Clinical trials: sponsored by Samsung Medical Center
Stroke, Intracranial Atherosclerosis
Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis
Purpose: Intracranial atherosclerosis is a common condition in Korean population consisting over 25% of ischemic stroke etiology.
- Trial name
- STAMINA-MRI (NCT02458755)
- Testing
- High-dose statin: Atorvastatin 40mg or Rosuvastatin 20mg
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Patients Who Underwent Surgery for Congenital Heart Disease
Influence of Tidal Volume During Mechanical Ventilation on Postoperative Clinical Outcome in Pediatric Patients Undergoing Congenital Heart Surgery
High tidal volume during mechanical ventilation has been reported to increase mortality in patients with acute lung injury or acute respiratory distress syndrome.
- Trial name
- NCT02081274
- Testing
- Surgery for congenital heart disease
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Samsung Medical Center
Deceased Donor Kidney Transplantation, Living Donor Kidney Transplantation
Adequate Definition of Delayed Graft Function in Living and Deceased Donor Kidney Transplantation
It is required to establish an adequate definition of delayed graft function in deceased donor kidney transplantation. We attempt to compare various definitions of delayed graft function and find the definition that can predict…
- Trial name
- NCT02080117
- Testing
- kidney transplantation, living or deceased donor
- Where
- South Korea
- Volunteers
- 800 people
- Sponsor
- Samsung Medical Center
Mesenchymal Stromal Cells
Phase 1 Clinical Trial of PNEUMOSTEM® Treatment in Premature Infants With Intraventricular Hemorrhage
Phase 1 clinical trial for the safety and dose determination of Pneumostem (human umbilical cord blood derived mesenchymal stem cells) in the premature infants with intraventricular hemorrhage (IVH, grade 3-4)
- Trial name
- NCT02274428
- Testing
- pneumostem
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Samsung Medical Center
Extranodal NK/T-cell Lymphoma, Nasal Type
International Extranodal NK/T-cell Lymphoma Project
This study is to explore risk factors for poor progression-free survival (PFS) and overall survival (OS) in ENKTL, and establish a prognostic model for ENKTL patients treated with non-anthracycline based treatment.
- Trial name
- PINK (NCT02386813)
- Where
- 2 sites in South Korea
- Volunteers
- 770 people
- Sponsor
- Samsung Medical Center
Astigmatism
Comparison of Clinical Outcomes of Toric Intraocular Lens
This study is to compare the clinical outcome of Precizon toric intraocular lens(IOL) to that of Tecnis toric IOL.
- Trial name
- NCT03085901
- Testing
- Precizon toric intraocular lens, Tecnis toric intraocular lens
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Refractory Solid Tumors
Single-arm Study to Evaluate the Safety and Efficacy of Sorafenib, in Subjects With BRAF Mutation Refractory Solid Tumors
This is a pilot study of sorafenib in patients with BRAF Mutation Refractory Solid Tumors. This study is a single-arm, pilot study of sorafenib in patients with Refractory Solid Tumors harboring BRAF Mutation Sorafenib 400 mg…
- Trial name
- NCT02450149
- Testing
- sorafenib
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Samsung Medical Center
Acute Coronary Syndromes
REal World Advanced Experience of BioResorbable ScaffolD by SMart Angioplasty Research Team (SMART REWARD)
Current drug-eluting stents (DES) has demonstrated excellent clinical outcomes in patients with coronary artery disease. However, a continued risk of clinical events even several years after the procedure is reported.
- Trial name
- NCT02601404
- Testing
- Bioresorbable scaffold (BRS)
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Samsung Medical Center
Gastric Outlet Obstruction Due to Gastric Adenocarcinoma
Covered Versus Uncovered Self-expandable Metallic Stents for Malignant Gastric Outlet Obstruction
Malignant gastric outlet obstruction can result from gastric adenocarcinoma, leading to intractable vomiting, nausea, and poor oral food intake.
- Trial name
- NCT01646476
- Testing
- Covered stent (Bona stent pyloric/duodenal covered) insertion, Uncovered stent (Bona stent, pyloric/duodenal) insertion
- Where
- South Korea
- Volunteers
- 102 people
- Sponsor
- Samsung Medical Center
Colorectal Cancer
Biomarker Analysis in Metastatic Colorectal Cancer Treated With Cetuximab
Prometheus's Onco dX assay platform provides technological breakthrough for immunoassay by obtaining a level of sensitivity down to single tumor cells without compromising specificity.
