamically optimized heart…
- Trial name
- OPTPACE-HF (NCT07563153)
- Testing
- Adjustment of the pacemaker/ICDs lower rate limit (LRL), Conventional lower rate (60bpm)
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Samsung Medical Center
Lung Cancer
Osimertinib to Suppress the Progression of GGN(EGFR Mutation-positive)
This study designed to assess the efficacy of osimertinib (80 mg, orally, once daily) to suppress the progression of remaining GGN(s) in other lobes following surgical resection for actionable EGFR mutation-positive stage I lung…
- Trial name
- NCT04591002
- Testing
- Osimertinib 80 MG
- Where
- 2 sites in South Korea
- Volunteers
- 43 people
- Sponsor
- Samsung Medical Center
Lung Adenocarcinoma
Osimertinib to Suppress the Progression of Remaining GGN for EGFR Mutation-positive Stage IB-IIIA Lung Adenocarcinoma
This is an open label, phase II study to assess the efficacy of osimertinib (80 mg, orally, once daily) to suppress the progression of remaining GGN(s) in other lobes following surgical resection for actionable EGFR…
- Trial name
- NCT05528458
- Testing
- Osimertinib 80Mg Tab
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Refractory Solid Cancer Patients Unexposed to Immunotherapy
T Cell Inflamed Gene Expression Profiling Score-guided Anti PD-1 Therapy (Tislelizumab Monotherapy) for Refractory Solid Cancer Patients Unexposed to Immunotherapy
This is a Phase 2, single-arm, multicenter study, evaluating the anti-tumor efficacy of tumor-infiltrating lymphocyte (TIL) directed tislelizumab monotherapy (also known as BGB-A317) for refractory solid tumors in approximately…
- Trial name
- NCT07300891
- Testing
- Tisleizumab(BGB-A317)
- Volunteers
- 72 people
- Sponsor
- Samsung Medical Center
Stroke
Korean Stroke Cohort for Functioning and Rehabilitation-II
Korean Stroke Cohort for functioning and rehabilitation (KOSCO)-II is a large, multi-centre prospective cohort study for all acute first-ever stroke patients admitted to participating hospitals in nine distinct areas of Korea.
- Trial name
- KOSCO-II (NCT04976894)
- Testing
- open
- Where
- South Korea
- Volunteers
- 2,431 people
- Sponsor
- Samsung Medical Center
Acute Respiratory Failure
A Clinical Study for Developing Artificial Intelligence(AI)-Based Clustering Model for Personalized Medicine in Acute Respiratory Failure
The investigators will prospectively collect clinical information to develop a clustering analysis model and confirm phenotype for patients with acute respiratory failure who admit to the intensive care unit and require oxygen…
- Trial name
- NCT06479421
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Samsung Medical Center
Parkinson's Disease and Parkinsonism
Personalized rTMS Protocol Based on Functional Reserve to Enhance Ambulatory Function in PD Patients
The objective of this study was to determine the effects of protocols of repetitive transcranial magnetic stimulation (rTMS) therapy based on the functional reserve of each patient with Parkinson's disease, compared to…
- Trial name
- NCT06350617
- Testing
- High-Frequency, ipsilateral M1, High-Frequency, bilateral M1, High-Frequency, Lt. DLPFC
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center