Clinical trials: sponsored by Samsung Medical Center
HER2-positive Gastric Cancer Patients With Liver Metastasis
Phase II Study of Neoadjuvant XELOX + Lapatinib in HER2(+) Gastric Cancer Patients With Liver Metastasis
We planned this study to investigate the efficacy and safety of XELOX (capecitabine and oxaliplatin) plus lapatinib treatment in HER2-positive gastric cancer patients with liver metastasis.
- Trial name
- NCT02015169
- Testing
- Lapatinib
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Colorectal Cancer
A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-line Chemotherapy in Metastatic Colorectal Cancer Patients
1. Study Objectives 1) Primary Objective: Progression-free survival 2) Secondary Objectives: 1. overall survival 2. response rate 3. incidence, nature and severity of all adverse events 4. lipid lowering effect of simvastatin 5.
- Trial name
- NCT02026583
- Testing
- Simvastatin
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Samsung Medical Center
Breast Cancer Stage IV
The Resistance and Immune Response to Palbociclib in Breast Cancer
The investigators propose to conduct a biomarker and molecular profiling study in longitudinally paired tumor biopsies and serum from patients with Hormone Receptor positive (HR+) metastatic Breast Cancer (BC) treated with…
- Trial name
- NCT03401359
- Testing
- tissue biopsy, blood sample
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Gastric Cancer
Pharmacogenomic Study (Adjuvant Chemotherapy)
To assess the role of germline polymorphisms in xenobiotic metabolism genes in toxicity profile. To assess the role of germline polymorphisms in genes associated with DNA repair, p53 tumor suppressor gene and angiogenesis pathway…
- Trial name
- NCT01470404
- Where
- South Korea
- Volunteers
- 792 people
- Sponsor
- Samsung Medical Center
Aging
Evaluation of the Effects of the New Program for Cognitive Enhancement and Improvement in the Elderly
The purpose of this study is to investigate the effect of cognitive rehabilitation program on the improvement of cognitive functions in normal elderly subjects.
- Trial name
- NCT03401775
- Testing
- Cognitive rehabilitation program
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Non-small Cell Lung Cancer
The Continuation of Gefitinib Treatment Beyond Progression in Non-small Cell Lung Cancer Patients With EGFR Mutation
Although EGFR-TKIs such as gefitinib, erlotinib or afatinib are recommended as first-line therapy in patients with advanced, recurrent or metastatic nonsquamous NSCLC patients who have known active EGFR mutation and achieved…
- Trial name
- NCT03399669
- Testing
- gefitinib
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Gait, Unsteady, Health Behavior
The Effect of a Wearable Hip Assist Robot on Cardiopulmonary Metabolic Efficiency During Stair Ascent in Elderly Adults
The aim of this study was to identify the assistance effect of the new wearable hip assist robot, gait enhancing mechatronic system (GEMS) developed by Samsung Advanced Institute of Technology (Samsung Electronics Co, Ltd.…
- Trial name
- NCT03389165
- Testing
- Wearable hip assist robot
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Samsung Medical Center
Stroke, Hemiplegia
Effects of Whole-body Vibration Exercise on Stroke Patients
The purpose of this study is to investigate the effect of the whole body vibration exercise on cortical activity and gait function in patients with chronic stroke.
- Trial name
- NCT03375346
- Testing
- Whole body vibration, Exercise
- Volunteers
- 29 people
- Sponsor
- Samsung Medical Center
Bladder Pain Syndrome
Comparison of the Efficacy Between Transurethral Coagulation and Transurethral Resection of Ulcer in Bladder Pain Syndrome Patients
On the EAU (European Association of Urology) guidelines, the ulcer type bladder pain syndrome (BPS) should be treated with transurethral resection (TUR) or coagulation (TUC) of ulcer.
- Trial name
- NCT01963988
- Testing
- Transurethral Coagulation (TUC), Transurethral Resection(TUR)
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Samsung Medical Center
Brain Metastases
Hippocampus-sparing WBRT and Simultaneous Integrated Boost for Multiple Brain Metastases From NSCLC
This study evaluates hippocampus-sparing whole-brain radiotherapy with simultaneous integrated boost for patients with multiple brain metastases from non-small cell lung cancer.
- Trial name
- KROG17-06 (NCT03366376)
- Testing
- WBRT with hippocampus-sparing and SIB
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Myocardial Ischemia
A Study on Improved Dynamic Myocardial Perfusion With Less Effective Radiation Dose in CT (SIMPLE CT)
Among the current myocardial CT perfusion techniques, dynamic CT perfusion technique is most advantageous in obtaining information on myocardial blood flow and volume.