- Trial name
- NCT02029326
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Solid Tumor
Study to Evaluate the Safety and Efficacy of Everolimus, in Subjects With PIK3CA Amplification, PTEN Loss and PIK3CA Mutation Refractory Solid Tumors
This study is a single-arm, phase II study of everolimus in patients with PTEN loss ,PIK3CA mutation and PIK3CA amplification Refractory Solid Tumors . Everolimus 10 mg will be administered orally qd daily.
- Trial name
- NCT02449538
- Testing
- everolimus
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Samsung Medical Center
Colorectal Carcinoma
A Trial of JX-594 in Refractory Colorectal Carcinoma
The purpose of this study is to: determine the maximally-tolerated dose (MTD) and/or maximum-feasible dose (MFD) of JX-594 administered by biweekly intravenous (IV) infusion.
- Trial name
- NCT01469611
- Testing
- JX-594
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Samsung Medical Center
HER2-positive Refractory Advanced Cancer
Safety and Clinical Activity of Lapatinib in Patients With HER2-positive Refractory Advanced Cancer
Although anti-HER2 (human epidermal growth factor receptor 2) therapy is currently approved for breast, gastric, and gastroesophageal cancers overexpressing the HER2 protein or amplified for the HER2 gene, HER2 aberrations (gene…
- Trial name
- NCT02342587
- Testing
- Lapatinib
- Where
- South Korea
- Volunteers
- 7 people
- Sponsor
- Samsung Medical Center
Gastric Cancer
Trial of XP (Capecitabine/CDDP) Simvastatin in Advanced Gastric Cancer Patients
Based on antitumor activity of statin, we designed a phase III study of capecitabine/CDDP chemotherapy plus a low-dose simvastatin that is equivalent to cardiovascular dose in advanced gastric cancer patients.
- Trial name
- NCT01099085
- Testing
- Simvastatin
- Where
- South Korea
- Volunteers
- 207 people
- Sponsor
- Samsung Medical Center
c-MET Positive Gastric Cancer
A Pilot Study of Crizotinib in Patients With c-MET Positive Gastric Adenocarcinoma as a Third-line Chemotherapy
This is a pilot study of crizotinib in patients with c-MET positive gastric adenocarcinoma.
- Trial name
- NCT02435108
- Testing
- crizotinib
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Samsung Medical Center
Pancreatic Cancer
Trial of Simvastatin and Gemcitabine in Pancreatic Cancer Patients
The purpose of this study is to determine whether simvastatin is effective in the treatment of advanced pancreatic cancer patients.
- Trial name
- NCT00944463
- Testing
- Gemcitabine+simvastatin
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Samsung Medical Center
Stage IIIA Non-small Cell Lung Cancer
Adjuvant Pembrolizumab in N2 Positive Non-small Cell Lung Cancer Patients
This is a single arm, single center phase II study of adjuvant pembrolizumab in N2 positive non-small cell lung cancer (NSCLC) patients treated with neoadjuvant concurrent chemoradiotherapy followed by curative resection.
- Trial name
- NCT03053856
- Testing
- Pembrolizumab, Curative resection, Neoadjuvant concurrent chemoradiotherapy
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Samsung Medical Center
Carcinoma, Non-Small-Cell Lung
A Study Comparing Pemetrexed Plus Cisplatin Versus Pemetrexed Alone in NSCLC Patients Who Have Progressed on First Line EGFR-TKI
It has not been established whether platinum-based doublets is better than single agent chemotherapy in EGFR mutant NSCLC patients who failed first-line EGFR TKI.
- Trial name
- NCT03050437
- Testing
- Cisplatin, Pemetrexed
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Samsung Medical Center
Cancer, Anemia
The Efficacy of Intravenous Iron for the Treatment of Anemia in Cancer Patients
Multifactorial pathogenesis is involved in anemia of cancer patients and defining the causes of anemia is not always simple. Currently, treatment options available for anemia in cancer patients include red blood cell (RBC)…
- Trial name
- NCT02599012
- Testing
- Ferinject®
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
ICU Patients
Assessment of Kidney Function for Drug Dosage Adjustments in Critically Ill Patients
The aim of the study is to determine if colistin dosage adjustment using 4hr CrCl contribute to better clinical outcomes compared with drug dosage adjustment using eGFR in critical ill patients.
- Trial name
- NCT03045692
- Testing
- kidney function assessment by 4 hour creatinine clearance, kidney function assessment by creatinine based eGFR
- Volunteers
- 172 people
- Sponsor
- Samsung Medical Center