- Trial name
- NCT02161081
- Testing
- Myocardial CT perfusion
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Samsung Medical Center
Relapsed or Refractory Peripheral T-cell Lymphoma
Pralatrexate for Relapsed or Refractory Peripheral T-cell Lymphoma
A non-interventional, multicenter, multinational retrospective analysis using electronic case report forms completed by the investigators based on information from patient medical records
- Trial name
- NCT03356678
- Testing
- Pralatrexate
- Where
- 2 sites in South Korea
- Volunteers
- 33 people
- Sponsor
- Samsung Medical Center
Patients With Diffuse Large B-cell Lymphoma or Follicular Lymphoma, Patients Treated With Rituximab-CHOP or Rituximab-CVP
Factors Influencing Hepatitis B Virus Reactivation in Lymphoma Patients Treated With Rituximab
This study is a retrospective analysis to identify factors influencing hepatitis B virus reactivation in patients treated with rituximab containing chemotherapy.
- Trial name
- NCT01311232
- Where
- 4 sites in China, Malaysia and 2 more
- Volunteers
- 600 people
- Sponsor
- Samsung Medical Center
Lymphoma
Samsung Medical Center-Lymphoma Cohort Study-II
The purpose of this study is to establish a model which can predict the treatment outcome and the risk of treatment-related morbidity in patients with lymphoma.
- Trial name
- SMC-LCS-II (NCT01877109)
- Where
- South Korea
- Volunteers
- 1,358 people
- Sponsor
- Samsung Medical Center
Stroke, Motor Disorder
Effects of Brain Network by Simultaneous Dual-mode Stimulation in Subacute Stroke Patients
Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of stroke patients' motor function by altering the cortical excitability.
- Trial name
- NCT03279640
- Testing
- rTMS on ipsilesional M1, tDCS on contralesional M1
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Atrial Fibrillation, Valve
The Concomitant Cryomaze Procedure Using Nitreous Oxide Cryoprobe: Comparison With Argon Based Cryoprobe
The aim of this study is compare the surgical convenience and early and long-term outcomes of cryomaze procedure using nitrous oxide with using Argon gas.
- Trial name
- NCT01812356
- Testing
- Cryomaze procedure using Nitrous oxide, Cryomaze procedure using Argon
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Thymic Cancer
A Phase II Study of Palbociclib for Recurrent or Refractory Advanced Thymic Epithelial Tumor
This is a phase II single center, open-label, single arm study of palbociclib treatment in patients with recurrent or metastatic advanced TETs after failure of one or more cytotoxic chemotherapy regimens.
- Trial name
- NCT03219554
- Testing
- Palbociclib
- Where
- South Korea
- Volunteers
- 33 people
- Sponsor
- Samsung Medical Center
Malignant Biliary Obstruction
Comparison Between Novel Flower-type Covered Stent and Conventional Covered Stent
The aim of this animal study is determining the technical feasibility of the novel flower-type covered self-expandable metal stent (F-CSEMS) and investigating whether the novel flower-type covered self-expandable metal stent…
- Trial name
- NCT03215108
- Testing
- Endoscopic Retrograde CholangioPancreatography(ERCP)
- Where
- South Korea
- Volunteers
- 256 people
- Sponsor
- Samsung Medical Center
Prostate Cancer
Comparison of Duration of Treatment Interruption With or Without Curcumin During the Off Treatment Periods in Patients With Prostate Cancer Undergoing Intermittent Androgen Deprivation Therapy
This was a placebo-controlled, double-blind, randomized trial designed with the aim of establishing whether curcumin influenced the duration of treatment interruption and rate of prostatic specific antigen(PSA) progression…
- Trial name
- NCT03211104
- Testing
- curcumin
- Volunteers
- 107 people
- Sponsor
- Samsung Medical Center
Subscapularis Tendon Tear, Arthroscopic Repair
Do You Arthroscopic Repair for Subscapularis Tendon Tear, Which Accounts for More Than Half of the 1st Facet? Or do You Perform Debridement?
The purpose of this study was to randomly classify the upper third of the subscapularis in 1/2 of the rupture patients as preoperative group (arthroscopic and arthroscopic debridement group) and the difference between clinical…
- Conditions
- Subscapularis Tendon Tear, Arthroscopic Repair, Arthroscopic Debridement
- Trial name
- NCT03183466
- Testing
- arthroscopic repair, arthroscopic debridement
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center